Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5987 | 0.5817 |
Echinococcus multilocularis | GMP synthase (glutamine hydrolyzing) | 0.0108 | 0.2533 | 0.7144 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5987 | 0.4626 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.3546 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.3546 | 0.3546 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5987 | 0.4626 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.3546 | 0.3546 |
Treponema pallidum | NAD synthetase | 0.027 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.5987 | 0.4626 |
Mycobacterium ulcerans | GMP synthase | 0.0108 | 0.2533 | 0.2533 |
Brugia malayi | thymidylate synthase | 0.013 | 0.3546 | 1 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0162 | 0.5026 | 0.5026 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | GMP synthase glutamine hydrolyzing | 0.0108 | 0.2533 | 0.7144 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.3546 | 1 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2533 | 0.7144 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.3546 | 0.3546 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.027 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0407 | 0.0407 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5987 | 0.4626 |
Leishmania major | NAD synthase, putative | 0.027 | 1 | 1 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.027 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0407 | 0.1148 |
Trichomonas vaginalis | nh(3)-dependent NAD(+) synthetase, putative | 0.027 | 1 | 1 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.027 | 1 | 1 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.027 | 1 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) | 0.027 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5987 | 0.4626 |
Schistosoma mansoni | GMP synthetase | 0.0108 | 0.2533 | 0.2533 |
Mycobacterium ulcerans | NAD synthetase | 0.027 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.3546 | 1 |
Mycobacterium tuberculosis | Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) | 0.027 | 1 | 1 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.3546 | 0.5 | |
Trypanosoma brucei | NAD+ synthase, putative | 0.027 | 1 | 1 |
Brugia malayi | GMP synthase | 0.0108 | 0.2533 | 0.7144 |
Giardia lamblia | NH3-dependent NAD+ synthetase | 0.027 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2X PT (functional) | 0 uM | In vitro anticoagulant activity of compound was determined in rat; ND: Not determined | ChEMBL. | 15225723 |
Cl (ADMET) | = 35 ml min-1 kg-1 | Plasma clearance of compound was determined in rat | ChEMBL. | 15225723 |
F (ADMET) | = 2.67 % | Bioavailability in rat | ChEMBL. | 15225723 |
IC50 (binding) | = 12 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
IC50 (binding) | = 12 nM | In vitro inhibitory activity against Factor Xa | ChEMBL. | 15225723 |
IC50 (binding) | = 12 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
Ki (binding) | = 7.55 nM | Binding affinity of compound towards Factor Xa | ChEMBL. | 15225723 |
T1/2 (ADMET) | = 1.77 hr | Half-life of compound was determined in rat | ChEMBL. | 15225723 |
TG 2X lag (functional) | = 14 uM | In vitro anticoagulant activity of compound was determined in rat | ChEMBL. | 15225723 |
Vz (ADMET) | = 5.4 l kg-1 | Vz of compound was determined in rat | ChEMBL. | 15225723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.