Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0268 | 0.3888 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0268 | 0.3888 | 0.3849 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | septate junction protein | 0.0087 | 0.0063 | 0.0162 |
Onchocerca volvulus | Peroxidasin homolog | 0.0268 | 0.3888 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0268 | 0.3888 | 0.3849 |
Schistosoma mansoni | cell polarity protein | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0268 | 0.3888 | 0.3849 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | peroxidasin | 0.0268 | 0.3888 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.0759 | 0.1819 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Echinococcus granulosus | peroxidasin | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0268 | 0.3888 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0268 | 0.3888 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0268 | 0.3888 | 0.3849 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.0759 | 0.1951 |
Brugia malayi | Animal haem peroxidase family protein | 0.0268 | 0.3888 | 0.3849 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Onchocerca volvulus | 0.0268 | 0.3888 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0268 | 0.3888 | 0.3849 |
Brugia malayi | hypothetical protein | 0.0268 | 0.3888 | 0.3849 |
Brugia malayi | Peroxidasin | 0.0268 | 0.3888 | 0.3849 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Onchocerca volvulus | Peroxidase homolog | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | peroxidasin | 0.0268 | 0.3888 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0087 | 0.0063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | slit | 0.0087 | 0.0063 | 0.0162 |
Giardia lamblia | High cysteine protein | 0.0087 | 0.0063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0087 | 0.0063 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.3888 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.0759 | 0.1819 |
Onchocerca volvulus | 0.0268 | 0.3888 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.0268 | 0.3888 | 1 |
Schistosoma mansoni | notch | 0.0087 | 0.0063 | 0.0162 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0063 | 0.0162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.