Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.4 nM | Inhibitory concentration against human butyrylcholinesterase | ChEMBL. | 15771436 |
IC50 (binding) | = 3.4 nM | Inhibitory concentration against human butyrylcholinesterase | ChEMBL. | 15771436 |
Ki (binding) | = 0.94 nM | Dissociation constant for inhibition of equine Butyrylcholinesterase (BuChE) | ChEMBL. | 15771436 |
Ki (binding) | = 0.94 nM | Dissociation constant for inhibition of equine Butyrylcholinesterase (BuChE) | ChEMBL. | 15771436 |
Ki (binding) | = 2.8 nM | Dissociation constant for inhibition of fetal bovine serum Acetylcholinesterase | ChEMBL. | 15771436 |
Ki (binding) | = 2.8 nM | Dissociation constant for inhibition of fetal bovine serum Acetylcholinesterase | ChEMBL. | 15771436 |
Ratio (binding) | = 2.9 | Inhibitory ratio for bovine acetylcholinesterase and equine butyrylcholinesterase | ChEMBL. | 15771436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.