TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.347 | Formula: C19H16F6N4O
H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CC2CC1CN2c1ncccc1C(F)(F)F)Nc1ccc(cc1)C(F)(F)F
InChi: 1S/C19H16F6N4O/c20-18(21,22)11-3-5-12(6-4-11)27-17(30)29-10-13-8-14(29)9-28(13)16-15(19(23,24)25)2-1-7-26-16/h1-7,13-14H,8-10H2,(H,27,30)
InChiKey: GGCUQWMATLQJPZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Giardia lamblia	Cyclin A	0.0573	0.526	0.4991
Schistosoma mansoni	cyclin d	0.0138	0.1212	0.1153
Onchocerca volvulus	Cyclin L homolog	0.0138	0.1212	0.1153
Plasmodium vivax	protein kinase Crk2	0.0323	0.293	1
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0015	0.0067	0.0067
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0095	0.0095
Trypanosoma brucei	cdc2-related kinase 1	0.0323	0.293	0.2862
Echinococcus multilocularis	cyclin	0.0138	0.1212	0.1212
Giardia lamblia	Kinase, CMGC CLK	0.0077	0.064	0.0108
Onchocerca volvulus	Cyclin L homolog	0.0138	0.1212	0.1153
Brugia malayi	Protein kinase domain containing protein	0.011	0.095	0.095
Leishmania major	hypothetical protein, conserved	0.0321	0.2911	0.2843
Echinococcus multilocularis	cyclin y	0.0138	0.1212	0.1212
Leishmania major	mitotic cyclin, putative	0.0138	0.1212	0.1128
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.0321	0.2911	0.2843
Loa Loa (eye worm)	cyclin C	0.0138	0.1212	0.1212
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0095	0.0095
Brugia malayi	Trypsin-like protease protein 5	0.0015	0.0067	0.0067
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Echinococcus granulosus	glycoprotein Antigen 5	0.0015	0.0067	0.0067
Echinococcus granulosus	cyclin y	0.0138	0.1212	0.1212
Echinococcus multilocularis	Mastin	0.0015	0.0067	0.0067
Trypanosoma cruzi	cdc2-related kinase 3	0.0323	0.293	0.2862
Trichomonas vaginalis	cyclin B, putative	0.1082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.1212	0.0713
Echinococcus multilocularis	Cyclin L1	0.0138	0.1212	0.1212
Giardia lamblia	G2/mitotic-specific cyclin B	0.1082	1	1
Echinococcus granulosus	cyclins	0.0573	0.526	0.526
Brugia malayi	MAP kinase sur-1	0.0066	0.0537	0.0537
Schistosoma mansoni	hypothetical protein	0.0042	0.0312	0.0247
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.064	0.0577
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.011	0.095	0.0863
Echinococcus multilocularis	cyclin dependent kinase 1	0.0323	0.293	0.293
Entamoeba histolytica	cell division protein kinase 2, putative	0.0323	0.293	0.2702
Echinococcus granulosus	cyclins	0.0573	0.526	0.526
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0323	0.293	0.293
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.011	0.095	0.095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Brugia malayi	Trypsin family protein	0.0015	0.0067	0.0067
Trichomonas vaginalis	cyclins, putative	0.0573	0.526	0.4991
Trichomonas vaginalis	CMGC family protein kinase	0.0323	0.293	0.2529
Trichomonas vaginalis	cyclin B, putative	0.1082	1	1
Trypanosoma brucei	cyclin 3	0.0138	0.1212	0.1128
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0138	0.1212	0.1212
Loa Loa (eye worm)	hypothetical protein	0.1082	1	1
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0138	0.1212	0.1212
Echinococcus multilocularis	enteropeptidase	0.0015	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2862	0.2862
Echinococcus granulosus	cyclin k	0.0138	0.1212	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Trichomonas vaginalis	cyclins, putative	0.0138	0.1212	0.0713
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0312	0.0247
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0066	0.0537	0.0447
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.011	0.095	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0882	0.0882
Brugia malayi	Cyclin, N-terminal domain containing protein	0.1082	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Trichomonas vaginalis	CMGC family protein kinase	0.0323	0.293	0.2529
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0077	0.064	0.055
Onchocerca volvulus		0.1082	1	1
Entamoeba histolytica	cyclin, putative	0.0573	0.526	0.5107
Toxoplasma gondii	hypothetical protein	0.0435	0.3972	1
Trypanosoma cruzi	cyclin 9, putative	0.0138	0.1212	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1212	0.1212
Plasmodium falciparum	cyclin 1	0.0138	0.1212	0.2163
Brugia malayi	cell division control protein 2 homolog	0.0323	0.293	0.293
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0138	0.1212	0.2163
Echinococcus granulosus	cyclins	0.0573	0.526	0.526
Loa Loa (eye worm)	hypothetical protein	0.1082	1	1
Echinococcus multilocularis	dual specificity	0.011	0.095	0.095
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0882	0.0882
Echinococcus granulosus	cyclins	0.0573	0.526	0.526
Echinococcus multilocularis	cyclin y	0.0138	0.1212	0.1212
Brugia malayi	Trypsin family protein	0.0015	0.0067	0.0067
Echinococcus multilocularis	cyclin G2	0.0138	0.1212	0.1212
Echinococcus multilocularis	cyclin B3 1	0.0573	0.526	0.526
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.011	0.095	0.0863
Entamoeba histolytica	cyclin, domain containing protein	0.0138	0.1212	0.0929
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0066	0.0537	0.0537
Entamoeba histolytica	hypothetical protein	0.011	0.095	0.0658
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Trichomonas vaginalis	cyclin B, putative	0.0573	0.526	0.4991
Schistosoma mansoni	cyclin l	0.0138	0.1212	0.1153
Giardia lamblia	Hypothetical protein	0.0573	0.526	0.4991
Trichomonas vaginalis	cyclin B3, putative	0.0138	0.1212	0.0713
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.1212	0.0713
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0077	0.064	0.055
Echinococcus granulosus	G1:S specific cyclin D1	0.0138	0.1212	0.1212
Echinococcus multilocularis	cyclin A3 4	0.0138	0.1212	0.1212
Echinococcus multilocularis	cyclin G2	0.0138	0.1212	0.1212
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0077	0.064	0.055
Brugia malayi	Trypsin family protein	0.0015	0.0067	0.0067
Trichomonas vaginalis	methylated-DNA--protein-cysteine methyltransferase, putative	0.0321	0.2911	0.2509
Leishmania major	protein kinase, putative	0.0077	0.064	0.055
Echinococcus granulosus	Mastin	0.0015	0.0067	0.0067
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0015	0.0067	0.0067
Schistosoma mansoni	serine/threonine protein kinase	0.0323	0.293	0.2882
Echinococcus multilocularis	cyclin dependent kinase 1	0.0323	0.293	0.293
Trichomonas vaginalis	cyclins, putative	0.0138	0.1212	0.0713
Echinococcus granulosus	transmembrane protease serine 3	0.0015	0.0067	0.0067
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0077	0.064	0.055
Entamoeba histolytica	cell division protein kinase 2, putative	0.0323	0.293	0.2702
Treponema pallidum	methylated-DNA-protein-cysteine S-methyltransferase (dat)	0.0321	0.2911	0.5
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0095	0.0028
Trichomonas vaginalis	cyclins, putative	0.1082	1	1
Schistosoma mansoni	hypothetical protein	0.0138	0.1212	0.1153
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0095	0.0095
Trichomonas vaginalis	cyclin D, putative	0.0573	0.526	0.4991
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0138	0.1212	0.1212
Trichomonas vaginalis	cyclin B, putative	0.0138	0.1212	0.0713
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0066	0.0537	0.0447
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Loa Loa (eye worm)	trypsin family protein	0.0015	0.0067	0.0067
Mycobacterium ulcerans	DNA-methyltransferase (modification methylase)	0.013	0.1139	0.12
Trichomonas vaginalis	cyclin A, putative	0.1082	1	1
Echinococcus multilocularis	cyclin B	0.1082	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0138	0.1212	0.2163
Brugia malayi	hypothetical protein	0.0138	0.1212	0.1212
Trichomonas vaginalis	cyclin D, putative	0.0573	0.526	0.4991
Trypanosoma cruzi	CYC2-like cyclin, putative	0.1082	1	1
Echinococcus granulosus	cyclin G2	0.0138	0.1212	0.1212
Mycobacterium tuberculosis	Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra	0.0975	0.9003	1
Toxoplasma gondii	cyclin 4, putative	0.0138	0.1212	0.2881
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0138	0.1212	0.2881
Schistosoma mansoni	g1/s-specific cyclin C	0.0138	0.1212	0.1153
Trypanosoma brucei	protein kinase, putative	0.0066	0.0537	0.0447
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0066	0.0537	0.0447
Echinococcus granulosus	hypothetical protein	0.0069	0.0571	0.0571
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0323	0.293	0.2862
Brugia malayi	Protein kinase domain containing protein	0.0077	0.064	0.064
Trypanosoma brucei	hypothetical protein, conserved	0.013	0.1139	0.1054
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Trichomonas vaginalis	cyclin B, putative	0.0138	0.1212	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Chlamydia trachomatis	methylated-DNA protein-cysteine methyltransferase	0.0321	0.2911	0.5
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0077	0.064	0.055
Echinococcus granulosus	cyclin y	0.0138	0.1212	0.1212
Trichomonas vaginalis	cyclin B, putative	0.1082	1	1
Echinococcus granulosus	cyclin A3 4	0.0138	0.1212	0.1212
Echinococcus multilocularis		0.0069	0.0571	0.0571
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0138	0.1212	0.1212
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.0321	0.2911	0.2843
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0323	0.293	0.293
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Echinococcus multilocularis	cyclin dependent kinase 5	0.0323	0.293	0.293
Trichomonas vaginalis	cyclins, putative	0.0647	0.5952	0.5723
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.011	0.095	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1212	0.1212
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0077	0.064	0.1405
Trichomonas vaginalis	conserved hypothetical protein	0.0573	0.526	0.4991
Plasmodium falciparum	cyclin	0.0573	0.526	1
Trypanosoma brucei	mitotic cyclin	0.0138	0.1212	0.1128
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0095	0.0095
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0138	0.1212	0.394
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0066	0.0537	0.1141
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Echinococcus granulosus	cyclin dependent kinase 5	0.0323	0.293	0.293
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0138	0.1212	0.2881
Echinococcus granulosus	mitogen activated protein kinase 3	0.0066	0.0537	0.0537
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0095	0.0095
Echinococcus granulosus	cyclins	0.0573	0.526	0.526
Onchocerca volvulus		0.0138	0.1212	0.1153
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.1041	0.9616	0.9616
Trypanosoma brucei	cyclin 9	0.0138	0.1212	0.1128
Trichomonas vaginalis	cyclins, putative	0.1082	1	1
Leishmania major	protein kinase, putative	0.0077	0.064	0.055
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0323	0.293	0.2862
Brugia malayi	hypothetical protein	0.0015	0.0067	0.0067
Plasmodium falciparum	protein kinase 5	0.0323	0.293	0.5489
Echinococcus granulosus	mitogen activated protein kinase	0.0066	0.0537	0.0537
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Loa Loa (eye worm)	hypothetical protein	0.0509	0.4665	0.4665
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.0537	0.0447
Trypanosoma brucei	cdc2-related kinase 3	0.0323	0.293	0.2862
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Giardia lamblia	Kinase, CMGC CDK	0.0323	0.293	0.2529
Trypanosoma cruzi	cyclin 6, putative	0.1082	1	1
Echinococcus multilocularis	cyclin b3	0.0573	0.526	0.526
Echinococcus granulosus	cyclins	0.0138	0.1212	0.1212
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.1212	0.0713
Trypanosoma cruzi	cdc2-related kinase 1	0.0323	0.293	0.2862
Trichomonas vaginalis	CMGC family protein kinase	0.0077	0.064	0.0108
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0066	0.0537	0.0537
Entamoeba histolytica	cyclin, domain containing protein	0.0138	0.1212	0.0929
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Echinococcus granulosus	cyclin	0.0138	0.1212	0.1212
Echinococcus multilocularis	cyclins	0.0573	0.526	0.526
Schistosoma mansoni	serine/threonine protein kinase	0.011	0.095	0.0889
Schistosoma mansoni	cyclin B3	0.1041	0.9616	0.9613
Brugia malayi	hypothetical protein	0.0042	0.0312	0.0312
Plasmodium vivax	hypothetical protein, conserved	0.0138	0.1212	0.394
Echinococcus multilocularis	cyclin dependent kinase	0.0323	0.293	0.293
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0312	0.0312
Schistosoma mansoni	cyclin k	0.0138	0.1212	0.1153
Schistosoma mansoni	cyclin G2	0.0138	0.1212	0.1153
Trypanosoma cruzi	cdc2-related kinase 3	0.0323	0.293	0.2862
Leishmania major	cyclin	0.1082	1	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.1212	0.0713
Giardia lamblia	Cyclin B-like protein	0.0138	0.1212	0.0713
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0077	0.064	0.064
Echinococcus granulosus	cyclin b3	0.0573	0.526	0.526
Echinococcus multilocularis	cyclin t1	0.0138	0.1212	0.1212
Plasmodium vivax	cyclin 4, putative	0.0138	0.1212	0.394
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0095	0.0095
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0138	0.1212	0.1128
Trichomonas vaginalis	cyclins, putative	0.1082	1	1
Trichomonas vaginalis	cyclins, putative	0.1082	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.0537	0.0447
Entamoeba histolytica	cyclin family protein	0.0573	0.526	0.5107
Trypanosoma brucei	mitotic cyclin 6	0.1082	1	1
Echinococcus granulosus	dual specificity protein kinase clk2	0.0077	0.064	0.064
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0077	0.064	0.064
Echinococcus granulosus	Cyclin L1	0.0138	0.1212	0.1212
Giardia lamblia	Cyclin fold protein 1, putative	0.0138	0.1212	0.0713
Trypanosoma cruzi	cyclin, putative	0.1082	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.064	0.0577
Loa Loa (eye worm)	CYL-1 protein	0.0138	0.1212	0.1212
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0015	0.0067	0.0067
Plasmodium vivax	serine/threonine kinase-1, putative	0.0077	0.064	0.1922
Schistosoma mansoni	hypothetical protein	0.0196	0.1751	0.1695
Echinococcus multilocularis	calcium activated potassium channel	0.0015	0.0066	0.0066
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Echinococcus granulosus	enteropeptidase	0.0015	0.0067	0.0067
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0095	0.0095
Plasmodium falciparum	protein serine/threonine kinase-1	0.0077	0.064	0.1055
Trichomonas vaginalis	cyclin D, putative	0.0138	0.1212	0.0713
Echinococcus multilocularis	glycoprotein Antigen 5	0.0015	0.0067	0.0067
Echinococcus granulosus	cyclin B	0.1082	1	1
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0138	0.1212	0.1153
Echinococcus multilocularis	G1:S specific cyclin D1	0.0138	0.1212	0.1212
Echinococcus granulosus	geminin	0.0196	0.1751	0.1751
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Mycobacterium leprae	PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA	0.0975	0.9003	0.5
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0015	0.0067	0.0067
Echinococcus granulosus	cyclin B3 1	0.0573	0.526	0.526
Giardia lamblia	Kinase, CMGC CDK	0.0323	0.293	0.2529
Trichomonas vaginalis	cyclin B3, putative	0.0138	0.1212	0.0713
Schistosoma mansoni	hypothetical protein	0.0138	0.1212	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Echinococcus multilocularis	geminin	0.0196	0.1751	0.1751
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0571	0.0571
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0939	0.8665	0.8665
Leishmania major	mitotic cyclin, putative	0.0138	0.1212	0.1128
Giardia lamblia	Hypothetical protein	0.0138	0.1212	0.0713
Brugia malayi	Cyclin C	0.0138	0.1212	0.1212
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.1041	0.9616	0.9616
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0066	0.0537	0.0447
Trypanosoma cruzi	mitotic cyclin, putative	0.0138	0.1212	0.1128
Echinococcus multilocularis	transmembrane protease serine 3	0.0015	0.0067	0.0067
Entamoeba histolytica	protein kinase, putative	0.011	0.095	0.0658
Echinococcus multilocularis	mitogen activated protein kinase	0.0066	0.0537	0.0537
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0323	0.293	0.7312
Toxoplasma gondii	hypothetical protein	0.0138	0.1212	0.2881
Schistosoma mansoni	Cyclin fold protein	0.0138	0.1212	0.1153
Schistosoma mansoni	cyclin G	0.0138	0.1212	0.1153
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.1082	1	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Brugia malayi	Protein kinase domain containing protein	0.0323	0.293	0.293
Trypanosoma cruzi	mitotic cyclin, putative	0.0138	0.1212	0.1128
Echinococcus granulosus	calcium activated potassium channel	0.0015	0.0066	0.0066
Brugia malayi	cyclin fold protein 1 variant b	0.0138	0.1212	0.1212
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0138	0.1212	0.1212
Brugia malayi	hypothetical protein	0.0138	0.1212	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0067
Loa Loa (eye worm)	cyclin domain-containing protein	0.1041	0.9616	0.9616
Echinococcus multilocularis	cyclin k	0.0138	0.1212	0.1212
Echinococcus granulosus	cyclin G2	0.0138	0.1212	0.1212
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0095	0.0095
Onchocerca volvulus	Protein CNPPD1 homolog	0.0138	0.1212	0.1153
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0066	0.0537	0.0447
Echinococcus granulosus	cyclin dependent kinase	0.0323	0.293	0.293
Schistosoma mansoni	cyclins	0.0573	0.526	0.5228
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0323	0.293	0.293
Schistosoma mansoni	serine/threonine protein kinase	0.0323	0.293	0.2882
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0312	0.0312
Trichomonas vaginalis	cyclin B3, putative	0.0573	0.526	0.4991
Mycobacterium ulcerans	methylated-DNA--protein-cysteine methyltransferase Ogt	0.0975	0.9003	1
Entamoeba histolytica	hypothetical protein	0.0138	0.1212	0.0929
Schistosoma mansoni	hypothetical protein	0.0196	0.1751	0.1695
Echinococcus granulosus	dual specificity	0.011	0.095	0.095
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0077	0.064	0.055
Giardia lamblia	Hypothetical protein	0.0138	0.1212	0.0713
Plasmodium vivax	cyclin homologue, putative	0.0138	0.1212	0.394
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0537	0.0473
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0095	0.0095
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0323	0.293	0.293
Trypanosoma cruzi	cdc2-related kinase 1	0.0323	0.293	0.2862
Entamoeba histolytica	cyclin C, putative	0.0138	0.1212	0.0929
Entamoeba histolytica	cyclin, putative	0.1082	1	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0323	0.293	0.293
Entamoeba histolytica	protein kinase domain containing protein	0.011	0.095	0.0658
Leishmania major	cyclin 9, putative	0.0138	0.1212	0.1128
Loa Loa (eye worm)	cyclin domain-containing protein	0.0138	0.1212	0.1212
Entamoeba histolytica	cyclin family protein	0.0573	0.526	0.5107
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0138	0.1212	0.1212
Brugia malayi	Trypsin family protein	0.0015	0.0067	0.0067
Trypanosoma cruzi	cyclin, putative	0.1082	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0138	0.1212	0.1128
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0015	0.0067	0.0067
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0138	0.1212	0.2881
Trichomonas vaginalis	CMGC family protein kinase	0.0323	0.293	0.2529
Echinococcus granulosus	cyclin t1	0.0138	0.1212	0.1212
Brugia malayi	Cyclin, N-terminal domain containing protein	0.1041	0.9616	0.9616
Schistosoma mansoni	cyclin B	0.1082	1	1
Entamoeba histolytica	protein kinase, putative	0.011	0.095	0.0658
Trichomonas vaginalis	cyclin A, putative	0.0138	0.1212	0.0713
Trichomonas vaginalis	cyclin B, putative	0.1082	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibition of human transient receptor potential vanilloid 1 receptor (n=4)	ChEMBL.	15771431
IC50 (binding)	> 10000 nM	Inhibition of rat transient receptor potential vanilloid 1 receptor (n=2)	ChEMBL.	15771431
IC50 (binding)	> 10000 nM	Inhibition of human transient receptor potential vanilloid 1 receptor (n=4)	ChEMBL.	15771431
IC50 (binding)	> 10000 nM	Inhibition of rat transient receptor potential vanilloid 1 receptor (n=2)	ChEMBL.	15771431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL178540

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 310412