Detailed information for compound 309559

Basic information

Technical information
  • TDR Targets ID: 309559
  • Name: (E)-N-[(1S)-1-(3,4-dihydro-2H-1,4-benzoxazin- 6-yl)ethyl]-3-(2-fluorophenyl)prop-2-enamide
  • MW: 326.365 | Formula: C19H19FN2O2
  • H donors: 2 H acceptors: 1 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](c1ccc2c(c1)NCCO2)C)/C=C/c1ccccc1F
  • InChi: 1S/C19H19FN2O2/c1-13(15-6-8-18-17(12-15)21-10-11-24-18)22-19(23)9-7-14-4-2-3-5-16(14)20/h2-9,12-13,21H,10-11H2,1H3,(H,22,23)/b9-7+/t13-/m0/s1
  • InChiKey: KJKISBSTHVUMEV-XOVSCCBYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-[(1S)-1-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)ethyl]-3-(2-fluorophenyl)-2-propenamide
  • (E)-N-[(1S)-1-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)ethyl]-3-(2-fluorophenyl)acrylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus potassium voltage-gated channel, subfamily Q, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma japonicum ko:K05324 potassium voltage-gated channel, KQT-like subfamily, invertebrate, putative Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus multilocularis potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma mansoni voltage-gated potassium channel KCNQ Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus granulosus potassium channel KvQLT family member kqt 1 Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) voltage-gated potassium channel Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma japonicum ko:K04927 potassium voltage-gated channel, KQT-like subfamily, member 2, putative Get druggable targets OG5_129255 All targets in OG5_129255
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus granulosus potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2524 0.3882
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0773 0.0773
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.029 0.6044 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0126 0.2524 0.3882
Plasmodium vivax delta tubulin, putative 0.0126 0.2524 0.3882
Echinococcus granulosus tubulin alpha chain 0.029 0.6044 0.6044
Entamoeba histolytica tubulin alpha chain, putative 0.029 0.6044 1
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0773 0.0773
Entamoeba histolytica tubulin alpha-1 chain 0.029 0.6044 1
Echinococcus multilocularis tubulin alpha chain 0.029 0.6044 0.6044
Loa Loa (eye worm) hypothetical protein 0.0126 0.2524 0.4133
Toxoplasma gondii beta-1 tubulin, putative 0.029 0.6044 1
Brugia malayi Tubulin gamma chain 0.029 0.6044 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.1891 0.3082
Schistosoma mansoni tubulin subunit alpha 0.0126 0.2524 0.2524
Loa Loa (eye worm) tubulin beta chain 0.0126 0.2524 0.4133
Plasmodium vivax tubulin epsilon chain, putative 0.029 0.6044 1
Trypanosoma cruzi zeta tubulin, putative 0.0126 0.2524 0.3882
Schistosoma mansoni loxhd1 0.0058 0.1065 0.1065
Plasmodium falciparum tubulin beta chain 0.029 0.6044 1
Echinococcus granulosus cpg binding protein 0.0035 0.0578 0.0578
Brugia malayi hypothetical protein 0.0058 0.1065 0.1705
Loa Loa (eye worm) tubulin beta-2A chain 0.029 0.6044 1
Echinococcus granulosus RUN 0.0058 0.1065 0.1065
Schistosoma mansoni cpg binding protein 0.0033 0.0537 0.0537
Leishmania major alpha tubulin 0.029 0.6044 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0078 0.1497 0.2423
Schistosoma mansoni tubulin subunit alpha 0.029 0.6044 0.6044
Echinococcus multilocularis tubulin delta chain 0.0126 0.2524 0.2524
Trypanosoma cruzi alpha tubulin, putative 0.029 0.6044 1
Trypanosoma brucei epsilon tubulin 0.029 0.6044 1
Loa Loa (eye worm) alpha-tubulin 0.029 0.6044 1
Echinococcus multilocularis dnaJ subfamily B 0.0475 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0404 0.0198
Echinococcus multilocularis peroxisome assembly protein 26 0.029 0.6044 0.6044
Schistosoma mansoni alpha tubulin 0.029 0.6044 0.6044
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0126 0.2524 0.3882
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1465 0.2041
Leishmania major beta tubulin 0.029 0.6044 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1497 0.2423
Leishmania major alpha tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0164 0.3343 0.5305
Echinococcus granulosus tubulin alpha 1C chain 0.029 0.6044 0.6044
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0174 0.3546 0.3546
Echinococcus granulosus tubulin subunit beta 0.029 0.6044 0.6044
Echinococcus multilocularis tubulin alpha 0.029 0.6044 0.6044
Leishmania major epsilon tubulin, putative 0.029 0.6044 1
Leishmania major alpha tubulin 0.029 0.6044 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0404 0.0198
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.6044 0.6044
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.6044 1
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.3343 0.5498
Echinococcus granulosus beta tubulin 0.029 0.6044 0.6044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0164 0.3343 0.5305
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.1065 0.1346
Echinococcus granulosus tubulin alpha chain 0.029 0.6044 0.6044
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.6044 0.6044
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.1065 0.1065
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Trypanosoma cruzi tubulin gamma chain 0.029 0.6044 1
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.6044 1
Trypanosoma cruzi zeta tubulin, putative 0.0126 0.2524 0.3882
Trypanosoma brucei alpha tubulin 0.029 0.6044 1
Mycobacterium leprae cell division protein FtsZ 0.0126 0.2524 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0404 0.0198
Brugia malayi alpha-tubulin 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Trypanosoma brucei beta tubulin 0.029 0.6044 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.1065 0.1065
Onchocerca volvulus 0.0058 0.1065 0.188
Loa Loa (eye worm) hypothetical protein 0.0058 0.1065 0.1702
Onchocerca volvulus 0.0164 0.3343 1
Trypanosoma brucei beta tubulin 0.029 0.6044 1
Trypanosoma cruzi epsilon tubulin, putative 0.029 0.6044 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1891 0.3079
Trichomonas vaginalis tubulin alpha chain, putative 0.0164 0.3343 0.5305
Echinococcus multilocularis tubulin alpha 3 chain 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin beta chain, putative 0.0164 0.3343 0.5305
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.6044 0.6044
Echinococcus multilocularis tubulin beta 1 chain 0.029 0.6044 0.6044
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.1891 0.1891
Brugia malayi hypothetical protein 0.0058 0.1065 0.1705
Schistosoma mansoni alpha tubulin 0.029 0.6044 0.6044
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0078 0.1497 0.1497
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1465 0.2041
Brugia malayi Tubulin alpha-2 chain 0.029 0.6044 1
Toxoplasma gondii alpha-tubulin I, putative 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.1465 0.1465
Echinococcus granulosus tubulin beta 4A class IVa 0.029 0.6044 0.6044
Loa Loa (eye worm) tubulin beta-1 chain 0.029 0.6044 1
Trypanosoma brucei beta tubulin 0.029 0.6044 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.029 0.029
Brugia malayi Tubulin beta chain 0.0126 0.2524 0.4136
Echinococcus multilocularis Tubulin alpha 1 chain 0.029 0.6044 0.6044
Entamoeba histolytica tubulin family protein 0.029 0.6044 1
Loa Loa (eye worm) doublecortin family protein 0.0058 0.1065 0.1702
Plasmodium vivax tubulin alpha chain, putative 0.029 0.6044 1
Giardia lamblia Alpha-tubulin 0.029 0.6044 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.029 0.6044 0.6044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0347 0.7253 0.7253
Brugia malayi CXXC zinc finger family protein 0.0033 0.0537 0.0827
Schistosoma mansoni tubulin subunit alpha 0.029 0.6044 0.6044
Leishmania major beta tubulin 0.029 0.6044 1
Brugia malayi Tubulin alpha chain 0.029 0.6044 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0404 0.0198
Loa Loa (eye worm) BEN-1 protein 0.029 0.6044 1
Trypanosoma brucei beta tubulin 0.029 0.6044 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0578 0.0578
Schistosoma mansoni polycystin 1-related 0.0058 0.1065 0.1065
Echinococcus granulosus Tubulin alpha 1 chain 0.029 0.6044 0.6044
Echinococcus multilocularis tubulin alpha chain 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Trypanosoma cruzi tubulin delta chain 0.0126 0.2524 0.3882
Mycobacterium ulcerans cell division protein FtsZ 0.0126 0.2524 1
Giardia lamblia Delta tubulin 0.0126 0.2524 0.3882
Leishmania major beta tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin, putative 0.0164 0.3343 0.5305
Loa Loa (eye worm) BEN-1 protein 0.029 0.6044 1
Echinococcus granulosus tubulin alpha 0.029 0.6044 0.6044
Brugia malayi Tubulin alpha-2 chain 0.029 0.6044 1
Schistosoma mansoni lipoxygenase 0.0242 0.5017 0.5017
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0174 0.3546 0.5838
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.1891 0.1891
Onchocerca volvulus 0.0096 0.1891 0.4826
Plasmodium vivax tubulin gamma chain, putative 0.029 0.6044 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.1065 0.1065
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.6044 0.6044
Toxoplasma gondii alpha tubulin TUBA1 0.029 0.6044 1
Treponema pallidum cell division protein FtsZ 0.0126 0.2524 1
Leishmania major alpha tubulin 0.029 0.6044 1
Plasmodium falciparum tubulin epsilon chain, putative 0.029 0.6044 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1176 0.154
Echinococcus multilocularis tubulin subunit TubB 0.029 0.6044 0.6044
Echinococcus granulosus Tubulin alpha 1 chain 0.029 0.6044 0.6044
Echinococcus granulosus beta tubulin 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.029 0.6044 1
Brugia malayi tubulin alpha chain - mouse 0.029 0.6044 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.6044 1
Trypanosoma cruzi epsilon tubulin, putative 0.029 0.6044 1
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.1065 0.1346
Echinococcus multilocularis tubulin alpha chain 0.029 0.6044 0.6044
Loa Loa (eye worm) hypothetical protein 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.6044 0.6044
Echinococcus granulosus Tubulin alpha 1 chain 0.029 0.6044 0.6044
Trypanosoma brucei epsilon tubulin 0.029 0.6044 1
Leishmania major alpha tubulin 0.029 0.6044 1
Loa Loa (eye worm) tubulin gamma chain 0.029 0.6044 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.1465 0.2372
Entamoeba histolytica hypothetical protein 0.0027 0.0404 0.0198
Echinococcus granulosus tubulin alpha chain 0.029 0.6044 0.6044
Giardia lamblia Beta tubulin 0.029 0.6044 1
Leishmania major gamma-tubulin 0.029 0.6044 1
Onchocerca volvulus 0.0058 0.1065 0.188
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus multilocularis hypothetical protein 0.029 0.6044 0.6044
Echinococcus granulosus tubulin alpha 3 chain 0.029 0.6044 0.6044
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0404 0.051
Trichomonas vaginalis tubulin, putative 0.0164 0.3343 0.5305
Brugia malayi Tubulin alpha chain 0.0126 0.2524 0.4136
Plasmodium vivax tubulin alpha chain, putative 0.029 0.6044 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.029 0.6044 0.6044
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.029 0.0411
Trypanosoma cruzi beta tubulin, putative 0.029 0.6044 1
Echinococcus multilocularis tubulin alpha chain 0.029 0.6044 0.6044
Leishmania major alpha tubulin 0.029 0.6044 1
Leishmania major alpha tubulin 0.029 0.6044 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.1065 0.1065
Trypanosoma brucei epsilon tubulin 0.029 0.6044 1
Schistosoma mansoni rab6-interacting 0.0058 0.1065 0.1065
Plasmodium vivax tubulin beta chain, putative 0.029 0.6044 1
Echinococcus multilocularis RUN 0.0058 0.1065 0.1065
Schistosoma mansoni cpg binding protein 0.0035 0.0578 0.0578
Leishmania major alpha tubulin 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.0126 0.2524 0.2524
Trypanosoma cruzi tubulin delta chain 0.0126 0.2524 0.3882
Loa Loa (eye worm) tubulin alpha chain 0.029 0.6044 1
Trypanosoma brucei zeta tubulin, putative 0.0126 0.2524 0.3882
Schistosoma mansoni tubulin subunit alpha 0.029 0.6044 0.6044
Echinococcus granulosus tubulin delta chain 0.0126 0.2524 0.2524
Echinococcus granulosus tubulin subunit TubB 0.029 0.6044 0.6044
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0404 0.051
Echinococcus multilocularis tubulin alpha chain 0.029 0.6044 0.6044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.029 0.029
Loa Loa (eye worm) tubulin beta-4 chain 0.029 0.6044 1
Loa Loa (eye worm) tubulin alpha chain 0.029 0.6044 1
Echinococcus multilocularis beta tubulin 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin alpha chain, putative 0.029 0.6044 1
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.1065 0.1065
Trichomonas vaginalis tubulin, putative 0.0126 0.2524 0.3882
Echinococcus granulosus tubulin epsilon chain 0.029 0.6044 0.6044
Entamoeba histolytica tubulin gamma chain 0.029 0.6044 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.1465 0.2041
Plasmodium falciparum tubulin delta chain, putative 0.0126 0.2524 0.3882
Leishmania major beta tubulin 0.029 0.6044 1
Trypanosoma brucei alpha tubulin 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Loa Loa (eye worm) tubulin alpha-2 chain 0.029 0.6044 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.1465 0.1465
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0174 0.3546 0.3546
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Entamoeba histolytica tubulin family protein 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus multilocularis beta tubulin 0.029 0.6044 0.6044
Echinococcus multilocularis tubulin alpha 1C chain 0.029 0.6044 0.6044
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.3343 0.5498
Echinococcus multilocularis tubulin alpha 1C chain 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.6044 1
Loa Loa (eye worm) tubulin beta chain 0.029 0.6044 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0404 0.051
Giardia lamblia Epsilon tubulin 0.0126 0.2524 0.3882
Echinococcus multilocularis tubulin alpha 3 chain 0.029 0.6044 0.6044
Mycobacterium tuberculosis Cell division protein FtsZ 0.0126 0.2524 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.6044 1
Echinococcus granulosus tubulin alpha chain 0.029 0.6044 0.6044
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Leishmania major beta tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0126 0.2524 0.3882
Plasmodium falciparum tubulin gamma chain 0.029 0.6044 1
Leishmania major alpha tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.6044 0.6044
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0126 0.2524 0.3882
Leishmania major delta tubulin, putative 0.0126 0.2524 0.3882
Plasmodium falciparum alpha tubulin 1 0.029 0.6044 1
Leishmania major alpha tubulin 0.029 0.6044 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.1465 0.2369
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus multilocularis tubulin subunit beta 0.029 0.6044 0.6044
Brugia malayi Doublecortin family protein 0.0058 0.1065 0.1705
Loa Loa (eye worm) hypothetical protein 0.0058 0.1065 0.1702
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0164 0.3343 0.5498
Giardia lamblia Gamma tubulin 0.029 0.6044 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0404 0.0198
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.6044 0.6044
Echinococcus granulosus tubulin alpha chain 0.029 0.6044 0.6044
Brugia malayi Tubulin beta chain 0.0164 0.3343 0.55
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0126 0.2524 0.3882
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.029 0.0416
Brugia malayi beta-tubulin, identical 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Plasmodium falciparum alpha tubulin 2 0.029 0.6044 1
Leishmania major zeta tubulin, putative 0.0126 0.2524 0.3882
Trypanosoma brucei tubulin delta chain 0.0126 0.2524 0.3882
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0537 0.0822
Schistosoma mansoni tubulin subunit gamma 0.029 0.6044 0.6044
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.1891 0.1891
Echinococcus granulosus tubulin gamma 1 chain 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.6044 1
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.6044 0.6044
Loa Loa (eye worm) alpha-tubulin 0.029 0.6044 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0171 0.3483 0.5731
Leishmania major alpha tubulin 0.029 0.6044 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0164 0.3343 0.5498
Schistosoma mansoni alpha tubulin 0.029 0.6044 0.6044
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.1465 0.2041
Leishmania major beta tubulin 0.029 0.6044 1
Trypanosoma brucei alpha tubulin, putative 0.0164 0.3343 0.5305
Trypanosoma brucei alpha tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0126 0.2524 0.3882
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0404 0.051
Echinococcus granulosus tubulin beta 1 chain 0.029 0.6044 0.6044
Schistosoma mansoni tubulin subunit epsilon 0.029 0.6044 0.6044
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0126 0.2524 1
Schistosoma mansoni lipoxygenase 0.0347 0.7253 0.7253
Loa Loa (eye worm) hypothetical protein 0.0078 0.1497 0.2423
Schistosoma mansoni tubulin subunit delta 0.0126 0.2524 0.2524
Brugia malayi tubulin alpha-2 chain 0.029 0.6044 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.1465 0.2041
Echinococcus granulosus tubulin alpha 1C chain 0.029 0.6044 0.6044
Schistosoma mansoni rab6-interacting 0.0058 0.1065 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2524 0.3882
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1338 0.1338
Schistosoma mansoni cpg binding protein 0.0035 0.0578 0.0578
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0404 0.5
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus granulosus tubulin alpha 3 chain 0.029 0.6044 0.6044
Leishmania major beta tubulin 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.6044 0.6044
Echinococcus granulosus alpha tubulin 0.029 0.6044 0.6044
Trichomonas vaginalis tubulin, putative 0.029 0.6044 1
Echinococcus granulosus peroxisome assembly protein 26 0.029 0.6044 0.6044
Schistosoma mansoni hypothetical protein 0.0475 1 1
Toxoplasma gondii beta-tubulin, putative 0.029 0.6044 1
Brugia malayi Tubulin beta-1 chain 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Giardia lamblia Alpha-tubulin 0.029 0.6044 1
Schistosoma mansoni tubulin subunit beta 0.029 0.6044 0.6044
Schistosoma mansoni ap endonuclease 0.0022 0.029 0.029
Schistosoma mansoni ap endonuclease 0.0022 0.029 0.029
Echinococcus multilocularis tubulin epsilon chain 0.029 0.6044 0.6044
Trypanosoma brucei alpha tubulin 0.029 0.6044 1
Trypanosoma brucei tubulin gamma chain 0.029 0.6044 1
Brugia malayi Cell division protein ftsZ 0.0126 0.2524 0.4136
Trichomonas vaginalis tubulin alpha chain, putative 0.0164 0.3343 0.5305
Trypanosoma brucei zeta tubulin 0.0126 0.2524 0.3882
Trypanosoma brucei beta tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0164 0.3343 0.5305
Echinococcus multilocularis Tubulin alpha 1 chain 0.029 0.6044 0.6044
Giardia lamblia Beta tubulin 0.029 0.6044 1
Echinococcus multilocularis tubulin gamma 1 chain 0.029 0.6044 0.6044
Toxoplasma gondii beta tubulin 0.029 0.6044 1
Loa Loa (eye worm) beta-tubulin 0.029 0.6044 1
Schistosoma mansoni hypothetical protein 0.0058 0.1065 0.1065
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0078 0.1497 0.1497
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.1065 0.1065
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.6044 1
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.6044 1
Leishmania major beta tubulin 0.029 0.6044 1
Trichomonas vaginalis tubulin alpha chain, putative 0.029 0.6044 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0404 0.0198
Giardia lamblia Beta tubulin 0.029 0.6044 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0174 0.3546 0.3546
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0347 0.7253 0.7253
Loa Loa (eye worm) tubulin alpha-3 chain 0.0126 0.2524 0.4133
Leishmania major alpha tubulin 0.029 0.6044 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0404 0.051

Activities

Activity type Activity value Assay description Source Reference
E/Eref (functional) = 1.2 Efficacy for mKCNQ2 expressed in HEK293 cells relative to reference compound ChEMBL. 15050644
E/Eref (functional) = 1.2 Efficacy for mKCNQ2 expressed in HEK293 cells relative to reference compound ChEMBL. 15050644
EC50 (functional) = 2 uM Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mV ChEMBL. 15050644
EC50 (functional) = 2 uM Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mV ChEMBL. 15050644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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