TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.769 | Formula: C33H44N10
H donors: 2 H acceptors: 3 LogP: 3.37 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CN1C2N=C(CNCCCCCCCNCc3ccc4c(n3)n(C)c3c(n4C)cccn3)C=CC2N(c2c1nccc2)C
InChi: 1S/C33H44N10/c1-40-26-12-10-20-36-30(26)42(3)32-28(40)16-14-24(38-32)22-34-18-8-6-5-7-9-19-35-23-25-15-17-29-33(39-25)43(4)31-27(41(29)2)13-11-21-37-31/h10-17,20-21,28,32,34-35H,5-9,18-19,22-23H2,1-4H3
InChiKey: CDAJXILITMUZNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0016	0.012	0.0105
Schistosoma mansoni	ets	0.0012	0.0075	0.0279
Echinococcus granulosus	geminin	0.0191	0.2046	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0053	0.0006
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0075	0.0021
Echinococcus multilocularis	Ankyrin	0.0016	0.0124	0.0071
Brugia malayi	Uncoordinated protein 44	0.0016	0.0123	0.026
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0209	0.0413
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0123	0.0188
Schistosoma mansoni	hypothetical protein	0.0016	0.012	0.0449
Onchocerca volvulus		0.0034	0.0315	0.0931
Mycobacterium tuberculosis	Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra	0.0608	0.6634	1
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0075	0.0021
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0016	0.012	0.0105
Loa Loa (eye worm)	CYP4Cod1	0.0026	0.0229	0.0464
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0016	0.012	0.0105
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0229	0.0693
Schistosoma mansoni	hypothetical protein	0.0191	0.2046	0.766
Echinococcus granulosus	cytochrome P450 2K1	0.0016	0.012	0.0333
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0016	0.012	0.0105
Brugia malayi	Ets-domain containing protein	0.0082	0.0842	0.2862
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0012	0.0075	0.0106
Schistosoma mansoni	hypothetical protein	0.0012	0.0075	0.0279
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0016	0.012	0.0105
Echinococcus multilocularis	ets variant gene 4	0.0012	0.0075	0.0021
Brugia malayi	Pre-SET motif family protein	0.0235	0.2525	0.8947
Echinococcus granulosus	dual specificity	0.0101	0.1051	0.5007
Entamoeba histolytica	protein kinase, putative	0.0101	0.1051	1
Echinococcus multilocularis	netrin receptor unc 5	0.0016	0.0123	0.0069
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0054	0.0007
Echinococcus granulosus	Ankyrin	0.0016	0.0124	0.0354
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0315	0.1178
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0012	0.0075	0.0021
Schistosoma mansoni	ets-related	0.0012	0.0075	0.0279
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0012	0.0075	0.0062
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0075	0.0106
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0016	0.012	0.0105
Schistosoma mansoni	hypothetical protein	0.0012	0.0075	0.0279
Plasmodium vivax	SET domain protein, putative	0.0034	0.0315	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0016	0.012	0.0105
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0016	0.012	0.0105
Echinococcus multilocularis	geminin	0.0191	0.2046	0.2003
Loa Loa (eye worm)	hypothetical protein	0.01	0.1045	0.2598
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0026	0.0229	0.027
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.02	0.2145	1
Schistosoma mansoni	ets-related	0.0248	0.2671	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0075	0.0062
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0016	0.012	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0315	0.0689
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0124	0.0465
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0229	0.0643
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0016	0.012	0.0105
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0016	0.012	0.0105
Mycobacterium leprae	PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA	0.0608	0.6634	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0016	0.012	0.0166
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0315	0.131
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0209	0.078
Brugia malayi	Ets-domain containing protein	0.0012	0.0075	0.0086
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0209	0.0559
Brugia malayi	Cytochrome P450 family protein	0.0016	0.012	0.025
Mycobacterium ulcerans	methylated-DNA--protein-cysteine methyltransferase Ogt	0.0608	0.6634	1
Echinococcus granulosus	netrin receptor unc 5	0.0016	0.0123	0.0347
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0106	0.0052
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0209	0.0572
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0016	0.012	0.0105
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0101	0.1051	0.4687
Echinococcus multilocularis	protein C ets 2	0.0012	0.0075	0.0021
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0106	0.0262
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0016	0.012	0.0105
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0016	0.012	0.0105
Loa Loa (eye worm)	cytochrome P450	0.0016	0.012	0.0181
Schistosoma mansoni	lamin	0.003	0.0279	0.1044
Echinococcus multilocularis	dual specificity	0.0101	0.1051	0.1003
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0315	0.1178
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.2525	0.6465
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0356	0.1105
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0229	0.0693
Echinococcus granulosus	GA binding protein alpha chain	0.0082	0.0842	0.396
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0016	0.012	0.0166
Loa Loa (eye worm)	hypothetical protein	0.001	0.0054	0.0007
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0016	0.012	0.0105
Trichomonas vaginalis	set domain proteins, putative	0.0267	0.2882	1
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0123	0.0459
Echinococcus granulosus	ETS transcription factor Elf 5	0.0012	0.0075	0.0106
Leishmania major	cytochrome p450-like protein	0.0016	0.012	0.0166
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0123	0.0263
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0012	0.0075	0.0062
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0054	1
Brugia malayi	Fli-1 protein	0.0248	0.2671	0.9473
Treponema pallidum	methylated-DNA-protein-cysteine S-methyltransferase (dat)	0.02	0.2145	0.5
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0012	0.0075	0.0021
Echinococcus granulosus	intermediate filament protein	0.003	0.0279	0.113
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0075	0.0106
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0209	0.0559
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0016	0.012	0.0105
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0596
Entamoeba histolytica	hypothetical protein	0.0101	0.1051	1
Echinococcus granulosus	ETS transcription factor Elf 1	0.0012	0.0075	0.0106
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0016	0.012	0.0105
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0123	0.0069
Echinococcus multilocularis	musashi	0.003	0.0279	0.0226
Echinococcus multilocularis	GA binding protein alpha chain	0.0082	0.0842	0.0793
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0016	0.012	0.0354
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0279	0.0824
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0016	0.012	0.0105
Loa Loa (eye worm)	hypothetical protein	0.003	0.0273	0.058
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0016	0.012	0.0105
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0016	0.012	0.0105
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0315	0.1178
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0279	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0106	0.0144
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0123	0.026
Leishmania major	hypothetical protein, conserved	0.02	0.2145	1
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0012	0.0075	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0101	0.1051	0.3617
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0315	0.0262
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0016	0.012	0.0105
Echinococcus multilocularis	lamin dm0	0.003	0.0279	0.0226
Leishmania major	cytochrome p450-like protein	0.0016	0.012	0.0166
Schistosoma mansoni	netrin receptor unc5	0.0016	0.0123	0.0459
Loa Loa (eye worm)	D-ets-2 protein	0.0012	0.0075	0.0062
Entamoeba histolytica	protein kinase, putative	0.0101	0.1051	1
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.1051	0.3936
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.0356	0.0799
Brugia malayi	follicle stimulating hormone receptor	0.0261	0.2816	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0016	0.012	0.0105
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0229	0.0643
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0083	0.0858	0.4036
Brugia malayi	transcription factor E74 isoform	0.0012	0.0075	0.0086
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0101	0.1051	0.4687
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0192
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0016	0.012	0.0105
Brugia malayi	cytochrome P450	0.0016	0.012	0.025
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.02	0.2145	1
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0128	0.028
Chlamydia trachomatis	methylated-DNA protein-cysteine methyltransferase	0.02	0.2145	0.5
Echinococcus granulosus	death domain containing protein	0.0016	0.0123	0.0347
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0315	0.0262
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0279	0.0596
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0016	0.012	0.0105
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0123	0.0347
Schistosoma mansoni	lamin	0.003	0.0279	0.1044
Loa Loa (eye worm)	hypothetical protein	0.01	0.1045	0.2598
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0016	0.012	0.3811
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0016	0.012	0.0166
Schistosoma mansoni	gabp alpha	0.0082	0.0842	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0014	0.01	0.0128
Schistosoma mansoni	DNA helicase recq5	0.001	0.0054	0.0201
Brugia malayi	DNA-binding protein D-ETS-3	0.0012	0.0075	0.0086
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0209	0.0156
Schistosoma mansoni	elf1	0.0012	0.0075	0.0279
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0016	0.012	0.0105
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0082	0.0842	0.2068
Leishmania major	cytochrome p450-like protein	0.0026	0.0229	0.0693
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0016	0.012	0.0105
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0016	0.012	0.0105
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0016	0.012	0.0105
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0229	0.0464
Brugia malayi	Death domain containing protein	0.0016	0.0123	0.026
Onchocerca volvulus		0.0267	0.2883	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0054	0.001
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0054	0.001
Onchocerca volvulus	Netrin receptor homolog	0.0016	0.0123	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0075	0.0062
Trichomonas vaginalis	methylated-DNA--protein-cysteine methyltransferase, putative	0.02	0.2145	0.7398
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0016	0.012	0.0105
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0016	0.012	0.0105
Loa Loa (eye worm)	hypothetical protein	0.007	0.0712	0.1728
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0054	0.1703
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0016	0.012	0.0105
Echinococcus granulosus	protein C ets 2	0.0012	0.0075	0.0106
Brugia malayi	hypothetical protein	0.0137	0.1454	0.5073
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0086	0.0815
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0153	0.0574
Brugia malayi	Pre-SET motif family protein	0.0034	0.0315	0.0954
Schistosoma mansoni	cytochrome P450	0.0016	0.012	0.0449
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0315	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0177	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0016	0.012	0.0105
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0054	0.1703
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0016	0.012	0.0166
Trypanosoma brucei	hypothetical protein, conserved	0.0081	0.0839	0.7807
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0229	0.0464
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0083	0.0858	0.0808
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.1051	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0016	0.012	0.0105
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0016	0.012	0.0105
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0016	0.012	0.0105
Schistosoma mansoni	intermediate filament proteins	0.003	0.0279	0.1044
Echinococcus multilocularis	lamin	0.003	0.0279	0.0226
Trypanosoma brucei	cytochrome P450, putative	0.0026	0.0229	0.1479
Mycobacterium ulcerans	DNA-methyltransferase (modification methylase)	0.0081	0.0839	0.1198
Brugia malayi	Ets-domain containing protein	0.0082	0.0842	0.2862
Echinococcus granulosus	ewsr:fli fusion protein type	0.0012	0.0075	0.0106
Brugia malayi	intermediate filament protein	0.003	0.0279	0.0824
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0121	0.3851
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0101	0.1051	0.4687
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0016	0.012	0.0105
Loa Loa (eye worm)	fli-1 protein	0.0248	0.2671	0.6845
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0012	0.0075	0.0021
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0016	0.012	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0155	0.0273
Schistosoma mansoni	hypothetical protein	0.0016	0.0123	0.0459
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0301	0.1242
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0315	0.1178
Schistosoma mansoni	DNA helicase recq1	0.001	0.0054	0.0201
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0016	0.012	0.0105
Echinococcus granulosus	lamin dm0	0.003	0.0279	0.113
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0086	0.0123
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0101	0.1051	1
Schistosoma mansoni	hypothetical protein	0.0191	0.2046	0.766
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0016	0.012	0.0105
Onchocerca volvulus		0.003	0.0279	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0123	0.0188
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0101	0.1051	0.2613
Onchocerca volvulus		0.003	0.0279	0.0805
Echinococcus granulosus	lamin	0.003	0.0279	0.113
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0123	0.019
Loa Loa (eye worm)	hypothetical protein	0.0358	0.3878	1
Echinococcus multilocularis		0.0016	0.012	0.0067
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0016	0.012	0.0105
Loa Loa (eye worm)	ets-domain-containing protein	0.0012	0.0075	0.0062
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0012	0.0075	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.01	0.0128
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0261	0.2816	0.7226

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	NA 0 %	Percentage of L1210 cell line in S-phase of cell cycle at 100 uM; NS = no specific effect (toxic at 5 uM)	ChEMBL.	14761199
IC50 (functional)	= 0.71 uM	Inhibitory concentration against L1210 murine leukemia cell line	ChEMBL.	14761199
IC50 (functional)	= 0.71 uM	Inhibitory concentration against L1210 murine leukemia cell line	ChEMBL.	14761199

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	14761199

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 312695