Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.4263 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4113 | 0.4113 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.4263 | 0.4001 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.4263 | 0.4263 |
Onchocerca volvulus | 0.0028 | 0.4263 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.4263 | 0.4263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0438 | 0.0438 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.4263 | 0.4263 |
Echinococcus multilocularis | musashi | 0.0028 | 0.4263 | 0.4263 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.4263 | 0.4001 |
Onchocerca volvulus | 0.0028 | 0.4263 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 mM | Percent inhibition of the compound against dihydrodipicolinic acid synthase at 10 mM | ChEMBL. | 7241506 |
IC50 (functional) | = 1.2 mM | Percent inhibition of the compound against dihydrodipicolinic acid synthase at 10 mM | ChEMBL. | 7241506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.