Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin I converting enzyme 2 | Starlite/ChEMBL | References |
Homo sapiens | angiotensin I converting enzyme | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | RNA directed DNA polymerase | 0.1197 | 0.4415 | 0.4415 |
Echinococcus granulosus | protein kinase C gamma type | 0.1622 | 0.7835 | 0.7835 |
Onchocerca volvulus | 0.1005 | 0.2864 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.104 | 0.3145 | 0.3145 |
Loa Loa (eye worm) | hypothetical protein | 0.1466 | 0.658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.2864 | 0.115 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1197 | 0.4415 | 0.4415 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.2864 | 0.115 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0726 | 0.0622 | 0.0622 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1891 | 1 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1197 | 0.4415 | 0.4415 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1622 | 0.7835 | 0.7835 |
Brugia malayi | Protein kinase c protein 2 | 0.1519 | 0.7004 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.125 | 0.4839 | 0.5853 |
Loa Loa (eye worm) | hypothetical protein | 0.1385 | 0.5926 | 0.8443 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.2864 | 0.115 |
Brugia malayi | protein kinase C II. | 0.104 | 0.3145 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.1197 | 0.4415 | 0.4843 |
Echinococcus granulosus | protein kinase c epsilon type | 0.104 | 0.3145 | 0.3145 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1891 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.104 | 0.3145 | 0.1819 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.104 | 0.3145 | 0.3145 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1891 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1274 | 0.5029 | 0.6307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -34 mmHg | Change in mean aortic blood pressure in the conscious renal hypertensive rat after oral administration of 3 mg/kg | ChEMBL. | 6173481 |
Change (functional) | = -11 mmHg | Change in mean aortic blood pressure in the conscious renal hypertensive rat after oral administration of 30 mg/kg | ChEMBL. | 6173481 |
IC50 (binding) | = 0.000000082 M | Concentration of the compound required to inhibit the activity of Angiotensin I converting enzyme by 50% | ChEMBL. | 6173481 |
IC50 (binding) | = 0.000000082 M | Concentration of the compound required to inhibit the activity of Angiotensin I converting enzyme by 50% | ChEMBL. | 6173481 |
Max effect (functional) | = 142 mmHg | Maximum effect of 30 mg/kg administered orally on mean aortic blood pressure in the conscious renal hypertensive rat | ChEMBL. | 6173481 |
Max effect (functional) | = 165 mmHg | Maximum effect of 3 mg/kg of compound administered orally on mean aortic blood pressure in the conscious renal hypertensive rat | ChEMBL. | 6173481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.