Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cyclooxygenase | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.1185 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.1185 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.1185 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1185 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.1185 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1185 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1185 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1185 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1185 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1185 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.7 uM | Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 1.7 uM | Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 6.1 uM | Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 6.1 uM | Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 36.8 uM | Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 36.8 uM | Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
Inhibition (binding) | = 86 % | Inhibitory activity against Cyclooxygenase(COX) using broken rat barophilic leukemia cells (RBL-1) at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 86 % | Inhibitory activity against Cyclooxygenase(COX) using broken rat barophilic leukemia cells (RBL-1) at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 100 % | Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 100 % | Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.