Detailed information for compound 311775

Basic information

Technical information
  • TDR Targets ID: 311775
  • Name: propyl 2-[2-[2,6-dichloro-4-(3,5-dioxo-1,2,4- triazin-2-yl)phenyl]propan-2-yl]-4-phenyl-1,3 -thiazole-5-carboxylate
  • MW: 545.438 | Formula: C25H22Cl2N4O4S
  • H donors: 1 H acceptors: 4 LogP: 6.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCOC(=O)c1sc(nc1c1ccccc1)C(c1c(Cl)cc(cc1Cl)n1ncc(=O)[nH]c1=O)(C)C
  • InChi: 1S/C25H22Cl2N4O4S/c1-4-10-35-22(33)21-20(14-8-6-5-7-9-14)30-23(36-21)25(2,3)19-16(26)11-15(12-17(19)27)31-24(34)29-18(32)13-28-31/h5-9,11-13H,4,10H2,1-3H3,(H,29,32,34)
  • InChiKey: CYKLPMXEWPCQGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • propyl 2-[1-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-1-methyl-ethyl]-4-phenyl-thiazole-5-carboxylate
  • 2-[1-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-1-methylethyl]-4-phenyl-5-thiazolecarboxylic acid propyl ester
  • 2-[1-[2,6-dichloro-4-(3,5-diketo-1,2,4-triazin-2-yl)phenyl]-1-methyl-ethyl]-4-phenyl-thiazole-5-carboxylic acid propyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0139 0.0812 0.0969
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1006 0.8376 1
Schistosoma mansoni hypothetical protein 0.0052 0.0052 0.0062
Schistosoma mansoni biogenic amine receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0056 0.0086 0.0102
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0151 0.0912 0.1089
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1006 0.8376 1
Plasmodium falciparum histone deacetylase, putative 0.0223 0.1546 0.1846
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0262 0.0313
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.0262 0.0262
Brugia malayi neuropeptide F receptor 0.0076 0.0262 0.0313
Echinococcus granulosus histone deacetylase 3 0.0307 0.2277 0.2277
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0262 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Schistosoma mansoni amine GPCR 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine receptor 0.0076 0.0262 0.0313
Schistosoma mansoni hypothetical protein 0.0171 0.1086 0.1297
Brugia malayi Histone deacetylase family protein 0.0223 0.1546 0.1846
Loa Loa (eye worm) dihydrofolate reductase 0.1006 0.8376 1
Echinococcus multilocularis somatostatin receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Trypanosoma brucei histone deacetylase, putative 0.0223 0.1546 0.1846
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi Histone deacetylase 1 0.0307 0.2277 0.2719
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0086 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.0262 0.0313
Brugia malayi putative neuropeptide receptor 0.0076 0.0262 0.0313
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus histone deacetylase 1 0.0307 0.2277 0.2277
Toxoplasma gondii hypothetical protein 0.0056 0.0086 0.0102
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus histone deacetylase 6 0.0235 0.1653 0.1653
Echinococcus multilocularis histone deacetylase 6 0.0235 0.1653 0.1653
Echinococcus granulosus allatostatin A receptor 0.0076 0.0262 0.0262
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi histone deacetylase 1 (HD1) 0.0307 0.2277 0.2719
Schistosoma mansoni opsin-like receptor 0.0076 0.0262 0.0313
Echinococcus granulosus carbonic anhydrase 0.0056 0.0086 0.0086
Brugia malayi follicle stimulating hormone receptor 0.0076 0.0262 0.0313
Plasmodium vivax histone deacetylase 1, putative 0.0307 0.2277 0.2719
Schistosoma mansoni histone deacetylase 4 5 0.0223 0.1546 0.1846
Leishmania major carbonic anhydrase-like protein 0.0151 0.0912 0.1089
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni hypothetical protein 0.0171 0.1086 0.1297
Schistosoma mansoni amine GPCR 0.0076 0.0262 0.0313
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.0262 0.0262
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0151 0.0912 0.1089
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1006 0.8376 1
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Schistosoma mansoni amine GPCR 0.0076 0.0262 0.0313
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0151 0.0912 0.1089
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0262 0.0262
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0086 0.0102
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0262 0.0313
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni myosin xvIII 0.0076 0.0262 0.0313
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0262 0.0313
Brugia malayi histone deacetylase 11 0.0139 0.0812 0.0969
Echinococcus granulosus geminin 0.0171 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Trypanosoma cruzi histone deacetylase, putative 0.0223 0.1546 0.1846
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0262 0.0262
Echinococcus granulosus neuropeptide s receptor 0.0076 0.0262 0.0262
Schistosoma mansoni histone deacetylase 4 5 0.0223 0.1546 0.1846
Brugia malayi Serotonin receptor 0.0076 0.0262 0.0313
Brugia malayi GnHR receptor homolog 0.0076 0.0262 0.0313
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0262 0.0262
Brugia malayi Dopamine receptor protein 2 0.0076 0.0262 0.0313
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0262 0.0262
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0151 0.0912 0.1089
Echinococcus multilocularis carbonic anhydrase II 0.0151 0.0912 0.0912
Onchocerca volvulus Histone deacetylase 10 homolog 0.0139 0.0812 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis serotonin receptor 0.0076 0.0262 0.0262
Brugia malayi neuropeptide F receptor 0.0076 0.0262 0.0313
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0307 0.2277 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1006 0.8376 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0262 0.0262
Trypanosoma brucei histone deacetylase 3 0.0223 0.1546 0.1846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Schistosoma mansoni histone deacetylase 0.0307 0.2277 0.2719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0262 0.0262
Schistosoma mansoni histone deacetylase hda2 0.0235 0.1653 0.1973
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0262 0.0313
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1006 0.8376 1
Trypanosoma brucei histone deacetylase 4 0.0223 0.1546 0.1846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0262 0.0262
Echinococcus granulosus g protein coupled receptor 0.0076 0.0262 0.0262
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1006 0.8376 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.0262 0.0262
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis serotonin receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0262 0.0313
Schistosoma mansoni neuropeptide receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0262 0.0262
Chlamydia trachomatis dihydrofolate reductase 0.1006 0.8376 0.5
Echinococcus granulosus histone deacetylase 7 0.0223 0.1546 0.1546
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0262 0.0262
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0086 0.0102
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0151 0.0912 0.1089
Brugia malayi Melatonin receptor type 1A 0.0076 0.0262 0.0313
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0262 0.0262
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0262 0.0313
Toxoplasma gondii Hsp90 domain-containing protein 0.0175 0.1123 0.1341
Trypanosoma cruzi histone deacetylase, putative 0.0139 0.0812 0.0969
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0262 0.0313
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0262 0.0313
Trypanosoma brucei histone deacetylase 1 0.0307 0.2277 0.2719
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus sex peptide receptor 0.0076 0.0262 0.0262
Toxoplasma gondii histone deacetylase HDAC2 0.0307 0.2277 0.2719
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Plasmodium vivax heat shock protein, putative 0.0175 0.1123 0.1341
Loa Loa (eye worm) histone deacetylase 7A 0.0223 0.1546 0.1846
Brugia malayi G-protein coupled receptor 0.0076 0.0262 0.0313
Plasmodium falciparum heat shock protein 90, putative 0.0175 0.1123 0.1341
Brugia malayi AKH receptor 0.0076 0.0262 0.0313
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0262 0.0262
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0262 0.0262
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0262 0.0262
Brugia malayi RE15519p 0.0076 0.0262 0.0313
Trypanosoma brucei histone deacetylase 2 0.0139 0.0812 0.0969
Trypanosoma cruzi histone deacetylase, putative 0.0223 0.1546 0.1846
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0056 0.0086 0.0102
Echinococcus multilocularis histone deacetylase 6 0.0223 0.1546 0.1546
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0262 0.0262
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0262 0.0313
Toxoplasma gondii histone deacetylase HDAC3 0.0307 0.2277 0.2719
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0262 0.0262
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0262 0.0313
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.0262 0.0262
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0084 0.0332 0.0396
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.0262 0.0262
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Toxoplasma gondii histone deacetylase HDAC4 0.0139 0.0812 0.0969
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0262 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0307 0.2277 0.2719
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0086 0.0102
Schistosoma mansoni hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni neuropeptide receptor 0.0076 0.0262 0.0313
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1192 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) histone deacetylase 3 0.0307 0.2277 0.2719
Echinococcus granulosus serotonin receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis histone deacetylase 3 0.0307 0.2277 0.2277
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Plasmodium vivax histone deacetylase, putative 0.0139 0.0812 0.0969
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0262 0.0313
Schistosoma mansoni hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Plasmodium falciparum histone deacetylase 1 0.0307 0.2277 0.2719
Echinococcus multilocularis histone deacetylase 6 0.0223 0.1546 0.1546
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0262 0.0262
Echinococcus multilocularis histone deacetylase 0.0223 0.1546 0.1546
Echinococcus granulosus neuropeptide receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0056 0.0086 0.0102
Echinococcus granulosus dihydrofolate reductase 0.1006 0.8376 0.8376
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0262 0.0313
Echinococcus granulosus carbonic anhydrase 0.0056 0.0086 0.0086
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0086 0.0102
Loa Loa (eye worm) carbonic anhydrase 3 0.0151 0.0912 0.1089
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis dihydrofolate reductase 0.1006 0.8376 0.8376
Echinococcus granulosus histone deacetylase 0.0223 0.1546 0.1546
Schistosoma mansoni hypothetical protein 0.0076 0.0262 0.0313
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1006 0.8376 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Toxoplasma gondii histone deacetylase HDAC5 0.0139 0.0812 0.0969
Brugia malayi histone deacetylase 3 (HD3) 0.0307 0.2277 0.2719
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0262 0.0262
Echinococcus granulosus g protein coupled receptor 0.0076 0.0262 0.0262
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0262 0.0262
Trypanosoma cruzi histone deacetylase, putative 0.0223 0.1546 0.1846
Echinococcus granulosus g protein coupled receptor 0.0076 0.0262 0.0262
Leishmania major histone deacetylase, putative 0.0307 0.2277 0.2719
Loa Loa (eye worm) histone deacetylase 1 0.0307 0.2277 0.2719
Plasmodium falciparum carbonic anhydrase 0.0056 0.0086 0.0102
Schistosoma mansoni opsin-like receptor 0.0076 0.0262 0.0313
Schistosoma mansoni histamine h1 receptor 0.0076 0.0262 0.0313
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi sulfakinin receptor protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0262 0.0313
Schistosoma mansoni opsin-like receptor 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0262 0.0313
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0262 0.0262
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Trypanosoma brucei carbonic anhydrase-like protein 0.0151 0.0912 0.1089
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0262 0.0262
Schistosoma mansoni dihydrofolate reductase 0.1006 0.8376 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi Dopamine receptor 0.0076 0.0262 0.0313
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0262 0.0262
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.0262 0.0262
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.0262 0.0313
Entamoeba histolytica histone deacetylase, putative 0.0307 0.2277 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0262 0.0313
Echinococcus multilocularis histone deacetylase 7 0.0223 0.1546 0.1546
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0086 0.0086
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0086 0.0086
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0151 0.0912 0.1089
Brugia malayi Histone deacetylase family protein 0.0223 0.1546 0.1846
Brugia malayi dihydrofolate reductase family protein 0.1006 0.8376 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0307 0.2277 1
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0262 0.0313
Brugia malayi G-protein coupled receptor 0.0076 0.0262 0.0313
Plasmodium falciparum histone deacetylase 2 0.0223 0.1546 0.1846
Brugia malayi larval opioid receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0262 0.0313
Echinococcus granulosus histone deacetylase 6 0.0223 0.1546 0.1546
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0262 0.0262
Toxoplasma gondii histone deacetylase HDAC1 0.0223 0.1546 0.1846
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0262 0.0262
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0262 0.0262
Schistosoma mansoni histone deacetylase 1 2 3 0.0139 0.0812 0.0969
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0262 0.0262
Trypanosoma cruzi histone deacetylase, putative 0.0139 0.0812 0.0969
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus carbonic anhydrase II 0.0151 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0056 0.0086 0.0102
Brugia malayi G protein-coupled receptor 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0096 0.0438 0.0523
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0262 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Brugia malayi Serotonin receptor 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0262 0.0313
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0307 0.2277 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0262 0.0262
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0056 0.0086 0.0102
Echinococcus granulosus carbonic anhydrase 0.0056 0.0086 0.0086
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) histone deacetylase 11 0.0139 0.0812 0.0969
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Echinococcus multilocularis histone deacetylase 1 0.0307 0.2277 0.2277
Echinococcus multilocularis sex peptide receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0262 0.0313
Plasmodium vivax histone deacetylase 2, putative 0.0223 0.1546 0.1846
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0262 0.0313
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0086 0.0102
Echinococcus multilocularis geminin 0.0171 0.1086 0.1086
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Brugia malayi Dihydrofolate reductase 0.1006 0.8376 1
Brugia malayi hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0262 0.0262
Brugia malayi Dopamine receptor protein 1 0.0076 0.0262 0.0313
Trichomonas vaginalis histone deacetylase, putative 0.0307 0.2277 1
Leishmania major histone deacetylase, putative 0.0223 0.1546 0.1846
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0262 0.0262
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0262 0.0262
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0262 0.0313
Schistosoma mansoni histone deacetylase hda2 0.0139 0.0812 0.0969
Plasmodium vivax histone deacetylase, putative 0.0223 0.1546 0.1846
Schistosoma mansoni hypothetical protein 0.0056 0.0086 0.0102
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Echinococcus granulosus orexin receptor type 2 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni histone deacetylase 0.0307 0.2277 0.2719
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1006 0.8376 0.5
Trypanosoma cruzi histone deacetylase 1, putative 0.0307 0.2277 0.2719
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0262 0.0313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0262 0.0262
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1006 0.8376 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0262 0.0313
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0262 0.0313
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0262 0.0313
Echinococcus granulosus histone deacetylase 6 0.0223 0.1546 0.1546
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Schistosoma mansoni carbonic anhydrase 0.0056 0.0086 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0262 0.0262
Loa Loa (eye worm) histone deacetylase 0.0223 0.1546 0.1846
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0262 0.0262
Schistosoma mansoni neuropeptide receptor 0.0076 0.0262 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0262 0.0262
Echinococcus granulosus histone deacetylase 8 0.0139 0.0812 0.0812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0262 0.0313
Leishmania major histone deacetylase, putative 0.0223 0.1546 0.1846
Echinococcus granulosus hypothetical protein 0.0076 0.0262 0.0262
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0151 0.0912 0.1089
Schistosoma mansoni amine GPCR 0.0076 0.0262 0.0313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0262 0.0313
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0056 0.0086 0.0102
Echinococcus granulosus fmrfamide receptor 0.0076 0.0262 0.0262
Echinococcus multilocularis histone deacetylase 8 0.0139 0.0812 0.0812
Schistosoma mansoni adenoreceptor 0.0076 0.0262 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0262 0.0313
Giardia lamblia Histone deacetylase 0.0307 0.2277 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0262 0.0313
Leishmania major histone deacetylase, putative 0.0307 0.2277 0.2719
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0262 0.0313
Schistosoma mansoni amine GPCR 0.0076 0.0262 0.0313
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0086 0.0102
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0262 0.0262
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0262 0.0313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0262 0.0262
Trypanosoma cruzi histone deacetylase 1, putative 0.0307 0.2277 0.2719
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0262 0.0262
Schistosoma mansoni neuropeptide receptor 0.0076 0.0262 0.0313
Echinococcus granulosus somatostatin receptor 0.0076 0.0262 0.0262
Brugia malayi ORL1-like opioid receptor 0.0076 0.0262 0.0313
Echinococcus granulosus neuropeptide receptor 0.0076 0.0262 0.0262

Activities

Activity type Activity value Assay description Source Reference
Conversion (ADMET) = 23 % Percent conversion of compound in human lung S9 fraction after 60 min of administration ChEMBL. 15771459
Conversion (ADMET) = 68 % Percent conversion of compound in human liver fraction after 60 min of administration ChEMBL. 15771459
Inhibition (functional) = 69 % Percent inhibition of interleukin-5 production in human whole blood assay after 10e-7 M treatment ChEMBL. 15771459
Inhibition (functional) = 96 % Percent inhibition of interleukin-5 production in human whole blood assay after 10e-6 M treatment ChEMBL. 15771459

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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