Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4685 | 0.6347 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1342 | 0.1624 | 0.1061 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.727 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.727 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.727 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4685 | 0.6347 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.727 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.727 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4685 | 0.6347 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.727 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.727 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0638 | 0.0629 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4685 | 0.6347 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.727 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1342 | 0.1624 | 0.1061 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4685 | 0.6347 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.727 | 1 | 1 |
Onchocerca volvulus | 0.1342 | 0.1624 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4685 | 0.6347 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37.8 uM | Inhibitory concentration against human Dipeptidyl-peptidase II | ChEMBL. | 15771423 |
IC50 (binding) | = 37.8 uM | Inhibitory concentration against human Dipeptidyl-peptidase II | ChEMBL. | 15771423 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against human Dipeptidyl-peptidase IV | ChEMBL. | 15771423 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against human Dipeptidyl-peptidase IV | ChEMBL. | 15771423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.