Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0012 | 0.5 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0012 | 0.5 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0012 | 0.5 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0012 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | 0.0012 | 0.5 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.5 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0012 | 0.5 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0012 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.5 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0012 | 0.5 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0012 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0012 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0012 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 nM | Inhibition of eotaxin-induced chemotaxis of human eosinophils; NT= Not tested | ChEMBL. | 15771462 |
IC50 (binding) | = 9 nM | Inhibition of [125I]-eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells | ChEMBL. | 15771462 |
Ki (binding) | 0 nM | Inhibitory constant for 5-hydroxytryptamine 2A receptor (NT= Not tested) | ChEMBL. | 15771462 |
Ki (binding) | 0 nM | Inhibitory constant for 5-hydroxytryptamine 2C receptor (NT= Not tested) | ChEMBL. | 15771462 |
Ki (binding) | 0 nM | Inhibitory constant for Dopamine receptor D2 (NT= Not tested) | ChEMBL. | 15771462 |
Ki (binding) | = 550 nM | Inhibitory constant for Dopamine receptor D2 | ChEMBL. | 15771462 |
Ki (binding) | = 1800 nM | Inhibitory constant for 5-hydroxytryptamine 2A receptor | ChEMBL. | 15771462 |
Ki (binding) | = 2600 nM | Inhibitory constant for 5-hydroxytryptamine 2C receptor | ChEMBL. | 15771462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.