Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0012 | 0.4534 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0012 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0012 | 0.4534 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0017 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0012 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0012 | 0.4534 | 0.4534 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0012 | 0.4534 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0012 | 0.4534 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0017 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0012 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0012 | 0.4534 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0017 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change in cholesterol (functional) | Compound tested for the change in liver cholesteryl ester (CE) levels by the inhibition of ACAT in hamster at 100 mg/kg p.o.; NE=No effect | ChEMBL. | 7241506 | |
Change in cholesterol (functional) | Compound was tested for the change in serum cholesterol (SC) levels by the inhibition of ACAT in hamster at 100 mg/kg p.o.; NE=No effect | ChEMBL. | 7241506 | |
Change in cholesterol (functional) | 0 | Compound tested for the change in liver cholesteryl ester (CE) levels by the inhibition of ACAT in hamster at 100 mg/kg p.o.; NE=No effect | ChEMBL. | 7241506 |
Change in cholesterol (functional) | 0 | Compound was tested for the change in serum cholesterol (SC) levels by the inhibition of ACAT in hamster at 100 mg/kg p.o.; NE=No effect | ChEMBL. | 7241506 |
Inhibition (binding) | = 64 % | In vitro percent inhibition of the compound against Acyl coenzyme A:cholesterol acyltransferase (ACAT) at a dose of 25 uM | ChEMBL. | 7241506 |
Inhibition (binding) | = 64 % | In vitro percent inhibition of the compound against Acyl coenzyme A:cholesterol acyltransferase (ACAT) at a dose of 25 uM | ChEMBL. | 7241506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.