Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0411 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0411 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0411 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0411 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0411 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.77 uM | Inhibitory activity of the compound against chymotrypsin-like active site (beta5 subunit) in proteasome from lymphoblastoid cell line | ChEMBL. | 15050638 |
IC50 (binding) | = 4.55 uM | Inhibitory activity of the compound against trypsin like active site (beta2 subunit) in proteasome from lymphoblastoid cell line | ChEMBL. | 15050638 |
IC50 (binding) | > 20 uM | Inhibitory activity of the compound against post-acidic like active site (beta1 subunit) in proteasome from lymphoblastoid cell line | ChEMBL. | 15050638 |
T1/2 (ADMET) | > 360 min | Half life of the compound in culture medium(RPMI) | ChEMBL. | 15050638 |
T1/2 (ADMET) | > 360 min | Half life of the compound in human plasma | ChEMBL. | 15050638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.