Detailed information for compound 309329

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.895 | Formula: C21H27ClNO6-
  • H donors: 3 H acceptors: 3 LogP: 3.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCc2c(C1Cc1cc(OC)c(c(c1)OC)OC)cc(c(c2)O)O.[Cl-]
  • InChi: 1S/C21H27NO6.ClH/c1-26-19-9-13(10-20(27-2)21(19)28-3)8-16-15-12-18(25)17(24)11-14(15)4-5-22(16)6-7-23;/h9-12,16,23-25H,4-8H2,1-3H3;1H/p-1
  • InChiKey: QHVFGSQIOAZSJU-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Brugia malayi hypothetical protein 0.0248 0.0365 0.0387
Schistosoma mansoni zinc finger protein 0.0311 0.0468 0.0474
Echinococcus granulosus FTZ F1 alpha 0.0659 0.1039 0.106
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.5493 0.8957 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0128 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0659 0.1039 0.1128
Echinococcus granulosus RUN 0.0062 0.0061 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0659 0.1039 0.1101
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0052 0.0023
Schistosoma mansoni hypothetical protein 0.0051 0.0042 0.0026
Brugia malayi ecdysone receptor 0.0311 0.0468 0.0497
Onchocerca volvulus Protein ultraspiracle homolog 0.0659 0.1039 0.1039
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0131 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0659 0.1039 0.1073
Brugia malayi Nuclear hormone receptor-like 1 0.0659 0.1039 0.1101
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0061 0.0033
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0282 0.028
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0348 0.0529 0.0558
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0 0.5
Schistosoma mansoni survival motor neuron protein 0.0051 0.0042 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0659 0.1039 0.1101
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0061 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0659 0.1039 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0032 0.5
Brugia malayi nuclear receptor NHR-67 0.0311 0.0468 0.0497
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0061 0.0065
Brugia malayi hypothetical protein 0.0062 0.0061 0.0065
Echinococcus multilocularis ecdysone induced protein 78C 0.0659 0.1039 0.1128
Mycobacterium ulcerans hypothetical protein 0.0025 0 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0061 0.0033
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0041 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0128 0.0136
Schistosoma mansoni coup transcription factor 0.0659 0.1039 0.1073
Schistosoma mansoni polycystin 1-related 0.0062 0.0061 0.0046
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Loa Loa (eye worm) hypothetical protein 0.005 0.0041 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0659 0.1039 0.1073
Loa Loa (eye worm) steroid hormone receptor 0.0659 0.1039 0.1101
Brugia malayi mbt repeat family protein 0.005 0.0041 0.0044
Loa Loa (eye worm) nuclear receptor NHR-67 0.0311 0.0468 0.0497
Brugia malayi Nuclear hormone receptor E75 0.0311 0.0468 0.0497
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Brugia malayi hypothetical protein 0.0348 0.0529 0.0561
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0311 0.0468 0.046
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0032 0.0034
Brugia malayi hypothetical protein 0.0311 0.0468 0.0497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0019
Loa Loa (eye worm) DR-78 0.0311 0.0468 0.0497
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0052 0.0022
Brugia malayi nuclear hormone receptor 0.0659 0.1039 0.1101
Brugia malayi CHE-14 protein 0.0044 0.0032 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0061 0.0031
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0365 0.0373
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0175 0.0245 0.0239
Onchocerca volvulus 0.005 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0048
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0041 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0659 0.1039 0.1073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0659 0.1039 0.1128
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0659 0.1039 0.106
Loa Loa (eye worm) nuclear hormone receptor 0.0311 0.0468 0.0497
Onchocerca volvulus 0.0311 0.0468 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0659 0.1039 0.1101
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0061 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0311 0.0468 0.0474
Echinococcus granulosus retinoic acid receptor rxr beta a 0.5841 0.9527 1
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0041 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.0659 0.1039 0.1039
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0052 0.0023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0348 0.0529 0.0538
Schistosoma mansoni hypothetical protein 0.0043 0.0029 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0348 0.0529 0.0561
Onchocerca volvulus 0.0659 0.1039 0.1039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0659 0.1039 0.106
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0061 0.0046
Loa Loa (eye worm) hypothetical protein 0.0057 0.0052 0.0056
Schistosoma mansoni nuclear receptor nhr-48 0.0311 0.0468 0.0474
Brugia malayi nuclear hormone receptor family member odr-7 0.0311 0.0468 0.0497
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0348 0.0529 0.0561
Brugia malayi orphan nuclear receptor NR2E1 0.0311 0.0468 0.0497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Schistosoma mansoni nuclear receptor 0.0311 0.0468 0.0474
Echinococcus multilocularis protein dispatched 1 0.0051 0.0042 0.0011
Brugia malayi nuclear hormone receptor family member nhr-6 0.0311 0.0468 0.0497
Brugia malayi ecdysteroid receptor 0.0659 0.1039 0.1101
Brugia malayi photoreceptor-specific nuclear receptor 0.0659 0.1039 0.1101
Loa Loa (eye worm) RNA binding protein 0.0062 0.0061 0.0065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0311 0.0468 0.0474
Loa Loa (eye worm) hypothetical protein 0.0348 0.0529 0.0561
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0659 0.1039 0.106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0659 0.1039 0.1101
Echinococcus granulosus thyroid hormone receptor alpha 0.0311 0.0468 0.046
Loa Loa (eye worm) hypothetical protein 0.0348 0.0529 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0659 0.1039 0.1101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0659 0.1039 0.1101
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0041 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0 0.5
Brugia malayi mbt repeat family protein 0.005 0.0041 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0061 0.0046
Brugia malayi tailless protein 0.0311 0.0468 0.0497
Brugia malayi hypothetical protein 0.0062 0.0061 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0311 0.0468 0.046
Echinococcus multilocularis FTZ F1 alpha 0.0659 0.1039 0.1128
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0201 0.0189
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0175 0.0245 0.0225
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0052 0.0056
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0348 0.0529 0.0561
Loa Loa (eye worm) hypothetical protein 0.0348 0.0529 0.0561
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0659 0.1039 0.1128
Schistosoma mansoni nuclear hormone receptor 0.0311 0.0468 0.0474
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0311 0.0468 0.0489
Schistosoma mansoni thyroid hormone receptor 0.0659 0.1039 0.1073
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0311 0.0468 0.0489
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0041 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0032 0.0034
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0348 0.0529 0.0524
Brugia malayi conserved hypotetical protein 0.0311 0.0468 0.0497
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0659 0.1039 0.106
Schistosoma mansoni hypothetical protein 0.0062 0.0061 0.0046
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0061 0.0033
Loa Loa (eye worm) nuclear receptor nhr-7B 0.5782 0.943 1
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0061 0.5
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0061 0.5
Schistosoma mansoni rab6-interacting 0.0062 0.0061 0.0046
Onchocerca volvulus 0.0062 0.0061 0.0061
Schistosoma mansoni lipoxygenase 0.0062 0.0061 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0659 0.1039 0.1101
Brugia malayi TAR-binding protein 0.0062 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.5471 0.8921 0.946
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0041 0.001
Brugia malayi nuclear receptor NHR-88 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0061 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0659 0.1039 0.1101
Echinococcus granulosus tar DNA binding protein 0.0062 0.0061 0.0031
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0128 0.0102
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0041 0.0041
Echinococcus multilocularis thyroid hormone receptor alpha 0.0659 0.1039 0.1128
Loa Loa (eye worm) hypothetical protein 0.0103 0.0128 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0659 0.1039 0.1101
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0061 0.0065
Schistosoma mansoni steroid hormone receptor ad4bp 0.0659 0.1039 0.1073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0659 0.1039 0.106
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0128 0.0108
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0282 0.0263
Echinococcus granulosus Nuclear hormone receptor HR96 0.0311 0.0468 0.046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0311 0.0468 0.0468
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0311 0.0468 0.0497
Schistosoma mansoni hypothetical protein 0.0043 0.0029 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Onchocerca volvulus 0.0311 0.0468 0.0468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0311 0.0468 0.0489
Schistosoma mansoni nuclear hormone receptor 0.0659 0.1039 0.1073
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0061 0.0031
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0659 0.1039 0.1128
Schistosoma mansoni hypothetical protein 0.0043 0.0029 0.0012
Brugia malayi nuclear receptor NHR-88 0.0311 0.0468 0.0497
Schistosoma mansoni retinoic acid receptor RXR 0.5841 0.9527 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0052 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0659 0.1039 0.106
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Schistosoma mansoni rab6-interacting 0.0062 0.0061 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0311 0.0468 0.0489
Brugia malayi hypothetical protein 0.0311 0.0468 0.0497
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0065
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0041 0.0025
Schistosoma mansoni loxhd1 0.0062 0.0061 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0061 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0659 0.1039 0.1073
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0311 0.0468 0.0474
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0659 0.1039 0.1128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0659 0.1039 0.1101
Onchocerca volvulus 0.0051 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0311 0.0468 0.0468
Loa Loa (eye worm) MBCTL1 0.0057 0.0052 0.0056
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0061 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0659 0.1039 0.1073
Schistosoma mansoni RAR-like nuclear receptor 0.0659 0.1039 0.1073
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0045 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0061 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0659 0.1039 0.1101
Echinococcus granulosus ecdysone induced protein 78C 0.0659 0.1039 0.106
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0348 0.0529 0.0561
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0201 0.0178
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0052 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0248 0.0365 0.0387
Echinococcus multilocularis expressed conserved protein 0.0097 0.0118 0.0097
Loa Loa (eye worm) hypothetical protein 0.0659 0.1039 0.1101
Brugia malayi steroid hormone receptor 0.0659 0.1039 0.1101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0849 0.1351 0.1478
Onchocerca volvulus 0.0062 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0054 0.0048 0.0051
Echinococcus granulosus nuclear receptor nhr 48 0.0311 0.0468 0.046
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0365 0.0351
Schistosoma mansoni hypothetical protein 0.0043 0.0029 0.0012
Brugia malayi RNA binding protein 0.0062 0.0061 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0659 0.1039 0.1101
Brugia malayi Nuclear hormone receptor E75 0.0311 0.0468 0.0497
Echinococcus multilocularis nuclear receptor nhr 48 0.0311 0.0468 0.0489
Echinococcus granulosus expressed conserved protein 0.0097 0.0118 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0659 0.1039 0.1101
Echinococcus multilocularis RUN 0.0062 0.0061 0.0033
Brugia malayi Doublecortin family protein 0.0062 0.0061 0.0065
Schistosoma mansoni hypothetical protein 0.0304 0.0457 0.0462
Brugia malayi nuclear receptor RXR 0.0348 0.0529 0.0561
Schistosoma mansoni lipoxygenase 0.0175 0.0245 0.0239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0311 0.0468 0.046
Brugia malayi hypothetical protein 0.0348 0.0529 0.0561
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0061 0.0065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0659 0.1039 0.1101
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0 0.5
Brugia malayi nuclear receptor RXR 0.0311 0.0468 0.0497
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0659 0.1039 0.1073
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0041 0.001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0042 0.0045
Brugia malayi nuclear hormone receptor 0.5782 0.943 1
Schistosoma mansoni patched 1 0.0044 0.0032 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0348 0.0529 0.0561
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0348 0.0529 0.0538
Loa Loa (eye worm) hypothetical protein 0.0311 0.0468 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0659 0.1039 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0659 0.1039 0.1101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0 0.5
Schistosoma mansoni nuclear receptor 0.0311 0.0468 0.0474
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0659 0.1039 0.1073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0659 0.1039 0.1101

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 71.6 uM Compound was evaluated for the inhibition of U-46,619-induced human platelet aggregation (Antiaggregatory activity) ChEMBL. 2875182
IC50 (functional) = 116.2 uM Compound was evaluated for the secretion of [14C]- Serotonin (Antisecretory activity) ChEMBL. 2875182
pD2 (binding) = 5.35 Compound was evaluated for beta-1 adrenergic receptor activity in spontaneously beating guinea pig right atria. ChEMBL. 2875182
pD2 (binding) = 5.73 Compound was evaluated for beta-2 adrenergic receptor activity on carbachol-contracted guinea pig tracheal strips ChEMBL. 2875182

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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