Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1257 | 0.1317 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.1257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1257 | 0.1317 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0891 | 0.0739 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.1257 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.1257 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0175 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.1257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4382 | 0.4709 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1257 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0175 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1257 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1257 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1257 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.1257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1257 | 0.1317 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.7965 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1257 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.1257 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0891 | 0.0679 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.1257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0142 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.3627 | 0.2711 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0559 | 0.0242 |
Onchocerca volvulus | 0.0026 | 0.1257 | 0.5 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.7343 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.1257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.405 | 0.4348 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.1257 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.7343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3639 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0142 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3216 | 0.4076 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0175 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1257 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.1257 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0891 | 0.0739 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0559 | 0.0559 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0175 | 0.139 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1302 | 0.0051 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.1257 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3216 | 0.4076 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.1257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 36 nM | Inhibition of [3H]-ZM-241,385 binding to adenosine A2a receptor of rat brain tissue | ChEMBL. | 15771443 |
Ki (binding) | = 36 nM | Inhibition of [3H]-ZM-241,385 binding to adenosine A2a receptor of rat brain tissue | ChEMBL. | 15771443 |
Ki (binding) | > 250 nM | Inhibition of [3H]-DPCPX binding to adenosine A1 receptor of rat cerebral cortex | ChEMBL. | 15771443 |
Ki (binding) | > 250 nM | Inhibition of [3H]-DPCPX binding to adenosine A1 receptor of rat cerebral cortex | ChEMBL. | 15771443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.