Detailed information for compound 311460

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.782 | Formula: C16H16ClN5O4
  • H donors: 4 H acceptors: 6 LogP: 0.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1ncnc2Nc1cccc(c1)Cl
  • InChi: 1S/C16H16ClN5O4/c17-8-2-1-3-9(4-8)21-14-11-15(19-6-18-14)22(7-20-11)16-13(25)12(24)10(5-23)26-16/h1-4,6-7,10,12-13,16,23-25H,5H2,(H,18,19,21)
  • InChiKey: TZNHRMFCCGYSTQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0232 0.0224
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0046 0.0037
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0046 0.008
Echinococcus multilocularis pyruvate kinase 0.0034 0.0146 0.0138
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0019 0.0022
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0164 0.0739
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0046 0.0037
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0067 0.0217
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0067 0.0278
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.0373
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.016
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0235 0.0485
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0088 0.0482 0.225
Brugia malayi AMP-binding enzyme family protein 0.0072 0.038 0.0812
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0297 0.1779 0.8399
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0046 0.0098
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.033 0.0662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0164 0.0739
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0067 0.0189
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0232 0.048
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0022
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0088 0.0482 0.225
Onchocerca volvulus 0.0049 0.024 0.11
Brugia malayi Myosin head containing protein 0.0012 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Echinococcus multilocularis protein patched 0.0085 0.0461 0.0453
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.0513
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0008 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Echinococcus multilocularis pyruvate kinase 0.0027 0.0102 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0482 0.1015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0232 0.048
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.033 0.1473
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0046 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0164 0.0307
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0044 0.0171
Schistosoma mansoni cpg binding protein 0.0031 0.0129 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0046 0.0098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0482 0.225
Entamoeba histolytica hypothetical protein 0.0037 0.0163 0.0734
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.024 0.0513
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0681 0.1418
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Toxoplasma gondii hypothetical protein 0.0012 0.0011 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0046 0.008
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.1007 0.214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0276 0.0574
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0067 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Onchocerca volvulus 0.0012 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0351 0.2114 0.4496
Onchocerca volvulus 0.0351 0.2114 1
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.033 0.1473
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0046 0.008
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0765 0.4676 1
Mycobacterium ulcerans hypothetical protein 0.0072 0.038 0.333
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.038 0.333
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0216 0.0446
Echinococcus granulosus cpg binding protein 0.0031 0.0129 0.0259
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0235 0.0485
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.1158 0.1151
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0164 0.0739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.025 0.2098
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.1683 0.1676
Echinococcus granulosus cathepsin L cysteine protease 0.0208 0.1227 0.2611
Trypanosoma cruzi cysteine protease, putative 0.0208 0.1227 0.259
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.1158 0.2464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0323 0.0674
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0765 0.4676 1
Trypanosoma cruzi cruzipain precursor, putative 0.012 0.0681 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0072 0.038 0.0796
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0197 0.0898
Schistosoma mansoni hypothetical protein 0.0082 0.0442 0.0929
Trypanosoma cruzi major cysteine proteinase, putative 0.0088 0.0482 0.099
Schistosoma mansoni alpha-glucosidase 0.0142 0.0819 0.1736
Echinococcus multilocularis cathepsin L 0.0208 0.1227 0.122
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Onchocerca volvulus 0.0029 0.0119 0.0524
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.1007 0.2118
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0461 0.097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0235 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0046 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.1275 0.599
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0197 0.0898
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.1007 0.4744
Onchocerca volvulus 0.0012 0.0011 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0046 0.008
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0235 0.0485
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1424 0.1417
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0046 0.008
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0375 0.1741
Loa Loa (eye worm) MBCTL1 0.0055 0.0276 0.0574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Brugia malayi fibroinase precursor 0.0088 0.0482 0.1031
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0765 0.4676 1
Giardia lamblia Cysteine protease 0.0088 0.0482 0.2523
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0208 0.1227 0.259
Schistosoma mansoni cpg binding protein 0.0029 0.0119 0.0236
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0235 0.0485
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0962 0.2056
Onchocerca volvulus 0.0012 0.0011 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0268 0.2138
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0046 0.008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0046 0.0098
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0008 0.0018
Echinococcus granulosus cathepsin l1 0.0231 0.1369 0.2916
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0027 0.0091
Echinococcus granulosus chromobox protein 1 0.0071 0.0375 0.0785
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0276 0.0574
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0077
Toxoplasma gondii preprocathepsin c precursor, putative 0.0088 0.0482 0.225
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0046 0.0037
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0208 0.1227 0.2611
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0201 0.0915
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0351 0.2114 0.4511
Echinococcus granulosus pyruvate kinase 0.0034 0.0146 0.0296
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0962 0.0954
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0125
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0146 0.0847
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.024 0.1424 0.3033
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0235 0.0485
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0011
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0091 0.0255
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0046 0.008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0351 0.2114 1
Echinococcus multilocularis cathepsin b 0.0765 0.4676 0.4672
Onchocerca volvulus 0.0012 0.0011 0.0011
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0067 0.0217
Echinococcus multilocularis cathepsin b 0.0765 0.4676 0.4672
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Echinococcus granulosus tumor protein p63 0.0343 0.2062 0.44
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0164 0.0739
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0046 0.0037
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.033 0.1473
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0088 0.0482 0.225
Schistosoma mansoni coup transcription factor 0.0018 0.0046 0.008
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.1683 0.3587
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0067 0.0278
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.0018
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0067 0.0278
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0067 0.0278
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0319 0.2677
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.033 0.0662
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0482 0.1031
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0044 0.0171
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0067 0.0278
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0556
Entamoeba histolytica cysteine proteinase, putative 0.0208 0.1227 0.5787
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0005
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0146 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0351 0.2114 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0067 0.0143
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0019 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0046 0.0098
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0067 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0163 0.0331
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0276 0.0574
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.038 0.1714
Schistosoma mansoni microtubule-associated protein tau 0.07 0.4278 0.9147
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0067 0.0189
Trypanosoma brucei glucosidase, putative 0.0037 0.0164 0.0682
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0273 0.0567
Schistosoma mansoni alpha glucosidase 0.0037 0.0164 0.0334
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0088 0.0482 0.225
Brugia malayi Patched related family protein 10 0.0012 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Plasmodium falciparum serine repeat antigen 6 0.0088 0.0482 0.225
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.1275 0.2693
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0164 0.0739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0146 0.0296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0046 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.012 0.0681 0.1442
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0088 0.0482 0.1015
Brugia malayi cathepsin L-like cysteine proteinase 0.0088 0.0482 0.1031
Trypanosoma cruzi cysteine proteinase, putative 0.0208 0.1227 0.259
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0012 0.0009
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.038 0.333
Brugia malayi CXXC zinc finger family protein 0.0029 0.0119 0.0254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0482 0.1015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0208 0.1227 0.2611
Brugia malayi AMP-binding enzyme family protein 0.0072 0.038 0.0812
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0046 0.008
Onchocerca volvulus 0.0012 0.0012 0.0019
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0091 0.0332
Plasmodium falciparum serine repeat antigen 2 0.0088 0.0482 0.225
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0482 0.1015
Trypanosoma cruzi cysteine peptidase, putative 0.0351 0.2114 0.4496
Brugia malayi cathepsin Z-like cysteine proteinase 0.0088 0.0482 0.1031
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0146 0.0296
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0146 0.0313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0216 0.0208
Onchocerca volvulus Cathepsin L homolog 0.0351 0.2114 1
Brugia malayi hypothetical protein 0.0012 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0216 0.0446
Brugia malayi Protein cec-1. 0.0012 0.0008 0.0018
Echinococcus granulosus GPCR family 2 0.0048 0.0232 0.048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0046 0.008
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0067 0.0217
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0164 0.0739
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.1007 1
Echinococcus granulosus cysteine protease 0.0208 0.1227 0.2611
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Onchocerca volvulus 0.0012 0.0011 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0046 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0823 0.0816
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.038 0.333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Onchocerca volvulus 0.0031 0.0129 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0046 0.0098
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0067 0.0125
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.1222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.0088 0.0482 0.225
Onchocerca volvulus Cathepsin F homolog 0.0351 0.2114 1
Plasmodium falciparum serine repeat antigen 8 0.0088 0.0482 0.225
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0319 0.142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0482 0.225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.025 0.2098
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0046 0.0178
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0164 0.0156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0072 0.038 0.0796
Entamoeba histolytica hypothetical protein 0.0037 0.0163 0.0734
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0046 0.0037
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.1007 0.4744
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.038 0.333
Loa Loa (eye worm) hypothetical protein 0.0151 0.0871 0.1849
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.038 0.3456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0216 0.0446
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0088 0.0482 0.2523
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0088 0.0482 0.225
Entamoeba histolytica cysteine proteinase, putative 0.0351 0.2114 1
Giardia lamblia Cathepsin L-like protease 0.0088 0.0482 0.2523
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0232 0.0497
Schistosoma mansoni hypothetical protein 0.0082 0.0442 0.0929
Trypanosoma cruzi cruzipain precursor, putative 0.0351 0.2114 0.4496
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0046 0.008
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0235 0.0227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0482 0.1015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0067 0.0189
Echinococcus multilocularis protein dispatched 1 0.0097 0.0535 0.0527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.038 0.333
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0556
Entamoeba histolytica cysteine proteinase, putative 0.0208 0.1227 0.5787
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0823 0.1761
Echinococcus multilocularis cpg binding protein 0.0031 0.0129 0.0121
Onchocerca volvulus 0.0351 0.2114 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0319 0.0665
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0067 0.0143
Plasmodium falciparum serine repeat antigen 3 0.0088 0.0482 0.225
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0297 0.1779 0.3777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Schistosoma mansoni hypothetical protein 0.0048 0.0232 0.048
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0208 0.1227 0.5787
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0871 0.1863
Brugia malayi nuclear receptor NHR-88 0.0018 0.0046 0.0098
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0067 0.0189
Plasmodium falciparum cysteine proteinase falcipain 1 0.0208 0.1227 0.5787
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0351 0.2114 0.4511
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0351 0.2114 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0046 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0297 0.2453
Brugia malayi cathepsin F-like cysteine proteinase 0.0088 0.0482 0.1031
Echinococcus granulosus cathepsin L cysteine proteinase 0.0351 0.2114 0.4511
Loa Loa (eye worm) ctsf protein 0.0351 0.2114 0.4511
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.1007 1
Schistosoma mansoni cathepsin s 0.012 0.0681 0.1442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Giardia lamblia Cysteine protease 0.0088 0.0482 0.2523
Onchocerca volvulus 0.0088 0.0482 0.225
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0088 0.0482 0.1015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0088 0.0482 0.225
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0375 0.0785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0046 0.0037
Schistosoma mansoni pyruvate kinase 0.0034 0.0146 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0208 0.1227 0.576
Loa Loa (eye worm) hypothetical protein 0.0351 0.2114 0.4511
Schistosoma mansoni hypothetical protein 0.0103 0.0576 0.1215
Plasmodium vivax vivapain-1 0.0208 0.1227 0.5787
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0197 0.0898
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.1007 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0146 0.0296
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0067 0.0143
Giardia lamblia Cysteine protease 0.0088 0.0482 0.2523
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.0482 0.1015
Trypanosoma cruzi cysteine proteinase, putative 0.0208 0.1227 0.259
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.1007 0.4711
Giardia lamblia Cathepsin L precursor 0.0088 0.0482 0.2523
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.1007 0.4744
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0164 0.0739
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0146 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.012 0.0681 0.1442
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Onchocerca volvulus 0.0096 0.0529 0.2474
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0482 0.225
Giardia lamblia Hypothetical protein 0.0088 0.0482 0.2523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0216 0.0208
Brugia malayi Cathepsin L-like cysteine proteinase 0.0231 0.1369 0.2928
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0067 0.0217
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) acetyltransferase 0.0143 0.0823 0.1746
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0164 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0062
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0164 0.0334
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0049 0.0196
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0297 0.0619
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0297 0.2596
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0276 0.0268
Brugia malayi Cathepsin L-like precursor 0.0231 0.1369 0.2928
Onchocerca volvulus 0.005 0.0248 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.003 0.0105
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0319 0.1473
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0146 0.0269
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.1007 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0319 0.0665
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.1007 0.4711
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0556
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0297 0.132
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0962 0.0954
Plasmodium vivax serine-repeat antigen (SERA) 0.0088 0.0482 0.225
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.1007 0.4711
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0046 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Onchocerca volvulus 0.0351 0.2114 1
Giardia lamblia Cathepsin B precursor 0.0297 0.1779 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0235 0.0485
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0005
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0091 0.0255
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0765 0.4676 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0146 0.102
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0067 0.0189
Plasmodium vivax unspecified product 0.0088 0.0482 0.225
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0091 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0962 0.2042
Plasmodium vivax unspecified product 0.0208 0.1227 0.5787
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0276 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0046 0.008
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0268 0.1232
Brugia malayi hypothetical protein 0.0037 0.0163 0.0348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0482 0.225
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0461 0.0453
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0091 0.0149
Echinococcus multilocularis chromobox protein 1 0.0071 0.0375 0.0367
Loa Loa (eye worm) hypothetical protein 0.0173 0.1007 0.214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.033 0.0662
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0231 0.1369 0.2896
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.038 0.1765
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.038 0.1765
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Brugia malayi CHE-14 protein 0.0085 0.0461 0.0985
Loa Loa (eye worm) cysteine protease 0.0351 0.2114 0.4511
Echinococcus multilocularis pyruvate kinase 0.0034 0.0146 0.0138
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0046 0.008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0164 0.0334
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.012 0.0681 0.1457
Plasmodium falciparum serine repeat antigen 7 0.0088 0.0482 0.225
Echinococcus multilocularis cathepsin L cysteine protease 0.0351 0.2114 0.2108
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.1007 0.4744
Brugia malayi SET domain containing protein 0.0012 0.0012 0.0026
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0067 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Entamoeba histolytica cysteine proteinase, putative 0.0208 0.1227 0.5787
Echinococcus granulosus cathepsin l cysteine peptidase 0.0351 0.2114 0.4511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0146 0.0656
Schistosoma mansoni chromobox protein 0.0071 0.0375 0.0785
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0297 0.0636
Giardia lamblia Pyruvate kinase 0.0034 0.0146 0.0589
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0046 0.0098
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.038 0.333
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0067 0.0125
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0046 0.008
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0067 0.0125
Loa Loa (eye worm) hypothetical protein 0.0053 0.0268 0.0556
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0046 0.008
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0176 0.0795
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Brugia malayi mbt repeat family protein 0.0048 0.0235 0.0502
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0036
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0091 0.0439
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0232 0.048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0351 0.2114 0.2108
Giardia lamblia Encystation-specific protease 0.0088 0.0482 0.2523
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0088 0.0482 0.1015
Brugia malayi steroid hormone receptor 0.0018 0.0046 0.0098
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0146 0.0296
Schistosoma mansoni chromobox protein 0.0071 0.0375 0.0785
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1394 0.298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0871 0.1849
Schistosoma mansoni cathepsin S (C01 family) 0.0088 0.0482 0.1015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0319 0.0311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1227 0.5787
Trypanosoma cruzi major cysteine proteinase, putative 0.0088 0.0482 0.099
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0823 0.1746
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0125
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0036
Brugia malayi Phosphoglycerate kinase 0.0173 0.1007 0.2154
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Echinococcus multilocularis cysteine protease 0.0351 0.2114 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0231 0.1369 0.6463
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.038 0.1765
Echinococcus granulosus cathepsin l1 0.0351 0.2114 0.4511
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0067 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0046 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0231 0.1369 0.6463
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0046 0.008
Brugia malayi hypothetical protein 0.0012 0.0011 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0232 0.0497
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.1007 0.214
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0482 0.225
Mycobacterium ulcerans hypothetical protein 0.0025 0.0091 0.0255
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0268 0.2287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0046 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Brugia malayi Patched related family protein 12 0.0012 0.0011 0.0023
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1112 0.2365
Echinococcus granulosus expressed conserved protein 0.0185 0.1084 0.2305
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.0482 0.1015
Schistosoma mansoni hypothetical protein 0.0048 0.0232 0.048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0303 0.1401
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0208 0.1227 0.576
Toxoplasma gondii cathepsin B 0.0297 0.1779 0.8409
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Brugia malayi hypothetical protein 0.0012 0.0011 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0351 0.2114 0.4521
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0232 0.0224
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0021 0.0045
Schistosoma mansoni cathepsin B (C01 family) 0.0088 0.0482 0.1015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0482 0.225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Loa Loa (eye worm) hypothetical protein 0.0085 0.0461 0.097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0216 0.0446
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0146 0.0656
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.1158 0.5461
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0067 0.0143
Schistosoma mansoni hypothetical protein 0.0082 0.0442 0.0929
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0164 0.0351
Schistosoma mansoni cathepsin F (C01 family) 0.0351 0.2114 0.4511
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0046 0.0098
Plasmodium falciparum pyruvate kinase 0.0034 0.0146 0.0656
Loa Loa (eye worm) hypothetical protein 0.0231 0.1369 0.2916
Schistosoma mansoni hypothetical protein 0.0082 0.0442 0.0929
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0297 0.0289
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0319 0.2816
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0208 0.1227 0.2611
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0146 0.0847
Onchocerca volvulus 0.0021 0.0067 0.0278
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0091 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0216 0.0446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Echinococcus multilocularis pyruvate kinase 0.0017 0.0044 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0046 0.0098
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0067 0.0189
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0248 0.0513
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0005
Schistosoma mansoni cpg binding protein 0.0031 0.0129 0.0259
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0197 0.0898
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0268 0.141
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0164 0.0739
Loa Loa (eye worm) hypothetical protein 0.0231 0.1369 0.2916
Loa Loa (eye worm) hypothetical protein 0.0231 0.1369 0.2916
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0088 0.0482 0.225
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0146 0.0656
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Brugia malayi cathepsin B-like cysteine proteinase 0.0765 0.4676 1
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Brugia malayi Papain family cysteine protease containing protein 0.0208 0.1227 0.2624
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0046 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0231 0.1369 0.6463
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0062
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0011
Onchocerca volvulus 0.0021 0.0067 0.0278
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0067 0.0098
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0146 0.0656
Onchocerca volvulus Protein patched homolog 0.0012 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.011 0.0485
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0049 0.0196
Onchocerca volvulus 0.0018 0.0046 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Entamoeba histolytica cysteine proteinase 2 0.0208 0.1227 0.5787
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Brugia malayi Papain family cysteine protease containing protein 0.0208 0.1227 0.2624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Brugia malayi Phosphoglycerate kinase 0.0063 0.033 0.0705
Plasmodium falciparum serine repeat antigen 5 0.0088 0.0482 0.225
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0164 0.0739
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0046 0.008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0201 0.0915
Giardia lamblia Cathepsin B precursor 0.0088 0.0482 0.2523
Brugia malayi hypothetical protein 0.0012 0.0011 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0232 0.048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.025 0.2098
Echinococcus multilocularis tumor protein p63 0.0343 0.2062 0.2056
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Onchocerca volvulus 0.0351 0.2114 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0182 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0182 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Echinococcus multilocularis expressed conserved protein 0.0185 0.1084 0.1077
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0088 0.0482 0.225
Onchocerca volvulus Protein patched homolog 0.0012 0.0011 0.0011
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0088 0.0482 0.225
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0962 0.2042
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.038 0.333
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0576 0.1231
Toxoplasma gondii cathepsin CPL 0.0351 0.2114 1
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0011 0.0011
Onchocerca volvulus 0.0351 0.2114 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0351 0.2114 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0072 0.038 0.0796
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0044 0.0171
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Brugia malayi cathepsin L-like precursor 0.0231 0.1369 0.2928
Schistosoma mansoni pyruvate kinase 0.0017 0.0044 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0297 0.1779 0.8409
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.1177 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Echinococcus multilocularis microtubule associated protein 2 0.07 0.4278 0.4273
Schistosoma mansoni pyruvate kinase 0.0034 0.0146 0.0296
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0023
Schistosoma mansoni patched 1 0.0085 0.0461 0.097
Loa Loa (eye worm) hypothetical protein 0.012 0.0681 0.1442
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0146 0.0656
Onchocerca volvulus 0.0048 0.0235 0.1076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0163 0.0155
Giardia lamblia Hypothetical protein 0.0088 0.0482 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0103 0.0576 0.1215
Trypanosoma cruzi cysteine peptidase, putative 0.0351 0.2114 0.4496
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.1007 0.1
Entamoeba histolytica cysteine protease, putative 0.0088 0.0482 0.225
Onchocerca volvulus Cathepsin L homolog 0.0351 0.2114 1
Brugia malayi mbt repeat family protein 0.0048 0.0235 0.0502
Mycobacterium tuberculosis Conserved protein 0.0025 0.0091 0.0439
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Brugia malayi Heterochromatin protein 1 0.0071 0.0375 0.0802
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0083 0.016
Giardia lamblia Cysteine protease 0.0088 0.0482 0.2523
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0297 0.1779 0.3794
Giardia lamblia Cathepsin B precursor 0.0297 0.1779 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0067 0.0125
Plasmodium vivax vivapain-2 0.0351 0.2114 1
Entamoeba histolytica hypothetical protein 0.0037 0.0163 0.0734
Loa Loa (eye worm) hypothetical protein 0.0048 0.0235 0.0485
Schistosoma mansoni hypothetical protein 0.0293 0.175 0.3731
Plasmodium vivax vivapain-3 0.0208 0.1227 0.5787
Giardia lamblia Cathepsin B precursor 0.0088 0.0482 0.2523
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0088 0.0482 0.225
Echinococcus granulosus cathepsin L 0.0088 0.0482 0.1015
Leishmania major cysteine peptidase A (CPA) 0.0351 0.2114 1
Trypanosoma cruzi cysteine peptidase, putative 0.0351 0.2114 0.4496
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0297 0.0619
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0091 0.0149
Giardia lamblia Cathepsin L-like protease 0.0088 0.0482 0.2523
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0067 0.0278
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.1007 0.214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Giardia lamblia Phosphoglycerate kinase 0.0173 0.1007 0.5551
Brugia malayi nuclear hormone receptor 0.0018 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0197 0.1158 0.2464
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0088 0.0482 0.225
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.011 0.0485
Echinococcus multilocularis cysteine protease 0.0351 0.2114 0.2108
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0088 0.0482 0.225
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0067 0.0189
Loa Loa (eye worm) hypothetical protein 0.012 0.0681 0.1442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0163 0.0331
Entamoeba histolytica cysteine proteinase 1, putative 0.0208 0.1227 0.5787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0088 0.0482 0.225
Giardia lamblia Cathepsin B precursor 0.0088 0.0482 0.2523
Mycobacterium ulcerans hypothetical protein 0.0025 0.0091 0.0255
Brugia malayi cathepsin L precursor 0.0088 0.0482 0.1031
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.1275 0.2693
Loa Loa (eye worm) oxidoreductase 0.0021 0.0067 0.0125
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0201 0.0915
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0197 0.0898
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Onchocerca volvulus 0.0012 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0062
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0008 0.0018
Brugia malayi Patched related family protein 4 0.0012 0.0011 0.0023
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.1007 0.4744
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0046 0.008
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Leishmania major pyruvate kinase 0.0034 0.0146 0.0598
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0146 0.0656
Entamoeba histolytica cysteine proteinase, putative 0.0351 0.2114 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0176 0.0757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0164 0.0739
Echinococcus granulosus chromobox protein 1 0.0071 0.0375 0.0785
Onchocerca volvulus 0.0072 0.038 0.1765
Echinococcus granulosus cathepsin L 0.0208 0.1227 0.2611
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0765 0.4676 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0028
Plasmodium falciparum serine repeat antigen 1 0.0088 0.0482 0.225
Loa Loa (eye worm) hypothetical protein 0.0055 0.0276 0.0574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1227 0.5787
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0091 0.0082
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.1158 0.2477
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Brugia malayi ecdysteroid receptor 0.0018 0.0046 0.0098
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0088 0.0482 0.1015
Brugia malayi Patched protein homolog 1 0.0012 0.0011 0.0023
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Entamoeba histolytica cysteine protease, putative 0.0351 0.2114 1
Onchocerca volvulus 0.0025 0.0091 0.0393
Brugia malayi Cathepsin L-like precursor 0.0351 0.2114 0.4521
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0067 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0351 0.2114 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.038 0.3456
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0798 0.1693
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0482 0.2523
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0461 0.2149
Brugia malayi cathepsin Z-like cysteine proteinase 0.0088 0.0482 0.1031
Brugia malayi cathepsin F-like cysteine proteinase 0.012 0.0681 0.1457
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.038 0.1714
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0046 0.0178
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0276 0.059
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0461 0.097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0297 0.1779 0.8399
Onchocerca volvulus 0.0351 0.2114 1
Entamoeba histolytica hypothetical protein 0.0088 0.0482 0.225
Onchocerca volvulus 0.0351 0.2114 1
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0146 0.0598
Echinococcus multilocularis chromobox protein 1 0.0071 0.0375 0.0367
Toxoplasma gondii cathepsin CPC1 0.0088 0.0482 0.225
Schistosoma mansoni hypothetical protein 0.0037 0.0163 0.0331
Schistosoma mansoni survival motor neuron protein 0.0049 0.024 0.0496
Echinococcus granulosus cathepsin b 0.0765 0.4676 1
Plasmodium vivax unspecified product 0.012 0.0681 0.3196
Giardia lamblia Cathepsin B precursor 0.0088 0.0482 0.2523
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0351 0.2114 0.2108
Echinococcus granulosus cathepsin b 0.0765 0.4676 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0088 0.0482 0.225
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0164 0.0739
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0146 0.0269
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.038 0.333
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.1007 0.2118
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0021 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0765 0.4676 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0351 0.2114 1
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.1007 0.4711
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0176 0.0795
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1424 0.3033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.033 0.0662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.1015
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0077
Giardia lamblia Cathepsin B precursor 0.0297 0.1779 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0216 0.0446
Schistosoma mansoni alpha-glucosidase 0.0142 0.0819 0.1736
Onchocerca volvulus 0.0231 0.1369 0.6463
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0319 0.2677
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0046 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0046 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0351 0.2114 1
Brugia malayi AMP-binding enzyme family protein 0.0072 0.038 0.0812
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0067 0.0098
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Leishmania major cathepsin L-like protease 0.0351 0.2114 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0351 0.2114 0.2108
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0297 0.2453
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1394 0.2968
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0268 0.1232
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0319 0.0665
Leishmania major pyruvate kinase 0.0034 0.0146 0.0598
Brugia malayi hypothetical protein 0.024 0.1424 0.3046
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0067 0.0189
Leishmania major hypothetical protein, conserved 0.0216 0.1275 0.599
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0083 0.0354
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0067 0.0098
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0046 0.0037
Schistosoma mansoni hypothetical protein 0.0048 0.0232 0.048
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0146 0.0598
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0088 0.0482 0.1015
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0067 0.0217
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.033 0.0662
Toxoplasma gondii cathepsin CPC2 0.0088 0.0482 0.225
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0197 0.0405
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0011
Brugia malayi Patched family protein 0.0012 0.0011 0.0023
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0164 0.0682
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0091 0.0176
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0088 0.0482 0.1031
Onchocerca volvulus Cathepsin L homolog 0.0088 0.0482 0.225
Echinococcus granulosus microtubule associated protein 2 0.07 0.4278 0.9147
Schistosoma mansoni cathepsin C 0.0088 0.0482 0.1015
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Entamoeba histolytica cysteine protease, putative 0.0208 0.1227 0.5787
Treponema pallidum phosphoglycerate kinase 0.0173 0.1007 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0088 0.0482 0.225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0088 0.0482 0.225
Schistosoma mansoni cathepsin F (C01 family) 0.0351 0.2114 0.4511
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0046 0.008
Brugia malayi hypothetical protein 0.0012 0.0008 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.0231 0.1369 0.2916
Brugia malayi chromobox protein homolog 3 0.004 0.0182 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0351 0.2114 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0461 0.097
Brugia malayi Cathepsin L-like precursor 0.012 0.0681 0.1457
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.038 0.1714
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0067 0.0278
Schistosoma mansoni hypothetical protein 0.0048 0.0232 0.048
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0375 0.1741
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0046 0.0178
Schistosoma mansoni hypothetical protein 0.0049 0.024 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0046 0.0098
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.008
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1112 0.1105
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0067 0.0189
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Echinococcus multilocularis cathepsin L 0.0088 0.0482 0.0474
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0482 0.1031
Giardia lamblia Cathepsin B precursor 0.0088 0.0482 0.2523
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.1007 0.4744
Plasmodium falciparum serine repeat antigen 4 0.0088 0.0482 0.225
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.1007 0.4744
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.038 0.333
Plasmodium vivax patched family protein, putative 0.0012 0.0011 0.0011
Echinococcus multilocularis GPCR, family 2 0.0048 0.0232 0.0224
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.0482 0.1031
Plasmodium vivax vivapain-2 0.0351 0.2114 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.1007 1
Plasmodium falciparum serine repeat antigen 9 0.0088 0.0482 0.225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.025 0.2098
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0482 0.2523
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0119 0.0236
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0319 0.2677
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0482 0.1015
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0208 0.1227 0.259
Onchocerca volvulus 0.0021 0.0067 0.0278
Brugia malayi Cathepsin L-like precursor 0.0231 0.1369 0.2928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0046 0.008
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0146 0.0656
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0871 0.1863
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0067 0.0189
Entamoeba histolytica hypothetical protein 0.0037 0.0163 0.0734
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0216 0.0463
Onchocerca volvulus 0.0012 0.0011 0.0011
Loa Loa (eye worm) fibroinase 0.0351 0.2114 0.4511
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0005
Loa Loa (eye worm) cathepsin B 0.0297 0.1779 0.3794
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0182 0.0826
Brugia malayi CHD4 protein 0.0013 0.0019 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0046 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.0482 0.225
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0088 0.0482 0.2523
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0164 0.0739
Echinococcus granulosus pyruvate kinase 0.0017 0.0044 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0049 0.0196
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0235 0.0227

Activities

Activity type Activity value Assay description Source Reference
k' (ADMET) = 5.05 Index of hydrophobicity (k') ChEMBL. 3012086
MPR (binding) = 0.2 Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery ChEMBL. 3012086
pka (binding) = 2.61 Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery ChEMBL. 3012086

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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