Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 % | Percent reduction of cataleptic effect in rat upon dosing at 3 mg/kg; Not tested | ChEMBL. | 15982882 |
Inhibition | 0 % | Percent inhibition of hERG by rubidium efflux FLIPR assay at concentration of 5 ug/mL; Not tested | ChEMBL. | 15982882 |
Inhibition | = 10 % | Percent inhibition of hERG by rubidium efflux FLIPR assay at concentration of 5 ug/mL | ChEMBL. | 15982882 |
Ki (binding) | = 1.3 nM | Inhibitory constant against Adenosine A2A receptor using [3H]-SCH-58,261 as radio ligand | ChEMBL. | 15982882 |
Selectivity (binding) | = 133 nM | Selectivity between A1 and A2A receptors | ChEMBL. | 15982882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.