Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.1186 | 0.2978 | 0.3658 |
Brugia malayi | Dihydrofolate reductase | 0.3075 | 0.8126 | 1 |
Brugia malayi | Adenosine kinase-like | 0.0105 | 0.0033 | 0.0028 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0433 | 0.0926 | 0.1132 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3075 | 0.8126 | 1 |
Leishmania major | adenosine kinase, putative | 0.0105 | 0.0033 | 0.0023 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.0033 | 0.0023 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.0033 | 0.0023 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0433 | 0.0926 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.0033 | 0.0028 |
Brugia malayi | thymidylate synthase | 0.2493 | 0.654 | 0.8046 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3763 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3075 | 0.8126 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0433 | 0.0926 | 0.1132 |
Schistosoma mansoni | dihydrofolate reductase | 0.3075 | 0.8126 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2493 | 0.654 | 0.8047 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3075 | 0.8126 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0097 | 0.001 | 0.0004 |
Mycobacterium ulcerans | thymidylate synthase | 0.2493 | 0.654 | 0.8047 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.0033 | 0.0028 |
Echinococcus granulosus | thymidylate synthase | 0.2493 | 0.654 | 0.8046 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2493 | 0.654 | 0.8046 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0097 | 0.001 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.2493 | 0.654 | 0.8046 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3763 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3075 | 0.8126 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.0033 | 0.0023 |
Echinococcus granulosus | dihydrofolate reductase | 0.3075 | 0.8126 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 0.0033 | 0.0028 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1186 | 0.2978 | 0.366 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3763 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.0007 | 0.001 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0033 | 0.0028 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 0.0033 | 0.0028 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3763 | 1 | 1 |
Onchocerca volvulus | 0.2493 | 0.654 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.1186 | 0.2978 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1186 | 0.2978 | 0.2971 |
Loa Loa (eye worm) | thymidylate synthase | 0.2493 | 0.654 | 0.8046 |
Brugia malayi | dihydrofolate reductase family protein | 0.3075 | 0.8126 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3763 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3075 | 0.8126 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0097 | 0.001 | 0.0004 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0097 | 0.001 | 0.0004 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.0033 | 0.0023 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0097 | 0.001 | 0.0015 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2493 | 0.654 | 0.8047 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3075 | 0.8126 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.0033 | 0.0023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.