Detailed information for compound 311648

Basic information

Technical information
  • TDR Targets ID: 311648
  • Name: (3-ethyl-2-methoxyquinolin-6-yl)-(4-methoxycy clohexyl)methanone
  • MW: 327.417 | Formula: C20H25NO3
  • H donors: 0 H acceptors: 2 LogP: 4.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1CCC(CC1)C(=O)c1ccc2c(c1)cc(c(n2)OC)CC
  • InChi: 1S/C20H25NO3/c1-4-13-11-16-12-15(7-10-18(16)21-20(13)24-3)19(22)14-5-8-17(23-2)9-6-14/h7,10-12,14,17H,4-6,8-9H2,1-3H3
  • InChiKey: IOCYQQQCJYMWDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3-ethyl-2-methoxy-6-quinolyl)-(4-methoxycyclohexyl)methanone
  • (3-ethyl-2-methoxy-quinolin-6-yl)-(4-methoxycyclohexyl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 1 Starlite/ChEMBL References
Homo sapiens glutamate receptor, metabotropic 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cysteinyl tRNA synthetase 0.0129 0.0125 0.0543
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Schistosoma mansoni ap endonuclease 0.0058 0.0045 0.0196
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0063 0.0061
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.123 0.137 0.5926
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0045 0.0196
Onchocerca volvulus 0.0129 0.0125 0.1242
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0014 0.0083
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0033 0.0144
Echinococcus granulosus metabotropic glutamate receptor 2 0.0082 0.0072 0.0311
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0002 0.001
Schistosoma mansoni ran 0.0022 0.0004 0.0017
Leishmania major basic transcription factor 3a, putative 0.0038 0.0022 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0004 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0632 0.0694 0.2994
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0261 0.2031
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0003 0.0003
Leishmania major importin beta-1 subunit, putative 0.0024 0.0006 0.0018
Brugia malayi intermediate filament protein 0.0083 0.0073 0.0317
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0052 0.0224
Echinococcus multilocularis carbonic anhydrase 0.123 0.137 0.5926
Schistosoma mansoni metabotropic glutamate receptor 0.0082 0.0072 0.0311
Plasmodium falciparum carbonic anhydrase 0.123 0.137 1
Echinococcus granulosus lysine specific demethylase 6a 0.0064 0.0052 0.0224
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0045 0.0186
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0055 0.0229
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.123 0.137 0.5926
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0013 0.0058
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.05 0.0545 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Schistosoma mansoni intermediate filament proteins 0.0083 0.0073 0.0317
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0015 0.0064
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2063 0.2313 1
Schistosoma mansoni jumonji domain containing protein 0.024 0.0251 0.1087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.008 0.0336
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0014 0.0851
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0063 0.0476
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0022 0.0142
Schistosoma mansoni lozenge 0.0114 0.0109 0.047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0003 0.0012
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0013 0.0055
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.0533
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0257 0.1112
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0003 0.0003
Plasmodium vivax JmjC domain containing protein 0.0064 0.0052 0.3947
Onchocerca volvulus 0.0249 0.0261 0.258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Schistosoma mansoni jumonji/arid domain-containing protein 0.024 0.0251 0.1087
Echinococcus granulosus dna polymerase kappa 0.002 0.0002 0.001
Onchocerca volvulus 0.0074 0.0063 0.0621
Brugia malayi jmjC domain containing protein 0.024 0.0251 0.1087
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0022 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0045 0.0173
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0006 0.0032
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0064 0.0052 0.0358
Brugia malayi Metabotropic glutamate receptor precursor. 0.0098 0.009 0.0389
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.0081 0.0072 0.0309
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.0324 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0045 0.031
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0148 0.0085
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0108 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.123 0.137 0.5926
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0608 0.0667 0.0665
Schistosoma mansoni glutaminase 0.1144 0.1274 0.5508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0015 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0148 0.0145
Schistosoma mansoni jumonji/arid domain-containing protein 0.024 0.0251 0.1087
Echinococcus granulosus dna polymerase eta 0.0047 0.0033 0.0141
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Echinococcus multilocularis carbonic anhydrase II 0.2063 0.2313 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0052 0.0224
Brugia malayi Pre-SET motif family protein 0.0031 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0911 0.101 0.4368
Treponema pallidum penicillin-binding protein (pbp-3) 0.1623 0.1815 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2063 0.2313 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0052 0.0224
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.0324 0.172
Loa Loa (eye worm) hypothetical protein 0.0129 0.0125 0.0543
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.0512 0.051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0063 0.0271
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0045 0.0196
Schistosoma mansoni hypothetical protein 0.0527 0.0576 0.2491
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0063 0.0271
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0022 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0023 0.0099
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0108 0.0046
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0108 0.0835
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0108 0.0835
Chlamydia trachomatis transglycolase/transpeptidase 0.0671 0.0738 0.5881
Brugia malayi phosphofructokinase 0.0114 0.0108 0.0469
Echinococcus multilocularis lamin dm0 0.0083 0.0073 0.0317
Echinococcus granulosus carbonic anhydrase 0.123 0.137 0.5926
Schistosoma mansoni DNA helicase recq5 0.0021 0.0003 0.0012
Brugia malayi beta-lactamase family protein 0.0074 0.0063 0.0271
Onchocerca volvulus 0.0052 0.0038 0.0379
Mycobacterium ulcerans beta-lactamase 0.0074 0.0063 0.0061
Mycobacterium tuberculosis Conserved protein 0.0074 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0023 0.0099
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0013 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0045 0.0186
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0015 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0063 0.0476
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0022 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0073 0.0317
Mycobacterium tuberculosis Conserved hypothetical protein 0.0333 0.0356 0.0354
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.123 0.137 0.5926
Leishmania major hypothetical protein, conserved 0.0064 0.0052 0.0215
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0073 0.0317
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0974 0.1081 0.1025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.024 0.0251 0.1087
Mycobacterium ulcerans penicillin-binding protein PbpA 0.05 0.0545 0.0543
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0022 0.0087
Treponema pallidum penicillin-binding protein (pbp-1) 0.1119 0.1245 0.6835
Onchocerca volvulus 0.0083 0.0073 0.0725
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0108 0.3299
Schistosoma mansoni survival motor neuron protein 0.0052 0.0038 0.0165
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0632 0.0694 0.2994
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0017
Trypanosoma brucei carbonic anhydrase-like protein 0.2063 0.2313 1
Schistosoma mansoni lamin 0.0083 0.0073 0.0317
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0055 0.0229
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Echinococcus granulosus lamin 0.0083 0.0073 0.0317
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0129 0.0125 0.0543
Toxoplasma gondii hypothetical protein 0.123 0.137 1
Chlamydia trachomatis transglycolase/transpeptidase 0.1119 0.1245 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0064 0.0052 0.0224
Echinococcus multilocularis lamin 0.0083 0.0073 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0015 0.0064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0015 0.0064
Echinococcus granulosus snurportin 1 0.0314 0.0335 0.1448
Mycobacterium tuberculosis Conserved protein 0.0074 0.0063 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0063 0.0262
Schistosoma mansoni hypothetical protein 0.0052 0.0038 0.0165
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.123 0.137 0.5926
Leishmania major GTP-binding protein, putative 0.0022 0.0004 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0002 0.001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0002 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0006 0.0032
Echinococcus multilocularis lysine specific demethylase 5A 0.024 0.0251 0.1087
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0033 0.0131
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0033 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0632 0.0694 0.2994
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0968 0.1074 0.1072
Echinococcus multilocularis dna polymerase eta 0.0047 0.0033 0.0141
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0022 0.0142
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0014 0.0094
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0108 0.0469
Brugia malayi jmjC domain containing protein 0.0064 0.0052 0.0224
Toxoplasma gondii hypothetical protein 0.0102 0.0095 0.0671
Trichomonas vaginalis esterase, putative 0.0074 0.0063 0.0476
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0334 0.0357 0.0296
Loa Loa (eye worm) hypothetical protein 0.123 0.137 0.5926
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0055 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0063 0.0262
Echinococcus granulosus jumonji domain containing 1A 0.0064 0.0052 0.0224
Schistosoma mansoni hypothetical protein 0.123 0.137 0.5926
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2063 0.2313 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0003 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0014 0.0083
Loa Loa (eye worm) hypothetical protein 0.123 0.137 0.5926
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0003 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0268 0.1159
Onchocerca volvulus 0.0083 0.0073 0.0725
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0108 0.0469
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0003 0.0012
Brugia malayi jmjC domain containing protein 0.0064 0.0052 0.0224
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.003 0.0128
Schistosoma mansoni importin beta-1 0.0029 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.0025 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0063 0.0061
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0045 0.0196
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0039 0.0158
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0003 0.0019
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0038 0.0165
Loa Loa (eye worm) glutaminase 2 0.1144 0.1274 0.5508
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0064 0.0052 0.0358
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0007
Schistosoma mansoni DNA helicase recq1 0.0021 0.0003 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0052 0.0224
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0022 0.1519
Brugia malayi beta-lactamase 0.0074 0.0063 0.0271
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0063 0.0476
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2063 0.2313 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0003 0.0005
Treponema pallidum cysteinyl-tRNA synthetase 0.0129 0.0125 0.0618
Loa Loa (eye worm) hypothetical protein 0.0083 0.0073 0.0317
Schistosoma mansoni carbonic anhydrase-related 0.123 0.137 0.5926
Loa Loa (eye worm) hypothetical protein 0.0047 0.0033 0.0141
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0004 0.0017
Brugia malayi 6-phosphofructokinase 0.0114 0.0108 0.0469
Echinococcus multilocularis snurportin 1 0.0314 0.0335 0.1448
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.123 0.137 0.5926
Schistosoma mansoni carbonic anhydrase-related 0.123 0.137 0.5926
Onchocerca volvulus 0.0911 0.101 1
Treponema pallidum hypothetical protein 0.0334 0.0357 0.1902
Toxoplasma gondii exonuclease III APE 0.0058 0.0045 0.031
Loa Loa (eye worm) carbonic anhydrase 3 0.2063 0.2313 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0025 0.0107
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.8858 1 1
Entamoeba histolytica hypothetical protein 0.0024 0.0006 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Leishmania major DNA polymerase eta, putative 0.0047 0.0033 0.0131
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0014 0.0083
Schistosoma mansoni hypothetical protein 0.0314 0.0335 0.1448
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.05 0.0545 0.0486
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0358 0.0384 0.0382
Echinococcus multilocularis transcription factor btf3 0.0038 0.0022 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0045 0.0338
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0055 0.0229
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0257 0.1112
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.3831
Echinococcus multilocularis Protein lozenge 0.0114 0.0109 0.047
Brugia malayi jmjC domain containing protein 0.0064 0.0052 0.0224
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.0324 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0002 0.001
Plasmodium vivax cysteine--tRNA ligase, putative 0.0129 0.0125 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2063 0.2313 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0013 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0045 0.0186
Brugia malayi RNA, U transporter 1 0.0084 0.0074 0.032
Echinococcus granulosus lysine specific demethylase 5A 0.024 0.0251 0.1087
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0108 0.0835
Brugia malayi hypothetical protein 0.0255 0.0268 0.1159
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0063 0.0476
Onchocerca volvulus 0.0074 0.0063 0.0621
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0017
Echinococcus multilocularis dna polymerase kappa 0.002 0.0002 0.001
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2063 0.2313 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0007 0.0031
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0608 0.0667 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0022 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0045 0.0186
Entamoeba histolytica Ran family GTPase 0.0022 0.0004 0.005
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.0533
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0064 0.0052 0.0215
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0129 0.0125 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0045 0.0338
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0025 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Treponema pallidum penicillin-binding protein (pbp-2) 0.0974 0.1081 0.5927
Echinococcus multilocularis lysine specific demethylase 6a 0.0064 0.0052 0.0224
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0968 0.1074 0.1018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0063 0.0271
Mycobacterium ulcerans lipase LipD 0.0074 0.0063 0.0061
Mycobacterium ulcerans glutaminase 0.1144 0.1274 0.1272
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.034 0.0364 0.0362
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0008 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0063 0.4843
Schistosoma mansoni carbonic anhydrase 0.123 0.137 0.5926
Leishmania major cathepsin L-like protease 0.0067 0.0055 0.0229
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1289 0.1438 0.1436
Schistosoma mansoni ap endonuclease 0.0058 0.0045 0.0196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0045 0.0196
Mycobacterium ulcerans hypothetical protein 0.0333 0.0356 0.0354
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0064 0.0052 0.0224
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0108 0.0469
Schistosoma mansoni lamin 0.0083 0.0073 0.0317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0129 0.0125 0.0668
Plasmodium falciparum cysteine--tRNA ligase 0.0129 0.0125 0.0896
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0045 0.1338
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0004 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0063 0.0061
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0064 0.0052 0.0224
Toxoplasma gondii ABC1 family protein 0.0074 0.0063 0.0438
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.0324 0.253
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Leishmania major cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.0533
Trichomonas vaginalis ran, putative 0.0022 0.0004 0.0013
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0003 0.0019
Giardia lamblia Cysteinyl-tRNA synthetase 0.0129 0.0125 0.3831
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0004 0.0017
Onchocerca volvulus 0.0074 0.0063 0.0621
Echinococcus multilocularis jumonji domain containing 1A 0.0064 0.0052 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0008 0.0033
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.0533
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0089 0.008 0.0344
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0299 0.0318 0.1365
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0004 0.0007
Echinococcus granulosus lamin dm0 0.0083 0.0073 0.0317
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0974 0.1081 0.1079
Plasmodium vivax importin-beta 2, putative 0.0029 0.0013 0.0723
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0226 0.0979
Schistosoma mansoni carbonic anhydrase-related 0.123 0.137 0.5926
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0108 0.3299
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.0335 0.1448
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0911 0.101 0.4368
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0063 0.0476
Brugia malayi jmjC domain containing protein 0.0064 0.0052 0.0224
Trichomonas vaginalis glutaminase, putative 0.1144 0.1274 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0089 0.008 0.0336
Loa Loa (eye worm) beta-lactamase 0.0074 0.0063 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0003 0.0012
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0358 0.0384 0.0323
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0014 0.0372
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0108 0.3299
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0108 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0063 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0129 0.0125 0.0543
Onchocerca volvulus 0.0031 0.0015 0.0147
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0045 0.0043
Echinococcus granulosus leucyl tRNA synthetase 0.0129 0.0125 0.0543
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0014 0.0083
Loa Loa (eye worm) RecQ helicase 0.0021 0.0003 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0063 0.0271
Loa Loa (eye worm) glutamate receptor 0.0098 0.009 0.0389
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0268 0.1159
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.008 0.0336
Brugia malayi hypothetical protein 0.0911 0.101 0.4368
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.024 0.0251 0.1087
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0094
Echinococcus multilocularis metabotropic glutamate receptor 5 0.012 0.0116 0.05
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0063 0.0271
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0017 0.0101
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0008 0.0033
Leishmania major mitochondrial DNA polymerase beta 0.0632 0.0694 0.2994
Mycobacterium ulcerans hypothetical protein 0.0074 0.0063 0.0061
Echinococcus multilocularis carbonic anhydrase 0.123 0.137 0.5926
Echinococcus granulosus JmjC domain containing protein 4 0.0064 0.0052 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0013 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0073 0.0317
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0022 0.0624
Brugia malayi Pre-SET motif family protein 0.0218 0.0226 0.0979
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0129 0.0125 0.0543
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0608 0.0667 0.0609
Echinococcus granulosus carbonic anhydrase 0.123 0.137 0.5926
Entamoeba histolytica hypothetical protein 0.0038 0.0022 0.0624
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0108 0.0106
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1119 0.1245 1
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0129 0.0125 0.0969
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0045 0.3406
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0108 0.0459
Plasmodium falciparum importin beta, putative 0.0029 0.0013 0.0072
Echinococcus multilocularis phd:f box containing protein 0.0064 0.0052 0.0224
Schistosoma mansoni DNA polymerase eta 0.0047 0.0033 0.0141
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0129 0.0125 0.0543
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0014 0.0083
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0082 0.0072 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0022 0.0158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0033
Brugia malayi beta-NAC-like protein 0.0038 0.0022 0.0097
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0334 0.0357 0.0354
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0013 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0012
Echinococcus multilocularis geminin 0.0527 0.0576 0.2491
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.8858 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0049 0.02
Echinococcus multilocularis carbonic anhydrase 0.123 0.137 0.5926
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0003 0.000000000078347
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0102 0.0431
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0003 0.0003
Schistosoma mansoni protein phosphatase 2C 0.0064 0.0052 0.0224
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0006 0.0018
Echinococcus granulosus importin subunit beta 1 0.0029 0.0013 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0052 0.0224
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0974 0.1081 0.8487
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0063 0.0061
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0045 0.1338
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.0324 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0108 0.0523
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0004 0.0007
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0334 0.0357 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0055
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0003 0.0012
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0003 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Schistosoma mansoni phd/f-box containing protein 0.0064 0.0052 0.0224
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0014 0.0851
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0089 0.008 0.0336
Loa Loa (eye worm) hypothetical protein 0.0064 0.0052 0.0224
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0064 0.0052 0.0215
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2063 0.2313 1
Brugia malayi jmjC domain containing protein 0.024 0.0251 0.1087
Echinococcus granulosus phd:f box containing protein 0.0064 0.0052 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.024 0.0251 0.1087
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.003 0.0128
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0108 0.0469
Echinococcus granulosus metabotropic glutamate receptor 5 0.012 0.0116 0.05
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0148 0.0145
Chlamydia trachomatis cysteine--tRNA ligase 0.0129 0.0125 0.0904
Loa Loa (eye worm) hypothetical protein 0.0074 0.0063 0.0271
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0108 0.0469
Mycobacterium tuberculosis Conserved protein 0.0074 0.0063 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0052 0.0224
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0064 0.0052 0.0224
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0063 0.0061
Plasmodium vivax SET domain protein, putative 0.0031 0.0015 0.0898
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0006 0.0032
Loa Loa (eye worm) runx1 0.0114 0.0109 0.047
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0033 0.0141
Brugia malayi glutaminase DH11.1 0.1144 0.1274 0.5508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0299 0.0318 0.1365
Leishmania major cathepsin L-like protease 0.0067 0.0055 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0055 0.0229
Echinococcus granulosus carbonic anhydrase 0.123 0.137 0.5926
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0002 0.001
Schistosoma mansoni phosphatidylserine receptor 0.0064 0.0052 0.0224
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0064 0.0052 0.0215
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0003 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0108 0.0469
Plasmodium falciparum cysteine--tRNA ligase 0.0129 0.0125 0.0896
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0003 0.0005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0002 0.001
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0108 0.0459
Leishmania major hypothetical protein, conserved 0.0074 0.0063 0.0262
Loa Loa (eye worm) glutamate receptor 0.0038 0.0023 0.0099
Echinococcus granulosus intermediate filament protein 0.0083 0.0073 0.0317
Schistosoma mansoni hypothetical protein 0.0527 0.0576 0.2491
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0063 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0015 0.0064
Schistosoma mansoni ran 0.0022 0.0004 0.0017
Loa Loa (eye worm) glutaminase 0.1144 0.1274 0.5508
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.123 0.137 0.5926
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0129 0.0125 0.0896
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0111 0.0105 0.0455
Plasmodium falciparum JmjC domain-containing protein, putative 0.0064 0.0052 0.0358
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0108 0.0469
Loa Loa (eye worm) hypothetical protein 0.012 0.0116 0.05
Echinococcus multilocularis musashi 0.0083 0.0073 0.0317
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0014 0.0372
Echinococcus granulosus transcription factor btf3 0.0038 0.0022 0.0097
Brugia malayi 6-phosphofructokinase 0.0114 0.0108 0.0469
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0017 0.0063
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0299 0.0318 0.1365
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0003 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0007 0.0031
Echinococcus granulosus geminin 0.0527 0.0576 0.2491
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0129 0.0125 0.0123
Echinococcus granulosus bloom syndrome protein 0.0021 0.0003 0.0012
Brugia malayi beta-lactamase family protein 0.0074 0.0063 0.0271
Leishmania major cathepsin L-like protease 0.0067 0.0055 0.0229
Schistosoma mansoni transcription factor btf3 0.0038 0.0022 0.0097
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0003 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0033 0.0131
Echinococcus granulosus carbonic anhydrase II 0.2063 0.2313 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0022 0.0158
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0108 0.0835
Leishmania major DNA polymerase eta, putative 0.0033 0.0017 0.0063
Leishmania major carbonic anhydrase-like protein 0.2063 0.2313 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.0268 0.1159
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0968 0.1074 0.1072
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0063 0.0271

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) nM In vitro metabolic stability of compound was tested in human liver microsomes; not determined ChEMBL. 15771457
IC50 (binding) 0 nM Inhibitory concentration against human metabotropic glutamate receptor; ND:Not determined ChEMBL. 15771457
IC50 (functional) 0 nM In vitro metabolic stability of compound was tested in human liver microsomes; not determined ChEMBL. 15771457
IC50 (binding) = 19 nM Inhibitory concentration against rat metabotropic glutamate receptor 1 ChEMBL. 15771457
IC50 (binding) = 19 nM Inhibitory concentration against rat metabotropic glutamate receptor 1 ChEMBL. 15771457
IC50 (binding) = 20 nM Inhibitory concentration against human metabotropic glutamate receptor 1 transmembrane domain ChEMBL. 15771457
IC50 (binding) = 20 nM Inhibitory concentration against human metabotropic glutamate receptor 1 transmembrane domain ChEMBL. 15771457
IC50 (functional) = 43 nM In vitro metabolic stability of compound was tested in human liver microsomes ChEMBL. 15771457
IC50 (functional) = 43 nM In vitro metabolic stability of compound was tested in human liver microsomes ChEMBL. 15771457
IC50 (binding) = 94 nM Inhibitory concentration against human metabotropic glutamate receptor ChEMBL. 15771457
IC50 (binding) = 94 nM Inhibitory concentration against human metabotropic glutamate receptor ChEMBL. 15771457
IC50 (binding) = 2370 nM Inhibitory concentration against rat metabotropic glutamate receptor 1 ChEMBL. 15771457
IC50 (binding) = 2370 nM Inhibitory concentration against rat metabotropic glutamate receptor 1 ChEMBL. 15771457

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15771457

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.