Detailed information for compound 310550

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 254.174 | Formula: C8H15O7P
  • H donors: 5 H acceptors: 7 LogP: -2.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](CP(=O)(O)O)C[C@@](C1)(O)C(=O)O
  • InChi: 1S/C8H15O7P/c9-6-1-5(4-16(13,14)15)2-8(12,3-6)7(10)11/h5-6,9,12H,1-4H2,(H,10,11)(H2,13,14,15)/t5-,6+,8+/m1/s1
  • InChiKey: SWEXPEKCRDSBSH-CHKWXVPMSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.003 0.022 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0173 0.0205
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.007 0.0024
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0044 0.0032
Loa Loa (eye worm) hypothetical protein 0.0589 0.6698 0.6937
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0796 0.0785
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Loa Loa (eye worm) hypothetical protein 0.0092 0.0939 0.0961
Entamoeba histolytica protein kinase, putative 0.0407 0.4592 1
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0214
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0584 0.0593
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0173 0.024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0173 0.0375
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0271 0.026
Echinococcus multilocularis retinol dehydrogenase 13 0.0015 0.0056 0.0045
Echinococcus multilocularis Chromo domain 0.0012 0.002 0.0008
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0015 0.0056 0.0065
Plasmodium falciparum glutathione reductase 0.0048 0.0433 0.5321
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1144 0.3865
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0056 0.0471
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0402 0.0665
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0433 0.0421
Entamoeba histolytica protein kinase, putative 0.0407 0.4592 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0069 0.0674 0.108
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 0.1113
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 0.1113
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0328 0.0472
Echinococcus multilocularis Chromobox protein 3 0.0012 0.002 0.0008
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0015 0.0056 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Echinococcus granulosus tumor protein p63 0.0364 0.4095 0.6108
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0015 0.0056 0.0064
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0044 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0173 0.0375
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0258 0.2871 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0433 0.063
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0015 0.0056 0.0045
Entamoeba histolytica hypothetical protein 0.0012 0.002 0.0041
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0015 0.0056 0.008
Plasmodium vivax steroid dehydrogenase, putative 0.0015 0.0056 0.0471
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.007 0.0024
Echinococcus multilocularis chromobox protein 1 0.0075 0.0747 0.0736
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0056 0.0084
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0056 0.0067
Toxoplasma gondii thioredoxin reductase 0.0048 0.0433 0.0718
Schistosoma mansoni 3-dehydroquinate synthase 0.0258 0.2871 0.4283
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0015 0.0056 0.008
Onchocerca volvulus 0.0044 0.0392 0.0586
Plasmodium falciparum glutathione reductase 0.0017 0.007 0.0645
Brugia malayi hypothetical protein 0.0012 0.002 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0173 0.0416
Plasmodium falciparum thioredoxin reductase 0.0048 0.0433 0.5321
Plasmodium vivax hypothetical protein, conserved 0.003 0.022 0.2578
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0328 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.0107
Giardia lamblia Kinase, CMGC CLK 0.0069 0.0674 0.108
Echinococcus multilocularis 0.0062 0.0595 0.0584
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.002 0.0025
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0021
Schistosoma mansoni chromobox protein 0.0075 0.0747 0.1111
Brugia malayi dehydrogenases, short chain protein 2 0.0015 0.0056 0.0065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Onchocerca volvulus 0.0015 0.0056 0.0084
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0098 0.1012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0463 0.0687
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0015 0.0056 0.0045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0173 0.0176
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0015 0.0056 0.0067
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.002 0.0025
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Brugia malayi Protein kinase domain containing protein 0.0069 0.0674 0.0988
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 1
Trypanosoma brucei protein kinase, putative 0.0509 0.5768 1
Schistosoma mansoni chromobox protein 0.0075 0.0747 0.1111
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0159 0.0233
Onchocerca volvulus Alhambra homolog 0.003 0.022 0.0328
Loa Loa (eye worm) hypothetical protein 0.0046 0.041 0.0412
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.002 0.0041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0509 0.5768 0.5972
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0392 0.0582
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0354 0.0343
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0056 0.0067
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0159 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0509 0.5768 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0015 0.0056 0.0064
Echinococcus granulosus tyrosine kinase 0.0035 0.0284 0.0407
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Brugia malayi Dehydrogenases, short chain protein 30 0.0015 0.0056 0.0065
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0069 0.0674 0.108
Plasmodium falciparum protein serine/threonine kinase-1 0.0069 0.0674 0.8424
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Onchocerca volvulus 0.0589 0.6698 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0069 0.0674 0.108
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0433 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2247 0.3875
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0328 0.0472
Brugia malayi Bromodomain containing protein 0.0041 0.0356 0.0512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0098 0.1012
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0056 0.0045
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.002 0.001
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0284 0.0272
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0509 0.5768 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0069 0.0674 0.108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0433 0.0435
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.007 0.0645
Onchocerca volvulus 0.0015 0.0056 0.0084
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0056 0.0045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 0.2592
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0056 0.012
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.002 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0674 0.1001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0173 0.0176
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0173 0.0176
Leishmania major protein kinase, putative 0.0069 0.0674 0.108
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0173 0.0176
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0316 0.0467
Loa Loa (eye worm) dehydrogenase 0.0015 0.0056 0.0045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.2475 0.2555
Brugia malayi CHD4 protein 0.0014 0.0044 0.0046
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Onchocerca volvulus 0.0015 0.0056 0.0084
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.009 0.013
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.022 0.0311
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0328 0.0316
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0328 0.0316
Onchocerca volvulus 0.0255 0.2834 0.4232
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0365 0.06
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0407 0.4592 0.4586
Schistosoma mansoni retinal dehydrogenase 0.0015 0.0056 0.008
Brugia malayi protein-tyrosine kinase 0.0035 0.0284 0.0405
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0056 0.012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0365 0.0545
Onchocerca volvulus 0.0015 0.0056 0.0084
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0173 0.0416
Echinococcus multilocularis chromobox protein 2 0.0012 0.002 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0056 0.012
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0589 0.6698 1
Brugia malayi Protein cec-1. 0.0012 0.002 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0098 0.0063
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0271 0.0388
Onchocerca volvulus 0.0015 0.0056 0.0084
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.007 0.0645
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1285 0.4367
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0089
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.007 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.009 0.0079
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0098 0.0088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0173 0.0416
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.022 0.0348
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.007 0.0183
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0595 0.0604
Schistosoma mansoni hypothetical protein 0.0016 0.0068 0.0098
Giardia lamblia PHD finger protein 15 0.003 0.022 0.0286
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0768 0.1143
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0589 0.6698 0.6937
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0509 0.5768 1
Loa Loa (eye worm) TK protein kinase 0.0031 0.0239 0.0234
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.009 0.013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0328 0.0316
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0056 0.012
Trichomonas vaginalis steroid dehydrogenase, putative 0.0015 0.0056 0.0064
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0205 0.2247 0.3875
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0166
Echinococcus multilocularis chromobox protein 1 0.0075 0.0747 0.0736
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0056 0.0045
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0194 0.2243
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0056 0.0064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0999 0.1476
Loa Loa (eye worm) hypothetical protein 0.0844 0.9649 1
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0623 0.0914
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.007 0.0087
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0015 0.0056 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.2326 0.347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0463 0.0452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.0107
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0056 0.012
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.007 0.0087
Echinococcus multilocularis tumor protein p63 0.0364 0.4095 0.4088
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0256
Trypanosoma brucei trypanothione reductase 0.0048 0.0433 0.0659
Echinococcus granulosus peregrin 0.0032 0.0249 0.0355
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Brugia malayi Bromodomain containing protein 0.0081 0.0814 0.1197
Loa Loa (eye worm) hypothetical protein 0.0041 0.0356 0.0356
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0173 0.0176
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0509 0.5768 1
Onchocerca volvulus 0.0589 0.6698 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0509 0.5768 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0044 0.0048
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0328 0.0316
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0056 0.0067
Plasmodium falciparum thioredoxin reductase 0.0017 0.007 0.0645
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0328 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Schistosoma mansoni hypothetical protein 0.003 0.022 0.0324
Loa Loa (eye worm) TK protein kinase 0.0035 0.0284 0.0281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Echinococcus granulosus oxidoreductase 0.0015 0.0056 0.0067
Brugia malayi SET domain containing protein 0.0013 0.0034 0.003
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0316 0.0455
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.007 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.0073
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0019 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.007 0.0024
Trypanosoma cruzi ISWI complex protein 0.0016 0.0068 0.0021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0098 0.0073
Brugia malayi PHD-finger family protein 0.0027 0.0188 0.0262
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0015 0.0056 0.012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0328 0.0316
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0479 0.1503
Plasmodium falciparum steroid dehydrogenase, putative 0.0015 0.0056 0.0471
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0056 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1018 0.1515
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Schistosoma mansoni chromobox protein 0.0012 0.002 0.0025
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.007 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.007 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0386 0.0387
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0056 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0365 0.0365
Brugia malayi Probable ClpP-like protease 0.0079 0.0796 0.1171
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0747 0.0762
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Toxoplasma gondii exonuclease III APE 0.0019 0.0098 0.0137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0099 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0092 0.0939 0.0961
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0674 0.1001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0326 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0365 0.06
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0402 0.06
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.007 0.0058
Echinococcus granulosus hypothetical protein 0.0015 0.0056 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0589 0.6698 0.6937
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0194 0.0489
Onchocerca volvulus 0.0015 0.0056 0.0084
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0056 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0173 0.024
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0139 0.1487 0.5061
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0796 0.1184
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.1018 0.1042
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0796 0.135
Echinococcus multilocularis mitogen activated protein kinase 0.0509 0.5768 0.5763
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0027 0.0021
Onchocerca volvulus 0.0012 0.002 0.003
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0284 0.0407
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0258 0.2871 0.4959
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0139 0.1487 0.5085
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0098 0.0149
Onchocerca volvulus 0.0015 0.0056 0.0084
Brugia malayi dehydrogenases, short chain protein 9 0.0015 0.0056 0.0065
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0015 0.0056 0.0045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1018 0.1683
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0015 0.0056 0.0067
Brugia malayi Heterochromatin protein 1 0.0075 0.0747 0.1098
Echinococcus multilocularis mitogen activated protein kinase 3 0.0509 0.5768 0.5763
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0326 0.0315
Schistosoma mansoni carbonyl reductase 0.0015 0.0056 0.008
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.1018 0.2214
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.007 0.0645
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0328 0.0472
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.002 0.001
Echinococcus granulosus dual specificity protein kinase clk2 0.0069 0.0674 0.099
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1285 0.4367
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.007 0.0087
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1285 0.4367
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0089
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0056 0.0471
Echinococcus granulosus chromobox protein 2 0.0012 0.002 0.0012
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0099 0.1015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0623 0.0612
Brugia malayi glutathione reductase 0.0048 0.0433 0.0628
Entamoeba histolytica protein kinase, putative 0.0031 0.0239 0.0517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0463 0.0687
Echinococcus granulosus Chromo domain 0.0012 0.002 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0173 0.0205
Toxoplasma gondii hypothetical protein 0.0027 0.0194 0.0303
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0044 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0509 0.5768 0.8611
Brugia malayi Retinol dehydrogenase 12 0.0015 0.0056 0.0065
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0796 1
Entamoeba histolytica hypothetical protein 0.0012 0.002 0.0041
Echinococcus granulosus dual specificity 0.0098 0.1018 0.1504
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0999 0.0988
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0015 0.0056 0.0064
Entamoeba histolytica hypothetical protein 0.0015 0.0056 0.012
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0056 0.0045
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0098 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0098 0.0073
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0328 0.0472
Entamoeba histolytica hypothetical protein 0.0012 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0509 0.5768 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0239 0.0339
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.007 0.0024
Brugia malayi oxidoreductase 0.0015 0.0056 0.0065
Loa Loa (eye worm) dehydrogenase 0.0015 0.0056 0.0045
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.0073
Brugia malayi Bromodomain containing protein 0.0032 0.0249 0.0353
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0098 0.0073
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0258 0.2871 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0069 0.0674 0.108
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0509 0.5768 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1144 0.3865
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0015 0.0056 0.0045
Brugia malayi jmjC domain containing protein 0.0097 0.0999 0.1474
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0089
Brugia malayi Ribonuclease 2-5A family protein 0.0407 0.4592 0.685
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0509 0.5768 1
Brugia malayi PHD-finger family protein 0.003 0.022 0.0309
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0284 0.0272
Onchocerca volvulus 0.0015 0.0056 0.0084
Brugia malayi Valyl-tRNA synthetase 0.0012 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0589 0.6698 0.6937
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0015 0.0056 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0402 0.0665
Trypanosoma cruzi ISWI complex protein 0.0016 0.0068 0.0021
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.022 0.0324
Entamoeba histolytica protein kinase, putative 0.0098 0.1018 0.2214
Schistosoma mansoni chromobox protein 0.0012 0.002 0.0025
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0407 0.4592 0.6851
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.007 0.0048
Schistosoma mansoni carbonyl reductase 0.0015 0.0056 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.0107
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0433 0.5321
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Brugia malayi SRC-1 0.0039 0.0328 0.047
Echinococcus granulosus translocator protein 0.0589 0.6698 1
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0258 0.2871 0.4237
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0069 0.0674 0.1137
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0056 0.0045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0173 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0173 0.024
Leishmania major protein kinase, putative 0.0069 0.0674 0.108
Schistosoma mansoni tyrosine kinase 0.0039 0.0328 0.0485
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0056 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0166
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.002 0.0025
Schistosoma mansoni zinc finger protein 0.0016 0.0068 0.0098
Echinococcus multilocularis oxidoreductase 0.0015 0.0056 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1144 0.3865
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0292 0.028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.025 0.0239
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0015 0.0056 0.008
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0328 0.0472
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0236 0.0336
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.002 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.0107
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Plasmodium falciparum phd finger protein, putative 0.003 0.022 0.2578
Brugia malayi hypothetical protein 0.0238 0.2631 0.3916
Onchocerca volvulus 0.0015 0.0056 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0509 0.5768 1
Loa Loa (eye worm) SRC-1 0.0039 0.0328 0.0326
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.025 0.0401
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0328 0.0472
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.0674 0.1137
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0015 0.0056 0.0067
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0479 0.1503
Echinococcus granulosus hypothetical protein 0.0062 0.0595 0.0872
Onchocerca volvulus 0.0015 0.0056 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0098 0.0129
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Onchocerca volvulus Sepiapterin reductase homolog 0.0015 0.0056 0.0084
Echinococcus granulosus Chromobox protein 3 0.0012 0.002 0.0012
Onchocerca volvulus 0.0015 0.0056 0.0084
Plasmodium vivax glutathione reductase, putative 0.0048 0.0433 0.5321
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0015 0.0056 0.0084
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.022 0.0208
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Echinococcus granulosus chromobox protein 1 0.0075 0.0747 0.11
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.002 0.0012
Schistosoma mansoni zinc finger protein 0.0021 0.0122 0.0177
Brugia malayi jmjC domain containing protein 0.0038 0.0316 0.0453
Brugia malayi chromobox protein homolog 3 0.0042 0.0365 0.0526
Loa Loa (eye worm) hypothetical protein 0.0051 0.0463 0.0467
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0173 0.0205
Echinococcus multilocularis dual specificity protein kinase clk2 0.0069 0.0674 0.0663
Trichomonas vaginalis set domain proteins, putative 0.0255 0.2834 0.4896
Chlamydia trachomatis dehyroquinate synthase 0.0258 0.2871 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0796 0.1173
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0589 0.6698 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0223 0.0353
Schistosoma mansoni bromodomain containing protein 0.0068 0.0667 0.0992
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0796 0.2627
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0015 0.0056 0.0471
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0316 0.0467
Loa Loa (eye worm) hypothetical protein 0.0079 0.0796 0.0812
Schistosoma mansoni hypothetical protein 0.0022 0.0135 0.0197
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0064
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0479 0.0699
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.007 0.0087
Onchocerca volvulus 0.0053 0.0495 0.0739
Loa Loa (eye worm) hypothetical protein 0.0076 0.076 0.0775
Entamoeba histolytica protein kinase, putative 0.0098 0.1018 0.2214
Trichomonas vaginalis CMGC family protein kinase 0.0509 0.5768 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0098 0.0088
Echinococcus granulosus zinc finger protein 0.0021 0.0122 0.0165
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.009 0.0117
Brugia malayi Protein kinase domain containing protein 0.0098 0.1018 0.1503
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0463 0.0675
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.0142
Onchocerca volvulus 0.0033 0.026 0.0388
Onchocerca volvulus 0.0589 0.6698 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0069 0.0674 0.8424
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Schistosoma mansoni tyrosine kinase 0.0039 0.0328 0.0485
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0019 0.0008
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0015 0.0056 0.0045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0796 0.2592
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.007 0.0183
Loa Loa (eye worm) hypothetical protein 0.0053 0.0495 0.05
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Schistosoma mansoni carbonyl reductase 0.0015 0.0056 0.008
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0098 0.0127
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0056 0.008
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.1018 0.1683
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.002 0.0041
Onchocerca volvulus 0.0026 0.0173 0.0259
Mycobacterium ulcerans hypothetical protein 0.0026 0.0173 0.0176
Brugia malayi Dehydrogenases, short chain protein 2 0.0015 0.0056 0.0065
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0284 0.0272
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Brugia malayi hypothetical protein 0.0015 0.0056 0.0065
Brugia malayi hypothetical protein 0.0015 0.0056 0.0065
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0796 0.135
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0069 0.0674 0.108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0069 0.0674 0.0685
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0015 0.0056 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0509 0.5768 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0015 0.0056 0.0064
Echinococcus multilocularis translocator protein 0.0589 0.6698 0.6694
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0099 0.1015
Plasmodium vivax SET domain protein, putative 0.0032 0.025 0.2968
Echinococcus granulosus hypothetical protein 0.0015 0.0056 0.0067
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0098 0.0567
Echinococcus granulosus steroid dehydrogenase 0.0015 0.0056 0.0067
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0099 0.0103
Onchocerca volvulus 0.0589 0.6698 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.022 0.0348
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0316 0.0314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0089
Loa Loa (eye worm) oxidoreductase 0.0015 0.0056 0.0045
Onchocerca volvulus 0.0012 0.002 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1144 0.3865
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0056 0.0045
Entamoeba histolytica hypothetical protein 0.0098 0.1018 0.2214
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0056 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0223 0.0353
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.0137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1285 0.4367
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0479 0.1503
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0015 0.0056 0.0064
Echinococcus granulosus mitogen activated protein kinase 3 0.0509 0.5768 0.8609
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.007 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0747 0.1265
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0194 0.2243
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0433 0.1337
Loa Loa (eye worm) IRE protein kinase 0.0407 0.4592 0.4752
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1144 0.3865
Trichomonas vaginalis CMGC family protein kinase 0.0509 0.5768 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.007 0.0024
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.007 0.0087
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0056 0.012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1144 0.3865
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0495 0.0735
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0056 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0065
Loa Loa (eye worm) helicase 0.0012 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0166
Loa Loa (eye worm) glutathione reductase 0.0048 0.0433 0.0435
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0056 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0479 0.0468
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0098 0.0212
Echinococcus multilocularis zinc finger protein 0.0021 0.0122 0.011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0099 0.015
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0328 0.0472
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0139 0.1487 0.2155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.025 0.0369
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0056 0.0064
Brugia malayi Thioredoxin reductase 0.0048 0.0433 0.0628
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0139 0.1487 0.5085
Brugia malayi Pre-SET motif family protein 0.0032 0.025 0.0354
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0015 0.0056 0.0065
Onchocerca volvulus 0.0023 0.0143 0.0214
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.1018 0.1683
Mycobacterium tuberculosis Probable reductase 0.0109 0.1144 0.3865
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.007 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0173 0.0375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0159 0.022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0354 0.0512
Trypanosoma brucei ISWI complex protein 0.0016 0.0068 0.0021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0464 0.0468
Echinococcus multilocularis peregrin 0.0032 0.0249 0.0238
Leishmania major trypanothione reductase 0.0048 0.0433 0.0659
Echinococcus granulosus WW domain containing oxidoreductase 0.0015 0.0056 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0173 0.0176
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0015 0.0056 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0173 0.0176
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0328 0.0316
Giardia lamblia Kinase, CMGC MAPK 0.0509 0.5768 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0056 0.0064
Echinococcus granulosus chromobox protein 1 0.0075 0.0747 0.11
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0135 0.0126
Brugia malayi MAP kinase sur-1 0.0509 0.5768 0.8609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0194 0.1708
Brugia malayi TspO/MBR family protein 0.0589 0.6698 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0284 0.0407
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.1018 0.1683
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0239 0.0227
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.0406 0.059
Echinococcus multilocularis dual specificity 0.0098 0.1018 0.1007
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0056 0.0067
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.007 0.0645
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0007
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0015 0.0056 0.0045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0098 0.0392
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0056 0.0045
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0056 0.0045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0056 0.0064
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0015 0.0056 0.0065
Echinococcus granulosus mitogen activated protein kinase 0.0509 0.5768 0.8609
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0747 0.1265
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0045
Onchocerca volvulus 0.0015 0.0056 0.0084
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0328 0.0316
Loa Loa (eye worm) hypothetical protein 0.0844 0.9649 1
Brugia malayi Pre-SET motif family protein 0.0224 0.2475 0.3683
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.007 0.0085
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.002 0.0008

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.00000054 M Compound was evaluated for its inhibitory constant against Dehydroquinate synthase enzyme ChEMBL. 7241506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.