TDR Targets

Basic information

Technical information

TDR Targets ID: 311998
Name: 3-[1-[3-(4-methylpiperazin-1-yl)propyl]indazo l-3-yl]-4-(1-naphthalen-2-ylindol-3-yl)pyrrol e-2,5-dione
MW: 594.705 | Formula: C37H34N6O2
H donors: 1 H acceptors: 3 LogP: 5.38 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: CN1CCN(CC1)CCCn1nc(c2c1cccc2)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)c1ccc2c(c1)cccc2
InChi: 1S/C37H34N6O2/c1-40-19-21-41(22-20-40)17-8-18-43-32-14-7-5-12-29(32)35(39-43)34-33(36(44)38-37(34)45)30-24-42(31-13-6-4-11-28(30)31)27-16-15-25-9-2-3-10-26(25)23-27/h2-7,9-16,23-24H,8,17-22H2,1H3,(H,38,44,45)
InChiKey: VJVSHXVHOJVSOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[1-[3-(4-methylpiperazin-1-yl)propyl]indazol-3-yl]-4-[1-(2-naphthyl)indol-3-yl]pyrrole-2,5-dione
3-[1-[3-(4-methyl-1-piperazinyl)propyl]-3-indazolyl]-4-[1-(2-naphthalenyl)-3-indolyl]pyrrole-2,5-dione
3-[1-[3-(4-methylpiperazino)propyl]indazol-3-yl]-4-[1-(2-naphthyl)indol-3-yl]-3-pyrroline-2,5-quinone
3-[1-[3-(4-methyl-1-piperazinyl)propyl]-3-indazolyl]-4-[1-(2-naphthyl)-3-indolyl]pyrrole-2,5-dione
3-[1-[3-(4-methylpiperazin-1-yl)propyl]indazol-3-yl]-4-[1-(2-naphthyl)indol-3-yl]-3-pyrroline-2,5-quinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	C1-like domain containing protein	0.0023	0.0667	0.0648
Echinococcus multilocularis	protein kinase c epsilon type	0.0058	0.2497	0.2398
Echinococcus granulosus	protein jagged 1	0.0019	0.0437	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0165	0.8105	1
Brugia malayi	intracellular kinase	0.0059	0.2535	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1483	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Echinococcus multilocularis	protein jagged 1	0.0019	0.0437	0.0311
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.2535	1
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Echinococcus granulosus	Rac GTPase activating protein 1	0.0022	0.0602	0.0479
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.1108	0.0991
Onchocerca volvulus		0.0026	0.0841	0.1927
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0019	0.0437	0.0311
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0032	0.1108	0.0991
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.25	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Echinococcus multilocularis	protein jagged 1	0.0019	0.0437	0.0311
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Onchocerca volvulus		0.0059	0.2535	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Onchocerca volvulus		0.0022	0.0602	0.0789
Brugia malayi	diacylglycerol kinase	0.0022	0.0602	0.0571
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.6955	0.6915
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.25	0.2863
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0023	0.0667	0.0544
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2007	0.1901
Echinococcus granulosus	protein jagged 1	0.0019	0.0437	0.0311
Echinococcus multilocularis	serine threonine protein kinase	0.0179	0.885	0.8835
Echinococcus multilocularis	protein jagged 2	0.0019	0.0437	0.0311
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1638	0.3983
Echinococcus multilocularis	neurogenic locus notch protein	0.0019	0.0437	0.0311
Echinococcus granulosus	neural cadherin	0.0019	0.0437	0.0311
Echinococcus granulosus	serine:threonine protein kinase N2	0.0032	0.1108	0.0991
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.25	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2007	0.1901
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Plasmodium falciparum	glycogen synthase kinase 3	0.0059	0.2535	0.5
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0032	0.1108	0.0991
Brugia malayi	Peroxidasin	0.0058	0.25	0.2863
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Echinococcus granulosus	unc 13 munc13	0.0026	0.0841	0.0721
Brugia malayi	Blistered cuticle protein 3	0.0058	0.25	0.2863
Loa Loa (eye worm)	raf kinase	0.0022	0.0602	0.0592
Loa Loa (eye worm)	notch protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0023	0.0667	0.0673
Entamoeba histolytica	protein kinase, putative	0.0032	0.1108	0.2617
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.1792	0.1684
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0019	0.0437	0.0311
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.2497	0.2398
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0841	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0022	0.0602	0.0479
Schistosoma mansoni	unc-13 (munc13)	0.0026	0.0841	0.0721
Brugia malayi	Cadherin domain containing protein	0.0019	0.0437	0.0371
Brugia malayi	Protein kinase c protein 2	0.0171	0.8408	1
Brugia malayi	hypothetical protein	0.0058	0.25	0.2863
Schistosoma mansoni	rac gtpase activating protein	0.0022	0.0602	0.0479
Schistosoma mansoni	peroxidasin	0.0058	0.25	0.2401
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.2535	1
Echinococcus granulosus	myotubularin protein 13	0.0022	0.0602	0.0479
Brugia malayi	RhoGAP domain containing protein	0.0022	0.0602	0.0571
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.25	0.2863
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.6955	0.6915
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.2535	0.3016
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.2535	1
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0667	0.0648
Echinococcus granulosus	neurogenic locus notch protein	0.0019	0.0437	0.0311
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0059	0.2535	0.2437
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0032	0.1108	0.0991
Brugia malayi	Protein kinase domain containing protein	0.0032	0.1108	0.1181
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.1108	0.0991
Schistosoma mansoni	cell polarity protein	0.0019	0.0437	0.0311
Schistosoma mansoni	atypical protein kinase C	0.0053	0.2258	0.2156
Onchocerca volvulus	Dual oxidase homolog	0.0058	0.25	0.9832
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Echinococcus granulosus	protein kinase c iota type	0.0053	0.2258	0.2156
Echinococcus multilocularis	protein kinase c iota type	0.0053	0.2258	0.2156
Schistosoma mansoni	laminin gamma-3 chain	0.0019	0.0437	0.0311
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.2535	0.3016
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0032	0.1108	0.0991
Onchocerca volvulus	Peroxidasin homolog	0.0058	0.25	0.9832
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0019	0.0437	0.0311
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0022	0.0602	0.0592
Onchocerca volvulus	Peroxidase homolog	0.0058	0.25	0.9832
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.1108	0.0991
Schistosoma mansoni	serine/threonine protein kinase	0.0201	1	1
Echinococcus multilocularis	protein kinase c eta type	0.0022	0.0602	0.0479
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0032	0.1108	0.0991
Echinococcus multilocularis	N chimaerin	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Echinococcus granulosus	protein jagged 2	0.0019	0.0437	0.0311
Onchocerca volvulus		0.0022	0.0602	0.0789
Echinococcus granulosus	N chimaerin	0.0022	0.0602	0.0479
Echinococcus multilocularis	myotubularin protein 13	0.0022	0.0602	0.0479
Echinococcus multilocularis	protein kinase shaggy	0.0059	0.2535	0.2437
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Toxoplasma gondii	diacylglycerol kinase, putative	0.0022	0.0602	0.0789
Echinococcus granulosus	protein kinase shaggy	0.0059	0.2535	0.2437
Schistosoma mansoni	vav2	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Echinococcus granulosus	fibropellin Ia	0.0019	0.0437	0.0311
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0437	0.0371
Onchocerca volvulus		0.0058	0.25	0.9832
Loa Loa (eye worm)	blistered cuticle protein 3	0.0058	0.25	0.2971
Brugia malayi	Hr1 repeat family protein	0.0032	0.1108	0.1181
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0022	0.0602	0.0479
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0032	0.1108	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Echinococcus multilocularis	neurogenic locus protein delta	0.0019	0.0437	0.0311
Echinococcus granulosus	raf serine:threonine protein kinase	0.0022	0.0602	0.0479
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0059	0.2535	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0032	0.1108	0.1226
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0059	0.2535	1
Schistosoma mansoni	serine/threonine kinase	0.0032	0.1108	0.0991
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0059	0.2535	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Brugia malayi	Protein kinase domain containing protein	0.0032	0.1108	0.1181
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0201	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0019	0.0437	0.0311
Brugia malayi	Ras association domain family 1 isoform A	0.0022	0.0602	0.0571
Echinococcus multilocularis	neurogenic locus notch protein	0.0019	0.0437	0.0311
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0026	0.0841	0.0721
Loa Loa (eye worm)	Notch2	0.0019	0.0437	0.0385
Echinococcus multilocularis	slit 2 protein	0.0019	0.0437	0.0311
Schistosoma mansoni	diacylglycerol kinase theta	0.0022	0.0602	0.0479
Entamoeba histolytica	protein kinase, putative	0.0032	0.1108	0.2617
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0032	0.1108	0.4371
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1638	0.3983
Schistosoma mansoni	protein kinase C mu	0.0022	0.0602	0.0479
Schistosoma mansoni	serine/threonine protein kinase	0.0201	1	1
Onchocerca volvulus	Peroxidase homolog	0.0058	0.25	0.9832
Schistosoma mansoni	septate junction protein	0.0019	0.0437	0.0311
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.25	0.2863
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.2535	1
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.25	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Brugia malayi	diacylglycerol kinase	0.0022	0.0602	0.0571
Schistosoma mansoni	protein kinase C	0.0026	0.0841	0.0721
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0022	0.0602	0.0479
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0437	0.0371
Echinococcus granulosus	neurogenic locus notch protein 4	0.0019	0.0437	0.0311
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0023	0.0667	0.0648
Schistosoma mansoni	slit	0.0019	0.0437	0.0311
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.2535	1
Echinococcus granulosus	protein kinase c epsilon type	0.0058	0.2497	0.2398
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Toxoplasma gondii	AGC kinase	0.0032	0.1108	0.3199
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0059	0.2535	0.2437
Brugia malayi	RhoGAP domain containing protein	0.0022	0.0602	0.0571
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0032	0.1108	0.0991
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.2535	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.1108	0.2617
Echinococcus granulosus	peroxidasin	0.0058	0.25	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0143	0.6955	0.8558
Echinococcus granulosus	notch	0.0019	0.0437	0.0311
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Brugia malayi	GCC2 and GCC3 family protein	0.0019	0.0437	0.0371
Onchocerca volvulus		0.0058	0.25	0.9832
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0032	0.1108	0.1226
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.25	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Brugia malayi	notch-like transmembrane receptor	0.0019	0.0437	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Brugia malayi	Pleckstrin Homology Domain	0.0022	0.0602	0.0571
Schistosoma mansoni	unc-13 (munc13)	0.0026	0.0841	0.0721
Echinococcus granulosus	protein kinase c eta type	0.0022	0.0602	0.0479
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0022	0.0602	0.0592
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0149	0.7258	0.8938
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Brugia malayi	protein kinase C3,putative	0.0023	0.0667	0.0648
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0667	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.1792	0.2084
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0032	0.1108	0.1226
Echinococcus granulosus	delta-like protein 1	0.0019	0.0437	0.0311
Echinococcus multilocularis	unc 13 (munc13)	0.0026	0.0841	0.0721
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Echinococcus multilocularis	notch	0.0019	0.0437	0.0311
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0032	0.1108	0.0991
Entamoeba histolytica	protein kinase, putative	0.0032	0.1108	0.2617
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0022	0.0602	0.0479
Onchocerca volvulus	Peroxidasin homolog	0.0058	0.25	0.9832
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0032	0.1108	0.0991
Echinococcus granulosus	slit 2 protein	0.0019	0.0437	0.0311
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.25	0.2863
Echinococcus granulosus	neurogenic locus protein delta	0.0019	0.0437	0.0311
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.1792	0.2007
Brugia malayi	protein kinase C II.	0.0058	0.2497	0.2859
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0667	0.0544
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0032	0.1108	0.0991
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0437	0.0371
Schistosoma mansoni	diacylglycerol kinase theta	0.0022	0.0602	0.0479
Trypanosoma brucei	protein kinase, putative	0.0059	0.2535	1
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0059	0.2535	1
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0602	0.0571
Schistosoma mansoni	hypothetical protein	0.0022	0.0602	0.0479
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0026	0.0841	0.0721
Brugia malayi	Protein kinase domain containing protein	0.0032	0.1108	0.1181
Echinococcus granulosus	protein jagged 2	0.0019	0.0437	0.0311
Onchocerca volvulus	Chorion peroxidase homolog	0.0058	0.25	0.9832
Echinococcus multilocularis	neurogenic locus protein delta	0.0019	0.0437	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0022	0.0602	0.0592
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.6955	0.6915
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0602	0.0592
Echinococcus granulosus	protein kinase C gamma type	0.0179	0.885	0.8835
Entamoeba histolytica	protein kinase, putative	0.0059	0.2535	1
Brugia malayi	RhoGEF domain containing protein	0.0022	0.0602	0.0571
Echinococcus multilocularis	neural cadherin	0.0019	0.0437	0.0311
Schistosoma mansoni	protein kinase C mu	0.0023	0.0667	0.0544
Onchocerca volvulus		0.0058	0.25	0.9832
Echinococcus multilocularis	peroxidasin	0.0058	0.25	0.2401
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0032	0.1108	0.1226
Schistosoma mansoni	notch	0.0019	0.0437	0.0311
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0022	0.0602	0.0592
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0059	0.2535	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0019	0.0437	0.0371
Echinococcus granulosus	NDR protein kinase	0.0032	0.1108	0.0991
Schistosoma mansoni	hypothetical protein	0.0019	0.0437	0.0311
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.1792	0.1684
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Echinococcus multilocularis	fibropellin Ia	0.0019	0.0437	0.0311
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.25	0.2863
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0032	0.1108	0.1226
Brugia malayi	Cadherin domain containing protein	0.0019	0.0437	0.0371
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.1108	0.0991
Echinococcus granulosus	Diacylglycerol kinase theta	0.0022	0.0602	0.0479
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0023	0.0667	0.0673
Brugia malayi	p70 ribosomal S6 kinase beta	0.0032	0.1108	0.1181
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0437	0.0385
Brugia malayi	Delta serrate ligand family protein	0.0019	0.0437	0.0371
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0602	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0058	0.25	0.2971
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0023	0.0667	0.0544
Brugia malayi	Muscle positioning protein 4	0.0019	0.0437	0.0371
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0058	0.2497	0.2968
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1108	0.1226
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.1108	0.0431
Brugia malayi	EGF-like domain containing protein	0.0019	0.0437	0.0371
Schistosoma mansoni	peroxidasin	0.0058	0.25	0.2401
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0032	0.1108	0.1226

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	uM	Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2; Not determined	ChEMBL.	15771419
IC50 (functional)	0 uM	Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2; Not determined	ChEMBL.	15771419
IC50 (binding)	= 0.062 uM	Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 0.062 uM	Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 0.092 uM	Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 0.092 uM	Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 0.32 uM	Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 0.32 uM	Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 1.2 uM	Inhibition of rabbit Glycogen synthase kinase-3 beta	ChEMBL.	15771419
IC50 (binding)	= 1.2 uM	Inhibition of rabbit Glycogen synthase kinase-3 beta	ChEMBL.	15771419
IC50 (binding)	= 1.3 uM	Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP	ChEMBL.	15771419
IC50 (binding)	= 1.3 uM	Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP	ChEMBL.	15771419
Ki (binding)	= 0.29 uM	Inhibition of [3H]-astemizole binding to Potassium channel HERG	ChEMBL.	15771419
Ki (binding)	= 0.29 uM	Inhibition of [3H]-astemizole binding to Potassium channel HERG	ChEMBL.	15771419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL175845
PubChem: 10188786

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 311998