Detailed information for compound 310776

Basic information

Technical information
  • TDR Targets ID: 310776
  • Name: 2-[4-chloro-5-phenyl-3-(trifluoromethyl)pyraz ol-1-yl]-5-methylsulfonylpyridine
  • MW: 401.791 | Formula: C16H11ClF3N3O2S
  • H donors: 0 H acceptors: 4 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1c(c2ccccc2)n(nc1C(F)(F)F)c1ccc(cn1)S(=O)(=O)C
  • InChi: 1S/C16H11ClF3N3O2S/c1-26(24,25)11-7-8-12(21-9-11)23-14(10-5-3-2-4-6-10)13(17)15(22-23)16(18,19)20/h2-9H,1H3
  • InChiKey: IICKIGHIYRLUSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-chloro-5-phenyl-3-(trifluoromethyl)pyrazol-1-yl]-5-methylsulfonyl-pyridine
  • 2-[4-chloro-5-phenyl-3-(trifluoromethyl)-1-pyrazolyl]-5-methylsulfonylpyridine
  • 2-[4-chloro-5-phenyl-3-(trifluoromethyl)pyrazol-1-yl]-5-mesyl-pyridine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Canis lupus familiaris Cyclooxygenase-2 Starlite/ChEMBL References
Canis lupus familiaris Cyclooxygenase-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0241 0.0619 0.058
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0374 0.1106 0.2776
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0374 0.1106 0.2776
Onchocerca volvulus 0.0258 0.0681 0.3921
Loa Loa (eye worm) hypothetical protein 0.0293 0.0809 0.1248
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0107 0.0132 0.0132
Schistosoma mansoni amine GPCR 0.0241 0.0619 0.0619
Echinococcus granulosus cyclin B 0.0258 0.0681 0.0642
Onchocerca volvulus 0.0145 0.0269 0.1438
Mycobacterium ulcerans oxidoreductase 0.01 0.0105 0.0825
Trichomonas vaginalis cyclin B, putative 0.0258 0.0681 0.1668
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0088 0.0135
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Echinococcus granulosus aminopeptidase N 0.0365 0.1073 0.1036
Brugia malayi Serotonin receptor 0.0241 0.0619 0.0954
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0241 0.0619 0.058
Echinococcus multilocularis G-protein coupled receptor, putative 0.0241 0.0619 0.058
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.01 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0095 0.0088 0.0341
Onchocerca volvulus Putative endochitinase 0.0293 0.0811 0.4704
Loa Loa (eye worm) TK/EGFR protein kinase 0.0191 0.0439 0.0677
Echinococcus granulosus peptide allatostatin:somatostatin 0.0241 0.0619 0.058
Loa Loa (eye worm) endoprotease bli-4 0.1845 0.6483 1
Onchocerca volvulus Peroxidase homolog 0.0095 0.0088 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Plasmodium falciparum protoporphyrinogen oxidase 0.01 0.0105 0.0677
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Mycobacterium ulcerans aminopeptidase N PepN 0.0107 0.0132 0.1181
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Trypanosoma cruzi Aminopeptidase M1, putative 0.0107 0.0132 0.1418
Echinococcus multilocularis 0.1471 0.5116 0.5096
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0149 0.0284 0.0284
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0241 0.0619 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Onchocerca volvulus 0.0241 0.0619 0.3544
Brugia malayi endochitinase 0.0293 0.0811 0.1251
Toxoplasma gondii subtilisin SUB12 0.0126 0.0201 0.1712
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Trichomonas vaginalis cyclin D, putative 0.0139 0.0248 0.054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0216 0.053 0.0817
Echinococcus granulosus cyclins 0.0139 0.0248 0.0208
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0139 0.0248 0.0208
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Entamoeba histolytica cyclin family protein 0.0139 0.0248 0.1713
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Loa Loa (eye worm) TK/ROR protein kinase 0.0121 0.0181 0.0279
Onchocerca volvulus 0.0095 0.0088 0.0341
Mycobacterium ulcerans zinc metalloprotease 0.0293 0.0809 1
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0148 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.01 0.0105 0.0162
Loa Loa (eye worm) hypothetical protein 0.0216 0.053 0.0817
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Mycobacterium leprae probable zinc metalloprotease 0.0293 0.0809 1
Echinococcus granulosus serotonin receptor 0.0241 0.0619 0.058
Onchocerca volvulus 0.0241 0.0619 0.3544
Schistosoma mansoni alpha-1 adrenergic receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.1304 0.1304
Echinococcus granulosus neuropeptide FF receptor 2 0.0469 0.1453 0.1417
Brugia malayi GnHR receptor homolog 0.0241 0.0619 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Schistosoma mansoni opsin-like receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0492 0.1537 0.2371
Onchocerca volvulus 0.0241 0.0619 0.3544
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2597 0.9232 0.9232
Schistosoma mansoni neprilysin 0.0076 0.0019 0.0019
Schistosoma mansoni amine oxidase 0.01 0.0105 0.0105
Brugia malayi hypothetical protein 0.0107 0.0132 0.0204
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.0619 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Schistosoma mansoni neuropeptide f receptor 76f 0.0241 0.0619 0.0619
Brugia malayi G protein-coupled receptor 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0293 0.0809 0.1248
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0241 0.0619 0.0619
Brugia malayi hypothetical protein 0.0095 0.0088 0.0135
Brugia malayi endochitinase 0.0293 0.0811 0.1251
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis serotonin receptor 0.0241 0.0619 0.058
Trichomonas vaginalis cyclins, putative 0.0258 0.0681 0.1668
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0107 0.0132 0.1178
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis neuropeptide receptor A26 0.0241 0.0619 0.058
Onchocerca volvulus 0.0083 0.0041 0.0063
Echinococcus granulosus g protein coupled receptor 0.0241 0.0619 0.058
Trypanosoma brucei mitotic cyclin 6 0.0258 0.0681 0.787
Echinococcus multilocularis g protein coupled receptor 0.0241 0.0619 0.058
Entamoeba histolytica cyclin, putative 0.0258 0.0681 0.8086
Brugia malayi hypothetical protein 0.01 0.0105 0.0162
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846
Onchocerca volvulus 0.0241 0.0619 0.3544
Loa Loa (eye worm) hypothetical protein 0.0082 0.004 0.0061
Schistosoma mansoni peroxidasin 0.0095 0.0088 0.0088
Brugia malayi Peptidase family M13 containing protein 0.0293 0.0809 0.1248
Mycobacterium ulcerans monoamine oxidase 0.01 0.0105 0.0825
Echinococcus multilocularis somatostatin receptor 0.0241 0.0619 0.058
Giardia lamblia G2/mitotic-specific cyclin B 0.0258 0.0681 0.2208
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.0619 0.0954
Trypanosoma cruzi cyclin, putative 0.0258 0.0681 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0107 0.0132 0.0091
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) CAMK/PKD protein kinase 0.008 0.0034 0.0052
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0241 0.0619 0.058
Echinococcus multilocularis neuropeptide s receptor 0.0241 0.0619 0.058
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.0619 0.058
Onchocerca volvulus Putative endochitinase 0.0293 0.0811 0.4704
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.0088 0.0135
Echinococcus granulosus neuropeptide receptor 0.0241 0.0619 0.058
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0619 0.0954
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0083 0.0041 0.0064
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0241 0.0619 0.0619
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1132 0.3877 0.3851
Trypanosoma brucei Aminopeptidase M1, putative 0.0107 0.0132 0.1116
Echinococcus granulosus cyclins 0.0139 0.0248 0.0208
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.0619 0.058
Brugia malayi G-protein coupled receptor 0.0241 0.0619 0.0954
Echinococcus multilocularis epidermal growth factor receptor 0.0191 0.0439 0.0399
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0105 0.0825
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni protein kinase C mu 0.008 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0216 0.053 0.0817
Leishmania major hypothetical protein, conserved 0.0121 0.0181 0.1815
Onchocerca volvulus 0.0107 0.0132 0.061
Loa Loa (eye worm) TYRA-2 protein 0.0241 0.0619 0.0954
Plasmodium falciparum cysteine repeat modular protein 1 0.0121 0.0181 0.1494
Schistosoma mansoni hypothetical protein 0.0121 0.0181 0.0181
Onchocerca volvulus 0.0365 0.1073 0.6286
Mycobacterium tuberculosis Possible chitinase 0.025 0.0653 0.7969
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0241 0.0619 0.3544
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0072 0.0001 0.0002
Toxoplasma gondii peptidase family M13 protein 0.0293 0.0809 0.821
Echinococcus granulosus tissue type plasminogen activator 0.0121 0.0181 0.014
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni furin-1 (S08 family) 0.0796 0.2647 0.2647
Echinococcus multilocularis sex peptide receptor 0.0241 0.0619 0.058
Echinococcus multilocularis cyclin B3 1 0.0139 0.0248 0.0208
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0107 0.0132 0.0236
Echinococcus granulosus somatostatin receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Brugia malayi larval opioid receptor 0.0241 0.0619 0.0954
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.0619 0.058
Onchocerca volvulus CoRest homolog 0.0176 0.0381 0.2112
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.0619 0.0619
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0148 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) cyclin domain-containing protein 0.0139 0.0248 0.0383
Plasmodium falciparum cyclin 0.0139 0.0248 0.2213
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0148 0.0279 0.0279
Loa Loa (eye worm) subtilase 0.0083 0.0041 0.0064
Brugia malayi Kringle domain containing protein 0.0121 0.0181 0.0279
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0312 0.0882 0.0882
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0121 0.0181 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Brugia malayi Tachykinin-like peptides receptor 99D 0.0469 0.1453 0.2241
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.0619 0.058
Trichomonas vaginalis cyclin B, putative 0.0258 0.0681 0.1668
Brugia malayi Cyclin, N-terminal domain containing protein 0.0258 0.0681 0.1051
Echinococcus multilocularis neuropeptide FF receptor 2 0.0469 0.1453 0.1417
Loa Loa (eye worm) blistered cuticle protein 3 0.0095 0.0088 0.0135
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0293 0.0809 1
Trypanosoma cruzi cyclin, putative 0.0258 0.0681 1
Echinococcus multilocularis neuropeptide receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846
Echinococcus granulosus neuropeptide s receptor 0.0241 0.0619 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0181 0.2184
Loa Loa (eye worm) peptidase family M1 containing protein 0.0295 0.0819 0.1263
Brugia malayi Dopamine receptor protein 2 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0241 0.0619 0.3544
Schistosoma mansoni hypothetical protein 0.0241 0.0619 0.0619
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0088 0.0135
Echinococcus granulosus cyclins 0.0139 0.0248 0.0208
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0241 0.0619 0.0619
Schistosoma mansoni hypothetical protein 0.0374 0.1106 0.1106
Echinococcus granulosus g-protein coupled receptor 0.0241 0.0619 0.058
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0241 0.0619 0.0954
Echinococcus granulosus 7TM GPCR rhodopsin 0.0241 0.0619 0.058
Schistosoma mansoni myosin xvIII 0.0241 0.0619 0.0619
Brugia malayi putative neuropeptide receptor 0.0241 0.0619 0.0954
Trichomonas vaginalis cyclins, putative 0.0152 0.0295 0.0661
Echinococcus multilocularis endothelin converting enzyme 1 0.0293 0.0809 0.0771
Brugia malayi Endochitinase 0.0293 0.0811 0.1251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Trypanosoma cruzi cyclin 6, putative 0.0258 0.0681 1
Schistosoma mansoni sortilin 0.0198 0.0464 0.0464
Schistosoma mansoni biogenic amine receptor 0.0241 0.0619 0.0619
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0148 0.0279 0.0279
Onchocerca volvulus Peroxidase homolog 0.0095 0.0088 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.0619 0.058
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Onchocerca volvulus 0.0082 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0492 0.1537 0.1537
Echinococcus granulosus lysine specific histone demethylase 1A 0.0492 0.1537 0.1502
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.017 0.0361 0.4159
Toxoplasma gondii kringle domain-containing protein 0.0121 0.0181 0.1494
Echinococcus granulosus alpha 1A adrenergic receptor 0.0241 0.0619 0.058
Echinococcus granulosus G protein coupled receptor 139 0.0241 0.0619 0.058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0241 0.0619 0.058
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0083 0.0041 0.0041
Schistosoma mansoni neuropeptide receptor 0.0241 0.0619 0.0619
Echinococcus multilocularis peroxidasin 0.0095 0.0088 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.0619 0.0954
Schistosoma mansoni cyclin B 0.0258 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni amine GPCR 0.0241 0.0619 0.0619
Onchocerca volvulus 0.0241 0.0619 0.3544
Loa Loa (eye worm) hypothetical protein 0.0171 0.0363 0.056
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni site-1 peptidase (S08 family) 0.0083 0.0041 0.0041
Schistosoma mansoni adenoreceptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1132 0.3877 0.3851
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0083 0.0041 0.0064
Plasmodium vivax hypothetical protein, conserved 0.01 0.0105 0.0677
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Entamoeba histolytica chitinase, putative 0.0293 0.0811 1
Onchocerca volvulus 0.0241 0.0619 0.3544
Schistosoma mansoni cyclins 0.0139 0.0248 0.0248
Onchocerca volvulus 0.0241 0.0619 0.3544
Loa Loa (eye worm) hypothetical protein 0.0258 0.0681 0.1051
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.0619 0.058
Echinococcus multilocularis fmrfamide receptor 0.0241 0.0619 0.058
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0241 0.0619 0.0619
Brugia malayi sulfakinin receptor protein 0.0241 0.0619 0.0954
Schistosoma mansoni growth hormone secretagogue receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) proprotein convertase 2 0.0456 0.1408 0.2172
Echinococcus granulosus orexin receptor type 2 0.0241 0.0619 0.058
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Onchocerca volvulus Dual oxidase homolog 0.0095 0.0088 0.0341
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0105 0.099
Loa Loa (eye worm) hypothetical protein 0.0216 0.053 0.0817
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0139 0.0248 0.0208
Loa Loa (eye worm) hypothetical protein 0.1845 0.6483 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0031 0.0048
Schistosoma mansoni neuropeptide receptor 0.0241 0.0619 0.0619
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0241 0.0619 0.058
Trichomonas vaginalis cyclins, putative 0.0258 0.0681 0.1668
Brugia malayi Blistered cuticle protein 3 0.0095 0.0088 0.0135
Onchocerca volvulus 0.0241 0.0619 0.3544
Brugia malayi G-protein coupled receptor 0.0241 0.0619 0.0954
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Schistosoma mansoni opsin-like receptor 0.0241 0.0619 0.0619
Echinococcus granulosus lysine specific histone demethylase 1A 0.01 0.0105 0.0064
Loa Loa (eye worm) hypothetical protein 0.0145 0.0269 0.0416
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Echinococcus granulosus cyclins 0.0139 0.0248 0.0208
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Brugia malayi Dopamine receptor 0.0241 0.0619 0.0954
Entamoeba histolytica cyclin family protein 0.0139 0.0248 0.1713
Schistosoma mansoni biogenic amine receptor 0.0241 0.0619 0.0619
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Echinococcus multilocularis protoporphyrinogen oxidase 0.01 0.0105 0.0064
Loa Loa (eye worm) microfilarial chitinase 0.025 0.0653 0.1008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0619 0.0954
Echinococcus granulosus neuropeptide receptor A26 0.0241 0.0619 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Trichomonas vaginalis cyclin B, putative 0.0139 0.0248 0.054
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0241 0.0619 0.3544
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.0619 0.058
Echinococcus multilocularis aminopeptidase N 0.0365 0.1073 0.1036
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.0619 0.058
Schistosoma mansoni hypothetical protein 0.0082 0.0038 0.0038
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0241 0.0619 0.058
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0312 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0107 0.0132 0.0236
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.0619 0.0954
Brugia malayi SWIRM domain containing protein 0.0533 0.1689 0.2606
Trichomonas vaginalis cyclin B3, putative 0.0139 0.0248 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Trichomonas vaginalis cyclin B, putative 0.0258 0.0681 0.1668
Echinococcus multilocularis cyclin b3 0.0139 0.0248 0.0208
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0088 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0118 0.0172 0.0266
Echinococcus granulosus sortilin 0.028 0.0763 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1132 0.3877 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.0619 0.058
Chlamydia trachomatis protoporphyrinogen oxidase 0.01 0.0105 0.5
Echinococcus multilocularis neuroendocrine convertase 2 0.117 0.4014 0.3989
Echinococcus granulosus cyclins 0.0139 0.0248 0.0208
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0293 0.0809 0.0809
Loa Loa (eye worm) hypothetical protein 0.0258 0.0681 0.105
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.0619 0.0619
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.0619 0.058
Schistosoma mansoni neuropeptide receptor 0.0241 0.0619 0.0619
Schistosoma mansoni amine GPCR 0.0241 0.0619 0.0619
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.0619 0.0619
Echinococcus multilocularis serotonin receptor 0.0241 0.0619 0.058
Echinococcus granulosus neuropeptide receptor 0.0241 0.0619 0.058
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.1304 0.1304
Echinococcus multilocularis dnaJ subfamily B 0.2807 1 1
Toxoplasma gondii cathepsin CPC2 0.0338 0.0977 1
Mycobacterium ulcerans epoxide hydrolase EphA 0.017 0.0361 0.4159
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Brugia malayi Furin-like cysteine rich region family protein 0.0191 0.0439 0.0677
Echinococcus multilocularis g protein coupled receptor 0.0241 0.0619 0.058
Onchocerca volvulus 0.0241 0.0619 0.3544
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.0619 0.058
Brugia malayi neuroendocrine convertase 1 precursor 0.117 0.4014 0.6192
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0176 0.0381 0.0588
Schistosoma mansoni histamine h1 receptor 0.0241 0.0619 0.0619
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.01 0.0105 0.0825
Trypanosoma cruzi CYC2-like cyclin, putative 0.0258 0.0681 1
Onchocerca volvulus Putative endochitinase 0.0293 0.0811 0.4704
Echinococcus multilocularis sortilin 0.028 0.0763 0.0724
Loa Loa (eye worm) hypothetical protein 0.0293 0.0809 0.1248
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0492 0.1537 0.1502
Brugia malayi Myb-like DNA-binding domain containing protein 0.0171 0.0363 0.056
Schistosoma mansoni biogenic amine receptor 0.0241 0.0619 0.0619
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Echinococcus granulosus peroxidasin 0.0095 0.0088 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Loa Loa (eye worm) aminopeptidase N 0.0107 0.0132 0.0204
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0241 0.0619 0.0954
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Echinococcus granulosus g protein coupled receptor 0.0241 0.0619 0.058
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.008 0.0034 0.0052
Brugia malayi C1-like domain containing protein 0.008 0.0034 0.0052
Echinococcus multilocularis 0.01 0.0105 0.0064
Mycobacterium ulcerans dehydrogenase 0.01 0.0105 0.0825
Onchocerca volvulus Peroxidasin homolog 0.0095 0.0088 0.0341
Onchocerca volvulus Chorion peroxidase homolog 0.0095 0.0088 0.0341
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.01 0.0105 0.0677
Onchocerca volvulus Peroxidasin homolog 0.0095 0.0088 0.0341
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.01 0.0105 0.0677
Onchocerca volvulus 0.0241 0.0619 0.3544
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0105 0.0825
Brugia malayi Melatonin receptor type 1A 0.0241 0.0619 0.0954
Echinococcus multilocularis orexin receptor type 2 0.0241 0.0619 0.058
Brugia malayi Subtilase family protein 0.0083 0.0041 0.0064
Schistosoma mansoni peroxidasin 0.0095 0.0088 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0241 0.0619 0.0954
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.0619 0.0619
Schistosoma mansoni hypothetical protein 0.0241 0.0619 0.0619
Echinococcus granulosus sex peptide receptor 0.0241 0.0619 0.058
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni opsin-like receptor 0.0241 0.0619 0.0619
Entamoeba histolytica cyclin, putative 0.0139 0.0248 0.1713
Trichomonas vaginalis cyclin B, putative 0.0258 0.0681 0.1668
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.0619 0.058
Echinococcus multilocularis dro:myosuppressin receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0241 0.0619 0.058
Brugia malayi endoprotease bli-4 precursor 0.1845 0.6483 1
Echinococcus multilocularis neuropeptide receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Onchocerca volvulus 0.0533 0.1689 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.0619 0.0619
Toxoplasma gondii hypothetical protein 0.0106 0.0126 0.09
Echinococcus granulosus fmrfamide receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Schistosoma mansoni hypothetical protein 0.2807 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0181 0.0279
Loa Loa (eye worm) hypothetical protein 0.0312 0.0882 0.136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Loa Loa (eye worm) peptidase family M13 containing protein 0.0216 0.053 0.0817
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0456 0.1408 0.1408
Echinococcus granulosus dro:myosuppressin receptor 0.0241 0.0619 0.058
Onchocerca volvulus 0.0095 0.0088 0.0341
Schistosoma mansoni neuropeptide receptor 0.0241 0.0619 0.0619
Plasmodium falciparum sortilin 0.028 0.0763 0.7713
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0083 0.0041 0.0041
Trypanosoma brucei Aminopeptidase M1, putative 0.0107 0.0132 0.1116
Loa Loa (eye worm) hypothetical protein 0.0713 0.2345 0.3618
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Mycobacterium ulcerans chitinase/cellulase 0.025 0.0653 0.7969
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Trichomonas vaginalis cyclin D, putative 0.0139 0.0248 0.054
Loa Loa (eye worm) chitinase I 0.0293 0.0811 0.1251
Echinococcus granulosus furin 0.1845 0.6483 0.6468
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1132 0.3877 1
Onchocerca volvulus Putative endochitinase 0.0293 0.0811 0.4704
Loa Loa (eye worm) hypothetical protein 0.0312 0.0882 0.136
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0258 0.0681 0.8312
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.0088 0.0135
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus multilocularis Furin 1 0.0456 0.1408 0.1372
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0241 0.0619 0.3544
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0241 0.0619 0.058
Brugia malayi putative neuropeptide receptor NPR1 0.0241 0.0619 0.0954
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0107 0.0132 0.1116
Loa Loa (eye worm) cuticular endochitinase 0.0293 0.0811 0.1251
Loa Loa (eye worm) hypothetical protein 0.0469 0.1453 0.2241
Echinococcus multilocularis cyclin B 0.0258 0.0681 0.0642
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.0619 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0241 0.0619 0.058
Echinococcus granulosus cyclin b3 0.0139 0.0248 0.0208
Plasmodium vivax sortilin, putative 0.028 0.0763 0.7713
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.0619 0.058
Plasmodium vivax hypothetical protein, conserved 0.01 0.0105 0.0677
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0456 0.1408 0.3563
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0338 0.0977 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Trichomonas vaginalis hypothetical protein 0.0374 0.1106 0.2776
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0241 0.0619 0.3544
Echinococcus multilocularis g-protein coupled receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Schistosoma mansoni amine GPCR 0.0241 0.0619 0.0619
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Onchocerca volvulus 0.0271 0.073 0.4214
Schistosoma mansoni hypothetical protein 0.0241 0.0619 0.0619
Trichomonas vaginalis cyclins, putative 0.0258 0.0681 0.1668
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.0619 0.0619
Schistosoma mansoni amine oxidase 0.01 0.0105 0.0105
Schistosoma mansoni site-1 peptidase (S08 family) 0.0083 0.0041 0.0041
Onchocerca volvulus Putative endochitinase 0.0293 0.0811 0.4704
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.0619 0.058
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Onchocerca volvulus 0.0312 0.0882 0.5129
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0327 0.0935 0.1443
Schistosoma mansoni hypothetical protein 0.0241 0.0619 0.0619
Brugia malayi celfurPC protein 0.1471 0.5116 0.7892
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0241 0.0619 0.0954
Schistosoma mansoni hypothetical protein 0.0305 0.0854 0.0854
Echinococcus granulosus expressed protein 0.075 0.2482 0.245
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0338 0.0977 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Brugia malayi Cyclin, N-terminal domain containing protein 0.0258 0.0681 0.1051
Brugia malayi neuropeptide F receptor 0.0241 0.0619 0.0954
Echinococcus multilocularis g protein coupled receptor 0.0241 0.0619 0.058
Schistosoma mansoni amine GPCR 0.0241 0.0619 0.0619
Echinococcus granulosus Furin 1 0.0456 0.1408 0.1372
Trypanosoma brucei RNA helicase, putative 0.0305 0.0854 1
Leishmania major chitinase 0.0293 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Loa Loa (eye worm) melatonin receptor type 1A 0.0241 0.0619 0.0954
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Leishmania major cyclin 0.0258 0.0681 0.8312
Echinococcus multilocularis allatostatin A receptor 0.0241 0.0619 0.058
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Trichomonas vaginalis cyclins, putative 0.0139 0.0248 0.054
Mycobacterium tuberculosis Possible oxidoreductase 0.01 0.0105 0.0825
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Brugia malayi Peroxidasin 0.0095 0.0088 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Mycobacterium ulcerans chitinase/cellulase 0.025 0.0653 0.7969
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Toxoplasma gondii histone lysine-specific demethylase 0.01 0.0105 0.0677
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.01 0.0105 0.0677
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0105 0.099
Echinococcus granulosus 7tm_1 domain containing protein 0.0241 0.0619 0.058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0241 0.0619 0.0954
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0241 0.0619 0.058
Loa Loa (eye worm) peptidase family M13 containing protein 0.0216 0.053 0.0817
Echinococcus granulosus allatostatin A receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0083 0.0041 0.0064
Brugia malayi Cyclin, N-terminal domain containing protein 0.0139 0.0248 0.0383
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0121 0.0181 0.1494
Plasmodium vivax protoporphyrinogen oxidase, putative 0.01 0.0105 0.0677
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Brugia malayi Trypsin family protein 0.0312 0.0882 0.136
Echinococcus granulosus tm gpcr rhodopsin 0.2356 0.8351 0.8344
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Mycobacterium ulcerans protoporphyrinogen oxidase 0.01 0.0105 0.0825
Trichomonas vaginalis cyclin A, putative 0.0258 0.0681 0.1668
Echinococcus granulosus neuroendocrine convertase 2 0.117 0.4014 0.3989
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Brugia malayi G protein-coupled receptor F59B2.13 0.0241 0.0619 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Echinococcus granulosus tachykinin peptides receptor 99D 0.0241 0.0619 0.058
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0107 0.0132 0.1178
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0293 0.0809 0.1248
Brugia malayi hypothetical protein 0.0241 0.0619 0.0954
Echinococcus granulosus cyclin B3 1 0.0139 0.0248 0.0208
Giardia lamblia Furin precursor putative serine protease 0.0374 0.1106 0.4376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Toxoplasma gondii sortilin, putative 0.028 0.0763 0.7713
Echinococcus multilocularis expressed protein 0.075 0.2482 0.245
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Giardia lamblia High cysteine membrane protein Group 2 0.0675 0.2208 1
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0241 0.0619 0.0954
Echinococcus granulosus g protein coupled receptor 0.0241 0.0619 0.058
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0105 0.0825
Echinococcus multilocularis cyclins 0.0139 0.0248 0.0208
Brugia malayi Serotonin receptor 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Trichomonas vaginalis cyclins, putative 0.0258 0.0681 0.1668
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.0088 0.0135
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1845 0.6483 0.6483
Onchocerca volvulus 0.0241 0.0619 0.3544
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2356 0.8351 0.8344
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0248 0.054
Brugia malayi Protein kinase domain containing protein 0.0121 0.0181 0.0279
Loa Loa (eye worm) hypothetical protein 0.0142 0.0257 0.0396
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0472 0.1465 0.1465
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0107 0.0132 0.0091
Schistosoma mansoni tyrosine kinase 0.0191 0.0439 0.0439
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0374 0.1106 0.2776
Loa Loa (eye worm) hypothetical protein 0.0258 0.0681 0.1051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.0619 0.0619
Brugia malayi RE15519p 0.0241 0.0619 0.0954
Schistosoma mansoni neprilysin-2 (M13 family) 0.0148 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0076 0.0019 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0241 0.0619 0.058
Loa Loa (eye worm) hypothetical protein 0.0492 0.1537 0.2371
Loa Loa (eye worm) hypothetical protein 0.0095 0.0088 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0374 0.1106 0.2776
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.0619 0.058
Echinococcus multilocularis tissue type plasminogen activator 0.0121 0.0181 0.014
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0088 0.0135
Brugia malayi amine oxidase, flavin-containing family protein 0.0142 0.0257 0.0396
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0107 0.0132 0.1418
Echinococcus multilocularis G protein coupled receptor 139 0.0241 0.0619 0.058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.025 0.0653 0.1008
Onchocerca volvulus Neuropeptide F receptor homolog 0.0241 0.0619 0.3544
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0076 0.0019 0.0019
Schistosoma mansoni cyclin B3 0.0139 0.0248 0.0248
Echinococcus granulosus epidermal growth factor receptor 0.0191 0.0439 0.0399
Echinococcus granulosus endothelin converting enzyme 1 0.0293 0.0809 0.0771
Onchocerca volvulus 0.0241 0.0619 0.3544
Echinococcus granulosus hypothetical protein 0.0241 0.0619 0.058
Brugia malayi ORL1-like opioid receptor 0.0241 0.0619 0.0954
Brugia malayi Peptidase family M1 containing protein 0.0107 0.0132 0.0204
Loa Loa (eye worm) hypothetical protein 0.01 0.0105 0.0162
Onchocerca volvulus 0.0241 0.0619 0.3544
Leishmania major UDP-galactopyranose mutase 0.01 0.0105 0.0823
Brugia malayi proprotein convertase 2 0.117 0.4014 0.6192
Brugia malayi Peptidase family M1 containing protein 0.0365 0.1073 0.1656
Loa Loa (eye worm) hypothetical protein 0.0533 0.1689 0.2606
Brugia malayi AKH receptor 0.0241 0.0619 0.0954
Brugia malayi Dopamine receptor protein 1 0.0241 0.0619 0.0954
Loa Loa (eye worm) hypothetical protein 0.0241 0.0619 0.0954
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0105 0.0677
Trypanosoma cruzi aminopeptidase, putative 0.0107 0.0132 0.1418
Loa Loa (eye worm) hypothetical protein 0.0221 0.0549 0.0846

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 2654 ng hr ml-1 AUC (Area Under Plasma concentration-time curve) of the compound was after oral administration at 5 mg/kg ChEMBL. 14684306
C24 (ADMET) = 34 ng ml-1 C24 of the compound was determined after oral administration at 5 mg/kg ChEMBL. 14684306
Cmax (ADMET) = 473 ng ml-1 Cmax (Maximum (Peak) plasma drug concentration) of the compound was after oral administration at 5 mg/kg ChEMBL. 14684306
IC50 (binding) = 0.06 uM In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. ChEMBL. 14684306
IC50 (binding) = 0.06 uM In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. ChEMBL. 14684306
IC50 (binding) = 7.9 uM In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. ChEMBL. 14684306
IC50 (binding) = 7.9 uM In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. ChEMBL. 14684306
Ratio (binding) = 132 Ratio of IC50 of COX-1 to that of COX-2. ChEMBL. 14684306
T max (ADMET) = 0.75 hr Tmax (time to reach maximum concentration) of the compound was after oral administration at 5 mg/kg ChEMBL. 14684306
T1/2 (ADMET) = 14.7 hr T1/2 (Half-life) of the compound was after oral administration at 5 mg/kg ChEMBL. 14684306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.