Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0128 | 0.1665 | 0.4065 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0217 | 0.3864 | 0.3864 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0115 | 0.1352 | 0.2968 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.009 | 0.0718 | 0.2977 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0137 | 0.1878 | 0.4917 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0103 | 0.104 | 0.2045 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0248 | 0.4629 | 0.4629 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.025 | 0.4677 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0248 | 0.4629 | 0.4629 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0279 | 0.5402 | 0.5402 |
Onchocerca volvulus | 0.0241 | 0.4464 | 0.9285 | |
Chlamydia trachomatis | glutamine binding protein | 0.0156 | 0.2356 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0129 | 0.1698 | 0.3585 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0156 | 0.0391 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0137 | 0.1878 | 0.481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0137 | 0.1878 | 0.481 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0092 | 0.0773 | 0.0773 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0128 | 0.1665 | 0.3515 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0128 | 0.1665 | 0.4187 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0156 | 0.2356 | 0.6554 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0129 | 0.1698 | 0.4248 |
Loa Loa (eye worm) | acyl carrier protein | 0.0064 | 0.007 | 0.0176 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0465 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0156 | 0.2356 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0156 | 0.2356 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0137 | 0.1878 | 0.481 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0128 | 0.1665 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0128 | 0.1665 | 0.4065 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.01 | 0.0957 | 0.1761 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0134 | 0.1818 | 0.4712 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.3998 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0137 | 0.1878 | 0.4917 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0279 | 0.5402 | 0.5402 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0197 | 0.3362 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0197 | 0.3362 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0137 | 0.1878 | 0.481 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0156 | 0.2356 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.034 | 0.6909 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0115 | 0.1352 | 0.2968 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0128 | 0.1665 | 0.4187 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0099 | 0.0935 | 0.4288 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0128 | 0.1665 | 0.4065 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0115 | 0.1352 | 0.3112 |
Mycobacterium ulcerans | thioesterase | 0.0115 | 0.1352 | 0.2968 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0128 | 0.1665 | 0.4065 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0252 | 0.4737 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0092 | 0.0773 | 0.0773 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0118 | 0.1406 | 0.1406 |
Loa Loa (eye worm) | fatty acid synthase | 0.0137 | 0.1878 | 0.4697 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0137 | 0.1878 | 0.4917 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0197 | 0.3362 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0134 | 0.1818 | 0.4712 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0118 | 0.1406 | 0.2035 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0128 | 0.1665 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0101 | 0.0995 | 0.172 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0137 | 0.1878 | 0.481 |
Mycobacterium ulcerans | polyketide synthase | 0.0128 | 0.1665 | 0.4065 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0197 | 0.3362 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0092 | 0.0773 | 0.0773 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0128 | 0.1665 | 0.4187 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0092 | 0.0773 | 0.0773 |
Mycobacterium ulcerans | polyketide synthase | 0.0137 | 0.1878 | 0.481 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0092 | 0.0773 | 0.0773 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0101 | 0.0995 | 0.172 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0137 | 0.1878 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0156 | 0.2356 | 0.6482 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0101 | 0.0995 | 0.172 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0118 | 0.1406 | 0.1406 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0129 | 0.1698 | 0.43 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.85 uM | Relative potency of the compound was evaluated for its ability to mobilize intracellular calcium in MDA MB-231 cells.*did not reach a maximal response at the highest concentration used | ChEMBL. | 10090779 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.