Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | <= 1 | Relative CNS activity of compound was measured in mice; (-) = 1 | ChEMBL. | 6106063 |
CAR (functional) | 0 | Conditioned avoidance response (CAR) was measured in rats at 5 mg/kg doses; I = inactive | ChEMBL. | 6106063 |
CAR (functional) | 0 | Conditioned avoidance response (CAR) was measured in rats at 20 mg/kg doses; I = inactive | ChEMBL. | 6106063 |
IC50 (binding) | = 0.00000075 M | Inhibition of [3H]-haloperidol binding to Dopamine receptor in calf caudate nuclei. | ChEMBL. | 6106063 |
IC50 (binding) | > 0.0001 M | Inhibition of [3H]-dopamine binding to Dopamine receptor in calf caudate nuclei. | ChEMBL. | 6106063 |
LD50 (ADMET) | = 146 mg kg-1 | Lethal dose was measured in mice 0.5 h post intraperitoneal administration | ChEMBL. | 6106063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.