Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cyclooxygenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1435 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0118 | 0.0172 | 0.0172 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.0071 | 0.0071 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1333 | 0.9236 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1435 | 1 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0102 | 0.005 | 0.005 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1333 | 0.9236 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0533 | 0.0533 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0118 | 0.0172 | 0.0172 |
Schistosoma mansoni | thyroid hormone receptor | 0.0118 | 0.0172 | 0.0172 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1333 | 0.9236 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0105 | 0.0071 | 0.0071 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1333 | 0.9236 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0102 | 0.005 | 0.005 |
Echinococcus granulosus | dihydrofolate reductase | 0.1435 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0105 | 0.0071 | 0.0071 |
Brugia malayi | Dihydrofolate reductase | 0.1435 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1435 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1435 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.0533 | 0.0533 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0533 | 0.0533 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.0071 | 0.0071 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.005 | 0.005 |
Schistosoma mansoni | dihydrofolate reductase | 0.1435 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 0.0071 | 1 | |
Echinococcus multilocularis | geminin | 0.0167 | 0.0533 | 0.0533 |
Echinococcus granulosus | thymidylate synthase | 0.0105 | 0.0071 | 0.0071 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1333 | 0.9236 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1333 | 0.9236 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.75 uM | Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 0.75 uM | Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 57.4 uM | Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
IC50 (binding) | = 57.4 uM | Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1) | ChEMBL. | 10230624 |
Inhibition (binding) | = 21 % | Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1) at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 21 % | Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1) at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 72 % | Inhibitory activity against Cyclooxygenase(COX) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 72 % | Inhibitory activity against Cyclooxygenase(COX) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 78 % | Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Inhibition (binding) | = 78 % | Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)at 10 uM | ChEMBL. | 10230624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.