Detailed information for compound 309361

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 608.728 | Formula: C32H44N6O6
  • H donors: 7 H acceptors: 6 LogP: 0.53 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H](C(=O)N[C@@H](CC(=O)N)/C=C/[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCc1ccccc1)C)Cc1ccccc1)C(C)C)N
  • InChi: 1S/C32H44N6O6/c1-20(2)25(15-14-24(17-28(34)40)37-31(43)26(33)19-39)30(42)38-27(16-22-10-6-4-7-11-22)32(44)36-21(3)29(41)35-18-23-12-8-5-9-13-23/h4-15,20-21,24-27,39H,16-19,33H2,1-3H3,(H2,34,40)(H,35,41)(H,36,44)(H,37,43)(H,38,42)/b15-14+/t21-,24+,25-,26-,27-/m0/s1
  • InChiKey: DMZGTBIECRSWTE-WYKMQVQCSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi 26S protease regulatory subunit 6A 0.0023 0.0019 0.0019
Brugia malayi proteasome subunit alpha type 1 0.0205 0.1866 0.1866
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0041 0.0209 0.0225
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0194 0.0194
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0128 0.0128
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0218 0.2004 0.216
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0197 0.1792 0.1932
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0052 0.0317 0.0342
Loa Loa (eye worm) hypothetical protein 0.0067 0.0466 0.0502
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0218 0.2004 0.216
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.018 0.0194
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0128 0.0128
Brugia malayi Proteasome subunit alpha type 1 0.0188 0.1693 0.1693
Leishmania major hypothetical protein, conserved 0.0052 0.0317 0.0342
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0253 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0041 0.0209 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0143 0.0155
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188 0.17 0.1832
Brugia malayi Trypsin family protein 0.004 0.0194 0.0194
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0046 0.0253 0.0273
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0257 0.2399 0.2399
Loa Loa (eye worm) proteasome subunit beta type 1 0.0228 0.2105 0.2269
Loa Loa (eye worm) hypothetical protein 0.01 0.0801 0.0863
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0171 0.1526 0.1645
Toxoplasma gondii PCI domain-containing protein 0.0038 0.018 0.0194
Echinococcus multilocularis proteasome subunit beta type 7 0.1007 1 1
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Plasmodium vivax proteasome subunit beta type-4, putative 0.0197 0.1792 0.1932
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0019 0.002
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0032 0.0113 0.0113
Echinococcus granulosus nuclear factor of activated T cells 5 0.0371 0.3547 0.3547
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0035 0.0143 0.0154
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0199 0.181 0.1951
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0099 0.0099
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0041 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0692 0.6806 0.7337
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0257 0.2399 0.2399
Plasmodium falciparum proteasome subunit beta type-5 0.0936 0.9277 1
Plasmodium vivax proteasome subunit beta type-3, putative 0.0199 0.181 0.1951
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.1889 0.2037
Onchocerca volvulus 0.0035 0.0143 0.076
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0218 0.2004 0.216
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0205 0.1872 0.2018
Trypanosoma brucei proteasome beta 7 subunit 0.0197 0.1792 0.1932
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0035 0.0143 0.0154
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0046 0.0253 0.0273
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0115 0.0124
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0019 0.002
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0113 0.0122
Echinococcus multilocularis adhesion regulating molecule 1 0.01 0.0801 0.0801
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0128 0.0128
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.2399 0.2586
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0113 0.0122
Brugia malayi PCI domain containing protein 0.0032 0.0113 0.0113
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0205 0.1872 0.2018
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0211 0.1925 0.2075
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0205 0.1872 0.2018
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0226 0.2086 0.2086
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0217 0.1994 0.2149
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0143 0.0155
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0063 0.0432 0.2287
Trichomonas vaginalis 26S proteasome subunit, putative 0.0032 0.0113 0.0122
Leishmania major proteasome beta-1 subunit, putative 0.0206 0.1876 0.2023
Mycobacterium ulcerans proteasome PrcB 0.0936 0.9277 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.003 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Toxoplasma gondii PCI domain-containing protein 0.0041 0.0209 0.0225
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0205 0.1866 0.1866
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0134 0.0134
Onchocerca volvulus 0.0035 0.0143 0.076
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0199 0.181 0.1951
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0217 0.1994 0.2149
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0194 0.0194
Onchocerca volvulus 0.0021 0.0005 0.0026
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0032 0.0113 0.0122
Entamoeba histolytica proteasome regulatory subunit, putative 0.0041 0.0209 0.0225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0175 0.0175
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0038 0.018 0.018
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0211 0.1925 0.2075
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0194 0.0194
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0041 0.0209 0.0225
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0253 0.0273
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0144 0.0155
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0257 0.2399 0.2586
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0228 0.2105 0.2269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0128 0.0128
Plasmodium vivax proteasome subunit beta type-2, putative 0.0199 0.181 0.1951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0199 0.181 0.1951
Brugia malayi proteasome subunit beta type 3 0.0199 0.181 0.181
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0936 0.9277 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0206 0.1876 0.2023
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0023 0.0019 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0228 0.0228
Onchocerca volvulus 0.0021 0.0006 0.0032
Loa Loa (eye worm) RPN-3 protein 0.0041 0.0209 0.0225
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0228 0.2105 0.2105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0007
Trypanosoma cruzi 20S proteasome subunit 0.0199 0.181 0.1951
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0006 0.0007
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.003 0.0099 0.0106
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0371 0.3547 0.3547
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0046 0.0253 0.0273
Onchocerca volvulus 0.004 0.0194 0.1026
Giardia lamblia Proteasome subunit beta type 3 0.0199 0.181 0.1951
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0217 0.1994 0.2149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0128 0.0128
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0257 0.2399 0.2399
Plasmodium vivax proteasome subunit beta type-6, putative 0.0206 0.1876 0.2023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0257 0.2399 0.2399
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.003 0.0099 0.0106
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0466 0.0466
Leishmania major proteasome beta 7 subunit, putative 0.0197 0.1792 0.1932
Schistosoma mansoni hypothetical protein 0.0203 0.1849 0.1849
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Echinococcus granulosus Ankyrin 0.0038 0.0176 0.0176
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0194 0.0194
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0128 0.0128
Schistosoma mansoni coup transcription factor 0.0033 0.0128 0.0128
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0218 0.2004 0.216
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0205 0.1872 0.2018
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0035 0.0144 0.0155
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0228 0.0228
Schistosoma mansoni proteasome regulatory subunit-related 0.0035 0.0144 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0143 0.0155
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0203 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0128 0.0128
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0024 0.0032 0.0034
Leishmania major proteasome alpha 7 subunit, putative 0.0207 0.1889 0.2037
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0199 0.181 0.1951
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0228 0.2105 0.2105
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0205 0.1866 0.2012
Entamoeba histolytica hypothetical protein 0.0041 0.0203 0.0219
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0199 0.181 0.181
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0128 0.0128
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0207 0.1889 0.2037
Brugia malayi Uncoordinated protein 44 0.0038 0.0175 0.0175
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0143 0.0154
Trypanosoma brucei proteasome alpha 7 subunit 0.0207 0.1889 0.2037
Echinococcus granulosus death domain containing protein 0.0038 0.0175 0.0175
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0205 0.1866 0.2012
Giardia lamblia 20S proteasome alpha subunit 1 0.0218 0.2004 0.216
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0128 0.0128
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0936 0.9277 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0217 0.1994 0.2149
Toxoplasma gondii proteasome subunit alpha type, putative 0.0205 0.1872 0.2018
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0035 0.0144 0.0155
Brugia malayi PCI domain containing protein 0.0035 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0128 0.0128
Brugia malayi ecdysteroid receptor 0.0033 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Echinococcus granulosus Mastin 0.004 0.0194 0.0194
Loa Loa (eye worm) trypsin family protein 0.004 0.0194 0.0209
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0099 0.0106
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0041 0.0209 0.0225
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.1889 0.2037
Giardia lamblia 20S proteasome alpha subunit 2 0.0211 0.1925 0.2075
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0936 0.9277 1
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0019 0.0019
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0199 0.181 0.181
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0128 0.0128
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0205 0.1866 0.1866
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0206 0.1876 0.2023
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0217 0.1994 0.2149
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0134 0.0134
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0228 0.2105 0.2269
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0199 0.181 0.1951
Brugia malayi proteasome subunit alpha type 3 0.0207 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0115 0.0115
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0006 0.0006
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0092 0.0726 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0128 0.0128
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.01 0.0801 0.0863
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0143 0.0155
Leishmania major proteasome alpha 7 subunit, putative 0.0257 0.2399 0.2586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0128 0.0138
Brugia malayi Kringle domain containing protein 0.0021 0.0005 0.0005
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0046 0.0253 0.0253
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0217 0.1994 0.1994
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0175 0.0175
Echinococcus granulosus proteasome subunit beta type 7 0.1007 1 1
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0115 0.0124
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0197 0.1792 0.1792
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0175 0.0175
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0023 0.0019 0.002
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0023 0.0019 0.002
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0466 0.0466
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0197 0.1792 0.1932
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0257 0.2399 0.2586
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0143 0.0154
Brugia malayi Trypsin-like protease protein 5 0.004 0.0194 0.0194
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0113 0.0122
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0211 0.1925 0.2075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0128 0.0128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0228 0.0228
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0035 0.0143 0.0154
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0038 0.018 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0128 0.0128
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0206 0.1876 0.2023
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0205 0.1872 0.2018
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0115 0.0124
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0143 0.0154
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0179 0.1609 0.1734
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0128 0.068
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0171 0.1526 0.1526
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0207 0.1889 0.2037
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0466 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0128 0.0128
Loa Loa (eye worm) beta-lactamase 0.0035 0.0143 0.0155
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0022 0.0019 0.002
Leishmania major proteasome alpha 2 subunit, putative 0.0211 0.1925 0.2075
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0197 0.1792 0.1932
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0205 0.1872 0.2018
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0005 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0115 0.0124
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0466 0.0466
Brugia malayi Trypsin family protein 0.004 0.0194 0.0194
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0199 0.181 0.181
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0041 0.0209 0.0209
Onchocerca volvulus 0.004 0.0194 0.1026
Entamoeba histolytica hypothetical protein 0.0043 0.0228 0.0246
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0115 0.0124
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0205 0.1866 0.2012
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0257 0.2399 0.2586
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0171 0.1526 0.1645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Echinococcus multilocularis carbonic anhydrase II 0.0179 0.1609 0.1609
Echinococcus multilocularis proteasome subunit alpha type 6 0.0218 0.2004 0.2004
Leishmania major carbonic anhydrase-like protein 0.0179 0.1609 0.1734
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Echinococcus granulosus geminin 0.0203 0.1849 0.1849
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0205 0.1866 0.2012
Brugia malayi Ubiquitin interaction motif family protein 0.0022 0.0018 0.0018
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0253 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0128 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Brugia malayi Protein kinase domain containing protein 0.0038 0.0175 0.0175
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0038 0.018 0.0194
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0115 0.0115
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0032 0.0113 0.0122
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0205 0.1866 0.2012
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0171 0.1526 0.1514
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0218 0.2004 0.216
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0171 0.1526 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0128 0.0128
Echinococcus granulosus Proteasome subunit alpha beta 0.0207 0.1889 0.1889
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0199 0.181 0.181
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0115 0.0124
Onchocerca volvulus 0.004 0.0194 0.1026
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0038 0.018 0.0194
Brugia malayi Trypsin family protein 0.004 0.0194 0.0194
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.002
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0179 0.1609 0.1609
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.003 0.0099 0.0106
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0023 0.0019 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0128 0.0128
Onchocerca volvulus 0.0035 0.0143 0.076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0175 0.0926
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0203 0.1849 0.1849
Entamoeba histolytica hypothetical protein 0.0043 0.0228 0.0246
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0279 0.2618 0.2822
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0115 0.0124
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.0018 0.002
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0128 0.0128
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0143 0.0143
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0007
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0115 0.0124
Brugia malayi nuclear receptor NHR-88 0.0033 0.0128 0.0128
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0128 0.068
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0197 0.1792 0.1792
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0006 0.0007
Brugia malayi hypothetical protein 0.0043 0.0228 0.0228
Toxoplasma gondii hypothetical protein 0.0028 0.0075 0.0081
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0218 0.2004 0.2004
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0128 0.0128
Echinococcus granulosus proteasome subunit beta type 6 0.0206 0.1876 0.1876
Entamoeba histolytica hypothetical protein 0.0043 0.0228 0.0246
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Onchocerca volvulus Notchless protein homolog 0.0207 0.1889 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0128 0.0128
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0176 0.0176
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0936 0.9277 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0257 0.2399 0.2586
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0143 0.0155
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0171 0.1526 0.1645
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0217 0.1994 0.1994
Mycobacterium ulcerans hypothetical protein 0.004 0.0194 0.0055
Brugia malayi steroid hormone receptor 0.0033 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0466 0.0502
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0038 0.018 0.0194
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0466 0.0466
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0113 0.0122
Giardia lamblia 20S proteasome alpha subunit 4 0.0257 0.2399 0.2586
Leishmania major hypothetical protein, conserved 0.0035 0.0143 0.0155
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0115 0.0124
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0203 0.0219
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0046 0.0253 0.0273
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0936 0.9277 1
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0006 0.0006
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0143 0.0143
Brugia malayi proteasome subunit alpha type 2 0.0211 0.1925 0.1925
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0279 0.2618 0.2822
Giardia lamblia Proteasome subunit beta type 1 0.0228 0.2105 0.2269
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0206 0.1876 0.2023
Schistosoma mansoni hypothetical protein 0.0067 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.0062 0.0419 0.0419
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0115 0.0124
Brugia malayi small heat shock protein 0.0692 0.6806 0.6806
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0128 0.0128
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0128 0.0128
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0171 0.1526 0.1645
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0113 0.0122
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0046 0.0253 0.0253
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0006 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0128 0.0128
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0197 0.1792 0.1932
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0024 0.0032 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0128 0.0128
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0006 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0128 0.0128
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0466 0.0466
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0228 0.2105 0.2105
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.1751 0.1888
Plasmodium vivax proteasome subunit beta type-1, putative 0.0228 0.2105 0.2269
Toxoplasma gondii hypothetical protein 0.0067 0.0466 0.0502
Echinococcus granulosus carbonic anhydrase 0.0067 0.0466 0.0466
Echinococcus granulosus carbonic anhydrase 0.0067 0.0466 0.0466
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0023 0.0019 0.0019
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0034 0.0134 0.0144
Schistosoma mansoni 26S proteasome subunit S9 0.0038 0.018 0.018
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0023 0.0019 0.002
Giardia lamblia 20S proteasome alpha subunit 5 0.0217 0.1994 0.2149
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0179 0.1609 0.1609
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0128 0.0128
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0466 0.0502
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0218 0.2004 0.216
Onchocerca volvulus 0.0033 0.0128 0.068
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0143 0.0155
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0143 0.0154
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0128 0.0128
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0041 0.0209 0.0209
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0197 0.1792 0.1932
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0207 0.1889 0.2037
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0207 0.1889 0.2037
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0194 0.0194
Loa Loa (eye worm) PAS-3 protein 0.0188 0.1698 0.183
Leishmania major hypothetical protein, conserved 0.0021 0.0005 0.0005
Echinococcus granulosus carbonic anhydrase II 0.0179 0.1609 0.1609
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0143 0.0155
Onchocerca volvulus 0.004 0.0194 0.1026
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0035 0.0144 0.0155
Leishmania major proteasome beta 5 subunit, putative 0.0936 0.9277 1
Leishmania major proteasome alpha 1 subunit, putative 0.0205 0.1866 0.2012
Giardia lamblia Proteasome subunit beta type 2 0.0199 0.181 0.1951
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0253 0.0253
Giardia lamblia 20S proteasome alpha subunit 3 0.0205 0.1872 0.2018
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Loa Loa (eye worm) proteasome regulatory particle 0.0038 0.018 0.0194
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0006 0.0007
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0099 0.0106
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0035 0.0143 0.0154
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0115 0.0115
Loa Loa (eye worm) proteasome subunit beta type 2 0.0199 0.181 0.1951
Brugia malayi Proteasome A-type and B-type family protein 0.0197 0.1792 0.1792
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0023 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.0194 0.0194
Brugia malayi nuclear hormone receptor 0.0033 0.0128 0.0128
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0038 0.018 0.0194
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0211 0.1925 0.2075
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0175 0.0175
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0197 0.1792 0.1932
Brugia malayi Trypsin family protein 0.004 0.0194 0.0194
Brugia malayi Proteasome A-type and B-type family protein 0.0206 0.1876 0.1876
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0041 0.0203 0.0203
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0113 0.0122
Echinococcus multilocularis proteasome subunit alpha type 2 0.0211 0.1925 0.1925
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0205 0.1866 0.2012
Schistosoma mansoni hypothetical protein 0.0226 0.2086 0.2086
Entamoeba histolytica hypothetical protein 0.0043 0.0228 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0226 0.2086 0.2249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0128 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0128 0.0128
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0128 0.068
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0175 0.0175
Echinococcus granulosus proteasome subunit alpha type 2 0.0211 0.1925 0.1925
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0143 0.0143
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0171 0.1526 0.1514
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0179 0.1609 0.1734
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0041 0.0203 0.0203
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0228 0.2105 0.2269
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.0113
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0005 0.0005
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0115 0.0115
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0199 0.181 0.1951
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0099 0.0099
Toxoplasma gondii peptidase, T1 family protein 0.0207 0.1889 0.2037
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0217 0.1994 0.2149
Brugia malayi 20S proteasome alpha5 subunit 0.0217 0.1994 0.1994
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0279 0.2618 0.2822
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0205 0.1866 0.1866
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0035 0.0144 0.0155
Trypanosoma brucei proteasome beta 6 subunit 0.0228 0.2105 0.2269
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0211 0.1925 0.2075
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.003 0.0099 0.0099
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0466 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0115 0.0124
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.002
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0023 0.0019 0.002
Leishmania major proteasome alpha 1 subunit, putative 0.0218 0.2004 0.216
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0046 0.0253 0.0273
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0217 0.1994 0.2149
Echinococcus granulosus Proteasome subunit alpha type 7 0.0257 0.2399 0.2399
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0179 0.1609 0.1609
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0128 0.0138
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0115 0.0124
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0211 0.1925 0.1925
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0279 0.2618 0.2822
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0012 0.0013
Loa Loa (eye worm) carbonic anhydrase 3 0.0179 0.1609 0.1734
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0143 0.0143
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0128 0.0128
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0005 0.0005
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0257 0.2399 0.2586
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0207 0.1889 0.1889
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0279 0.2618 0.2822
Onchocerca volvulus 0.004 0.0194 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0128 0.0138
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0041 0.0203 0.0219
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0205 0.1872 0.2018
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0466 0.0466
Toxoplasma gondii proteasome subunit alpha1, putative 0.0218 0.2004 0.216
Toxoplasma gondii ABC1 family protein 0.0035 0.0143 0.0155
Brugia malayi beta-lactamase 0.0035 0.0143 0.0143
Brugia malayi proteasome subunit beta type 2 0.0199 0.181 0.181
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0199 0.181 0.1951
Leishmania major proteasome alpha 3 subunit, putative 0.0205 0.1872 0.2018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0128 0.0128
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Loa Loa (eye worm) proteasome Regulatory Particle 0.0035 0.0143 0.0154
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0019 0.0019
Echinococcus granulosus subfamily T1A non peptidase ue 0.0217 0.1994 0.1994
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0205 0.1872 0.1872
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0144 0.0144
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0207 0.1889 0.1889
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0257 0.2399 0.2586
Schistosoma mansoni hypothetical protein 0.004 0.0194 0.0194
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0936 0.9277 1
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0128 0.0138
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0205 0.1866 0.2012
Echinococcus granulosus carbonic anhydrase 0.0067 0.0466 0.0466
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0228 0.2105 0.2269
Trypanosoma brucei carbonic anhydrase-like protein 0.0179 0.1609 0.1734
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0199 0.181 0.181
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0194 0.0194
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0143 0.0143
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0206 0.1876 0.2023
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0143 0.0143
Toxoplasma gondii proteasome subunit 0.0206 0.1876 0.2023
Toxoplasma gondii proteasome subunit beta type, putative 0.0936 0.9277 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0936 0.9277 1
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0006 0.0007
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0199 0.181 0.1951
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0217 0.1994 0.2149
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0006 0.0007
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0032 0.0113 0.0113
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0067 0.0466 0.0502
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0043 0.0228 0.0228
Onchocerca volvulus 0.004 0.0194 0.1026
Plasmodium falciparum carbonic anhydrase 0.0067 0.0466 0.0502
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0217 0.1994 0.1994
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0257 0.2399 0.2586
Echinococcus granulosus adhesion regulating molecule 1 0.01 0.0801 0.0801
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0041 0.0209 0.0209
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0006 0.0007
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0115 0.0124
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0218 0.2004 0.216
Brugia malayi beta-lactamase family protein 0.0035 0.0143 0.0143
Brugia malayi beta-lactamase family protein 0.0035 0.0143 0.0143
Leishmania major proteasome beta 2 subunit, putative 0.0199 0.181 0.1951
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0228 0.2105 0.2269
Onchocerca volvulus 0.0021 0.0006 0.0032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0128 0.0128
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0032 0.0113 0.0122
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0171 0.1526 0.1645
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0179 0.1609 0.1609
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0175 0.0175
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0206 0.1876 0.2023
Giardia lamblia 26S protease regulatory subunit 6A 0.0023 0.0019 0.002
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0005
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0197 0.1792 0.1932
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0279 0.2618 0.2822
Plasmodium vivax proteasome subunit beta type-5, putative 0.0936 0.9277 1
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0206 0.1876 0.1876
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0005 0.0005
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0099 0.0106
Brugia malayi Adhesion regulating molecule conserved region family protein 0.01 0.0801 0.0801
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2044 0.2081
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0197 0.1792 0.1792
Leishmania major proteasome beta 3 subunit, putative 0.0199 0.181 0.1951
Schistosoma mansoni multiubiquitin binding protein S5a 0.0022 0.0018 0.0018
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0023 0.0019 0.002
Echinococcus granulosus proteasome prosome macropain 0.0936 0.9277 0.9277
Toxoplasma gondii proteasome beta subunit 0.0199 0.181 0.1951
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0143 0.0143
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0211 0.1925 0.2075
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.019
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0019 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0128 0.0128
Loa Loa (eye worm) PCI domain-containing protein 0.0035 0.0144 0.0155
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0205 0.1872 0.1872
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0115 0.0124
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0175 0.0189
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0228 0.2105 0.2269
Toxoplasma gondii SAC3/GANP family protein 0.003 0.0099 0.0106
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0099 0.0106
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0115 0.0124
Echinococcus multilocularis proteasome subunit beta type 6 0.0206 0.1876 0.1876
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0279 0.2618 0.2822
Echinococcus multilocularis Mastin 0.004 0.0194 0.0194
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0205 0.1866 0.2012
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0228 0.2105 0.2269
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0006 0.0006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0006 0.0006
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.01 0.0801 0.0801
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0207 0.1889 0.2037
Schistosoma mansoni hypothetical protein 0.0038 0.0175 0.0175
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0046 0.0253 0.0273
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0035 0.0144 0.0155
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0217 0.1994 0.2149
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0466 0.0466
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0211 0.1925 0.2075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0128 0.0128
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0253 0.0253
Brugia malayi Protein kinase domain containing protein 0.0021 0.0005 0.0005
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0099 0.0099
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0038 0.018 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0035 0.0144 0.0155
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0006 0.0006
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0217 0.1994 0.2149
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0206 0.1876 0.2023
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.02 0.182 0.182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0128 0.0128
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0936 0.9277 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0128 0.0138
Giardia lamblia 20S proteasome alpha subunit 7 0.0207 0.1889 0.2037
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0205 0.1872 0.1872
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0006 0.0006
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0199 0.181 0.1951
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0035 0.0144 0.0155
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0279 0.2618 0.2822
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0115 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0128 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0143 0.0155
Brugia malayi proteasome subunit beta type 1 0.0228 0.2105 0.2105
Schistosoma mansoni netrin receptor unc5 0.0038 0.0175 0.0175
Loa Loa (eye worm) proteasome subunit beta type 3 0.0199 0.181 0.1951
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0128 0.0128
Giardia lamblia Hypothetical protein 0.0038 0.018 0.0194
Echinococcus granulosus proteasome subunit alpha type 6 0.0218 0.2004 0.2004
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.0143 0.0154
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.0143 0.0143
Leishmania major proteasome beta 2 subunit, putative 0.0279 0.2618 0.2822
Brugia malayi hypothetical protein 0.004 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0155
Mycobacterium ulcerans proteasome PrcA 0.0171 0.1526 0.1514
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0193 0.1751 0.1888
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.0018 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0128 0.0128
Brugia malayi proteasome subunit alpha type 6 0.0218 0.2004 0.2004
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.1007 1 1
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0104 0.0112
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0038 0.018 0.018
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0006 0.0007
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0041 0.0203 0.0219
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0046 0.0253 0.0253
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0023 0.0019 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0128 0.0128
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0081
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0006 0.0007
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0205 0.1872 0.2018
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0207 0.1889 0.2037
Plasmodium falciparum proteasome subunit beta type-4 0.0197 0.1792 0.1932
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0194 0.0194
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0171 0.1526 0.1645
Toxoplasma gondii proteasome subunit alpha type, putative 0.0086 0.0664 0.0715
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0128 0.0128
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0099 0.0106
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0199 0.181 0.181
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0115 0.0115
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0179 0.1609 0.1734
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0199 0.181 0.1951
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0038 0.018 0.018
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0194 0.0194
Echinococcus multilocularis enteropeptidase 0.004 0.0194 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0115 0.0124
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.003 0.0099 0.0106
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0199 0.181 0.181
Toxoplasma gondii heat shock protein hslv, putative 0.0171 0.1526 0.1645
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0128 0.0128
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0199 0.181 0.1951
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0199 0.181 0.1951
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0128 0.0128
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0218 0.2004 0.216
Schistosoma mansoni carbonic anhydrase 0.0067 0.0466 0.0466
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0206 0.1876 0.2023
Echinococcus multilocularis geminin 0.0203 0.1849 0.1849
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0006 0.0007
Brugia malayi proteasome subunit alpha type 4 0.0188 0.1698 0.1698
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0194 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0106
Brugia malayi Proteasome A-type and B-type family protein 0.0936 0.9277 0.9277
Trichomonas vaginalis esterase, putative 0.0035 0.0143 0.0155
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0006 0.0006
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0115 0.0115
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0143 0.0155
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0217 0.1994 0.2149
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0041 0.0203 0.0203
Plasmodium vivax proteasome subunit beta type-7, putative 0.0279 0.2618 0.2822
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0171 0.1526 0.1645
Echinococcus granulosus proteasome subunit beta t family 0.0199 0.181 0.181
Echinococcus multilocularis Ankyrin 0.0038 0.0176 0.0176
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0936 0.9277 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0143 0.0143
Echinococcus multilocularis proteasome (prosome, macropain) 0.0936 0.9277 0.9277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0128 0.0138
Echinococcus granulosus enteropeptidase 0.004 0.0194 0.0194
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0199 0.181 0.1951
Schistosoma mansoni hypothetical protein 0.0092 0.0726 0.0726
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0128 0.0128
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0034 0.0134 0.0144
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0257 0.2399 0.2586
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0041 0.0209 0.0209
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0128 0.0128
Brugia malayi Proteasome subunit alpha type 7-1 0.0257 0.2399 0.2399
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0936 0.9277 0.9277
Giardia lamblia 20S proteasome alpha subunit 6 0.0205 0.1866 0.2012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0128 0.0138
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0092 0.0726 0.0726
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0005 0.0005
Brugia malayi Death domain containing protein 0.0038 0.0175 0.0175
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0194 0.0194

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 278 uM Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard. ChEMBL. 2308147
IC50 (binding) = 278 uM Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard. ChEMBL. 2308147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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