Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0083 | 0.6456 | 1 |
Brugia malayi | tailless protein | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | thyroid hormone receptor | 0.0083 | 0.6456 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0039 | 0.224 | 0.224 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0083 | 0.6456 | 0.6456 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0083 | 0.6456 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1588 | 0.1588 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0039 | 0.224 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0083 | 0.6456 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0039 | 0.224 | 0.3469 |
Echinococcus granulosus | FTZ F1 alpha | 0.0083 | 0.6456 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0039 | 0.224 | 0.224 |
Brugia malayi | nuclear receptor NHR-88 | 0.0083 | 0.6456 | 0.6456 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1588 | 0.2459 |
Brugia malayi | nuclear receptor RXR | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | nuclear hormone receptor | 0.0039 | 0.224 | 0.3469 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0044 | 0.2691 | 0.2691 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0083 | 0.6456 | 0.6456 |
Schistosoma mansoni | thyroid hormone receptor | 0.0083 | 0.6456 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.52 | 0.52 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0083 | 0.6456 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0039 | 0.224 | 0.224 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0039 | 0.224 | 0.3469 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0044 | 0.2691 | 0.4168 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0083 | 0.6456 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | DR-78 | 0.0039 | 0.224 | 0.224 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0039 | 0.224 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1588 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Brugia malayi | nuclear receptor RXR | 0.0044 | 0.2691 | 0.2691 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0039 | 0.224 | 0.224 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0044 | 0.2691 | 0.4168 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Brugia malayi | nuclear receptor NHR-67 | 0.0039 | 0.224 | 0.224 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0083 | 0.6456 | 0.6456 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0083 | 0.6456 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0039 | 0.224 | 0.3469 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0039 | 0.224 | 0.3469 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0044 | 0.2691 | 0.2691 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Schistosoma mansoni | nuclear receptor | 0.0039 | 0.224 | 0.3469 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0083 | 0.6456 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0044 | 0.2691 | 0.4168 |
Brugia malayi | nuclear hormone receptor | 0.0039 | 0.224 | 0.224 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0039 | 0.224 | 0.3469 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0044 | 0.2691 | 0.2691 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1588 | 0.2459 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0083 | 0.6456 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0083 | 0.6456 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0039 | 0.224 | 0.3469 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0083 | 0.6456 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1588 | 0.2459 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0083 | 0.6456 | 0.6456 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1588 | 0.2459 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1588 | 0.2459 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0083 | 0.6456 | 0.6456 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0039 | 0.224 | 0.3469 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0083 | 0.6456 | 0.6456 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0083 | 0.6456 | 0.6456 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0083 | 0.6456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.52 | 0.52 |
Brugia malayi | nuclear receptor NHR-88 | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | coup transcription factor | 0.0083 | 0.6456 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0083 | 0.6456 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0083 | 0.6456 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0083 | 0.6456 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1588 | 0.1588 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0083 | 0.6456 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | nuclear hormone receptor | 0.0039 | 0.224 | 0.3469 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0083 | 0.6456 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0083 | 0.6456 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0039 | 0.224 | 0.3469 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0039 | 0.224 | 0.3469 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0083 | 0.6456 | 0.6456 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0083 | 0.6456 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0083 | 0.6456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.8313 | 0.8313 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1588 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0083 | 0.6456 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0083 | 0.6456 | 1 |
Brugia malayi | steroid hormone receptor | 0.0083 | 0.6456 | 0.6456 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0039 | 0.224 | 0.3469 |
Brugia malayi | ecdysteroid receptor | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.8313 | 0.8313 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1588 | 0.1588 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0083 | 0.6456 | 1 |
Onchocerca volvulus | 0.0083 | 0.6456 | 1 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0083 | 0.6456 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0083 | 0.6456 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0039 | 0.224 | 0.224 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0083 | 0.6456 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0083 | 0.6456 | 0.6456 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1588 | 0.2459 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0039 | 0.224 | 0.3469 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0044 | 0.2691 | 0.4168 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1588 | 0.2459 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0083 | 0.6456 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0039 | 0.224 | 0.3469 |
Schistosoma mansoni | nuclear hormone receptor | 0.0083 | 0.6456 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0039 | 0.224 | 0.3469 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0083 | 0.6456 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1588 | 0.2459 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.52 | 0.8054 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1588 | 0.1588 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0083 | 0.6456 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | ecdysone receptor | 0.0039 | 0.224 | 0.224 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0039 | 0.224 | 0.3469 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0039 | 0.224 | 0.3469 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0083 | 0.6456 | 0.6456 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0039 | 0.224 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.224 | 0.224 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0083 | 0.6456 | 0.6456 |
Brugia malayi | hypothetical protein | 0.0044 | 0.2691 | 0.2691 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0083 | 0.6456 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.8313 | 0.8313 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.8313 | 0.8313 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0083 | 0.6456 | 0.6456 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of human cAMP-dependent protein kinase (PKA) | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Protein kinase C alpha | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Rho-dependent protein kinase-II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of rat Calcium/calmodulin-dependent protein kinase type II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human c-Jun N-terminal kinase-1 alpha1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of rat c-Jun N-terminal kinase-3 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human lymphocyte protein tyrosine kinase Lck at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Mitogen-activated protein kinase 2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human cAMP-dependent protein kinase (PKA) | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Protein kinase C alpha | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Rho-dependent protein kinase-II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of rat Calcium/calmodulin-dependent protein kinase type II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human c-Jun N-terminal kinase-1 alpha1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of rat c-Jun N-terminal kinase-3 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human lymphocyte protein tyrosine kinase Lck at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Mitogen-activated protein kinase 2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human c-Jun N-terminal kinase-2 alpha2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human Mitogen-activated protein kinase 1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human c-Jun N-terminal kinase-2 alpha2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human Mitogen-activated protein kinase 1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 3 % | Inhibition of human Glycogen synthase kinase-3 beta at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 3 % | Inhibition of human Glycogen synthase kinase-3 beta at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 4 % | Inhibition of human Mitogen activated protein kinase kinase 1 (MEK1) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 4 % | Inhibition of human Mitogen activated protein kinase kinase 1 (MEK1) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 5 % | Inhibition of human RAF proto-oncogene serine/threonine-protein kinase at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 5 % | Inhibition of human Protein kinase B alpha at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 5 % | Inhibition of human RAF proto-oncogene serine/threonine-protein kinase at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 5 % | Inhibition of human Protein kinase B alpha at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 11 % | Inhibition of human stress-activated protein kinase-2 alpha (p38 MAP-kinase) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 11 % | Inhibition of human stress-activated protein kinase-2 alpha (p38 MAP-kinase) at 30 uM | ChEMBL. | 15689155 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.