Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.5171 | 0.7682 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1162 | 0.0984 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.1241 | 0.1065 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0101 | 0.5025 | 0.4925 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1861 | 0.2545 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2192 | 0.3053 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0032 | 0.0841 | 0.0656 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.5025 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.1241 | 0.1065 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1286 | 0.1111 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.1241 | 0.1598 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0066 | 0.2914 | 0.5626 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.5025 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0033 | 0.0896 | 0.1448 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0032 | 0.0841 | 0.0656 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1286 | 0.1111 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0032 | 0.0841 | 0.0656 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1286 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0101 | 0.5025 | 0.7389 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1286 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.0799 |
Leishmania major | DNA polymerase eta, putative | 0.0049 | 0.1861 | 0.3445 |
Echinococcus granulosus | peregrin | 0.0032 | 0.0841 | 0.0656 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.011 | 0.5567 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2192 | 0.3053 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.2868 | 0.4086 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1286 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0049 | 0.1861 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1286 | 0.1111 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.1586 | 0.1417 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.1241 | 0.1065 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.6732 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0992 | 0.1645 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0841 | 0.0656 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0049 | 0.1861 | 0.2764 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1286 | 0.1911 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0.0841 | 0.1198 |
Schistosoma mansoni | jumonji domain containing protein | 0.0082 | 0.389 | 0.3767 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.011 | 0.5567 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 0.1861 | 0.3445 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.1241 | 0.1844 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2192 | 0.3256 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0841 | 0.0985 |
Echinococcus multilocularis | dna polymerase eta | 0.0049 | 0.1861 | 0.1697 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 0.5171 | 0.5074 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.0992 | 0.082 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0841 | 0.0517 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0841 | 0.0517 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5025 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 0.5171 | 0.5074 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.011 | 0.5567 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 1 | 1 |
Echinococcus multilocularis | peregrin | 0.0032 | 0.0841 | 0.0656 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.0841 | 0.1249 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2192 | 0.3256 |
Schistosoma mansoni | DNA polymerase eta | 0.0049 | 0.1861 | 0.1697 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.1586 | 0.1417 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5025 | 0.4925 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5025 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5025 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0035 | 0.1049 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1162 | 0.1477 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0992 | 0.1645 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0032 | 0.0841 | 0.0985 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0583 | 0.0799 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0198 | 0.0293 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0034 | 0.0955 | 0.1569 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0101 | 0.5025 | 0.7465 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0066 | 0.2914 | 0.4676 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.011 | 0.5567 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.011 | 0.5567 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.6732 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.011 | 0.5567 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.6732 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.1241 | 0.1065 |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0.0841 | 0.0517 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0101 | 0.5025 | 0.4925 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0049 | 0.1861 | 0.3445 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0841 | 0.0517 |
Onchocerca volvulus | Alhambra homolog | 0.0032 | 0.0841 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.0799 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1286 | 0.1111 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1162 | 0.1727 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.011 | 0.5567 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1286 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0583 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0583 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2201 | 0.3066 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.0841 | 0.1249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logD | = 1.58 | Compound was evaluated for apparent partition coefficient (log P) between octanol and 0.05 M phosphate buffer solution of pH 7.40 | ChEMBL. | 4020836 |
T1/2 (ADMET) | = 820 min | Half life of cyclization to pilocarpine at pH 7.40 and 37 degrees centigrade tempareture | ChEMBL. | 4020836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.