Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) II beta 180kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.8539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5226 | 0.4634 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0026 | 0.0264 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0026 | 0.0264 | 0.0264 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0056 | 0.6011 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0049 | 0.4579 | 0.2069 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0061 | 0.69 | 0.586 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0061 | 0.69 | 0.6717 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4579 | 0.3908 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0049 | 0.4579 | 0.3908 |
Leishmania major | p450 reductase, putative | 0.0049 | 0.4579 | 0.2069 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0049 | 0.4579 | 0.3908 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0049 | 0.4579 | 0.3908 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.003 | 0.1102 | 0.1102 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0061 | 0.69 | 0.586 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0078 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.8539 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.007 | 0.8539 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0056 | 0.6011 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0049 | 0.4579 | 0.1601 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0049 | 0.4579 | 0.3908 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0049 | 0.4579 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0026 | 0.0264 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0043 | 0.3546 | 0.3371 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0026 | 0.0264 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0056 | 0.6011 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0049 | 0.4579 | 0.4579 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0061 | 0.69 | 0.586 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0024 | 0.0069 | 0.0069 |
Brugia malayi | flavodoxin family protein | 0.0049 | 0.4579 | 0.3908 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1904 | 0.09 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0078 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0078 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0078 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0078 | 1 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0078 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0049 | 0.4579 | 0.4432 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5226 | 0.4634 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.007 | 0.8539 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0074 | 0.9359 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0049 | 0.4579 | 0.3908 |
Leishmania major | DNA topoisomerase ii | 0.007 | 0.8539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1904 | 0.09 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0049 | 0.4579 | 0.4432 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0078 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0042 | 0.3364 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.003 | 0.1102 | 0.2704 |
Brugia malayi | FAD binding domain containing protein | 0.0049 | 0.4579 | 0.3908 |
Brugia malayi | Probable DNA topoisomerase II | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0078 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.93 ug ml-1 | The inhibitory activity of the compound was measured for the supercoiling activity of DNA gyrase isolated from E. coli K-12 C600. | ChEMBL. | 1310116 |
IC50 (binding) | = 0.9300000000000004 ug ml-1 | The inhibitory activity of the compound was measured for the supercoiling activity of DNA gyrase isolated from E. coli K-12 C600. | ChEMBL. | 1310116 |
MIC (functional) | = 0.025 ug ml-1 | In vitro antibacterial activity against staphylococcus aureus FDA 209P JC-1,Sa(F)(gram-positive) | ChEMBL. | 1310116 |
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity against staphylococcus aureus IID 803,(gram-positive) | ChEMBL. | 1310116 |
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity against staphylococcus epidermidis IAM 1296, (gram-positive) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against E. faecalis IID 682,Ec (N),(gram-positive) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against E. coli NIHJ JC-2,(gram-negative) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against E. coli KC-14,Ec(K),(gram-negative) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against klebsiella pneumoniae B54,Kp,(gram-negative) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity of the compound for the supercoiling activity of DNA gyrase isolated from E. coli K-12 C600. | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against E. coli KC-14,Ec(K),(gram-negative) | ChEMBL. | 1310116 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity of the compound for the supercoiling activity of DNA gyrase isolated from E. coli K-12 C600. | ChEMBL. | 1310116 |
MIC (functional) | = 1.56 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445,Pa(I),(gram-negative) | ChEMBL. | 1310116 |
MIC (functional) | = 1.56 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa E-2,Pa(E),(gram-negative) | ChEMBL. | 1310116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.