Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.008 | 0.015 | 0.015 |
Brugia malayi | Adenosine kinase-like | 0.0105 | 0.0442 | 0.1056 |
Echinococcus granulosus | laminin | 0.008 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0263 | 0.2249 | 0.7466 | |
Schistosoma mansoni | egf-like domain protein | 0.008 | 0.015 | 0.015 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.008 | 0.015 | 0.0358 |
Onchocerca volvulus | 0.0172 | 0.1203 | 0.3994 | |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0939 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0329 | 0.3013 | 0.7199 |
Brugia malayi | Kringle domain containing protein | 0.0172 | 0.1203 | 0.2875 |
Mycobacterium leprae | TWO COMPONENT SENSOR HISTIDINE KINASE PRRB | 0.0174 | 0.1233 | 0.5 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0201 | 0.1542 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.0442 | 0.5 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0174 | 0.1233 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.015 | 0.015 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.008 | 0.015 | 0.015 |
Onchocerca volvulus | Arrow homolog | 0.008 | 0.015 | 0.0498 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0939 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.015 | 0.015 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0329 | 0.3013 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.3013 | 0.3013 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0329 | 0.3013 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.3013 | 0.3013 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 0.0442 | 0.0442 |
Brugia malayi | hypothetical protein | 0.0431 | 0.4185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.015 | 0.015 |
Leishmania major | hypothetical protein, conserved | 0.0172 | 0.1203 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.008 | 0.015 | 0.015 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.0442 | 0.0442 |
Onchocerca volvulus | 0.0329 | 0.3013 | 1 | |
Echinococcus multilocularis | Tolloid protein 1 | 0.008 | 0.015 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1203 | 0.1203 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0174 | 0.1233 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.0442 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1203 | 0.1203 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0116 | 0.0572 | 0.0572 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.0442 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.008 | 0.015 | 0.015 |
Echinococcus granulosus | Tolloid protein 1 | 0.008 | 0.015 | 0.015 |
Echinococcus multilocularis | laminin | 0.008 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0442 | 0.0442 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0172 | 0.1203 | 0.1203 |
Onchocerca volvulus | 0.0093 | 0.0304 | 0.1011 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.008 | 0.015 | 0.0358 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.0442 | 0.0442 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0172 | 0.1203 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0939 | 1 | 1 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0174 | 0.1233 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0172 | 0.1203 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0172 | 0.1203 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.008 | 0.015 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.015 | 0.015 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0172 | 0.1203 | 0.1203 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0172 | 0.1203 | 0.1203 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.015 | 0.015 |
Brugia malayi | Protein kinase domain containing protein | 0.0172 | 0.1203 | 0.2875 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.008 | 0.015 | 0.015 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0172 | 0.1203 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k' (ADMET) | = 1.66 | Index of hydrophobicity (k') | ChEMBL. | 3012086 |
MPR (functional) | = 0.04 | Molar potency ratio (MPR) against A2 adenosine receptor of coronary artery | ChEMBL. | 3012086 |
pka (binding) | = 3.06 | Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery | ChEMBL. | 3012086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.