Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0032 | 0 | 0.5 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0668 | 0.4992 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.026 | 0.1789 | 0.3389 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0051 | 0.0147 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0051 | 0.0147 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0051 | 0.0147 | 0.0147 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0051 | 0.0147 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0408 | 0.2951 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trichomonas vaginalis | sulfite reductase, putative | 0.0051 | 0.0147 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0408 | 0.2951 | 0.5787 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0444 | 0.3235 | 0.3235 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.0444 | 0.3235 | 0.3235 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0051 | 0.0147 | 0.0147 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0051 | 0.0147 | 0.0147 |
Trypanosoma cruzi | p450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.1305 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0051 | 0.0147 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0051 | 0.0147 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0147 | 0.0454 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0408 | 0.2951 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0051 | 0.0147 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1305 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0444 | 0.3235 | 0.3235 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0668 | 0.4992 | 1 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.026 | 0.1789 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0668 | 0.4992 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0668 | 0.4992 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0051 | 0.0147 | 0.0147 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0051 | 0.0147 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.3235 | 1 |
Giardia lamblia | Hypothetical protein | 0.0045 | 0.0101 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0051 | 0.0147 | 1 |
Brugia malayi | flavodoxin family protein | 0.0051 | 0.0147 | 1 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0408 | 0.2951 | 0.3627 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0051 | 0.0147 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0444 | 0.3235 | 0.3235 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.026 | 0.1789 | 0.1789 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.026 | 0.1789 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0045 | 0.0101 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0051 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.3235 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Active/total cultures (functional) | = 43 % | Total cultures(14) versus active (6) at 10e-10 M conc. in hamster tracheal organ culture assay (TOC) | ChEMBL. | 6887203 |
Active/total cultures (functional) | = 71 % | Total cultures(14) versus active (10) at 10e-9 M conc. in hamster tracheal organ culture assay (TOC) | ChEMBL. | 6887203 |
Active/total cultures (functional) | = 100 % | Total cultures(13) versus active (13) at 10e-8 M conc. in hamster tracheal organ culture assay (TOC) | ChEMBL. | 6887203 |
ED50 (functional) | = 0.00000000002 M | ED50 of retinoid required to effect reversal of keratinization | ChEMBL. | 6887203 |
inhibition of control (functional) | = 67 % | Percent inhibition of the induction of ornithine decarboxylase at 1.7 nmol in mouse dorsal epidermis (ODC assay) | ChEMBL. | 6887203 |
inhibition of control (functional) | = 67 % | Percent inhibition of the induction of ornithine decarboxylase at 1.7 nmol in mouse dorsal epidermis (ODC assay) | ChEMBL. | 6887203 |
inhibition of control (functional) | = 77 % | Percent inhibition of the induction of ornithine decarboxylase at 17 nmol dose in mouse dorsal epidermis (ODC assay) | ChEMBL. | 6887203 |
inhibition of control (functional) | = 77 % | Percent inhibition of the induction of ornithine decarboxylase at 17 nmol dose in mouse dorsal epidermis (ODC assay) | ChEMBL. | 6887203 |
Relative activity (functional) | = 3 | Relative potency with respect to retinoic acid in hamster tracheal organ culture assay (TOC) | ChEMBL. | 6887203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.