TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.639 | Formula: C8H13Cl3N2Pt++
H donors: 1 H acceptors: 0 LogP: 3.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC[NH2+]Cc1cccc[n+]1[Pt](Cl)(Cl)Cl
InChi: 1S/C8H12N2.3ClH.Pt/c1-2-9-7-8-5-3-4-6-10-8;;;;/h3-6,9H,2,7H2,1H3;3*1H;/q;;;;+4/p-2
InChiKey: GTSLCXBWIPPUJY-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0469	0.2704
Echinococcus granulosus	tyrosine protein kinase Srms	0.0049	0.0224	0.0152
Schistosoma mansoni	diacylglycerol kinase theta	0.0136	0.1216	0.1151
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0051	0.0244	0.0221
Onchocerca volvulus		0.0049	0.0224	0.025
Brugia malayi	SRC-1	0.0064	0.0395	0.0518
Schistosoma mansoni	tyrosine kinase	0.0064	0.0395	0.0324
Echinococcus granulosus	protein kinase C gamma type	0.0404	0.4274	0.4232
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Echinococcus multilocularis	epidermal growth factor receptor	0.0316	0.3273	0.3223
Schistosoma mansoni	hypothetical protein	0.0163	0.152	0.1458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.01	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0564	0.61	0.7795
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0469	0.0637
Brugia malayi	Pleckstrin Homology Domain	0.0144	0.1312	0.1995
Echinococcus multilocularis	protein kinase c iota type	0.0454	0.4842	0.4804
Schistosoma mansoni	unc-13 (munc13)	0.0149	0.1363	0.1299
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.015	0.1371	0.1679
Brugia malayi	p70 ribosomal S6 kinase beta	0.015	0.1371	0.209
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.007	0.0469	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0907	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0064	0.0395	0.0324
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0175	0.1665	0.1603
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0224	0.0242
Entamoeba histolytica	protein kinase, putative	0.0158	0.1467	0.4719
Schistosoma mansoni	tyrosine kinase	0.0064	0.0395	0.0324
Echinococcus granulosus	Protein kinase C brain isozyme	0.054	0.5824	0.5793
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2504	0.3145
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0172	0.1623	0.1561
Echinococcus multilocularis		0.0094	0.0743	0.0674
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.007	0.0469	0.3199
Entamoeba histolytica	diacylglycerol kinase, putative	0.0136	0.1216	0.3871
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0224	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.015	0.1371	0.1679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.1264	0.1199
Entamoeba histolytica	protein kinase, putative	0.004	0.0121	0.016
Entamoeba histolytica	protein kinase, putative	0.015	0.1371	0.4395
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0064	0.0395	0.0324
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0149	0.1363	0.1299
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0068	0.0442	0.0371
Entamoeba histolytica	protein kinase, putative	0.015	0.1371	0.4395
Echinococcus granulosus	RNA directed DNA polymerase	0.0242	0.2424	0.2368
Echinococcus multilocularis	epidermal growth factor receptor	0.0175	0.1665	0.1603
Echinococcus multilocularis	c src tyrosine kinase	0.0129	0.1133	0.1067
Onchocerca volvulus		0.0149	0.1363	0.2139
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0158	0.1467	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Brugia malayi	protein kinase C II.	0.058	0.6283	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0259	0.2617	0.3291
Echinococcus multilocularis	NCK adaptor protein	0.0051	0.0244	0.0172
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0224	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0305	0.1504
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0064	0.0395	0.0324
Trichomonas vaginalis	AGC family protein kinase	0.015	0.1371	0.9301
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0158	0.1467	0.1802
Echinococcus granulosus	serine:threonine protein kinase N2	0.0286	0.293	0.2878
Echinococcus multilocularis	N chimaerin	0.0172	0.1623	0.1561
Schistosoma mansoni	tyrosine kinase	0.0064	0.0395	0.0324
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0136	0.1216	0.1479
Echinococcus granulosus	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Onchocerca volvulus		0.0049	0.0224	0.025
Echinococcus multilocularis	insulin receptor	0.0109	0.0908	0.0841
Loa Loa (eye worm)	TK/ABL protein kinase	0.0049	0.0224	0.0195
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Giardia lamblia	GTOR	0.007	0.0469	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0188	0.0646
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.015	0.1371	0.1679
Echinococcus granulosus	protein kinase c epsilon type	0.058	0.6283	0.6256
Schistosoma mansoni	protein kinase C mu	0.0136	0.1216	0.1151
Echinococcus granulosus	protein kinase c eta type	0.0136	0.1216	0.1151
Schistosoma mansoni	protein kinase C	0.0149	0.1363	0.1299
Schistosoma mansoni	rac gtpase activating protein	0.0136	0.1216	0.1151
Echinococcus granulosus	epidermal growth factor receptor	0.0175	0.1665	0.1603
Brugia malayi	Variant SH3 domain containing protein	0.0051	0.0244	0.0276
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0049	0.0224	0.0152
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0714	0.7804	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.054	0.5824	0.5793
Loa Loa (eye worm)	raf kinase	0.0136	0.1216	0.1479
Brugia malayi	protein kinase C3,putative	0.0309	0.3185	0.5011
Loa Loa (eye worm)	hypothetical protein	0.0564	0.61	0.7795
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.007	0.0469	0.0399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0469	0.2704
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0136	0.1216	0.1151
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0224	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0305	0.1504
Echinococcus granulosus	geminin	0.0163	0.152	0.1458
Brugia malayi	Protein kinase domain containing protein	0.015	0.1371	0.209
Schistosoma mansoni	tyrosine kinase	0.0175	0.1665	0.1603
Brugia malayi	hypothetical protein	0.0049	0.0224	0.0242
Schistosoma mansoni	serine/threonine protein kinase	0.054	0.5824	0.5793
Entamoeba histolytica	hypothetical protein	0.0136	0.1216	0.3871
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0224	0.0242
Brugia malayi	Furin-like cysteine rich region family protein	0.0316	0.3273	0.5153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Schistosoma mansoni	vav2	0.018	0.1718	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0064	0.0395	0.0324
Echinococcus granulosus	NDR protein kinase	0.015	0.1371	0.1307
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.01	0.0005
Echinococcus multilocularis	serine threonine protein kinase	0.0404	0.4274	0.4232
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0469	0.0512
Schistosoma mansoni	protein kinase C mu	0.0389	0.4101	0.4057
Echinococcus granulosus	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Loa Loa (eye worm)	TK/CSK protein kinase	0.0078	0.0555	0.0624
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0136	0.1216	0.1479
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0051	0.0244	0.0172
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0051	0.0244	0.0221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0141	0.0308
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0051	0.0244	0.0172
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0064	0.0395	0.0324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0146	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Schistosoma mansoni	tyrosine kinase	0.0109	0.0908	0.0841
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0316	0.3273	0.4139
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0064	0.0395	0.0324
Schistosoma mansoni	tyrosine kinase	0.0316	0.3273	0.3223
Echinococcus granulosus	unc 13 munc13	0.0149	0.1363	0.1299
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0049	0.0224	0.0152
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.1371	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2504	0.3145
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0064	0.0395	0.0324
Toxoplasma gondii	AGC kinase	0.015	0.1371	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Echinococcus multilocularis	serine:threonine protein kinase N2	0.015	0.1371	0.1307
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0064	0.0395	0.0324
Echinococcus granulosus	tyrosine kinase	0.0049	0.0224	0.0152
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Echinococcus multilocularis	geminin	0.0163	0.152	0.1458
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.007	0.0469	0.3199
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0172	0.1623	0.1561
Echinococcus multilocularis	myotubularin protein 13	0.0144	0.1312	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1312	0.1602
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0057	0.0315	0.0313
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.007	0.0469	0.1341
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.1371	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0141	0.0308
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0064	0.0395	0.0324
Schistosoma mansoni	nck2/grb4	0.0051	0.0244	0.0172
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.015	0.1371	0.1679
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0253	0.2551	0.3206
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.007	0.0469	1
Loa Loa (eye worm)	SRC-1	0.0064	0.0395	0.0416
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0242	0.2424	0.2368
Onchocerca volvulus		0.0049	0.0224	0.025
Brugia malayi	Protein kinase c protein 2	0.0395	0.4167	0.6592
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0109	0.0908	0.0841
Schistosoma mansoni	tyrosine kinase	0.0162	0.1514	0.1452
Schistosoma mansoni	serine/threonine protein kinase	0.058	0.6283	0.6256
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0172	0.1623	0.1561
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.007	0.0469	1
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0136	0.1216	0.1151
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0305	0.1504
Onchocerca volvulus		0.0249	0.2504	0.4034
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Brugia malayi	diacylglycerol kinase	0.0136	0.1216	0.1841
Onchocerca volvulus		0.0049	0.0224	0.025
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.007	0.0469	1
Echinococcus granulosus	protein kinase c iota type	0.0454	0.4842	0.4804
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.058	0.6283	0.8033
Schistosoma mansoni	adapter molecule crk	0.0051	0.0244	0.0172
Schistosoma mansoni	tyrosine kinase	0.0175	0.1665	0.1603
Loa Loa (eye worm)	AGC/PKN protein kinase	0.015	0.1371	0.1679
Echinococcus multilocularis	tyrosine kinase	0.0049	0.0224	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1216	0.1479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0469	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0564	0.61	0.7795
Trichomonas vaginalis	AGC family protein kinase	0.015	0.1371	0.9301
Brugia malayi	Protein kinase domain containing protein	0.0109	0.0908	0.1344
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.1264	0.1199
Echinococcus granulosus	Rac GTPase activating protein 1	0.0136	0.1216	0.1151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.006	0.0352	0.1846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.01	0.0005
Brugia malayi	Variant SH3 domain containing protein	0.0172	0.1623	0.2495
Entamoeba histolytica	diacylglycerol kinase, putative	0.0136	0.1216	0.3871
Toxoplasma gondii	diacylglycerol kinase, putative	0.0136	0.1216	0.8603
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0049	0.0224	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0136	0.1216	0.1479
Brugia malayi	Protein kinase domain containing protein	0.0158	0.1467	0.2244
Onchocerca volvulus		0.0114	0.0962	0.1474
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.007	0.0469	0.1341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Schistosoma mansoni	diacylglycerol kinase theta	0.0136	0.1216	0.1151
Brugia malayi	Protein kinase domain containing protein	0.015	0.1371	0.209
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.015	0.1371	0.1307
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0378	0.3973	0.5045
Brugia malayi	Tyrosine-protein kinase abl-1	0.0064	0.0395	0.0518
Brugia malayi	Protein kinase domain containing protein	0.014	0.1264	0.1917
Echinococcus granulosus	epidermal growth factor receptor	0.0316	0.3273	0.3223
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0305	0.1504
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0778	0.8537	0.8526
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0064	0.0395	0.0324
Echinococcus granulosus	tyrosine kinase	0.0049	0.0224	0.0152
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.015	0.1371	0.1307
Loa Loa (eye worm)	AGC/NDR protein kinase	0.015	0.1371	0.1679
Brugia malayi	Sex muscle abnormal protein 5	0.0051	0.0244	0.0276
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0295	0.3026	1
Echinococcus granulosus	N chimaerin	0.0172	0.1623	0.1561
Schistosoma mansoni	growth factor receptor-bound protein	0.0051	0.0244	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0051	0.0244	0.0172
Brugia malayi	SH2 domain containing protein	0.0049	0.0224	0.0242
Echinococcus multilocularis	RNA directed DNA polymerase	0.0242	0.2424	0.2368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0146	0.0343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.01	0.0005
Schistosoma mansoni	unc-13 (munc13)	0.0149	0.1363	0.1299
Brugia malayi	C1-like domain containing protein	0.0389	0.4101	0.6486
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0389	0.4101	0.521
Echinococcus granulosus	tyrosine protein kinase Blk	0.0049	0.0224	0.0152
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.1367	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1363	0.1668
Echinococcus multilocularis	unc 13 (munc13)	0.0149	0.1363	0.1299
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0049	0.0224	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0244	0.0221
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0172	0.1623	0.2004
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Trichomonas vaginalis	AGC family protein kinase	0.0158	0.1467	1
Entamoeba histolytica	protein kinase, putative	0.0158	0.1467	0.4719
Onchocerca volvulus		0.0049	0.0224	0.025
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0321	0.3326	0.4208
Loa Loa (eye worm)	hypothetical protein	0.0385	0.4054	0.5149
Echinococcus granulosus	raf serine:threonine protein kinase	0.0149	0.1367	0.1303
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0064	0.0395	0.0324
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.015	0.1371	0.1307
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Brugia malayi	RhoGAP domain containing protein	0.0172	0.1623	0.2495
Brugia malayi	SH2 domain containing protein	0.0114	0.0962	0.1431
Schistosoma mansoni	hypothetical protein	0.0136	0.1216	0.1151
Schistosoma mansoni	tyrosine kinase	0.0871	0.9593	0.959
Schistosoma mansoni	tyrosine kinase	0.0129	0.1133	0.1067
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0149	0.1363	0.1299
Echinococcus multilocularis	serine:threonine protein kinase 38	0.015	0.1371	0.1307
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0109	0.0908	0.0841
Brugia malayi	RhoGEF domain containing protein	0.0136	0.1216	0.1841
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0224	0.0242
Echinococcus granulosus	insulin receptor	0.0109	0.0908	0.0841
Echinococcus granulosus	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Schistosoma mansoni	tyrosine kinase	0.0162	0.1514	0.1452
Loa Loa (eye worm)	hypothetical protein	0.07	0.7649	0.98
Echinococcus multilocularis	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.014	0.1264	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0242	0.2424	0.304
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.007	0.0469	0.0399
Onchocerca volvulus		0.0564	0.61	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0169	0.0124
Echinococcus multilocularis	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0205	0.0772
Echinococcus granulosus	Diacylglycerol kinase theta	0.0136	0.1216	0.1151
Schistosoma mansoni	tyrosine kinase	0.0162	0.1514	0.1452
Echinococcus multilocularis	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Onchocerca volvulus		0.0393	0.4149	0.6764
Echinococcus multilocularis	protein kinase c epsilon type	0.058	0.6283	0.6256
Brugia malayi	diacylglycerol kinase	0.0136	0.1216	0.1841
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0432	0.4587	0.4547
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0064	0.0395	0.0324
Echinococcus multilocularis	protein kinase c eta type	0.0136	0.1216	0.1151
Brugia malayi	RhoGAP domain containing protein	0.0136	0.1216	0.1841
Brugia malayi	Variant SH3 domain containing protein	0.0051	0.0244	0.0276
Brugia malayi	protein-tyrosine kinase	0.0049	0.0224	0.0242
Brugia malayi	Hr1 repeat family protein	0.015	0.1371	0.209
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.1371	0.1307
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.015	0.1371	0.1307
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.004	0.0121	0.016
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0224	0.0242
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0064	0.0395	0.0324
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.0395	0.0324
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0049	0.0224	0.0509
Schistosoma mansoni	atypical protein kinase C	0.0466	0.4983	0.4946
Echinococcus multilocularis	tyrosine protein kinase csk	0.0078	0.0555	0.0486
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.015	0.1371	0.1307
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.015	0.1371	0.1307
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0389	0.4101	0.6486
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0149	0.1367	0.1303
Schistosoma mansoni	serine/threonine protein kinase	0.054	0.5824	0.5793
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0146	0.0343
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0056	0.0306	0.2084
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0033	0.0046	0.0315
Brugia malayi	Variant SH3 domain containing protein	0.0057	0.0315	0.039
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.007	0.0469	0.0399
Schistosoma mansoni	tyrosine kinase	0.0907	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.1371	0.1307
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.014	0.1264	0.1199
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0049	0.0224	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0305	0.1504
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.015	0.1371	0.1307
Schistosoma mansoni	tyrosine kinase	0.0049	0.0224	0.0152
Loa Loa (eye worm)	SH2 domain-containing protein	0.01	0.0811	0.0955
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0145	0.1324	0.8955
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0049	0.0224	0.0152
Onchocerca volvulus		0.0385	0.4054	0.6605
Echinococcus granulosus	c src tyrosine kinase	0.0129	0.1133	0.1067
Schistosoma mansoni	serine/threonine kinase	0.015	0.1371	0.1307
Loa Loa (eye worm)	TK/INSR protein kinase	0.0109	0.0908	0.108
Echinococcus granulosus	growth factor receptor bound protein 2	0.0051	0.0244	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0393	0.4149	0.5273
Schistosoma mansoni	tyrosine kinase	0.0109	0.0908	0.0841
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0224	0.0195
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0064	0.0395	0.0324
Echinococcus granulosus	NCK adaptor protein	0.0051	0.0244	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0224	0.0195
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0172	0.1623	0.1561
Schistosoma mansoni	hypothetical protein	0.0163	0.152	0.1458
Echinococcus granulosus	myotubularin protein 13	0.0144	0.1312	0.1248
Brugia malayi	Ras association domain family 1 isoform A	0.0136	0.1216	0.1841
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0049	0.0224	0.0152
Trichomonas vaginalis	AGC family protein kinase	0.015	0.1371	0.9301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0263	0.1201

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	> 10 ug ml-1	In vitro inhibition of L1210 leukemia cells growth.	ChEMBL.	7120284
ID50 (functional)	> 10 ug ml-1	In vitro inhibition of PDD resistant subline L1210/PDD growth.	ChEMBL.	7120284
T/C (functional)	= 119 %	Activity against L1210 leukemia cells was measured as treated by control on ip administration of 2.5 mg/kg in mice	ChEMBL.	7120284
T/C (functional)	= 122 %	Activity against L1210 leukemia cells was measured as treated by control on ip administration of 5 mg/kg in mice	ChEMBL.	7120284
T/C (functional)	= 139 %	Activity against L1210 leukemia cells was measured as treated by control on ip administration of 10 mg/kg in mice	ChEMBL.	7120284
T/C (functional)	= 140 %	Activity against L1210 leukemia cells was measured as treated by control on ip administration of 20 mg/kg in mice	ChEMBL.	7120284
T/C (functional)	= 148 %	Activity against L1210 leukemia cells was measured as treated by control on ip administration of 40 mg/kg in mice	ChEMBL.	7120284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 393316

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 308487