Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1116 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0691 | 0.5847 | 0.5847 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0691 | 0.5847 | 0.5847 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1116 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0691 | 0.5847 | 0.5847 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1116 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1116 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1116 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1116 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1116 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1116 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1116 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1116 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1116 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0691 | 0.5847 | 0.5847 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1116 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1116 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1116 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0092 | 0 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1116 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1116 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1116 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1116 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.035 | 0.2524 | 0.2524 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = -25 % | Inhibition of human Prostaglandin G/H synthase 1 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = -25 % | Inhibition of human Prostaglandin G/H synthase 1 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 10 % | Inhibition of human Prostaglandin G/H synthase 2 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 10 % | Inhibition of human Prostaglandin G/H synthase 2 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 11 % | Inhibition of human Prostaglandin G/H synthase 1 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 11 % | Inhibition of human Prostaglandin G/H synthase 1 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 16 % | Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 16 % | Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 20 % | Inhibition of human Prostaglandin G/H synthase 2 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 20 % | Inhibition of human Prostaglandin G/H synthase 2 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 28 % | Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Inhibition (binding) | = 28 % | Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production | ChEMBL. | 9083488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.