Detailed information for compound 312619

Basic information

Technical information
  • TDR Targets ID: 312619
  • Name: (2E)-2-[2-(1-adamantylamino)-1-fluoroethylide ne]cyclopentane-1-carbonitrile
  • MW: 288.403 | Formula: C18H25FN2
  • H donors: 1 H acceptors: 1 LogP: 3.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1CCC/C/1=C(/CNC12CC3CC(C2)CC(C1)C3)\F
  • InChi: 1S/C18H25FN2/c19-17(16-3-1-2-15(16)10-20)11-21-18-7-12-4-13(8-18)6-14(5-12)9-18/h12-15,21H,1-9,11H2/b17-16+
  • InChiKey: JEDUEOGDJJUJOB-WUKNDPDISA-N  

Network

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Synonyms

  • (2E)-2-[2-(1-adamantylamino)-1-fluoro-ethylidene]cyclopentanecarbonitrile
  • (2E)-2-[2-(1-adamantylamino)-1-fluoroethylidene]cyclopentanecarbonitrile
  • (2E)-2-[2-(1-adamantylamino)-1-fluoro-ethylidene]cyclopentane-1-carbonitrile
  • (2E)-2-[2-(1-adamantylamino)-1-fluoroethylidene]-1-cyclopentanecarbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis epidermal growth factor receptor 0.0123 0.1146 0.1134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0067 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0067 0.0054
Schistosoma mansoni tyrosine kinase 0.0073 0.0622 0.0609
Onchocerca volvulus 0.0051 0.0392 0.1629
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0048 0.0585
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0048 0.0585
Loa Loa (eye worm) TK/EGFR protein kinase 0.0229 0.226 0.226
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0281 0.1134
Schistosoma mansoni amine GPCR 0.002 0.0067 0.0054
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Schistosoma mansoni biogenic amine receptor 0.002 0.0067 0.0054
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0067 0.0054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0067 0.0054
Schistosoma mansoni tyrosine kinase 0.0073 0.0622 0.0609
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0048 0.0378
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0054
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0035
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0027 0.0014
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0392 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0266 0.0253
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0067 0.0054
Echinococcus multilocularis fmrfamide receptor 0.002 0.0067 0.0054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0067 0.0149
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Onchocerca volvulus 0.002 0.0067 0.018
Brugia malayi Dopamine receptor protein 1 0.002 0.0067 0.0149
Schistosoma mansoni amine GPCR 0.002 0.0067 0.0054
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptide receptor 0.002 0.0067 0.0054
Onchocerca volvulus 0.0051 0.0392 0.1629
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0048 0.0585
Echinococcus granulosus serotonin receptor 0.002 0.0067 0.0054
Echinococcus multilocularis 0.0019 0.0048 0.0035
Echinococcus granulosus epidermal growth factor receptor 0.0123 0.1146 0.1134
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0067 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Echinococcus multilocularis JmjC domain containing protein 4 0.0024 0.0109 0.0095
Loa Loa (eye worm) cytochrome P450 0.0019 0.0048 0.0048
Echinococcus multilocularis chromobox protein 1 0.0068 0.0563 0.055
Brugia malayi larval opioid receptor 0.002 0.0067 0.0149
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0067 0.0054
Brugia malayi jmjC domain containing protein 0.0024 0.0109 0.024
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0281 0.1134
Schistosoma mansoni intermediate filament proteins 0.0026 0.0128 0.0114
Echinococcus multilocularis insulin receptor 0.0073 0.0622 0.0609
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi Heterochromatin protein 1 0.0068 0.0563 0.1246
Onchocerca volvulus 0.004 0.0273 0.1099
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.0622 0.0622
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0273 0.026
Echinococcus granulosus chromobox protein 1 0.0068 0.0563 0.055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0027 0.0014
Toxoplasma gondii aminopeptidase n, putative 0.0051 0.0392 0.6454
Echinococcus granulosus g protein coupled receptor 0.002 0.0067 0.0054
Echinococcus multilocularis serotonin receptor 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0067 0.0054
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0048 0.0585
Brugia malayi G-protein coupled receptor 0.002 0.0067 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0027 0.00000022547
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0048 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.02 0.0443
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi jmjC domain containing protein 0.0091 0.0812 0.1797
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0067 0.0054
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0051 0.0392 0.0379
Schistosoma mansoni biogenic amine receptor 0.002 0.0067 0.0054
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0592 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0048 0.0378
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0048 0.0585
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0027 0.0014
Echinococcus granulosus sex peptide receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0392 0.6454
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0048 0.0585
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0392 0.1629
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0251 0.0999
Echinococcus multilocularis epidermal growth factor receptor 0.0229 0.226 0.2249
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0521 0.0521
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0392 0.6454
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0051 0.0392 1
Schistosoma mansoni amine GPCR 0.002 0.0067 0.0054
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0048 0.0585
Brugia malayi TATA binding protein associated factor 0.0051 0.0392 0.0867
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0392 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0027 0.00000022547
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0592 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0048 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0048 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0135 0.048
Echinococcus multilocularis jumonji domain containing 1A 0.0024 0.0109 0.0095
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0027 0.0014
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0473
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0067 0.0054
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0067 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0135 0.048
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0392 0.6454
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0051 0.0392 0.0379
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0563 0.2392
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0592 0.058
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Echinococcus granulosus lysine specific demethylase 6a 0.0024 0.0109 0.0095
Onchocerca volvulus 0.002 0.0067 0.018
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0048 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0067 0.0054
Brugia malayi jmjC domain containing protein 0.0024 0.0109 0.024
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0024 0.0109 0.144
Echinococcus multilocularis aminopeptidase N 0.0051 0.0392 0.0379
Loa Loa (eye worm) hypothetical protein 0.0051 0.0392 0.0392
Schistosoma mansoni amine GPCR 0.002 0.0067 0.0054
Echinococcus granulosus orexin receptor type 2 0.002 0.0067 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0067 0.0054
Schistosoma mansoni lamin 0.0026 0.0128 0.0114
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0109 0.0109
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0392 0.6454
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0067 0.018
Brugia malayi Cytochrome P450 family protein 0.0019 0.0048 0.0107
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0592 0.058
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0067 0.0067
Brugia malayi Serotonin receptor 0.002 0.0067 0.0149
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0067 0.0054
Echinococcus granulosus chromobox protein 1 0.0068 0.0563 0.055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0067 0.0054
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.015 0.0137
Onchocerca volvulus 0.002 0.0067 0.018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0281 0.1134
Brugia malayi G-protein coupled receptor 0.002 0.0067 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0361 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0048 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0157
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0067 0.0054
Echinococcus multilocularis 0.0071 0.0598 0.0585
Echinococcus multilocularis fmrfamide receptor 0.002 0.0067 0.0054
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0392 1
Schistosoma mansoni neuropeptide receptor 0.002 0.0067 0.0054
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0048 0.0585
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0067 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0048 1
Schistosoma mansoni hypothetical protein 0.0033 0.02 0.0187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0067 0.0054
Brugia malayi sulfakinin receptor protein 0.002 0.0067 0.0149
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0067 0.0054
Brugia malayi AKH receptor 0.002 0.0067 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi jmjC domain containing protein 0.0024 0.0109 0.024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0067 0.0054
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0048 0.0585
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0466 0.0466
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0027 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.0999
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Schistosoma mansoni neuropeptide receptor 0.002 0.0067 0.0054
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0392 0.1629
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0048 1
Brugia malayi hypothetical protein 0.0054 0.0418 0.0925
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0392 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0051 0.0392 1
Echinococcus granulosus phd:f box containing protein 0.0024 0.0109 0.0095
Schistosoma mansoni aminopeptidase A (M01 family) 0.0051 0.0392 0.0379
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Brugia malayi hypothetical protein 0.0051 0.0392 0.0867
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0067 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0048 0.0585
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0027 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0091 0.0812 0.0799
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0146 0.0132
Schistosoma mansoni chromobox protein 0.0068 0.0563 0.055
Brugia malayi intermediate filament protein 0.0026 0.0128 0.0282
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0157 0.0144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0123
Brugia malayi Dopamine receptor 0.002 0.0067 0.0149
Schistosoma mansoni tyrosine kinase 0.0123 0.1146 0.1134
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0048 0.0378
Toxoplasma gondii aminopeptidase N protein 0.0051 0.0392 0.6454
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0109 0.0109
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0592 0.1311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0091 0.0812 0.0812
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0128 0.0282
Onchocerca volvulus 0.002 0.0067 0.018
Onchocerca volvulus 0.002 0.0067 0.018
Brugia malayi Pre-SET motif family protein 0.0202 0.1974 0.4369
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Schistosoma mansoni opsin-like receptor 0.002 0.0067 0.0054
Schistosoma mansoni histamine h1 receptor 0.002 0.0067 0.0054
Echinococcus granulosus g protein coupled receptor 0.002 0.0067 0.0054
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Onchocerca volvulus 0.002 0.0067 0.018
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0054
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0048 1
Brugia malayi Dopamine receptor protein 2 0.002 0.0067 0.0149
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0024 0.0109 0.144
Schistosoma mansoni tyrosine kinase 0.0122 0.1132 0.112
Schistosoma mansoni phd/f-box containing protein 0.0024 0.0109 0.0095
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0392 0.6454
Onchocerca volvulus 0.0026 0.0128 0.0449
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.015 0.0137
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.015 0.1425 0.1414
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0067 0.0054
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0392 0.6454
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Onchocerca volvulus 0.002 0.0067 0.018
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.0622 0.0609
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0157 0.2298
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0014 0.003
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0054
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0048 0.0585
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0064 0.0522 0.0522
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0067 0.0067
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0027 0.0014
Echinococcus multilocularis musashi 0.0026 0.0128 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0048 1
Echinococcus granulosus somatostatin receptor 0.002 0.0067 0.0054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0067 0.0149
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1974 0.1974
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0067 0.0054
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0392 0.6454
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0048 1
Onchocerca volvulus 0.002 0.0067 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.0812 0.0799
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0048 0.0585
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0048 0.0378
Echinococcus granulosus jumonji domain containing 1A 0.0024 0.0109 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0048 0.0585
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.0622 0.0609
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0067 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0048 1
Leishmania major hypothetical protein, conserved 0.0024 0.0109 0.144
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0067 0.0054
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0067 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0067 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0965 1 1
Echinococcus granulosus g-protein coupled receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0048 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0067 0.0054
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0048 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.2052 0.2052
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0473
Loa Loa (eye worm) peptidase family M1 containing protein 0.0051 0.0392 0.0392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Schistosoma mansoni amine GPCR 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0067 0.0054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0473
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0048 0.0585
Echinococcus granulosus JmjC domain containing protein 4 0.0024 0.0109 0.0095
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0067 0.0149
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0067 0.0054
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0067 0.0054
Onchocerca volvulus 0.0059 0.0473 0.199
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0067 0.0054
Echinococcus multilocularis g protein coupled receptor 0.002 0.0067 0.0054
Schistosoma mansoni chromobox protein 0.0068 0.0563 0.055
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni adenoreceptor 0.002 0.0067 0.0054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Schistosoma mansoni biogenic amine receptor 0.002 0.0067 0.0054
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0592 0.058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0144
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0067 0.0054
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0048 0.0378
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Leishmania major cytochrome p450-like protein 0.0019 0.0048 0.0378
Onchocerca volvulus 0.002 0.0067 0.018
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.015 0.1425 0.1414
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0067 0.0054
Echinococcus multilocularis lamin dm0 0.0026 0.0128 0.0114
Echinococcus multilocularis g protein coupled receptor 0.002 0.0067 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0067 0.0054
Trypanosoma brucei aminopeptidase, putative 0.0051 0.0392 0.6454
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.2052 0.2041
Schistosoma mansoni tyrosine kinase 0.0122 0.1132 0.112
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0054
Leishmania major cytochrome p450-like protein 0.0019 0.0048 0.0378
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0109 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Brugia malayi Melatonin receptor type 1A 0.002 0.0067 0.0149
Onchocerca volvulus 0.0051 0.0392 0.1629
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0157 0.0144
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0392 0.1629
Onchocerca volvulus 0.002 0.0067 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0109 0.0109
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0027 0.006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0067 0.0054
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0067 0.0054
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0048 0.0378
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0048 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0157 0.0144
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0392 0.6454
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0014 0.003
Loa Loa (eye worm) TATA binding protein associated factor 0.0051 0.0392 0.0392
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0024 0.0109 0.0095
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0067 0.0054
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0067 0.0054
Brugia malayi Furin-like cysteine rich region family protein 0.0229 0.226 0.5002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0157 0.0144
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Onchocerca volvulus 0.002 0.0067 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0048 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0392 0.0392
Schistosoma mansoni myosin xvIII 0.002 0.0067 0.0054
Echinococcus multilocularis neuropeptide receptor 0.002 0.0067 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0563 0.2392
Onchocerca volvulus 0.003 0.0165 0.0615
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0027 0.006
Brugia malayi Cytochrome P450 family protein 0.0019 0.0048 0.0107
Echinococcus granulosus aminopeptidase N 0.0051 0.0392 0.0379
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Brugia malayi Protein kinase domain containing protein 0.0073 0.0622 0.1377
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0048 1
Loa Loa (eye worm) aminopeptidase N 0.0051 0.0392 0.0392
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0067 0.0054
Echinococcus granulosus lamin dm0 0.0026 0.0128 0.0114
Echinococcus multilocularis lamin 0.0026 0.0128 0.0114
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0392 0.0867
Loa Loa (eye worm) hypothetical protein 0.0024 0.0109 0.0109
Schistosoma mansoni jumonji domain containing protein 0.0131 0.1225 0.1213
Brugia malayi jmjC domain containing protein 0.0024 0.0109 0.024
Brugia malayi Serotonin receptor 0.002 0.0067 0.0149
Echinococcus multilocularis serotonin receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Toxoplasma gondii aminopeptidase N, putative 0.0051 0.0392 0.6454
Echinococcus multilocularis somatostatin receptor 0.002 0.0067 0.0054
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0067 0.0054
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0109 0.144
Echinococcus multilocularis sex peptide receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0109 0.0109
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0048 0.0585
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0067 0.0054
Brugia malayi G protein-coupled receptor 0.002 0.0067 0.0149
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0067 0.0054
Echinococcus multilocularis lysine specific demethylase 5A 0.0091 0.0812 0.0799
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0067 0.0067
Echinococcus granulosus peregrin 0.0028 0.015 0.0137
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0266 0.0253
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Echinococcus multilocularis peregrin 0.0028 0.015 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0067 0.0149
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0965 1 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0157 0.0347
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0392 0.6454
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0067 0.0054
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0067 0.0054
Onchocerca volvulus 0.002 0.0067 0.018
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0067 0.0054
Brugia malayi cytochrome P450 0.0019 0.0048 0.0107
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi neuropeptide F receptor 0.002 0.0067 0.0149
Echinococcus granulosus g protein coupled receptor 0.002 0.0067 0.0054
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0067 0.0149
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0048 0.0378
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0048 0.0585
Schistosoma mansoni phosphatidylserine receptor 0.0024 0.0109 0.0095
Schistosoma mansoni tyrosine kinase 0.0122 0.1132 0.112
Brugia malayi RE15519p 0.002 0.0067 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0048 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Entamoeba histolytica aminopeptidase, putative 0.0051 0.0392 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0157 0.3561
Schistosoma mansoni neuropeptide receptor 0.002 0.0067 0.0054
Brugia malayi hypothetical protein 0.0051 0.0392 0.0867
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi Cytochrome P450 family protein 0.0019 0.0048 0.0107
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0067 0.0054
Onchocerca volvulus 0.002 0.0067 0.018
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0392 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0027 0.0014
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0067 0.0054
Schistosoma mansoni opsin-like receptor 0.002 0.0067 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Echinococcus granulosus epidermal growth factor receptor 0.0229 0.226 0.2249
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi ORL1-like opioid receptor 0.002 0.0067 0.0149
Onchocerca volvulus 0.002 0.0067 0.018
Echinococcus multilocularis orexin receptor type 2 0.002 0.0067 0.0054
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0067 0.0054
Schistosoma mansoni neuropeptide receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi follicle stimulating hormone receptor 0.002 0.0067 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus neuropeptide receptor 0.002 0.0067 0.0054
Trypanosoma cruzi Aminopeptidase M1, putative 0.0051 0.0392 0.6454
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0165
Schistosoma mansoni lamin 0.0026 0.0128 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0048 0.0585
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0048 0.0048
Echinococcus multilocularis chromobox protein 1 0.0068 0.0563 0.055
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0965 1 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0051 0.0392 0.0379
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi Cytochrome P450 family protein 0.0019 0.0048 0.0107
Brugia malayi chromobox protein homolog 3 0.0038 0.0251 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0048 0.0378
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi Bromodomain containing protein 0.0028 0.015 0.0332
Schistosoma mansoni protein phosphatase 2C 0.0024 0.0109 0.0095
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0392 0.0379
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0048 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0067 0.0054
Schistosoma mansoni opsin-like receptor 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0067 0.0054
Giardia lamblia PHD finger protein 15 0.0028 0.015 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0067 0.0054
Echinococcus granulosus intermediate filament protein 0.0026 0.0128 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0048 1
Onchocerca volvulus 0.023 0.2267 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0392 0.0867
Echinococcus granulosus hypothetical protein 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0054 0.0418 0.0418
Onchocerca volvulus 0.0026 0.0128 0.0449
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0067 0.0054
Plasmodium vivax JmjC domain containing protein 0.0024 0.0109 0.2232
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0109 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Leishmania major cytochrome p450-like protein 0.0019 0.0048 0.0378
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0067 0.0149
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0067 0.0054
Onchocerca volvulus Alhambra homolog 0.0028 0.015 0.0548
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.02
Brugia malayi jmjC domain containing protein 0.015 0.1425 0.3155
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0067 0.0067
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0051 0.0392 0.0379
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0067 0.0067
Brugia malayi neuropeptide F receptor 0.002 0.0067 0.0149
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.2052 0.2041
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0067 0.0054
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0024 0.0109 0.144
Schistosoma mansoni hypothetical protein 0.0028 0.015 0.0137
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0067 0.0054
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.015 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0048 0.0035
Brugia malayi GnHR receptor homolog 0.002 0.0067 0.0149
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Echinococcus multilocularis phd:f box containing protein 0.0024 0.0109 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0028 0.015 0.3366
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0592 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.2052 0.2041
Echinococcus granulosus insulin receptor 0.0073 0.0622 0.0609
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0048 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0024 0.0109 0.2232
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0392 0.6454
Schistosoma mansoni cytochrome P450 0.0019 0.0048 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0048 1
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0563 0.0563
Onchocerca volvulus 0.002 0.0067 0.018
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0067 0.018
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0067 0.0149
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0062 0.0507 0.0507
Plasmodium falciparum phd finger protein, putative 0.0028 0.015 0.3366
Onchocerca volvulus 0.002 0.0067 0.018
Trichomonas vaginalis set domain proteins, putative 0.023 0.2267 1
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0067 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0361 0.0361
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0027 0.0014
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0048 0.0378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0128 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0048 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Echinococcus granulosus fmrfamide receptor 0.002 0.0067 0.0054
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0392 0.0867
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0392 0.6454
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0361
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.015 0.015
Echinococcus multilocularis lysine specific demethylase 6a 0.0024 0.0109 0.0095
Brugia malayi putative neuropeptide receptor 0.002 0.0067 0.0149
Brugia malayi hypothetical protein 0.002 0.0067 0.0149
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0123 0.1146 0.1134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Brugia malayi PHD-finger family protein 0.0028 0.015 0.0332
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0048 1
Echinococcus granulosus allatostatin A receptor 0.002 0.0067 0.0054
Echinococcus granulosus neuropeptide s receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0067 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0128
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0067 0.0054
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.2052 0.9042
Echinococcus multilocularis g protein coupled receptor 0.002 0.0067 0.0054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.0999
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.0812 0.0799
Echinococcus multilocularis allatostatin A receptor 0.002 0.0067 0.0054
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0067 0.0054
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0109 0.144
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0392 0.6454
Echinococcus granulosus lamin 0.0026 0.0128 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.015 0.2173
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0067 0.0054
Schistosoma mansoni tyrosine kinase 0.0229 0.226 0.2249
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0109 0.0095
Schistosoma mansoni tyrosine kinase 0.0123 0.1146 0.1134
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0048 0.0585
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0392 0.6454
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0048 0.0585
Mycobacterium leprae putative cytochrome p450 0.0019 0.0048 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.015 0.2173
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0048 0.0585
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0361 0.0799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0067 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0067 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0128 0.0128
Echinococcus multilocularis neuropeptide receptor 0.002 0.0067 0.0054
Brugia malayi hypothetical protein 0.0444 0.4518 1
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Onchocerca volvulus 0.002 0.0067 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0392 0.6454
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.2052 0.4542

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 15 uM Inhibitory concentration against human Dipeptidyl-peptidase IV ChEMBL. 15771423
IC50 (binding) = 15 uM Inhibitory concentration against human Dipeptidyl-peptidase IV ChEMBL. 15771423
IC50 (binding) > 100 uM Inhibitory concentration against human Dipeptidyl-peptidase II ChEMBL. 15771423
IC50 (binding) > 100 uM Inhibitory concentration against human Dipeptidyl-peptidase II ChEMBL. 15771423

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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