TDR Targets

Basic information

Technical information

TDR Targets ID: 310184
Name: 2-pyridin-4-ylbenzo[h]chromen-4-one
MW: 273.285 | Formula: C18H11NO2
H donors: 0 H acceptors: 2 LogP: 3.36 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(oc2c1ccc1c2cccc1)c1ccncc1
InChi: 1S/C18H11NO2/c20-16-11-17(13-7-9-19-10-8-13)21-18-14-4-2-1-3-12(14)5-6-15(16)18/h1-11H
InChiKey: LZCOBWKVDSSOBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-pyridyl)benzo[h]chromen-4-one
2-(4-pyridyl)-4-benzo[h][1]benzopyranone
2-(4-pyridyl)-4-benzo[h]chromenone
2110-25-0
2-Pyridin-4-yl-benzo[h]chromen-4-one
BAS 12813734
ST5294170

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Rattus norvegicus	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.0137	0.0747	0.0744
Brugia malayi	hypothetical protein	0.0087	0.0444	0.0439
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.008	0.0077
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0052	0.0049
Trypanosoma brucei	elongation of very long chain fatty acids protein, putative	0.0081	0.0411	0.5479
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0215	0.0205
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0088	0.045	0.5879
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Brugia malayi	TATA binding protein associated factor	0.0088	0.045	0.0444
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0108	0.0573	0.7579
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0049	0.0617
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0058	0.0914
Brugia malayi	fatty acid elongation protein 3	0.0064	0.0309	0.0303
Trypanosoma cruzi	fatty acid elongase, putative	0.0064	0.0309	0.3921
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.0557	0.0551
Brugia malayi	hypothetical protein	0.0043	0.0183	0.0177
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0153	0.013
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0025	0.0073	0.117
Brugia malayi	hypothetical protein	0.024	0.1376	0.1371
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0049	0.0325
Trypanosoma cruzi	fatty acid elongase, putative	0.0081	0.0411	0.5338
Onchocerca volvulus		0.0049	0.0217	0.2636
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0052	0.066
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0146	0.0807	0.0801
Loa Loa (eye worm)	hypothetical protein	0.005	0.0221	0.0218
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0049	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Trypanosoma brucei	trypanothione reductase	0.005	0.0225	0.2979
Echinococcus granulosus	dnaJ subfamily B	0.0452	0.266	0.2679
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0052	0.0369
Mycobacterium tuberculosis	Probable esterase LipL	0.0112	0.0599	0.1393
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0064	0.0309	0.4404
Trypanosoma cruzi	fatty acid elongase, putative	0.0064	0.0309	0.3921
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0793	0.079
Schistosoma mansoni	elongation of fatty acids protein 1	0.0081	0.0411	0.039
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0793	0.079
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0095	0.0084
Mycobacterium leprae	conserved hypothetical protein	0.0112	0.0599	0.8559
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.0693	0.1615
Echinococcus granulosus	elongation of very long chain fatty acids	0.0081	0.0411	0.0403
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0064	0.0309	0.0306
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.0219	0.2685
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0052	0.0369
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.0573	0.7579
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0557	0.0554
Schistosoma mansoni	hypothetical protein	0.0105	0.0557	0.0538
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0183	0.0173
Echinococcus granulosus	beta LACTamase domain containing family member	0.0112	0.0599	0.0593
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0026	0.0303
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0035	0.013	0.1711
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0716	0.4255	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0215	0.0192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0019	0.0038	0.0074
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Echinococcus multilocularis	peregrin	0.0029	0.0095	0.0084
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0078	0.0074
Schistosoma mansoni	hypothetical protein	0.0049	0.0215	0.0192
Brugia malayi	beta-lactamase family protein	0.0112	0.0599	0.0593
Entamoeba histolytica	protein kinase, putative	0.0108	0.0573	1
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0049	0.0347
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0019	0.0038	0.0074
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0026	0.0014
Trypanosoma brucei	Fatty acid elongase	0.0137	0.0747	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0052	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0569	0.0566
Echinococcus granulosus	aminopeptidase N	0.0088	0.045	0.0443
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0026	0.0303
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0004	0.0017
Leishmania major	fatty acid elongase, putative	0.0137	0.0747	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0095	0.0071
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.0851	0.0846
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0088	0.045	0.0447
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0052	0.0061
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0095	0.124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0009	0.0079
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.0599	1
Brugia malayi	Peptidase family M1 containing protein	0.0088	0.045	0.0444
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0088	0.045	0.5879
Echinococcus multilocularis	muscleblind protein	0.0153	0.0846	0.0844
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.0153	0.015
Trypanosoma cruzi	fatty acid elongase, putative	0.0064	0.0309	0.3921
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0052	0.004
Trypanosoma brucei	Fatty acid elongase	0.0064	0.0309	0.4105
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0137	0.0747	0.0744
Onchocerca volvulus		0.0112	0.0599	1
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0049	0.0325
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0019	0.0038	0.0184
Echinococcus granulosus	leukotriene A 4 hydrolase	0.1647	0.9894	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Loa Loa (eye worm)	aminopeptidase N	0.0088	0.045	0.0447
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.0807	0.0791
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0025	0.0073	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0215	0.0212
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Brugia malayi	PHD-finger family protein	0.0029	0.0095	0.0089
Leishmania major	fatty acid elongase, putative	0.0137	0.0747	1
Plasmodium falciparum	thioredoxin reductase	0.005	0.0225	0.3009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0309	0.0306
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0026	0.0303
Brugia malayi	CXXC zinc finger family protein	0.0061	0.0291	0.0285
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0164	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0219	0.0216
Brugia malayi	glutathione reductase	0.005	0.0225	0.0219
Plasmodium vivax	hypothetical protein, conserved	0.0112	0.0599	0.8009
Leishmania major	long chain polyunsaturated fatty acid elongation enzyme-like protein	0.0081	0.0411	0.5338
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0584	0.7735
Leishmania major	hypothetical protein, conserved	0.0112	0.0599	0.7939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Giardia lamblia	PHD finger protein 15	0.0029	0.0095	1
Brugia malayi	intermediate filament protein	0.0026	0.008	0.0075
Trypanosoma brucei	Long chain fatty acyl elongase	0.0081	0.0411	0.5479
Schistosoma mansoni	hypothetical protein	0.0049	0.0217	0.0194
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0026	0.0343
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.0494	0.0488
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0215	0.0205
Mycobacterium tuberculosis	Probable hydrolase	0.0112	0.0599	0.1393
Plasmodium falciparum	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0081	0.0411	0.5498
Trypanosoma cruzi	fatty acid elongase, putative	0.0137	0.0747	1
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0081	0.0411	0.0403
Mycobacterium ulcerans	beta-lactamase	0.0112	0.0599	0.8488
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0052	0.0046
Entamoeba histolytica	hypothetical protein	0.0043	0.0183	0.256
Trypanosoma cruzi	fatty acid elongase, putative	0.0137	0.0747	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0049	0.0099
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0049	0.0024
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0035	0.0032
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0025	0.0073	0.117
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0026	0.0303
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.1376	0.138
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0049	0.0043
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0058	1
Toxoplasma gondii	aminopeptidase N, putative	0.0088	0.045	0.6004
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0026	0.0343
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0019	0.0038	0.0074
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.008	0.0075
Echinococcus granulosus	cpg binding protein	0.0065	0.0312	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.0108	0.0573	0.0554
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Echinococcus granulosus	peregrin	0.0029	0.0095	0.0084
Trypanosoma cruzi	fatty acid elongase, putative	0.0137	0.0747	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0035	0.013	0.1452
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0019	0.0038	0.264
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0019	0.0038	0.0184
Trypanosoma brucei	aminopeptidase, putative	0.0088	0.045	0.6004
Loa Loa (eye worm)	ELO-9 protein	0.0064	0.0309	0.0306
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0095	0.0071
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0052	0.004
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	0.0137	0.0747	1
Schistosoma mansoni	microtubule-associated protein tau	0.071	0.4218	0.4249
Onchocerca volvulus	Elongation of very long chain fatty acids protein 5 homolog	0.0064	0.0309	0.4404
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0049	0.0325
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0058	0.6763
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0017	0.0026	0.0044
Echinococcus granulosus	lamin	0.0026	0.008	0.0069
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1647	0.9894	1
Mycobacterium ulcerans	two component sensor kinase MprB	0.0019	0.0038	0.0184
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0019	0.0038	0.0184
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0058	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0846	0.0843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Brugia malayi	Fatty acid elongation protein 3	0.0137	0.0747	0.0742
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0282	0.0279
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0064	0.0309	0.03
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0025	0.0073	0.117
Onchocerca volvulus		0.0088	0.045	0.7131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0052	0.066
Toxoplasma gondii	aminopeptidase n, putative	0.0088	0.045	0.6004
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Trypanosoma brucei	unspecified product	0.0021	0.0049	0.0617
Echinococcus multilocularis	dual specificity	0.0108	0.0573	0.0567
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0183	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.0599	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0052	0.0369
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0052	0.0369
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0064	0.0309	0.0306
Schistosoma mansoni	intermediate filament proteins	0.0026	0.008	0.0056
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.0807	0.0791
Schistosoma mansoni	elongation of fatty acids protein 1	0.0064	0.0309	0.0287
Entamoeba histolytica	protein kinase domain containing protein	0.0108	0.0573	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.0807	0.0804
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0058	0.0046
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0217	0.0211
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0215	0.0205
Trypanosoma cruzi	aminopeptidase, putative	0.0088	0.045	0.5879
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0444	0.0441
Entamoeba histolytica	hypothetical protein	0.0108	0.0573	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0058	0.0032
Leishmania major	fatty acid elongase, putative	0.0081	0.0411	0.5338
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0052	0.066
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.0851	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0088	0.045	0.0447
Entamoeba histolytica	protein kinase, putative	0.0108	0.0573	1
Brugia malayi	fatty acid elongation protein 3	0.0064	0.0309	0.0303
Schistosoma mansoni	DNA polymerase eta	0.0049	0.0219	0.0196
Brugia malayi	beta-lactamase family protein	0.0112	0.0599	0.0593
Mycobacterium tuberculosis	Probable lipase LipD	0.0112	0.0599	0.1393
Toxoplasma gondii	thioredoxin reductase	0.005	0.0225	0.2979
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0052	0.0369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0064	0.0309	0.0306
Onchocerca volvulus		0.0112	0.0599	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0112	0.0599	0.0596
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0153	0.013
Echinococcus multilocularis	dna polymerase eta	0.0049	0.0219	0.021
Brugia malayi	Muscleblind-like protein	0.0153	0.0846	0.084
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Plasmodium vivax	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0081	0.0411	0.5498
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0146	0.0807	0.0804
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0112	0.0599	0.8488
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.0846	0.0844
Brugia malayi	Hypothetical 34.1 kDa protein C40H1.4 in chromosome III	0.0064	0.0309	0.0303
Leishmania major	DNA polymerase eta, putative	0.0035	0.013	0.1452
Entamoeba histolytica	hypothetical protein	0.0043	0.0183	0.256
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.0615	0.1432
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0052	0.0369
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0052	0.0369
Mycobacterium ulcerans	lipase LipD	0.0112	0.0599	0.8488
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0129	0.0701	0.9353
Toxoplasma gondii	aminopeptidase N protein	0.0088	0.045	0.6004
Schistosoma mansoni	lamin	0.0026	0.008	0.0056
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0088	0.045	0.7504
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0088	0.045	0.043
Echinococcus multilocularis	aminopeptidase N	0.0088	0.045	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0215	0.0212
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0049	0.0325
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0088	0.045	0.7504
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0026	0.0378
Brugia malayi	Thioredoxin reductase	0.005	0.0225	0.0219
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.013	0.0707	0.0691
Brugia malayi	fatty acid elongation protein 3	0.0064	0.0309	0.0303
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0052	0.066
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0019	0.0038	0.0074
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0088	0.045	0.6021
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0215	0.0209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Brugia malayi	Peptidase family M1 containing protein	0.0088	0.045	0.0444
Onchocerca volvulus		0.0061	0.0291	0.4069
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Mycobacterium ulcerans	hypothetical protein	0.0112	0.0599	0.8488
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0026	0.0303
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0049	0.0617
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	0.1818	0.1827
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0088	0.045	0.5879
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0058	0.077
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0058	0.0442
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0049	0.0347
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0052	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.008	0.0077
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0004	0.0017
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0313	0.1818	0.1827
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0049	0.0099
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1647	0.9894	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0088	0.045	0.5879
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.0599	0.7939
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0026	0.0343
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0058	0.0914
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0052	0.0369
Echinococcus granulosus	lamin dm0	0.0026	0.008	0.0069
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0019	0.0038	0.0184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Echinococcus granulosus	intermediate filament protein	0.0026	0.008	0.0069
Echinococcus granulosus	geminin	0.0339	0.1974	0.1985
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0095	0.1277
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0116	0.0623	0.8335
Leishmania major	fatty acid elongase, putative	0.0137	0.0747	1
Echinococcus multilocularis	lamin	0.0026	0.008	0.0069
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.0701	0.0684
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0026	0.0378
Toxoplasma gondii	exonuclease III APE	0.0023	0.0058	0.0731
Schistosoma mansoni	ap endonuclease	0.0023	0.0058	0.0032
Schistosoma mansoni	elongation of fatty acids protein 1	0.0081	0.0411	0.039
Trypanosoma brucei	DNA polymerase eta, putative	0.0049	0.0219	0.2906
Trypanosoma brucei	unspecified product	0.0015	0.0009	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0058	0.0472
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0019	0.0038	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0095	0.0092
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0129	0.0701	0.0697
Leishmania major	trypanothione reductase	0.005	0.0225	0.276
Giardia lamblia	GTOR	0.0022	0.0052	0.3814
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0019	0.0038	0.0184
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.1376	0.138
Mycobacterium tuberculosis	Conserved protein	0.0112	0.0599	0.1393
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0088	0.045	0.5879
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0058	0.077
Echinococcus multilocularis	microtubule associated protein 2	0.071	0.4218	0.4256
Trypanosoma brucei	unspecified product	0.0015	0.0009	0.0079
Toxoplasma gondii	aldehyde dehydrogenase	0.0129	0.0701	0.9373
Brugia malayi	F/Y-rich N-terminus family protein	0.0028	0.0091	0.0085
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0025	0.007	0.0045
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0225	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0088	0.045	0.7504
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0061	0.0291	0.0288
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0052	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0088	0.045	0.0447
Trypanosoma brucei	hypothetical protein, conserved	0.0112	0.0599	0.8001
Leishmania major	hypothetical protein, conserved	0.0114	0.0609	0.8088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma cruzi	fatty acid elongase, putative	0.0064	0.0309	0.3921
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0088	0.045	0.6021
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Brugia malayi	beta-lactamase	0.0112	0.0599	0.0593
Mycobacterium tuberculosis	Conserved protein	0.0112	0.0599	0.1393
Mycobacterium ulcerans	aminopeptidase N PepN	0.0088	0.045	0.6286
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0088	0.045	0.043
Plasmodium vivax	GNS1/SUR4 domain containing protein	0.0137	0.0747	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0225	0.0215
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0035	0.0023
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.0693	0.1615
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0052	0.0369
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0019	0.0038	0.0184
Mycobacterium tuberculosis	Probable lipase LipE	0.0112	0.0599	0.1393
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0215	0.0205
Onchocerca volvulus	Alhambra homolog	0.0029	0.0095	0.0289
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.0615	0.8815
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0058	0.0162
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Toxoplasma gondii	fatty acid elongase	0.0081	0.0411	0.5479
Echinococcus granulosus	GPCR family 2	0.0049	0.0215	0.0205
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0035	0.0023
Trichomonas vaginalis	helicase, putative	0.0014	0.0004	0.0017
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0095	0.0084
Brugia malayi	fatty acid elongation protein 3	0.0064	0.0309	0.0303
Echinococcus granulosus	elongation of very long chain fatty acids	0.0064	0.0309	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Echinococcus granulosus	dual specificity	0.0108	0.0573	0.0567
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Entamoeba histolytica	aminopeptidase, putative	0.0088	0.045	0.7657
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0026	0.002
Schistosoma mansoni	hypothetical protein	0.0339	0.1974	0.1974
Schistosoma mansoni	hypothetical protein	0.0452	0.266	0.2669
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0052	0.0049
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0132	0.0122
Toxoplasma gondii	ABC1 family protein	0.0112	0.0599	0.8001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.0701	1
Brugia malayi	jmjC domain containing protein	0.0095	0.0494	0.0489
Schistosoma mansoni	cpg binding protein	0.0065	0.0312	0.0291
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.0807	0.0804
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0004	0.0017
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0058	0.0054
Schistosoma mansoni	hypothetical protein	0.0339	0.1974	0.1974
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0088	0.045	0.0443
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0095	0.1277
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0225	0.0215
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.0701	0.0684
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0019	0.0038	0.0074
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.0599	0.7939
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0164	0.0154
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0019	0.0038	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0052	0.0369
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.008	0.0077
Echinococcus multilocularis	cpg binding protein	0.0065	0.0312	0.0304
Trypanosoma cruzi	fatty acid elongase, putative	0.0137	0.0747	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0026	0.0303
Brugia malayi	hypothetical protein	0.0088	0.045	0.0444
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0019	0.0038	0.0074
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0112	0.0599	0.0593
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0108	0.0573	0.057
Loa Loa (eye worm)	hypothetical protein	0.0088	0.045	0.0447
Echinococcus granulosus	dna polymerase eta	0.0049	0.0219	0.021
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0049	0.0046
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0049	0.0037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.0807	0.0804
Onchocerca volvulus		0.0088	0.045	0.7131
Schistosoma mansoni	fatty acid acyl transferase-related	0.0081	0.0411	0.039
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0215	0.0205
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.0807	0.0804
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0095	0.0092
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0095	0.124
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0049	0.0772
Mycobacterium tuberculosis	Conserved protein	0.0112	0.0599	0.1393
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0006	0.0003
Trichomonas vaginalis	receptor histidine kinase, putative	0.0025	0.0073	0.117
Entamoeba histolytica	hypothetical protein	0.0043	0.0183	0.256
Brugia malayi	hypothetical protein	0.0088	0.045	0.0444
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0088	0.045	0.6004
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0225	0.0222
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	0.0137	0.0747	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.0573	0.7579
Onchocerca volvulus		0.0064	0.0309	0.4404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Brugia malayi	hypothetical protein	0.0757	0.4505	0.4502
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0058	0.0119
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0112	0.0599	0.0593
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0064	0.0309	0.4404
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0049	0.0037
Schistosoma mansoni	lamin	0.0026	0.008	0.0056
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0108	0.0573	0.7652
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.0599	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0052	0.066
Echinococcus multilocularis	geminin	0.0339	0.1974	0.1985
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0088	0.045	0.5879
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0052	0.004
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Brugia malayi	MH2 domain containing protein	0.0144	0.0793	0.0787
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.0153	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0851	0.0848
Trypanosoma brucei	Aminopeptidase M1, putative	0.0088	0.045	0.6004
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0025	0.0073	0.117
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0026	0.0343
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.0701	1
Trypanosoma cruzi	aminopeptidase, putative	0.0088	0.045	0.5879
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0009	0.0079
Entamoeba histolytica	hypothetical protein	0.0043	0.0183	0.256
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.0615	0.1432
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.0494	0.0488
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0052	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma cruzi	fatty acid elongase, putative	0.0081	0.0411	0.5338
Leishmania major	DNA polymerase eta, putative	0.0049	0.0219	0.2685
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.0599	0.0581
Mycobacterium ulcerans	aminopeptidase N PepN	0.0088	0.045	0.6286
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.0615	0.1432
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.0807	0.0791
Echinococcus multilocularis	musashi	0.0026	0.008	0.0069
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0129	0.0701	0.0697
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0112	0.0599	0.1393
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Onchocerca volvulus		0.0064	0.0309	0.4404
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0019	0.0038	0.0184
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0112	0.0599	0.1393
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0217	0.0194
Brugia malayi	Bromodomain containing protein	0.0029	0.0095	0.0089
Schistosoma mansoni	hypothetical protein	0.0049	0.0215	0.0192
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0058	0.0442
Schistosoma mansoni	cpg binding protein	0.0061	0.0291	0.0269
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0049	0.3358
Schistosoma mansoni	hypothetical protein	0.0049	0.0215	0.0192
Toxoplasma gondii	GNS1/SUR4 family protein	0.0137	0.0747	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.0693	1
Plasmodium falciparum	glutathione reductase	0.0017	0.0026	0.0343
Trichomonas vaginalis	receptor histidine kinase, putative	0.0025	0.0073	0.117
Mycobacterium tuberculosis	Probable reductase	0.0115	0.0615	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0569	0.0566
Loa Loa (eye worm)	TATA binding protein associated factor	0.0088	0.045	0.0447
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0444	0.0441
Loa Loa (eye worm)	glutathione reductase	0.005	0.0225	0.0222
Mycobacterium leprae	Probable lipase LipE	0.0112	0.0599	0.8559
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0049	0.0325
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0088	0.045	0.5879
Echinococcus multilocularis	dnaJ subfamily B	0.0452	0.266	0.2679
Brugia malayi	GNS1/SUR4 family protein	0.0137	0.0747	0.0742
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.0701	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.5849	0.5907
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0088	0.045	0.5879
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Loa Loa (eye worm)	hypothetical protein	0.024	0.1376	0.1373
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0088	0.045	0.043
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0049	0.0325
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Echinococcus granulosus	microtubule associated protein 2	0.071	0.4218	0.4256
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.0693	0.1615
Trypanosoma brucei	Aminopeptidase M1, putative	0.0088	0.045	0.6004
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0052	0.066
Trichomonas vaginalis	esterase, putative	0.0112	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	0.0137	0.0747	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.0615	0.1432
Schistosoma mansoni	elongation of fatty acids protein 1	0.0064	0.0309	0.0287
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.0615	0.1432
Onchocerca volvulus		0.0112	0.0599	1
Brugia malayi	Peptidase family M1 containing protein	0.0088	0.045	0.0444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0009	0.0079
Loa Loa (eye worm)	beta-lactamase	0.0112	0.0599	0.0596
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0058	0.0442
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0049	0.0772
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0183	0.0173
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1647	0.9894	0.9894
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0088	0.045	0.6021
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0049	0.0024
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0088	0.045	0.0443
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0058	0.0052
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0225	0.3009
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0088	0.045	0.043
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0026	0.0343
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0026	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0846	0.0843
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0088	0.045	0.6021
Schistosoma mansoni	eyes absent homolog	0.0087	0.0444	0.0424
Plasmodium vivax	elongation of very long chain fatty acids protein 3, putative	0.0064	0.0309	0.413
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0049	0.0617
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0049	0.0617
Trypanosoma brucei	Fatty acid elongase	0.0064	0.0309	0.4105
Trichomonas vaginalis	sensor histidine kinase, putative	0.0025	0.0073	0.117
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.0851	0.0848
Onchocerca volvulus		0.0088	0.045	0.7131
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0058	0.0731
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0129	0.0701	0.1633
Echinococcus multilocularis	lamin dm0	0.0026	0.008	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0599	0.0596
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0052	0.0046
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0376	0.0355
Brugia malayi	jmjC domain containing protein	0.0039	0.0153	0.0148
Echinococcus granulosus	muscleblind protein	0.0153	0.0846	0.0844
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0049	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0052	0.0825
Mycobacterium ulcerans	esterase/lipase LipP	0.0112	0.0599	0.8488
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.0599	0.0581
Plasmodium falciparum	glutathione reductase	0.005	0.0225	0.3009
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0058	0.4571
Schistosoma mansoni	hypothetical protein	0.0043	0.0183	0.016
Schistosoma mansoni	cpg binding protein	0.0065	0.0312	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0004	0.0017
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0112	0.0599	0.1393
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.1665	1	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0088	0.045	0.5879
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0215	0.0209
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Plasmodium vivax	glutathione reductase, putative	0.005	0.0225	0.3009
Brugia malayi	ImpB/MucB/SamB family protein	0.0049	0.0219	0.0214
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0088	0.045	0.5879
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0225	0.276
Leishmania major	fatty acid elongase, putative	0.0064	0.0309	0.3921
Brugia malayi	Protein kinase domain containing protein	0.0108	0.0573	0.0567

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.496 uM	PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442]	ChEMBL.	No reference
IC50 (binding)	> 10 uM	Inhibition of DNA dependent protein kinase isolated from HeLa cells	ChEMBL.	15658870
IC50 (binding)	> 10 uM	Inhibition of DNA dependent protein kinase isolated from HeLa cells	ChEMBL.	15658870
Potency (functional)	1.7783 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.3048 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	11.9173 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.7865 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL177991
PubChem: 3163532

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 310184