Detailed information for compound 31075

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.51 | Formula: C23H32N2O6
  • H donors: 2 H acceptors: 5 LogP: 2.99 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)NC(C(=O)CC(C(=O)N1CCCC1C(=O)O)C)Cc1ccccc1
  • InChi: 1S/C23H32N2O6/c1-3-4-13-31-23(30)24-18(15-17-9-6-5-7-10-17)20(26)14-16(2)21(27)25-12-8-11-19(25)22(28)29/h5-7,9-10,16,18-19H,3-4,8,11-15H2,1-2H3,(H,24,30)(H,28,29)
  • InChiKey: SJZSCNBOYIWMHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin I converting enzyme References
Homo sapiens angiotensin I converting enzyme 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis expressed conserved protein 0.0091 0.0612 0.0937
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.0218 0.0195
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0032 0.0095
Brugia malayi hypothetical protein 0.0023 0.007 0.007
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.007 0.0327
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0658 0.2989
Brugia malayi Melatonin receptor type 1A 0.0041 0.0218 0.0218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0218 0.0334
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0218 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.003 0.0088
Onchocerca volvulus 0.0108 0.0743 0.3059
Schistosoma mansoni hypothetical protein 0.0041 0.0218 0.0647
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0032 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.007 0.0327
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0599 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Onchocerca volvulus 0.0041 0.0218 0.0827
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0218 0.0334
Schistosoma mansoni zinc finger protein 0.0015 0.0011 0.0032
Onchocerca volvulus 0.0041 0.0218 0.0827
Schistosoma mansoni hypothetical protein 0.0041 0.0218 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.2147 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0108 0.0743 0.1139
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.0218 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Brugia malayi Angiotensin-converting enzyme family protein 0.0945 0.734 0.734
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.0218 0.0334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0194 0.0575
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0041 0.0193
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.007 0.0208
Schistosoma mansoni hypothetical protein 0.004 0.0209 0.0621
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0096 0.0446
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0202 0.0277
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.0221
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.007 0.0208
Onchocerca volvulus 0.0041 0.0218 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.1124 0.1124
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0218 0.0647
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0041 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0032 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.0218 0.0647
Plasmodium falciparum phd finger protein, putative 0.0029 0.0118 0.0347
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0041 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.1124 0.1124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0032 0.0095
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.0218 0.0647
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.007 0.0221
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0658 0.1953
Plasmodium falciparum glutathione reductase 0.0039 0.0202 0.0597
Trypanosoma brucei trypanothione reductase 0.0039 0.0202 0.0597
Schistosoma mansoni ap endonuclease 0.0019 0.0041 0.0123
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0444 0.3391 1
Trichomonas vaginalis esterase, putative 0.0147 0.1053 0.4906
Schistosoma mansoni amine GPCR 0.0041 0.0218 0.0647
Schistosoma mansoni adenoreceptor 0.0041 0.0218 0.0647
Onchocerca volvulus 0.0041 0.0218 0.0827
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0041 0.0057
Brugia malayi neuropeptide F receptor 0.0041 0.0218 0.0218
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0032 0.0096
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.0218 0.0195
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.0218 0.0647
Echinococcus multilocularis thymidylate synthase 0.0315 0.2378 0.3642
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.0218 0.0647
Schistosoma mansoni alpha glucosidase 0.0035 0.0171 0.0508
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0218 0.0334
Schistosoma mansoni hypothetical protein 0.004 0.0209 0.0621
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Mycobacterium tuberculosis Hypothetical protein 0.015 0.1075 0.1471
Schistosoma mansoni cpg binding protein 0.0035 0.0165 0.0491
Plasmodium falciparum thioredoxin reductase 0.0039 0.0202 0.0597
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.0505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0629 0.0964
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0077 0.0501 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0032 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0084 0.0249
Schistosoma mansoni hypothetical protein 0.0023 0.007 0.0208
Onchocerca volvulus 0.0023 0.007 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0023 0.0069
Loa Loa (eye worm) hypothetical protein 0.0108 0.0743 0.0722
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus tyrosine protein kinase Blk 0.0017 0.0023 0.0069
Schistosoma mansoni patched 1 0.0042 0.0221 0.0656
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0033 0.0096
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0838
Schistosoma mansoni amine GPCR 0.0041 0.0218 0.0647
Brugia malayi CHD4 protein 0.0026 0.0099 0.0099
Brugia malayi AKH receptor 0.0041 0.0218 0.0218
Schistosoma mansoni neuropeptide receptor 0.0041 0.0218 0.0647
Schistosoma mansoni biogenic amine receptor 0.0041 0.0218 0.0647
Schistosoma mansoni hypothetical protein 0.0073 0.047 0.1394
Onchocerca volvulus 0.0315 0.2378 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0076 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0218 0.0647
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0041 0.0193
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.0798
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0032 0.0032
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0171 0.0798
Echinococcus multilocularis dihydrofolate reductase 0.0129 0.0906 0.1388
Echinococcus multilocularis geminin 0.0342 0.2586 0.3962
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0041 0.0063
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Onchocerca volvulus 0.0031 0.0137 0.0482
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0032
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0218 0.0647
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0023 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0994 0.136
Onchocerca volvulus Huntingtin homolog 0.0123 0.0861 0.3559
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Echinococcus granulosus neuropeptide receptor 0.0041 0.0218 0.0647
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0501 0.2027
Onchocerca volvulus 0.0041 0.0218 0.0827
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0184
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.1053 0.3127
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.0218 0.0195
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.007 0.0207
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0032 0.0095
Echinococcus granulosus cpg binding protein 0.0035 0.0165 0.0491
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0041 0.0086
Schistosoma mansoni hypothetical protein 0.004 0.0209 0.0621
Brugia malayi SH2 domain containing protein 0.0017 0.0023 0.0023
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Brugia malayi Thioredoxin reductase 0.0039 0.0202 0.0202
Echinococcus granulosus expressed conserved protein 0.0091 0.0612 0.1816
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0032 0.0095
Echinococcus granulosus tyrosine protein kinase Srms 0.0017 0.0023 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni amine GPCR 0.0041 0.0218 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0218 0.0647
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0032 0.0095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni alpha-glucosidase 0.0137 0.0973 0.2889
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Loa Loa (eye worm) dihydrofolate reductase 0.0129 0.0906 0.0885
Echinococcus granulosus allatostatin A receptor 0.0041 0.0218 0.0647
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.1053 0.443
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0218 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.2147 1
Brugia malayi Dihydrofolate reductase 0.0129 0.0906 0.0906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0221 0.0198
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0987 0.1511
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.0218 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Mycobacterium tuberculosis Probable reductase 0.009 0.0599 0.0819
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1053 0.4906
Chlamydia trachomatis dihydrofolate reductase 0.0129 0.0906 1
Echinococcus granulosus neuropeptide s receptor 0.0041 0.0218 0.0647
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0041 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0658 0.1008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0599 0.0819
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0478 0.1418
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0108 0.0743 0.2207
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0282 0.0282
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0023 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0373 0.1101
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0032 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.01 0.0465
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni neuropeptide receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.047 0.1394
Brugia malayi PHD-finger family protein 0.0026 0.0099 0.0099
Echinococcus granulosus Chromobox protein 3 0.0023 0.007 0.0208
Loa Loa (eye worm) thymidylate synthase 0.0315 0.2378 0.236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0245 0.0728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Brugia malayi Protein kinase domain containing protein 0.0017 0.0023 0.0023
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Echinococcus granulosus inhibitor of apoptosis protein 0.0108 0.0743 0.2207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0032 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0393
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.0218 0.0647
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1053 0.3127
Schistosoma mansoni chromobox protein 0.0138 0.0977 0.29
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0032 0.0095
Onchocerca volvulus 0.0041 0.0218 0.0827
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0099 0.0151
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0023 0.0036
Echinococcus granulosus Chromo domain 0.0023 0.007 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0814 0.0792
Mycobacterium leprae conserved hypothetical protein 0.0147 0.1053 0.2555
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Schistosoma mansoni opsin-like receptor 0.0041 0.0218 0.0647
Brugia malayi CXXC zinc finger family protein 0.0031 0.0137 0.0137
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0218 0.0647
Onchocerca volvulus 0.0147 0.1053 0.4375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0171 0.0171
Plasmodium vivax glutathione reductase, putative 0.0039 0.0202 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0023 0.0036
Echinococcus multilocularis zinc finger protein 0.0021 0.0058 0.0088
Schistosoma mansoni neuropeptide receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1148 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0017 0.0023 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0218 0.0647
Echinococcus granulosus somatostatin receptor 0.0041 0.0218 0.0647
Brugia malayi larval opioid receptor 0.0041 0.0218 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0245 0.0728
Leishmania major hypothetical protein, conserved 0.0147 0.1053 0.3107
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1148 0.1148
Echinococcus multilocularis protein dispatched 1 0.0048 0.0268 0.041
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0017 0.0023 0.0036
Brugia malayi SRC-1 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0108 0.0743 0.0722
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0501 0.2331
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0032 0.0095
Brugia malayi glutathione reductase 0.0039 0.0202 0.0202
Onchocerca volvulus 0.0041 0.0218 0.0827
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0444 0.3391 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.017 0.026
Brugia malayi follicle stimulating hormone receptor 0.0041 0.0218 0.0218
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1053 0.3107
Echinococcus multilocularis chromobox protein 2 0.0023 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni inhibitor of apoptosis protein 0.0108 0.0743 0.2207
Loa Loa (eye worm) hypothetical protein 0.0107 0.0735 0.0713
Brugia malayi SH2 domain containing protein 0.0017 0.0023 0.0023
Echinococcus multilocularis GPCR, family 2 0.0049 0.0282 0.0433
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.0218 0.0827
Echinococcus granulosus neuropeptide receptor 0.0041 0.0218 0.0647
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0735 0.0735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0245 0.0728
Schistosoma mansoni histamine h1 receptor 0.0041 0.0218 0.0647
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0315 0.2378 0.7057
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0032 0.0095
Schistosoma mansoni hypothetical protein 0.0029 0.0118 0.0349
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.2147 1
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Onchocerca volvulus 0.0041 0.0218 0.0827
Brugia malayi SET domain containing protein 0.0023 0.0076 0.0076
Schistosoma mansoni opsin-like receptor 0.0041 0.0218 0.0647
Onchocerca volvulus Huntingtin homolog 0.0123 0.0861 0.3559
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.3369 0.5161
Trichomonas vaginalis chromobox protein, putative 0.0023 0.007 0.0327
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0125 0.0584
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.0218 0.0334
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0084 0.0249
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Echinococcus granulosus g protein coupled receptor 0.0041 0.0218 0.0647
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0994 0.2222
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0118 0.0347
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1053 0.4906
Loa Loa (eye worm) hypothetical protein 0.0049 0.0278 0.0256
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0017 0.0023 0.0069
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0218 0.0195
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0218 0.0334
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0221 0.0339
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0032 0.0095
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0032 0.0095
Echinococcus multilocularis tyrosine protein kinase Blk 0.0017 0.0023 0.0036
Onchocerca volvulus 0.0041 0.0218 0.0827
Loa Loa (eye worm) hypothetical protein 0.006 0.0369 0.0347
Brugia malayi Dopamine receptor protein 1 0.0041 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0108 0.0743 0.2207
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0171 0.0508
Brugia malayi Bromodomain containing protein 0.0075 0.0485 0.0485
Echinococcus granulosus zinc finger protein 0.0021 0.0058 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.0798
Echinococcus granulosus tyrosine kinase 0.0017 0.0023 0.0069
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0118 0.0095
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0118 0.018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0032 0.0096
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0041 0.0122
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0032 0.0096
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0084 0.025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0678 0.0443
Echinococcus granulosus tyrosine protein kinase Src64B 0.0017 0.0023 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0245 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.003 0.0088
Echinococcus multilocularis tyrosine protein kinase Srms 0.0017 0.0023 0.0036
Schistosoma mansoni dihydrofolate reductase 0.0129 0.0906 0.2689
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.0218 0.0647
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.0977 0.0956
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0245 0.0376
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1148 0.3408
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0245 0.0728
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.007 0.0208
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0218 0.0334
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0032 0.0049
Brugia malayi ORL1-like opioid receptor 0.0041 0.0218 0.0218
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0123 0.0861 0.084
Brugia malayi hypothetical protein 0.0123 0.0861 0.0861
Brugia malayi Protein cec-1. 0.0023 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Brugia malayi G-protein coupled receptor 0.0041 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0095
Trypanosoma cruzi ISWI complex protein 0.0015 0.0011 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0245 0.0245
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.0218 0.0334
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0218 0.0647
Giardia lamblia PHD finger protein 15 0.0029 0.0118 0.0548
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0017 0.0023 0.0036
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0129 0.0906 0.381
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1053 0.4906
Brugia malayi Dopamine receptor protein 2 0.0041 0.0218 0.0218
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0032 0.0049
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.0798
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0838
Schistosoma mansoni amine GPCR 0.0041 0.0218 0.0647
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0678 0.0927
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.1382 0.5772
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.007 0.0207
Loa Loa (eye worm) hypothetical protein 0.0069 0.0438 0.0416
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0941 0.7308 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0206 0.0315
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0041 0.0041
Brugia malayi putative neuropeptide receptor 0.0041 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1075 0.5006
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0171 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Brugia malayi PHD-finger family protein 0.0029 0.0118 0.0118
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0081 0.0123
Brugia malayi GnHR receptor homolog 0.0041 0.0218 0.0218
Schistosoma mansoni cpg binding protein 0.0035 0.0165 0.0491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0034
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.0218 0.0334
Schistosoma mansoni zinc finger protein 0.0021 0.0058 0.0171
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.015 0.1075 0.317
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0171 0.0148
Trypanosoma brucei glucosidase, putative 0.0035 0.0171 0.0505
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0282 0.0838
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0108 0.0743 0.2207
Brugia malayi Valyl-tRNA synthetase 0.0023 0.007 0.007
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0994 0.4181
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0171 0.0798
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis serotonin receptor 0.0041 0.0218 0.0334
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0315 0.2378 1
Entamoeba histolytica hypothetical protein 0.0073 0.047 0.2101
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0017 0.0023 0.0069
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0084 0.025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0017 0.0023 0.0036
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.007 0.0207
Brugia malayi hypothetical protein 0.0073 0.047 0.047
Entamoeba histolytica hypothetical protein 0.0073 0.047 0.2101
Brugia malayi Protein kinase domain containing protein 0.0017 0.0023 0.0023
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0017 0.0023 0.0036
Brugia malayi G protein-coupled receptor 0.0041 0.0218 0.0218
Brugia malayi jmjC domain containing protein 0.0093 0.0629 0.0629
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.0218 0.0647
Onchocerca volvulus 0.0041 0.0218 0.0827
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1053 0.4906
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.0218 0.0195
Schistosoma mansoni hypothetical protein 0.004 0.0209 0.0621
Onchocerca volvulus 0.0041 0.0218 0.0827
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.0221
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0171 0.0798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.1053 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.041 0.1218
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.0743 0.0743
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.1053 0.1441
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.0218 0.0334
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1053 0.3107
Echinococcus granulosus g-protein coupled receptor 0.0041 0.0218 0.0647
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0282 0.0433
Brugia malayi RE15519p 0.0041 0.0218 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0206 0.0613
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.007 0.0207
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0282 0.026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.1053 0.1441
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis Chromobox protein 3 0.0023 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0213
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.0218 0.0647
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) beta-lactamase 0.0147 0.1053 0.1033
Brugia malayi beta-lactamase 0.0147 0.1053 0.1053
Brugia malayi N-terminal motif family protein 0.0189 0.1382 0.1382
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0023 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0032 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.1053 0.1441
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0218 0.0334
Trypanosoma cruzi ISWI complex protein 0.0015 0.0011 0.0032
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0052 0.0029
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0017 0.0023 0.0069
Loa Loa (eye worm) glutathione reductase 0.0039 0.0202 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0118 0.0347
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.0218 0.0195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0218 0.0647
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0218 0.0334
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0084 0.0129
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.007 0.0221
Echinococcus granulosus dihydrofolate reductase 0.0129 0.0906 0.2689
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1148 0.1759
Brugia malayi Protein kinase domain containing protein 0.0017 0.0023 0.0023
Echinococcus granulosus chromobox protein 1 0.0138 0.0977 0.29
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.0218 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0323 0.1505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0838
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0315 0.2378 0.3253
Toxoplasma gondii exonuclease III APE 0.0019 0.0041 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0024 0.0037
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.0218 0.0334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0041 0.0123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0501 0.2331
Plasmodium vivax hypothetical protein, conserved 0.0147 0.1053 0.3107
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0194 0.0171
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0023 0.0036
Echinococcus granulosus g protein coupled receptor 0.0041 0.0218 0.0647
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0099 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0282 0.0282
Schistosoma mansoni hypothetical protein 0.0107 0.0735 0.2181
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0137 0.0114
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.1053 0.1441
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.007 0.007
Brugia malayi G-protein coupled receptor 0.0041 0.0218 0.0218
Onchocerca volvulus Deterin homolog 0.0108 0.0743 0.3059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.1124 0.1104
Echinococcus multilocularis serotonin receptor 0.0041 0.0218 0.0334
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0658 0.0658
Trichomonas vaginalis chromobox protein, putative 0.0023 0.007 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0323 0.1505
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0444 0.3391 1
Schistosoma mansoni hypothetical protein 0.0041 0.0218 0.0647
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0218 0.0647
Echinococcus granulosus chromobox protein 2 0.0023 0.007 0.0208
Brugia malayi protein-tyrosine kinase 0.0017 0.0023 0.0023
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.007 0.0207
Schistosoma mansoni biogenic amine receptor 0.0041 0.0218 0.0647
Brugia malayi Dopamine receptor 0.0041 0.0218 0.0218
Onchocerca volvulus 0.0147 0.1053 0.4375
Schistosoma mansoni opsin-like receptor 0.0041 0.0218 0.0647
Echinococcus granulosus tyrosine protein kinase shark 0.0017 0.0023 0.0069
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0838
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Echinococcus granulosus dnaJ subfamily B 0.0441 0.3369 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0814 0.0792
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.007 0.0207
Plasmodium falciparum heterochromatin protein 1 0.0023 0.007 0.0207
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.0218 0.0334
Trypanosoma brucei ISWI complex protein 0.0015 0.0011 0.0032
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.0218 0.0334
Onchocerca volvulus 0.0023 0.0076 0.0222
Echinococcus multilocularis tyrosine kinase 0.0017 0.0023 0.0036
Brugia malayi CHE-14 protein 0.0042 0.0221 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0218 0.0647
Plasmodium vivax hypothetical protein, conserved 0.0023 0.007 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0987 0.2928
Schistosoma mansoni chromobox protein 0.0023 0.007 0.0208
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0977 0.455
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0023 0.0036
Echinococcus granulosus serotonin receptor 0.0041 0.0218 0.0647
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0118 0.0347
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0033 0.0096
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.0218 0.0218
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0221 0.0656
Loa Loa (eye worm) hypothetical protein 0.1282 1 1
Echinococcus multilocularis chromobox protein 1 0.0138 0.0977 0.1497
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0367 0.109
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0171 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0221 0.0198
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.0218 0.0195
Schistosoma mansoni amine GPCR 0.0041 0.0218 0.0647
Brugia malayi MH2 domain containing protein 0.0117 0.0814 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.0218 0.0647
Brugia malayi chromobox protein homolog 3 0.0077 0.0501 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0599 0.0819
Echinococcus multilocularis orexin receptor type 2 0.0041 0.0218 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0171 0.0798
Trichomonas vaginalis chromobox protein, putative 0.0023 0.007 0.0327
Echinococcus multilocularis chromobox protein 1 0.0138 0.0977 0.1497
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0032 0.0095
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0547 0.2546
Mycobacterium ulcerans thymidylate synthase 0.0315 0.2378 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus fmrfamide receptor 0.0041 0.0218 0.0647
Echinococcus multilocularis sex peptide receptor 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus granulosus GPCR family 2 0.0049 0.0282 0.0838
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Mycobacterium ulcerans lipase LipD 0.0147 0.1053 0.443
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0123 0.0861 0.084
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Schistosoma mansoni myosin xvIII 0.0041 0.0218 0.0647
Echinococcus granulosus chromobox protein 1 0.0138 0.0977 0.29
Onchocerca volvulus Alhambra homolog 0.0029 0.0118 0.0401
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0023 0.0036
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0129 0.0906 0.124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0041 0.0193
Mycobacterium ulcerans hypothetical protein 0.0147 0.1053 0.443
Mycobacterium tuberculosis Conserved protein 0.0147 0.1053 0.1441
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1053 0.4906
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.0218 0.0218
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0099 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.0505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0282 0.0433
Onchocerca volvulus 0.0092 0.0619 0.253
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0218 0.0647
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0218 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0599 0.0819
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0945 0.734 0.7334
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.0218 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.0218 0.0827
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0084 0.0249
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Brugia malayi Bromodomain containing protein 0.0037 0.0188 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0547 0.2546
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0218 0.0195
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0218 0.0334
Entamoeba histolytica hypothetical protein 0.0073 0.047 0.2101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0017 0.0023 0.0036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.6528 1
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.1053 0.443
Loa Loa (eye worm) hypothetical protein 0.0156 0.1124 0.1104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0032 0.0095
Schistosoma mansoni hypothetical protein 0.0441 0.3369 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.047 0.1394
Onchocerca volvulus 0.0147 0.1053 0.4375
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.067 0.1988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0444 0.3391 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0058 0.017
Echinococcus granulosus tyrosine kinase 0.0017 0.0023 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0218 0.0647
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.003 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Brugia malayi thymidylate synthase 0.0315 0.2378 0.2378
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0678 0.0927
Echinococcus granulosus sex peptide receptor 0.0041 0.0218 0.0647
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Loa Loa (eye worm) hypothetical protein 0.0097 0.0658 0.0636
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.007 0.0221
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0218 0.0334
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0041 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Mycobacterium ulcerans beta-lactamase 0.0147 0.1053 0.443
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Schistosoma mansoni tyrosine kinase 0.0017 0.0023 0.0069
Echinococcus multilocularis somatostatin receptor 0.0041 0.0218 0.0334
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Mycobacterium tuberculosis Conserved protein 0.0147 0.1053 0.1441
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0041 0.0122
Schistosoma mansoni chromobox protein 0.0138 0.0977 0.29
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0118 0.0349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0282 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0129 0.0906 0.1727
Mycobacterium leprae Probable lipase LipE 0.0147 0.1053 0.2555
Echinococcus granulosus peregrin 0.0031 0.0136 0.0403
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0282 0.026
Brugia malayi hypothetical protein 0.015 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0599 0.0819
Brugia malayi Protein kinase domain containing protein 0.0017 0.0023 0.0023
Brugia malayi dihydrofolate reductase family protein 0.0129 0.0906 0.0906
Toxoplasma gondii thioredoxin reductase 0.0039 0.0202 0.0597
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0218 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.1053 0.1441
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0202 0.0597
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0444 0.3391 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.0798
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi Protein kinase domain containing protein 0.0017 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Schistosoma mansoni cpg binding protein 0.0031 0.0137 0.0406
Echinococcus multilocularis tyrosine protein kinase shark 0.0017 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.1053 0.1053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.047 0.0719
Echinococcus granulosus g protein coupled receptor 0.0041 0.0218 0.0647
Giardia lamblia GTOR 0.0018 0.0032 0.015
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0218 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.007 0.007
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.0218 0.0647
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0367 0.0562
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.0218 0.0334
Trichomonas vaginalis hypothetical protein 0.0023 0.007 0.0327
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.01 0.0465
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0023 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0245 0.0222
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0017 0.0023 0.0036
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0017 0.0023 0.0036
Brugia malayi Serotonin receptor 0.0041 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0327
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0218 0.0647
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0041 0.0174
Brugia malayi jmjC domain containing protein 0.0038 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.0218 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0202 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Schistosoma mansoni hypothetical protein 0.0041 0.0218 0.0647
Echinococcus multilocularis peregrin 0.0031 0.0136 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.017 0.0504
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.0218 0.0647
Schistosoma mansoni neuropeptide receptor 0.0041 0.0218 0.0647
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.1053 0.1441
Echinococcus granulosus tyrosine protein kinase ABL1 0.0017 0.0023 0.0069
Schistosoma mansoni bromodomain containing protein 0.0064 0.0395 0.1172
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0023 0.0023
Schistosoma mansoni alpha-glucosidase 0.0137 0.0973 0.2889
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0154
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.0221
Echinococcus granulosus thymidylate synthase 0.0315 0.2378 0.7057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0189 0.0166
Echinococcus granulosus orexin receptor type 2 0.0041 0.0218 0.0647
Toxoplasma gondii ABC1 family protein 0.0147 0.1053 0.3107
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0357 0.0335
Brugia malayi sulfakinin receptor protein 0.1282 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0218 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0218 0.0334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0194 0.0575
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0218 0.0647
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.0218 0.0195
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.0798
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0081 0.0239
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.0218 0.0647
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1053 0.3107
Loa Loa (eye worm) helicase 0.0023 0.007 0.0047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.0218 0.0334
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0017 0.0023 0.0069
Echinococcus granulosus geminin 0.0342 0.2586 0.7677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Onchocerca volvulus 0.0023 0.007 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Brugia malayi beta-lactamase family protein 0.0147 0.1053 0.1053
Brugia malayi neuropeptide F receptor 0.0041 0.0218 0.0218
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1148 0.1759
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0023 0.0069
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0024 0.0072
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0023 0.0069
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0081 0.0239
Onchocerca volvulus 0.0041 0.0218 0.0827
Onchocerca volvulus 0.0041 0.0218 0.0827
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0027 0.008
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0218 0.0334
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0118 0.0349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0245 0.0728
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.2147 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0547 0.2223
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.0218 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0218 0.0334
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.0218 0.0218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.2147 1
Onchocerca volvulus 0.0041 0.0218 0.0827
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis allatostatin A receptor 0.0041 0.0218 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.0505
Schistosoma mansoni ap endonuclease 0.0019 0.0041 0.0123
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0977 0.455
Echinococcus granulosus hypothetical protein 0.0041 0.0218 0.0647
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.0218 0.0218
Brugia malayi hypothetical protein 0.0041 0.0218 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0041 0.0122
Echinococcus granulosus jumonji domain containing protein 0.004 0.0206 0.0611
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Mycobacterium tuberculosis Conserved protein 0.0147 0.1053 0.1441
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.1053 0.1441
Leishmania major trypanothione reductase 0.0039 0.0202 0.0597
Echinococcus granulosus tyrosine protein kinase Src42A 0.0017 0.0023 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.007 0.0327
Loa Loa (eye worm) hypothetical protein 0.0051 0.0295 0.0272
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0125 0.0584
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.1053 0.1614
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.0697
Onchocerca volvulus 0.0041 0.0218 0.0827
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0221 0.0656
Onchocerca volvulus 0.0041 0.0218 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Entamoeba histolytica hypothetical protein 0.0073 0.047 0.2101
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.0743 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Brugia malayi Heterochromatin protein 1 0.0138 0.0977 0.0977
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0202 0.0179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0218 0.0647
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0108 0.0743 0.1139
Echinococcus multilocularis Chromo domain 0.0023 0.007 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0032 0.015
Onchocerca volvulus 0.0041 0.0218 0.0827
Schistosoma mansoni biogenic amine receptor 0.0041 0.0218 0.0647
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0444 0.3391 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0165 0.0253
Schistosoma mansoni hypothetical protein 0.0342 0.2586 0.7677
Onchocerca volvulus 0.006 0.0369 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0221 0.103
Schistosoma mansoni chromobox protein 0.0023 0.007 0.0208
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0678 0.0927
Brugia malayi beta-lactamase family protein 0.0147 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0206 0.0316
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0023 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.0218 0.0647
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0147 0.1053 0.1033
Plasmodium vivax hypothetical protein, conserved 0.0023 0.007 0.0207
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0629 0.1868
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0032 0.0096
Schistosoma mansoni hypothetical protein 0.0342 0.2586 0.7677
Brugia malayi Serotonin receptor 0.0041 0.0218 0.0218
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0125 0.0584
Loa Loa (eye worm) hypothetical protein 0.0189 0.1382 0.1362
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.007 0.0208
Leishmania major hypothetical protein, conserved 0.0015 0.0011 0.0032
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.007 0.007
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0218 0.0334
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0218 0.0647
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1053 0.3127
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0032 0.0095
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.0218 0.0334
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0041 0.0193
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0032 0.0095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Echinococcus multilocularis protein patched 0.0042 0.0221 0.0339
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.007 0.0327
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0023 0.0069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.0218 0.0647
Brugia malayi Bromodomain containing protein 0.0031 0.0136 0.0136
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0194 0.0575
Echinococcus multilocularis cpg binding protein 0.0035 0.0165 0.0253
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0218 0.0195
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0041 0.0018

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -12 hr Change in mean aortic blood pressure expressed in hours after an oral administration of 3 mg/kg in conscious normotensive rats ChEMBL. 6292422
I50 (binding) = 0.000000029 M Inhibition of guinea pig serum Angiotensin I converting enzyme ChEMBL. 6292422
IC50 (binding) = 0.000000029 M Inhibition of guinea pig serum Angiotensin I converting enzyme ChEMBL. 6292422
Mean aortic blood pressure (functional) = 176 mmHg Maximum effect on blood pressure in the conscious Renal hypertensive rat after oral administration of 30 mg/kg ChEMBL. 6292422
Mean aortic blood pressure (functional) = 188 mmHg Base line of mean aortic blood pressure in the conscious Renal hypertensive rat was determined after oral administration of 30 mg/kg ChEMBL. 6292422

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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