Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.013 | 0.5922 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.5922 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.5922 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.5922 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.5922 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.068 | 0.5 |
Brugia malayi | thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | > 5 uM | Concentration required to double the lag time of maximum thrombin generation in human plasma-based thrombin generation assay. | ChEMBL. | 15013006 |
Activity (functional) | > 5 uM | Concentration required to double the lag time of maximum thrombin generation in human plasma-based thrombin generation assay. | ChEMBL. | 15013006 |
cLog D (ADMET) | = 2.4 | Hidrophilicity of the compound was determined at pH 7 | ChEMBL. | 15013006 |
F (ADMET) | NT 0 % | Oral bioavailability in rat | ChEMBL. | 15013006 |
IC50 (binding) | = 4.4 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
IC50 (binding) | = 4.4 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
Ki (binding) | = 1.8 nM | Inhibition of Coagulation factor X | ChEMBL. | 15013006 |
Ki (binding) | = 1.8 nM | Inhibition of Coagulation factor X | ChEMBL. | 15013006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.