Detailed information for compound 311527

Basic information

Technical information
  • TDR Targets ID: 311527
  • Name: methyl 3-benzyl-6,7-dimethyl-4-oxido-1-oxoqui noxalin-1-ium-2-carboxylate
  • MW: 338.357 | Formula: C19H18N2O4
  • H donors: 0 H acceptors: 3 LogP: 2.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(Cc2ccccc2)[n+]([O-])c2c([n+]1[O-])cc(c(c2)C)C
  • InChi: 1S/C19H18N2O4/c1-12-9-15-16(10-13(12)2)21(24)18(19(22)25-3)17(20(15)23)11-14-7-5-4-6-8-14/h4-10H,11H2,1-3H3
  • InChiKey: BQGTYHUWGRTFCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 3-benzyl-6,7-dimethyl-4-oxido-1-oxo-quinoxalin-1-ium-2-carboxylate
  • 3-benzyl-6,7-dimethyl-4-oxido-1-oxo-2-quinoxalin-1-iumcarboxylic acid methyl ester
  • methyl 6,7-dimethyl-4-oxidanidyl-1-oxo-3-(phenylmethyl)quinoxalin-1-ium-2-carboxylate
  • 3-benzyl-1-keto-6,7-dimethyl-4-oxido-quinoxalin-1-ium-2-carboxylic acid methyl ester
  • methyl 6,7-dimethyl-4-oxido-1-oxo-3-(phenylmethyl)quinoxalin-1-ium-2-carboxylate
  • 6,7-dimethyl-4-oxido-1-oxo-3-(phenylmethyl)-2-quinoxalin-1-iumcarboxylic acid methyl ester
  • 3-(benzyl)-1-keto-6,7-dimethyl-4-oxido-quinoxalin-1-ium-2-carboxylic acid methyl ester
  • 2-Quinoxalinecarboxylic acid, 6,7-dimethyl-3-(phenylmethyl)-, methyl ester, 1,4-dioxide
  • AIDS-220645
  • AIDS220645

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylserine receptor 0.0065 0.0053 0.0376
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0974 0.1074 0.1072
Echinococcus granulosus transcription factor btf3 0.0038 0.0023 0.0401
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0109 0.0856
Echinococcus granulosus phd:f box containing protein 0.0065 0.0053 0.0912
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0109 0.0856
Mycobacterium tuberculosis Conserved protein 0.0073 0.0062 0.0059
Onchocerca volvulus 0.0032 0.0016 0.0154
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0003 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0008 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.0367
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0016 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0001 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0062 0.0898
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0033 0.0437
Mycobacterium tuberculosis Conserved protein 0.0073 0.0062 0.0059
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0003 0.0093
Treponema pallidum penicillin-binding protein (pbp-2) 0.0981 0.1082 0.5927
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0062 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Giardia lamblia Cysteinyl-tRNA synthetase 0.013 0.0126 0.3832
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0001 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0917 0.101 0.7929
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.0269 0.4661
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0004 0.0289
Schistosoma mansoni DNA helicase recq1 0.0021 0.0004 0.0026
Schistosoma mansoni cysteinyl-tRNA synthetase 0.013 0.0126 0.0901
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0636 0.0694 1
Leishmania major DNA polymerase eta, putative 0.0047 0.0033 0.0479
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0017 0.0252
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0046 0.0361
Mycobacterium tuberculosis Conserved protein 0.0073 0.0062 0.0059
Schistosoma mansoni ran 0.0022 0.0005 0.0033
Brugia malayi beta-lactamase family protein 0.0073 0.0062 0.0489
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0105
Onchocerca volvulus 0.0073 0.0062 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0001 0.0006
Toxoplasma gondii ABC1 family protein 0.0073 0.0062 0.4939
Chlamydia trachomatis transglycolase/transpeptidase 0.1127 0.1245 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0004 0.0029
Chlamydia trachomatis cysteine--tRNA ligase 0.013 0.0126 0.0904
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0148 0.0145
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0109 0.3362
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0004 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0001 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0109 0.0103 0.1477
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.1782
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0001 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0039 0.0306
Brugia malayi cysteinyl tRNA synthetase protein 1 0.013 0.0126 0.0991
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0001 0.0005
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0056 0.0804
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.013 0.0126 0.0991
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0062 0.0489
Schistosoma mansoni survival motor neuron protein 0.0052 0.0039 0.0278
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0005 0.008
Brugia malayi beta-lactamase family protein 0.0073 0.0062 0.0489
Brugia malayi beta-NAC-like protein 0.0038 0.0023 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0001 0.0006
Onchocerca volvulus 0.013 0.0126 0.1249
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0003 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Leishmania major DNA polymerase eta, putative 0.0033 0.0017 0.0252
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0504 0.0546 0.0487
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.0325 0.172
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0004 0.0029
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0005 0.0367
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0109 0.0047
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0974 0.1074 0.1072
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0046 0.0043
Plasmodium vivax SET domain protein, putative 0.0032 0.0016 0.1232
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0109 0.3362
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0109 0.0779
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0981 0.1082 0.1026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Trichomonas vaginalis glutaminase, putative 0.1152 0.1274 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Entamoeba histolytica hypothetical protein 0.0024 0.0007 0.022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0046 0.0361
Echinococcus granulosus JmjC domain containing protein 4 0.0065 0.0053 0.0912
Mycobacterium ulcerans glutaminase 0.1152 0.1274 0.1272
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0046 0.1337
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.0238 0.1702
Loa Loa (eye worm) runx1 0.0115 0.0109 0.0858
Trichomonas vaginalis set domain proteins, putative 0.025 0.0261 0.205
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0074 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0181
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0301 0.0318 0.4558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0001 0.0006
Loa Loa (eye worm) beta-lactamase 0.0073 0.0062 0.0489
Leishmania major cathepsin L-like protease 0.0067 0.0056 0.0804
Echinococcus granulosus geminin 0.0531 0.0577 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0001 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0016 0.027
Onchocerca volvulus 0.0084 0.0074 0.0732
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0062 0.0489
Onchocerca volvulus 0.0073 0.0062 0.0617
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Schistosoma mansoni DNA helicase recq5 0.0021 0.0004 0.0026
Echinococcus multilocularis transcription factor btf3 0.0038 0.0023 0.0401
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0005 0.0067
Echinococcus multilocularis jumonji domain containing 1A 0.0065 0.0053 0.0912
Leishmania major cathepsin L-like protease 0.0067 0.0056 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Schistosoma mansoni jumonji/arid domain-containing protein 0.0242 0.0252 0.1799
Loa Loa (eye worm) hypothetical protein 0.0917 0.101 0.7929
Schistosoma mansoni ap endonuclease 0.0059 0.0046 0.0329
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0015 0.0461
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0001 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0074 0.0581
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0062 0.0898
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0336 0.0357 0.0297
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0016 0.027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.0325 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0062 0.0489
Echinococcus multilocularis snurportin 1 0.0316 0.0336 0.582
Loa Loa (eye worm) hypothetical protein 0.013 0.0126 0.0991
Brugia malayi hypothetical protein 0.0257 0.0269 0.2109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0014 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0001 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0062 0.0489
Schistosoma mansoni phd/f-box containing protein 0.0065 0.0053 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0062 0.0059
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0109 0.1571
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Loa Loa (eye worm) glutaminase 2 0.1152 0.1274 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0005 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0001 0.0006
Echinococcus multilocularis lysine specific demethylase 5A 0.0242 0.0252 0.4369
Leishmania major GTP-binding protein, putative 0.0022 0.0005 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0065 0.0053 0.0413
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0336 0.0357 0.0354
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0636 0.0694 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.004 0.0571
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0062 0.1081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0001 0.0013
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0003 0.0022
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.1818
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0016 0.1232
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0046 0.0361
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0065 0.0053 0.0912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0016 0.0111
Leishmania major mitochondrial DNA polymerase beta 0.0636 0.0694 1
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0001 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0001 0.0008
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0015 0.1186
Brugia malayi Importin beta-1 subunit 0.003 0.0013 0.0105
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0004 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Echinococcus granulosus snurportin 1 0.0316 0.0336 0.582
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0001 0.0006
Onchocerca volvulus 0.0917 0.101 1
Leishmania major cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.1818
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0001 0.0006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0046 0.0043
Echinococcus granulosus lamin 0.0084 0.0074 0.1283
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0046 0.3647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Loa Loa (eye worm) jmjC domain-containing protein 0.0242 0.0252 0.1977
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0186
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0065 0.0053 0.0912
Schistosoma mansoni coup transcription factor 0.0018 0.0001 0.0005
Loa Loa (eye worm) glutaminase 0.1152 0.1274 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0636 0.0694 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0001 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0001 0.0013
Echinococcus granulosus cysteinyl tRNA synthetase 0.013 0.0126 0.219
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0001 0.0013
Brugia malayi beta-lactamase 0.0073 0.0062 0.0489
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0062 0.0489
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0974 0.1074 0.1018
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.005
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0015 0.1186
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0004 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0001 0.0006
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0065 0.0053 0.4167
Schistosoma mansoni transcription factor btf3 0.0038 0.0023 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0025 0.02
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0001 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0001 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0016 0.027
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0504 0.0546 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0001 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0033 0.0479
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0001 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0016 0.0111
Brugia malayi steroid hormone receptor 0.0018 0.0001 0.0006
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1265 0.1401 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0081 0.116
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0062 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0015 0.0118
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0613 0.0668 0.061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0046 0.0663
Plasmodium falciparum importin beta, putative 0.003 0.0013 0.1063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0053 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Brugia malayi jmjC domain containing protein 0.0065 0.0053 0.0413
Brugia malayi hypothetical protein 0.0917 0.101 0.7929
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0181
Treponema pallidum penicillin-binding protein (pbp-1) 0.1127 0.1245 0.6835
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0242 0.0252 0.4369
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0613 0.0668 0.0665
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0001 0.0005
Echinococcus multilocularis dna polymerase kappa 0.002 0.0003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0084 0.0074 0.0581
Echinococcus granulosus lysine specific demethylase 5A 0.0242 0.0252 0.4369
Loa Loa (eye worm) hypothetical protein 0.0257 0.0269 0.2109
Onchocerca volvulus 0.025 0.0261 0.2586
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0015 0.0118
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.8922 1 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0003 0.0044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0015 0.1186
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0005 0.0367
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0148 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0242 0.0252 0.4369
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.013 0.0126 0.0669
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0089 0.0081 0.116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0072 0.0567
Toxoplasma gondii exonuclease III APE 0.0059 0.0046 0.3647
Brugia malayi Cytochrome P450 family protein 0.0025 0.0008 0.0062
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0023 0.0333
Brugia malayi ecdysteroid receptor 0.0018 0.0001 0.0006
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0049 0.0709
Brugia malayi intermediate filament protein 0.0084 0.0074 0.0581
Plasmodium falciparum cysteine--tRNA ligase 0.013 0.0126 1
Leishmania major hypothetical protein, conserved 0.0065 0.0053 0.0758
Brugia malayi Pre-SET motif family protein 0.022 0.0227 0.1782
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0001 0.0005
Leishmania major basic transcription factor 3a, putative 0.0038 0.0023 0.0333
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0004 0.0289
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1127 0.1245 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0062 0.0059
Echinococcus multilocularis Protein lozenge 0.0115 0.0109 0.1897
Schistosoma mansoni cysteinyl-tRNA synthetase 0.013 0.0126 0.0901
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0013 0.1063
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0023 0.0333
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0109 0.1893
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0003 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0001 0.0013
Schistosoma mansoni glutaminase 0.1152 0.1274 0.9098
Schistosoma mansoni protein phosphatase 2C 0.0065 0.0053 0.0376
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0001 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0004 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0015 0.1186
Entamoeba histolytica hypothetical protein 0.0038 0.0023 0.0712
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0004 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0335 0.0356 0.0353
Schistosoma mansoni hypothetical protein 0.0316 0.0336 0.2396
Schistosoma mansoni DNA polymerase eta 0.0047 0.0033 0.0237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0001 0.0006
Brugia malayi nuclear receptor NHR-88 0.0018 0.0001 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0046 0.0798
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0109 0.1534
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0053 0.0376
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0053 0.0413
Echinococcus multilocularis geminin 0.0531 0.0577 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0053 0.0758
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0981 0.1082 0.1079
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0181
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0023 0.029
Echinococcus multilocularis lysine specific demethylase 6a 0.0065 0.0053 0.0912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Brugia malayi follicle stimulating hormone receptor 0.0247 0.0258 0.2024
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.036 0.0385 0.0324
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0004 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0062 0.0445
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0062 0.0059
Brugia malayi jmjC domain containing protein 0.0242 0.0252 0.1977
Loa Loa (eye worm) hypothetical protein 0.0047 0.0033 0.0261
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0023 0.0181
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0003 0.0024
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0148 0.0087
Plasmodium vivax cysteine--tRNA ligase, putative 0.013 0.0126 1
Brugia malayi 6-phosphofructokinase 0.0115 0.0109 0.0856
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0109 0.1893
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0227 0.1782
Echinococcus granulosus bloom syndrome protein 0.0021 0.0004 0.0063
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0005 0.008
Brugia malayi phosphofructokinase 0.0115 0.0109 0.0856
Echinococcus granulosus dna polymerase kappa 0.002 0.0003 0.0053
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0109 0.0779
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0001 0.0013
Brugia malayi jmjC domain containing protein 0.0065 0.0053 0.0413
Brugia malayi jmjC domain containing protein 0.0065 0.0053 0.0413
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.003 0.0239
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.3889
Echinococcus multilocularis JmjC domain containing protein 4 0.0065 0.0053 0.0912
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0046 0.0622
Echinococcus granulosus dna polymerase eta 0.0047 0.0033 0.0577
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0029
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0109 0.0856
Echinococcus multilocularis cysteinyl tRNA synthetase 0.013 0.0126 0.219
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0109 0.0856
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0062 0.4939
Onchocerca volvulus 0.0018 0.0001 0.0008
Mycobacterium ulcerans beta-lactamase 0.0073 0.0062 0.0059
Mycobacterium ulcerans hypothetical protein 0.0335 0.0356 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Echinococcus multilocularis dna polymerase eta 0.0047 0.0033 0.0577
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0613 0.0668 0.0665
Schistosoma mansoni jumonji domain containing protein 0.0242 0.0252 0.1799
Echinococcus multilocularis musashi 0.0084 0.0074 0.1283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0017 0.1384
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0001 0.0008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.0258 0.2024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.0505 0.0503
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0062 0.0059
Brugia malayi jmjC domain containing protein 0.0065 0.0053 0.0413
Loa Loa (eye worm) hypothetical protein 0.0065 0.0053 0.0413
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0046 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0001 0.0006
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0004 0.0029
Onchocerca volvulus 0.0084 0.0074 0.0732
Trichomonas vaginalis esterase, putative 0.0073 0.0062 0.0489
Toxoplasma gondii hypothetical protein 0.0103 0.0095 0.7552
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0065 0.0053 0.0376
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0046 0.0663
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0109 0.0856
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0005 0.0067
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0023 0.1831
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.013 0.0126 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0062 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.0036
Mycobacterium ulcerans hypothetical protein 0.0073 0.0062 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0001 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0004 0.0063
Schistosoma mansoni intermediate filament proteins 0.0084 0.0074 0.0528
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0053 0.0758
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0004 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0007 0.0056
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.0325 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0056 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0001 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.0325 0.2547
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0007 0.0056
Plasmodium falciparum cysteine--tRNA ligase 0.013 0.0126 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0004 0.0063
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0015 0.0372
Mycobacterium ulcerans lipase LipD 0.0073 0.0062 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0981 0.1082 0.849
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.0325 1
Brugia malayi 6-phosphofructokinase 0.0115 0.0109 0.0856
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0109 0.1571
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0013 0.015
Chlamydia trachomatis transglycolase/transpeptidase 0.0675 0.0739 0.588
Schistosoma mansoni ap endonuclease 0.0059 0.0046 0.0329
Schistosoma mansoni hypothetical protein 0.0052 0.0039 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0001 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0015 0.1186
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0109 0.0856
Trichomonas vaginalis ran, putative 0.0022 0.0005 0.0036
Schistosoma mansoni lamin 0.0084 0.0074 0.0528
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0336 0.0357 0.0354
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0023 0.0712
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0109 0.0523
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0004 0.0053
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0013 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0062 0.0858
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0004 0.0063
Echinococcus multilocularis importin subunit beta 1 0.003 0.0013 0.0233
Schistosoma mansoni hypothetical protein 0.0531 0.0577 0.4117
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0053 0.0413
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0001 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0062 0.0445
Onchocerca volvulus 0.0052 0.0039 0.0386
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0003 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0001 0.0013
Brugia malayi jmjC domain containing protein 0.0242 0.0252 0.1977
Loa Loa (eye worm) RecQ helicase 0.0021 0.0004 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0046 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0001 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.0269 0.4661
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0023 0.1831
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.8922 1 1
Echinococcus granulosus lysine specific demethylase 6a 0.0065 0.0053 0.0912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0016 0.0111
Treponema pallidum cysteinyl-tRNA synthetase 0.013 0.0126 0.0618
Echinococcus multilocularis lamin 0.0084 0.0074 0.1283
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0046 0.3647
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0004 0.0053
Leishmania major hypothetical protein, conserved 0.0073 0.0062 0.0898
Treponema pallidum hypothetical protein 0.0336 0.0357 0.1902
Entamoeba histolytica Ran family GTPase 0.0022 0.0005 0.0143
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0004 0.0112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0001 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0001 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0242 0.0252 0.1799
Schistosoma mansoni ran 0.0022 0.0005 0.0033
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0065 0.0053 0.4167
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0001 0.0013
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0025 0.0441
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0046 0.1418
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0046 0.0663
Brugia malayi glutaminase DH11.1 0.1152 0.1274 1
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.1818
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0062 0.1081
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0109 0.0106
Echinococcus granulosus lamin dm0 0.0084 0.0074 0.1283
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0109 0.0856
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0023 0.1831
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0109 0.3362
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0015 0.1186
Schistosoma mansoni lamin 0.0084 0.0074 0.0528
Plasmodium vivax JmjC domain containing protein 0.0065 0.0053 0.4167
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0033 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0001 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0056 0.0804
Echinococcus granulosus intermediate filament protein 0.0084 0.0074 0.1283
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0004 0.0289
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0186
Echinococcus granulosus jumonji domain containing 1A 0.0065 0.0053 0.0912
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0001 0.0013
Brugia malayi Pre-SET motif family protein 0.0032 0.0016 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0001 0.0006
Brugia malayi RNA, U transporter 1 0.0084 0.0075 0.0587
Brugia malayi nuclear hormone receptor 0.0018 0.0001 0.0006
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0065 0.0053 0.0717
Echinococcus multilocularis phd:f box containing protein 0.0065 0.0053 0.0912
Schistosoma mansoni hypothetical protein 0.0531 0.0577 0.4117
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0001 0.0005
Plasmodium falciparum JmjC domain-containing protein, putative 0.0065 0.0053 0.4167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0342 0.0365 0.0362
Echinococcus granulosus leucyl tRNA synthetase 0.013 0.0126 0.219
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0062 0.0489
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0109 0.0106
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0046 0.0798
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0001 0.0013
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0025 0.0441
Echinococcus granulosus importin subunit beta 1 0.003 0.0013 0.0233
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0062 0.0489
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0062 0.0059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0001 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0001 0.0008
Onchocerca volvulus 0.0073 0.0062 0.0617
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0504 0.0546 0.0543
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0003 0.0053
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.036 0.0385 0.0382
Schistosoma mansoni lozenge 0.0115 0.0109 0.0781
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.0318 0.4582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0056 0.0764
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.0036
Leishmania major importin beta-1 subunit, putative 0.0024 0.0007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0073 0.0062 0.0489
Schistosoma mansoni importin beta-1 0.003 0.0013 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0001 0.0006
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.013 0.0126 0.0991
Echinococcus multilocularis lamin dm0 0.0084 0.0074 0.1283
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.003 0.0239
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0089 0.0081 0.1121
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0062 0.0059
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0004 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0056 0.0804
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0001 0.0013
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0004 0.0063
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0001 0.0005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.0318 0.4582
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0081 0.116
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0074 0.0581
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0007 0.0056
Treponema pallidum penicillin-binding protein (pbp-3) 0.1634 0.1815 1
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.013 0.0126 1
Leishmania major cathepsin L-like protease 0.0067 0.0056 0.0804
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.0336 0.2633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0001 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0053 0.0413
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0007 0.0103
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0015 0.1186
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1298 0.1438 0.1435
Plasmodium vivax importin-beta 2, putative 0.003 0.0013 0.1063

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) 0 ug ml-1 Compound was tested for cytotoxicity in Vero cells; Insoluble ChEMBL. 15771444
MIC (functional) = 3.13 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444
MIC (functional) = 3.13 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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