Detailed information for compound 310452

Basic information

Technical information
  • TDR Targets ID: 310452
  • Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-4-[3-(t rifluoromethyl)pyridin-2-yl]piperazine-1-carb oxamide
  • MW: 410.39 | Formula: C19H21F3N4O3
  • H donors: 2 H acceptors: 3 LogP: 2.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CNC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)ccc1O
  • InChi: 1S/C19H21F3N4O3/c1-29-16-11-13(4-5-15(16)27)12-24-18(28)26-9-7-25(8-10-26)17-14(19(20,21)22)3-2-6-23-17/h2-6,11,27H,7-10,12H2,1H3,(H,24,28)
  • InChiKey: FCYHNCUTCOCVHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-hydroxy-3-methoxy-phenyl)methyl]-4-[3-(trifluoromethyl)-2-pyridyl]piperazine-1-carboxamide
  • N-[(4-hydroxy-3-methoxyphenyl)methyl]-4-[3-(trifluoromethyl)-2-pyridyl]-1-piperazinecarboxamide
  • N-[(4-hydroxy-3-methoxy-phenyl)methyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
  • 4-[3-(trifluoromethyl)-2-pyridyl]-N-vanillyl-piperazine-1-carboxamide
  • N-(4-hydroxy-3-methoxy-benzyl)-4-[3-(trifluoromethyl)-2-pyridyl]piperazine-1-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major proteasome beta 2 subunit, putative 0.0038 0.0111 0.2103
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0188 0.3618
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0111 0.0108
Echinococcus granulosus proteasome subunit beta type 7 0.0016 0.0037 0.0035
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0103 0.1947
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Echinococcus granulosus proteasome prosome macropain 0.008 0.0245 0.0243
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0016 0.0037 0.0674
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0016 0.0037 0.0674
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0016 0.0037 0.0674
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0016 0.0037 0.0674
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0188 0.3585
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0016 0.0037 0.0674
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.0245 0.4703
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0005 0.0004 0.0034
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0016 0.0037 0.0722
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0005 0.0004 0.0073
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0037 0.0674
Toxoplasma gondii proteasome subunit alpha type, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.0111 0.2103
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0016 0.0037 0.0722
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0005 0.0004 0.0073
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0016 0.0037 0.0674
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.1401 0.1398
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0121 0.2294
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0048 0.1861
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0016 0.0037 0.0037
Echinococcus granulosus proteasome subunit alpha type 6 0.0016 0.0037 0.0035
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0011 0.0009
Echinococcus multilocularis zinc finger protein 0.0005 0.0003 0.0001
Brugia malayi proteasome subunit alpha type 4 0.0016 0.0037 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0103 0.1947
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0048 0.4496
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0164 0.0519 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0131 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0016 0.0037 0.0674
Brugia malayi Proteasome subunit alpha type 1 0.0016 0.0037 0.0076
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0016 0.0037 0.0674
Toxoplasma gondii aminopeptidase n, putative 0.0164 0.0519 1
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0016 0.0037 0.0035
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0037 0.0035
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0005 0.0004 0.0034
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0005 0.0004 0.0073
Leishmania major proteasome alpha 3 subunit, putative 0.0016 0.0037 0.0674
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Echinococcus multilocularis leukotriene A 4 hydrolase 0.3089 1 1
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0005 0.0004 0.0034
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0188 0.3585
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0005 0.0004 0.0073
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0164 0.0519 1
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0016 0.0037 0.0035
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0164 0.0519 1
Loa Loa (eye worm) inositol-1 0.0036 0.0103 0.01
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0016 0.0037 0.1434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0011 0.001
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0188 0.0185
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0016 0.0037 0.0035
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0065 0.1209
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0037 0.0674
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.0111 0.011
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0164 0.0519 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0111 0.011
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0188 0.3585
Giardia lamblia Proteasome subunit beta type 2 0.0038 0.0111 0.4471
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0005 0.0004 0.0034
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0188 0.0187
Leishmania major proteasome alpha 1 subunit, putative 0.0016 0.0037 0.0674
Schistosoma mansoni cpg binding protein 0.0032 0.0092 0.0091
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0037 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Brugia malayi Peptidase family M1 containing protein 0.0164 0.0519 0.1125
Entamoeba histolytica aminopeptidase, putative 0.0164 0.0519 1
Plasmodium vivax proteasome subunit beta type-3, putative 0.0016 0.0037 0.0722
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0017 0.0031
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0091 0.3636
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0016 0.0037 0.0674
Leishmania major proteasome alpha 2 subunit, putative 0.0016 0.0037 0.0674
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0016 0.0037 0.0037
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0188 0.0185
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0016 0.0037 0.0035
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0016 0.0037 0.0722
Plasmodium vivax heat shock protein 86, putative 0.0005 0.0003 0.0051
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.0111 0.2103
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0016 0.0037 0.0722
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.3089 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0103 0.1947
Echinococcus granulosus aminopeptidase N 0.0164 0.0519 0.0516
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0005 0.0004 0.0073
Brugia malayi proteasome subunit beta type 2 0.0038 0.0111 0.0237
Trichomonas vaginalis sensor histidine kinase, putative 0.0005 0.0004 0.0034
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0005 0.0004 0.0034
Mycobacterium leprae Probable two component sensor kinase MprB 0.0019 0.0047 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0164 0.0519 1
Loa Loa (eye worm) acetyltransferase 0.0141 0.0444 0.0441
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0016 0.0037 0.0035
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0065 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0016 0.0037 0.0674
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0016 0.0037 0.0035
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0005 0.0004 0.0034
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0005 0.0004 0.0399
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0005 0.0004 0.0034
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0016 0.0037 0.0674
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0016 0.0037 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.0098
Leishmania major proteasome beta 5 subunit, putative 0.008 0.0245 0.4703
Toxoplasma gondii proteasome subunit 0.0016 0.0037 0.0674
Giardia lamblia 20S proteasome alpha subunit 7 0.0016 0.0037 0.1434
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0016 0.0037 0.0037
Loa Loa (eye worm) proteasome subunit beta type 2 0.0038 0.0111 0.0109
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0245 0.4703
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0065 0.1209
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0016 0.0037 0.1434
Echinococcus granulosus Proteasome subunit alpha type 7 0.0016 0.0037 0.0035
Giardia lamblia Proteasome subunit beta type 3 0.0016 0.0037 0.1434
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Echinococcus multilocularis aminopeptidase N 0.0164 0.0519 0.0516
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0016 0.0037 0.0674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0131 0.0128
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.0875
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0016 0.0037 0.0035
Plasmodium vivax proteasome subunit beta type-7, putative 0.0016 0.0037 0.0722
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0164 0.0519 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Echinococcus multilocularis proteasome subunit beta type 7 0.0016 0.0037 0.0035
Schistosoma mansoni endoplasmin 0.0005 0.0003 0.0002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0103 0.1947
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0001
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0037 0.0076
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0038 0.0111 0.2103
Loa Loa (eye worm) hypothetical protein 0.0164 0.0519 0.0516
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0016 0.0037 0.0674
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0016 0.0037 0.0722
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0121 0.2334
Brugia malayi TATA binding protein associated factor 0.0164 0.0519 0.1125
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.0245 0.0244
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0038 0.0111 0.0109
Brugia malayi proteasome subunit alpha type 3 0.0016 0.0037 0.0076
Schistosoma mansoni hypothetical protein 0.0038 0.0111 0.011
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0019 0.0047 0.0864
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0048 0.0875
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0164 0.0519 1
Onchocerca volvulus 0.0164 0.0519 1
Trypanosoma cruzi aminopeptidase, putative 0.0164 0.0519 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0037 0.0674
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0103 0.1947
Plasmodium vivax proteasome subunit beta type-2, putative 0.0038 0.0111 0.2144
Loa Loa (eye worm) hypothetical protein 0.0164 0.0519 0.0516
Entamoeba histolytica hypothetical protein 0.0038 0.0111 0.21
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0164 0.0519 1
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0016 0.0037 0.0674
Trypanosoma cruzi Aminopeptidase M1, putative 0.0164 0.0519 1
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0019 0.0047 0.0864
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0016 0.0037 0.0674
Giardia lamblia 20S proteasome alpha subunit 6 0.0016 0.0037 0.1434
Brugia malayi Inositol-1 0.0036 0.0103 0.0219
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.0245 0.4703
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0019 0.0047 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Trichomonas vaginalis helicase, putative 0.0007 0.0009 0.0125
Trypanosoma brucei proteasome alpha 7 subunit 0.0016 0.0037 0.0674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0875
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0016 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.0045
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0016 0.0037 0.0035
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0019 0.0047 0.0864
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0121 0.2294
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0037 0.0076
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0188 0.7622
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0016 0.0037 0.0035
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0016 0.0037 0.0674
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.011 0.2077
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0121 0.0118
Schistosoma mansoni heat shock protein 0.0005 0.0003 0.0002
Loa Loa (eye worm) TATA binding protein associated factor 0.0164 0.0519 0.0516
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Mycobacterium ulcerans aminopeptidase N PepN 0.0164 0.0519 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0164 0.0519 0.0518
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0016 0.0037 0.0722
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.0245 0.0529
Leishmania major proteasome beta 7 subunit, putative 0.0016 0.0037 0.0674
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0016 0.0037 0.0674
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0019 0.0047 0.1836
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0037 0.0076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0922
Toxoplasma gondii peptidase, T1 family protein 0.0016 0.0037 0.0674
Brugia malayi hypothetical protein 0.0038 0.0111 0.0236
Leishmania major proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0131 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0131 0.013
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0016 0.0037 0.0674
Loa Loa (eye worm) peptidase family M1 containing protein 0.0164 0.0519 0.0516
Brugia malayi hypothetical protein 0.0164 0.0519 0.1125
Trypanosoma cruzi 20S proteasome subunit 0.0038 0.0111 0.2103
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0164 0.0519 1
Schistosoma mansoni endoplasmin 0.0005 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0164 0.0519 0.0516
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0016 0.0037 0.0674
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0016 0.0037 0.0674
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Loa Loa (eye worm) proteasome subunit beta type 3 0.0016 0.0037 0.0035
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0037 0.0674
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0164 0.0519 1
Leishmania major proteasome alpha 1 subunit, putative 0.0016 0.0037 0.0674
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0016 0.0037 0.0674
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0186 0.3552
Plasmodium vivax DNA gyrase subunit B, putative 0.0005 0.0003 0.0051
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0016 0.0037 0.0037
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0103 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0016 0.0037 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0009
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.0245 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0016 0.0037 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0009
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.0245 0.4731
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0016 0.0037 0.0035
Plasmodium vivax proteasome subunit beta type-6, putative 0.0016 0.0037 0.0722
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0016 0.0037 0.0674
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.0245 0.0243
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0103 0.1947
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0038 0.0111 0.2103
Echinococcus granulosus proteasome subunit beta type 6 0.0016 0.0037 0.0035
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0188 0.0185
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0875
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.0111 0.011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Toxoplasma gondii heat shock protein hslv, putative 0.0016 0.0037 0.0674
Brugia malayi proteasome subunit beta type 3 0.0016 0.0037 0.0076
Mycobacterium ulcerans proteasome PrcA 0.0016 0.0037 0.0674
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0016 0.0037 0.0674
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0005 0.0004 0.0034
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0016 0.0037 0.0674
Echinococcus granulosus Proteasome subunit alpha beta 0.0016 0.0037 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0125
Echinococcus granulosus proteasome subunit alpha type 2 0.0016 0.0037 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0131 0.013
Echinococcus multilocularis proteasome subunit alpha type 6 0.0016 0.0037 0.0035
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0005 0.0004 0.0073
Brugia malayi proteasome subunit alpha type 2 0.0016 0.0037 0.0076
Plasmodium falciparum proteasome subunit beta type-4 0.0016 0.0037 0.0674
Giardia lamblia 20S proteasome alpha subunit 5 0.0016 0.0037 0.1434
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0038 0.0111 0.2103
Onchocerca volvulus Notchless protein homolog 0.0016 0.0037 0.0674
Toxoplasma gondii aminopeptidase N protein 0.0164 0.0519 1
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0016 0.0037 0.0037
Schistosoma mansoni aminopeptidase A (M01 family) 0.0164 0.0519 0.0518
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0016 0.0037 0.0674
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0016 0.0037 0.0674
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0016 0.0037 0.0037
Loa Loa (eye worm) leukotriene A4 hydrolase 0.3089 1 1
Mycobacterium ulcerans hypothetical protein 0.0005 0.0004 0.0034
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0019 0.0047 0.1836
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0164 0.0519 1
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0047
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0016 0.0037 0.0035
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0103 0.1947
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0016 0.0037 0.3465
Echinococcus granulosus zinc finger protein 0.0005 0.0003 0.0001
Mycobacterium ulcerans two-component system transcriptional regulator 0.0005 0.0004 0.0034
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0444 0.0961
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0047 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0086 0.0083
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0015
Loa Loa (eye worm) PAS-3 protein 0.0016 0.0037 0.0035
Entamoeba histolytica hypothetical protein 0.0038 0.0111 0.21
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Brugia malayi proteasome subunit alpha type 6 0.0016 0.0037 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0875
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0005 0.0004 0.0034
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0188 0.3585
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0164 0.0519 1
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0016 0.0037 0.0037
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0065 0.1209
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0038 0.0111 0.2103
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0444 0.0441
Leishmania major proteasome beta 3 subunit, putative 0.0016 0.0037 0.0674
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0016 0.0037 0.0674
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0164 0.0519 0.0518
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0016 0.0037 0.0674
Schistosoma mansoni bromodomain containing protein 0.0005 0.0003 0.0003
Brugia malayi proteasome subunit beta type 1 0.0062 0.0188 0.0403
Schistosoma mansoni sensor histidine kinase/response regulator 0.0005 0.0004 0.0004
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0019 0.0047 0.1836
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0444 0.0443
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Schistosoma mansoni pyruvate dehydrogenase 0.0005 0.0003 0.0002
Echinococcus multilocularis proteasome subunit alpha type 2 0.0016 0.0037 0.0035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0188 0.3585
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0125
Brugia malayi Peptidase family M1 containing protein 0.0164 0.0519 0.1125
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0103 0.01
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Brugia malayi Proteasome subunit alpha type 7-1 0.0016 0.0037 0.0076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0015
Brugia malayi hypothetical protein 0.0164 0.0519 0.1125
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0019 0.0047 0.4436
Trypanosoma brucei proteasome beta 7 subunit 0.0016 0.0037 0.0674
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0016 0.0037 0.0674
Brugia malayi hypothetical protein 0.142 0.459 1
Brugia malayi 20S proteasome alpha5 subunit 0.0016 0.0037 0.0076
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0016 0.0037 0.0674
Leishmania major proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0103 0.01
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0016 0.0037 0.0674
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0016 0.0037 0.0674
Schistosoma mansoni hypothetical protein 0.0436 0.1401 0.14
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0131 0.013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0016 0.0037 0.0674
Trypanosoma brucei Aminopeptidase M1, putative 0.0164 0.0519 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0037 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Trypanosoma brucei Aminopeptidase M1, putative 0.0164 0.0519 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Giardia lamblia 20S proteasome alpha subunit 1 0.0016 0.0037 0.1434
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0016 0.0037 0.0037
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.011 0.2077
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0048 1
Brugia malayi PHD-finger family protein 0.0005 0.0003 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0131 0.0279
Leishmania major proteasome beta 2 subunit, putative 0.0016 0.0037 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.011 0.4417
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0038 0.0111 0.2103
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0016 0.0037 0.1434
Schistosoma mansoni bromodomain containing protein 0.0005 0.0003 0.0003
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0188 0.3585
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0019 0.0047 0.0864
Brugia malayi Bromodomain containing protein 0.0005 0.0003 0.0002
Mycobacterium ulcerans aminopeptidase N PepN 0.0164 0.0519 1
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0016 0.0037 0.0035
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0037 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0197 0.0196
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0016 0.0037 0.0722
Mycobacterium ulcerans two component transcriptional regulator 0.0005 0.0004 0.0034
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0164 0.0519 1
Brugia malayi proteasome subunit alpha type 1 0.0016 0.0037 0.0076
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0091 0.3636
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0005 0.0004 0.0034
Mycobacterium leprae TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) 0.0005 0.0004 0.0073
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0037 0.0037
Wolbachia endosymbiont of Brugia malayi response regulator 0.0005 0.0004 0.0177
Schistosoma mansoni zinc finger protein 0.0005 0.0003 0.0003
Plasmodium vivax DNA topoisomerase II, putative 0.0005 0.0003 0.0051
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0037 0.0035
Plasmodium vivax endoplasmin, putative 0.0005 0.0003 0.0051
Mycobacterium ulcerans two component regulator - sensor kinase 0.0019 0.0047 0.0864
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0016 0.0037 0.0674
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0019 0.0047 0.1836
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0065 0.621
Loa Loa (eye worm) aminopeptidase N 0.0164 0.0519 0.0516
Schistosoma mansoni heat shock protein 0.0005 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0125
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0016 0.0037 0.1434
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0019 0.0047 0.1836
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.0245 0.4703
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0019 0.0047 0.0864
Schistosoma mansoni inositol monophosphatase 0.0036 0.0103 0.0102
Echinococcus granulosus subfamily T1A non peptidase ue 0.0016 0.0037 0.0035
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0164 0.0519 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0037 0.0674
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0005 0.0004 0.0394
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0164 0.0519 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Echinococcus granulosus cpg binding protein 0.0032 0.0092 0.0089
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0037 0.0674
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0005 0.0004 0.0073
Trypanosoma cruzi aminopeptidase, putative 0.0164 0.0519 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0103 0.1947
Onchocerca volvulus 0.0164 0.0519 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0065 0.1209
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.0045
Brugia malayi Peptidase family M1 containing protein 0.0164 0.0519 0.1125
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0037 0.0035
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Echinococcus multilocularis cpg binding protein 0.0032 0.0092 0.0089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0048 0.0875
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0164 0.0519 1
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0103 0.1947
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0164 0.0519 1
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0016 0.0037 0.0674
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0016 0.0037 0.0035
Giardia lamblia 20S proteasome alpha subunit 3 0.0016 0.0037 0.1434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0875
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0037 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0125
Mycobacterium ulcerans proteasome PrcB 0.008 0.0245 0.4703
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0011 0.0009
Schistosoma mansoni cpg binding protein 0.0032 0.0092 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0875
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0016 0.0037 0.0674
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0164 0.0519 0.0518
Echinococcus multilocularis proteasome subunit beta type 6 0.0016 0.0037 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0003 0.0001
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0005 0.0004 0.0034
Mycobacterium leprae TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA 0.0005 0.0004 0.0073
Mycobacterium ulcerans two component sensor kinase MprB 0.0019 0.0047 0.0864
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0121 0.2294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0131 0.0128
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0048 0.1861
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Onchocerca volvulus 0.0031 0.0086 0.1614
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0005 0.0004 0.0177
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0016 0.0037 0.0037
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0016 0.0037 0.0674
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0016 0.0037 0.0722
Schistosoma mansoni cpg binding protein 0.0031 0.0086 0.0085
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0164 0.0519 0.0516
Onchocerca volvulus 0.0164 0.0519 1
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0005 0.0004 0.0073
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0164 0.0519 0.0516
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0245 0.4703
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0016 0.0037 0.0674
Plasmodium vivax proteasome subunit beta type-4, putative 0.0016 0.0037 0.0722
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0016 0.0037 0.0674
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0015
Mycobacterium tuberculosis Two component sensor kinase [first part] 0.0014 0.0031 0.1175
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0037 0.0035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0003 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0121 0.2294
Toxoplasma gondii aminopeptidase N, putative 0.0164 0.0519 1
Giardia lamblia 20S proteasome alpha subunit 4 0.0016 0.0037 0.1434
Trypanosoma brucei aminopeptidase, putative 0.0164 0.0519 1
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0016 0.0037 0.0674
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0016 0.0037 0.0674
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0016 0.0037 0.0674
Schistosoma mansoni inositol monophosphatase 0.0036 0.0103 0.0102
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0016 0.0037 0.0674
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0016 0.0037 0.0674
Brugia malayi CXXC zinc finger family protein 0.0031 0.0086 0.0181
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0016 0.0037 0.0674
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0019 0.0047 0.1836
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0019 0.0047 0.1836
Giardia lamblia 20S proteasome alpha subunit 2 0.0016 0.0037 0.1434
Entamoeba histolytica hypothetical protein 0.0038 0.0111 0.21
Treponema pallidum response regulatory protein (atoC) 0.0005 0.0004 0.0394
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0005 0.0004 0.0073
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0016 0.0037 0.0674
Mycobacterium ulcerans two component transcriptional regulator 0.0005 0.0004 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0103 0.1947
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0037 0.0674
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0005 0.0004 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0431 0.0428
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0016 0.0037 0.0674
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0016 0.0037 0.0674
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0111 0.0108
Toxoplasma gondii proteasome beta subunit 0.0016 0.0037 0.0674
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0016 0.0037 0.0674
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0016 0.0037 0.0674
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.0245 0.4703
Schistosoma mansoni DNA topoisomerase II 0.0005 0.0003 0.0002
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0016 0.0037 0.0674
Mycobacterium leprae Probable two-component system transcriptional regulator 0.0005 0.0004 0.0073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.0045
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0019 0.0047 0.1836
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.0245 0.0243
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0065 0.1209
Entamoeba histolytica hypothetical protein 0.0038 0.0111 0.21
Echinococcus granulosus proteasome subunit beta t family 0.0016 0.0037 0.0035
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0245 0.4703
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0188 0.3585
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0001
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0188 0.3585
Leishmania major proteasome beta-1 subunit, putative 0.0016 0.0037 0.0674
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0016 0.0037 0.0674
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0038 0.0111 0.0109
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0019 0.0047 0.0864
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0005 0.0004 0.0073
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.0245 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0065 0.1209
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0875
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0875
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0016 0.0037 0.0037
Treponema pallidum chemotaxis response regulator (cheY) 0.0005 0.0004 0.0394
Echinococcus granulosus dnaJ subfamily B 0.0436 0.1401 0.1398
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0005 0.0004 0.0034
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0016 0.0037 0.1434
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0016 0.0037 0.0674
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0016 0.0037 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0131 0.0128
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.0245 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0016 0.0037 0.0674
Plasmodium vivax hypothetical protein, conserved 0.0005 0.0003 0.0051

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antagonistic activity against vanilloid receptor 1 (TRPV1) ChEMBL. 15139748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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