Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.5922 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Onchocerca volvulus | 0.013 | 0.5922 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.5922 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.068 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.5922 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.5922 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.4 uM | Concentration required to double the lag time of maximum thrombin generation in human plasma-based thrombin generation assay. | ChEMBL. | 15013006 |
Activity (functional) | = 1.4 uM | Concentration required to double the lag time of maximum thrombin generation in human plasma-based thrombin generation assay. | ChEMBL. | 15013006 |
cLog D (ADMET) | = 2.03 | Hidrophilicity of the compound was determined at pH 7 | ChEMBL. | 15013006 |
F (ADMET) | NT 0 % | Oral bioavailability in rat | ChEMBL. | 15013006 |
IC50 (binding) | = 0.2 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
IC50 (binding) | = 0.2 nM | Inhibitory concentration against coagulation factor Xa. | ChEMBL. | 15013006 |
Ki (binding) | = 0.1 nM | Inhibition of Coagulation factor X | ChEMBL. | 15013006 |
Ki (binding) | = 0.1 nM | Inhibition of Coagulation factor X | ChEMBL. | 15013006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.