TDR Targets

Basic information

Technical information

TDR Targets ID: 311776
Name: 5-ethyl-3-[5-hydroxypentyl(methyl)amino]-6-me thyl-4-[(3-methylphenyl)methyl]-1H-pyridin-2- one
MW: 356.502 | Formula: C22H32N2O2
H donors: 2 H acceptors: 2 LogP: 3.48 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OCCCCCN(c1c(=O)[nH]c(c(c1Cc1cccc(c1)C)CC)C)C
InChi: 1S/C22H32N2O2/c1-5-19-17(3)23-22(26)21(24(4)12-7-6-8-13-25)20(19)15-18-11-9-10-16(2)14-18/h9-11,14,25H,5-8,12-13,15H2,1-4H3,(H,23,26)
InChiKey: AVHFITFFUBSKNU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-ethyl-3-[5-hydroxypentyl(methyl)amino]-6-methyl-4-(m-tolylmethyl)-1H-pyridin-2-one
5-ethyl-3-[5-hydroxypentyl(methyl)amino]-6-methyl-4-(3-methylbenzyl)-2-pyridone
5-ethyl-3-(5-hydroxypentyl-methylamino)-6-methyl-4-[(3-methylphenyl)methyl]-1H-pyridin-2-one
5-ethyl-3-(5-hydroxypentyl-methyl-amino)-6-methyl-4-[(3-methylphenyl)methyl]-1H-pyridin-2-one
5-ethyl-3-(5-hydroxypentyl-methyl-amino)-6-methyl-4-(3-methylbenzyl)-2-pyridone
2(1H)-Pyridinone, 5-ethyl-3-(5-hydroxypentyl)methylamino-6-methyl-4-(3-methylphenyl)methyl-
AIDS-109454
AIDS109454

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Reverse transcriptase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	226 aa	24.3 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	245 aa	25.7 %
Candida albicans	polyprotein of retrotransposon Tca8	Reverse transcriptase	259 aa	238 aa	26.5 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	208 aa	26.4 %
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	Reverse transcriptase	259 aa	227 aa	26.4 %
Candida albicans	ReverseTranscriptase similar to fruit fly Tom element	Reverse transcriptase	259 aa	244 aa	27.9 %
Dictyostelium discoideum	hypothetical protein	Reverse transcriptase	259 aa	222 aa	22.5 %
Trypanosoma congolense	Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative	Reverse transcriptase	259 aa	237 aa	29.1 %
Candida albicans	hypothetical protein	Reverse transcriptase	259 aa	223 aa	29.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0167	0.2287	0.1924
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0103	0.0479
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0103	0.5
Brugia malayi	Heterochromatin protein 1	0.0068	0.0786	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.5
Onchocerca volvulus		0.0314	0.4526	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.045	0.2407
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0103	0.0479
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0692	0.0253
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0103	0.0479
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0331	0.0431
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0692	0.1502
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0053	0.0562	0.0117
Onchocerca volvulus		0.0046	0.045	0.0785
Echinococcus multilocularis	serotonin transporter	0.0314	0.4526	0.4268
Echinococcus granulosus	geminin	0.0165	0.2268	0.1903
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0103	0.0552
Echinococcus multilocularis	carboxylesterase 5A	0.0272	0.3889	0.3601
Loa Loa (eye worm)	norepinephrine transporter	0.0314	0.4526	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0272	0.3889	0.8589
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Plasmodium falciparum	amino acid transporter, putative	0.0053	0.0562	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Onchocerca volvulus		0.0053	0.0562	0.1037
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0692	0.1502
Onchocerca volvulus		0.0046	0.045	0.0785
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0786	0.1588
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Brugia malayi	Carboxylesterase family protein	0.0046	0.045	0.0785
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0046	0.045	0.2407
Mycobacterium ulcerans	carboxylesterase, LipT	0.0046	0.045	0.2348
Echinococcus granulosus	acetylcholinesterase	0.0272	0.3889	0.3601
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0053	0.0562	0.0117
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0103	0.0552
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0103	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0375	0.0543
Echinococcus granulosus	carboxylesterase 5A	0.0272	0.3889	0.3601
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.4092	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0206	0.0425
Treponema pallidum	sodium- and chloride- dependent transporter	0.0314	0.4526	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.3889	0.8589
Plasmodium falciparum	transporter, putative	0.0053	0.0562	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0103	0.0197
Plasmodium vivax	hypothetical protein, conserved	0.0053	0.0562	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0375	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0314	0.4526	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0786	0.171
Brugia malayi	MH2 domain containing protein	0.0117	0.1524	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0314	0.4526	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.1037
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0692	0.0253
Schistosoma mansoni	sodium/chloride dependent transporter	0.0053	0.0562	0.0117
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.045	0.2407
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0053	0.0562	0.0117
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.1872	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.1037
Echinococcus multilocularis	microtubule associated protein 2	0.0674	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0053	0.0562	0.0117
Loa Loa (eye worm)	carboxylesterase	0.0272	0.3889	0.8589
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.4092	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.3889	0.8589
Echinococcus multilocularis	acetylcholinesterase	0.0272	0.3889	0.3601
Onchocerca volvulus		0.003	0.0206	0.0232
Onchocerca volvulus		0.0046	0.045	0.0785
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0053	0.0562	0.0117
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0053	0.0562	0.0117
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0053	0.0562	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0103	0.0479
Trichomonas vaginalis	spcc417.12 protein, putative	0.0046	0.045	0.0734
Onchocerca volvulus		0.0046	0.045	0.0785
Brugia malayi	Carboxylesterase family protein	0.0046	0.045	0.0785
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0692	0.0253
Schistosoma mansoni	chromobox protein	0.0068	0.0786	0.0351
Brugia malayi	RNA binding protein	0.0062	0.0692	0.1331
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0053	0.0562	0.0117
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0692	0.0253
Brugia malayi	Carboxylesterase family protein	0.0272	0.3889	0.856
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0053	0.0562	0.0117
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0103	0.0479
Echinococcus granulosus	acetylcholinesterase	0.0272	0.3889	0.3601
Plasmodium vivax	amine transporter, putative	0.0053	0.0562	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0053	0.0562	0.0117
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0053	0.0562	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0285	0.4092	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0331	0.0431
Brugia malayi	Carboxylesterase family protein	0.0046	0.045	0.0785
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0314	0.4526	0.4268
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0692	0.0253
Echinococcus granulosus	chromobox protein 1	0.0068	0.0786	0.0351
Brugia malayi	Carboxylesterase family protein	0.0272	0.3889	0.856
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0314	0.4526	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0692	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0103	0.0197
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Echinococcus granulosus	chromobox protein 1	0.0068	0.0786	0.0351
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0331	0.0515
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.1872	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0046	0.045	0.0734
Brugia malayi	TAR-binding protein	0.0062	0.0692	0.1331
Loa Loa (eye worm)	carboxylesterase	0.0046	0.045	0.0967
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.1872	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Echinococcus granulosus	serotonin transporter	0.0314	0.4526	0.4268
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0103	0.0479
Echinococcus granulosus	sodium and chloride dependent glycine	0.0053	0.0562	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0786	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0314	0.4526	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4092	1
Schistosoma mansoni	microtubule-associated protein tau	0.0674	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0786	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0103	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1524	0.3347
Onchocerca volvulus		0.0053	0.0562	0.1037
Onchocerca volvulus		0.0046	0.045	0.0785
Trypanosoma brucei	RNA helicase, putative	0.0167	0.2287	0.5
Loa Loa (eye worm)	carboxylesterase	0.0046	0.045	0.0967
Echinococcus multilocularis	acetylcholinesterase	0.0272	0.3889	0.3601
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Toxoplasma gondii	hypothetical protein	0.0053	0.0562	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0375	0.0615
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0103	0.0479
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0786	0.0351
Schistosoma mansoni	chromobox protein	0.0068	0.0786	0.0351
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.1037
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0014	0.0077
Toxoplasma gondii	hypothetical protein	0.0053	0.0562	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0562	0.1213
Brugia malayi	hypothetical protein	0.0046	0.045	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0103	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0562	0.0117
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0103	0.0479
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0053	0.0562	0.0117
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0692	0.1502
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0272	0.3889	0.3601
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0331	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0046	0.045	0.0967
Brugia malayi	chromobox protein homolog 3	0.0038	0.0331	0.0515
Loa Loa (eye worm)	serotonin transporter b	0.0314	0.4526	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.1213
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1524	0.3347
Brugia malayi	Carboxylesterase family protein	0.0046	0.045	0.0785
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0692	0.0253
Echinococcus multilocularis	geminin	0.0165	0.2268	0.1903
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0053	0.0562	0.0117
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0053	0.0562	0.1213
Brugia malayi	hypothetical protein	0.0053	0.0562	0.1037
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0692	0.0253
Schistosoma mansoni	hypothetical protein	0.0165	0.2268	0.1903
Onchocerca volvulus		0.0053	0.0562	0.1037
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0053	0.0562	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0314	0.4526	1
Schistosoma mansoni	hypothetical protein	0.0165	0.2268	0.1903
Schistosoma mansoni	sodium/chloride dependent transporter	0.0314	0.4526	0.4268

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV V179E mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV G190A mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV G190S mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV F227C mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV L100I and K103N mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV K101E and K103N mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration value against HIV K103N and Y181C mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV F227L and V106A mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV L100I mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV K101E mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV V106A mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0 uM	In vitro inhibitory concentration against HIV E138K mutant strain	ChEMBL.	15771439
IC50 (functional)	= 0.01 uM	In vitro inhibitory concentration against HIV LAI cell line	ChEMBL.	15771439
IC50 (binding)	= 0.01 uM	Inhibition of HIV1 reverse transcriptase in human LAI cells	ChEMBL.	18410080
IC50 (binding)	= 0.01 uM	Inhibition of HIV1 reverse transcriptase	ChEMBL.	18410085
IC50 (functional)	= 0.501 uM	In vitro inhibitory concentration against HIV K103N mutant strain	ChEMBL.	15771439
IC50 (functional)	= 1.585 uM	In vitro inhibitory concentration against HIV-1 Y181C mutant strain	ChEMBL.	15771439
IC50 (functional)	= 5.012 uM	In vitro inhibitory concentration against HIV Y188L mutant strain	ChEMBL.	15771439
SI (functional)	= 6310 uM	Selective index value (ratio of CC50 to IC50 value)against HIV LAI cell line	ChEMBL.	15771439

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL367745
PubChem: 486970

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 311776