Detailed information for compound 312803

Basic information

Technical information
  • TDR Targets ID: 312803
  • Name: (2R,3R,4R,5R)-3,4-dihydroxy-N,N'-bis[(1S,2R)- 2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis[ (2E,4E)-5-phenylpenta-2,4-dienoxy]hexanediami de
  • MW: 756.882 | Formula: C46H48N2O8
  • H donors: 6 H acceptors: 6 LogP: 6.01 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C([C@@H]([C@@H]([C@H]([C@H](C(=O)N[C@@H]1[C@H](O)Cc2c1cccc2)OC/C=C/C=C/c1ccccc1)O)O)OC/C=C/C=C/c1ccccc1)N[C@@H]1[C@H](O)Cc2c1cccc2
  • InChi: 1S/C46H48N2O8/c49-37-29-33-23-11-13-25-35(33)39(37)47-45(53)43(55-27-15-3-9-21-31-17-5-1-6-18-31)41(51)42(52)44(56-28-16-4-10-22-32-19-7-2-8-20-32)46(54)48-40-36-26-14-12-24-34(36)30-38(40)50/h1-26,37-44,49-52H,27-30H2,(H,47,53)(H,48,54)/b15-3+,16-4+,21-9+,22-10+/t37-,38-,39+,40+,41-,42-,43-,44-/m1/s1
  • InChiKey: HIOJWRWWICUWBL-KFBKXKRRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,4R,5R)-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxyindan-1-yl]-2,5-bis[(2E,4E)-5-phenylpenta-2,4-dienoxy]hexanediamide
  • (2R,3R,4R,5R)-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E,4E)-5-phenylpenta-2,4-dienoxy]hexanediamide
  • (2R,3R,4R,5R)-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxyindan-1-yl]-2,5-bis[(2E,4E)-5-phenylpenta-2,4-dienoxy]adipamide
  • C2-symmetric compound 18

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum plasmepsin II Starlite/ChEMBL References
Plasmodium falciparum plasmepsin I Starlite/ChEMBL References
Homo sapiens cathepsin D Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin X cathepsin D 412 aa 339 aa 28.9 %
Plasmodium vivax aspartyl protease, putative plasmepsin I 452 aa 368 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0624 0.1408 0.1397
Schistosoma mansoni protein kinase 0.0472 0.0976 0.0965
Trichomonas vaginalis STE family protein kinase 0.0291 0.0465 0.1356
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0222 0.0273 0.0261
Brugia malayi Protein kinase domain containing protein 0.0959 0.2353 0.2344
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis serine:threonine protein kinase N2 0.0621 0.1398 0.1398
Brugia malayi Protein kinase domain containing protein 0.0638 0.1446 0.1436
Echinococcus multilocularis roundabout 2 0.0392 0.0752 0.0752
Echinococcus multilocularis Glutaredoxin protein 5 0.0264 0.0391 0.0391
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0203 0.0218 0.0218
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0337 0.0596 0.3138
Entamoeba histolytica serine/threonine protein kinase, putative 0.0166 0.0114 0.0461
Loa Loa (eye worm) hypothetical protein 0.0184 0.0163 0.0151
Plasmodium vivax aspartyl proteinase, putative 0.0236 0.0311 0.0181
Entamoeba histolytica protein kinase, putative 0.0624 0.1408 0.7642
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Trichomonas vaginalis STE family protein kinase 0.0183 0.0162 0.0409
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0475 0.0985 0.0974
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0264 0.0391 0.0391
Leishmania major protein kinase, putative 0.0181 0.0154 0.0118
Schistosoma mansoni protein kinase 0.0412 0.0808 0.0796
Entamoeba histolytica protein kinase, putative 0.0194 0.0193 0.0897
Schistosoma mansoni hypothetical protein 0.0239 0.0319 0.0307
Schistosoma mansoni atypical protein kinase C 0.0623 0.1405 0.1395
Echinococcus granulosus casein kinase I alpha 0.0232 0.0299 0.0299
Leishmania major protein kinase, putative 0.0215 0.0252 0.0216
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0351 0.0339
Echinococcus multilocularis dual specificity 0.0297 0.0482 0.0482
Onchocerca volvulus 0.017 0.0123 0.0452
Entamoeba histolytica p21-activated kinase 0.02 0.0208 0.0981
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0179 0.0148 0.0112
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0297 0.0482 0.0447
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0461 0.0948 0.0948
Echinococcus granulosus thioredoxin glutathione reductase 0.3665 1 1
Toxoplasma gondii rhoptry neck protein RON9 0.0684 0.1576 0.1545
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0578 0.1276 0.1276
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Schistosoma mansoni slit 0.017 0.0125 0.0113
Entamoeba histolytica PH domain containing protein kinase, putative 0.0257 0.0371 0.1887
Schistosoma mansoni serine/threonine protein kinase 0.0695 0.1607 0.1597
Echinococcus multilocularis casein kinase I alpha 0.0232 0.0299 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0754 0.1773 0.1763
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.127 0.3233 0.3208
Echinococcus multilocularis fat cadherin tumor suppressor 0.037 0.069 0.069
Onchocerca volvulus 0.017 0.0123 0.0452
Plasmodium vivax casein kinase 1, putative 0.0232 0.0299 0.0169
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.127 0.3233 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0183 0.0162 0.0162
Brugia malayi Protein kinase domain containing protein 0.0299 0.0489 0.0477
Echinococcus granulosus casein kinase I alpha 0.0232 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Giardia lamblia Kinase, CMGC MAPK 0.0179 0.0148 0.0034
Brugia malayi basement membrane proteoglycan precursor 0.0203 0.0218 0.0206
Echinococcus multilocularis neuroglian 0.0839 0.2014 0.2014
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0754 0.1773 0.1773
Plasmodium vivax serine/threonine kinase-1, putative 0.0328 0.0571 0.0445
Brugia malayi Hr1 repeat family protein 0.0621 0.1398 0.1388
Echinococcus multilocularis mitogen activated protein kinase 11 0.034 0.0604 0.0604
Schistosoma mansoni tyrosine kinase 0.0443 0.0896 0.0885
Giardia lamblia Kinase, CMGC CK2 0.0214 0.0247 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Echinococcus granulosus casein kinase I delta 0.0232 0.0299 0.0299
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0387 0.0736 0.0736
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0337 0.0596 0.0562
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Loa Loa (eye worm) TK protein kinase 0.0324 0.056 0.0549
Echinococcus granulosus epidermal growth factor receptor 0.0734 0.1717 0.1717
Giardia lamblia NADH oxidase lateral transfer candidate 0.127 0.3233 1
Onchocerca volvulus 0.0189 0.0178 0.0701
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.0948 0.0937
Echinococcus granulosus defective proboscis extension response 0.0669 0.1535 0.1535
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.127 0.3233 0.3208
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0337 0.0596 0.1766
Brugia malayi Myb-like DNA-binding domain containing protein 0.017 0.0123 0.0111
Giardia lamblia High cysteine protein 0.037 0.069 0.1785
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0337 0.0596 0.0585
Schistosoma mansoni serine/threonine kinase 0.0344 0.0615 0.0603
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0502 0.1063 0.1063
Loa Loa (eye worm) cyclin C 0.1531 0.3971 0.3963
Giardia lamblia Kinase, STE STE20 0.0183 0.0162 0.0079
Echinococcus multilocularis expressed conserved protein 0.0178 0.0147 0.0147
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0784 0.1859 0.1849
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Trypanosoma cruzi aurora B kinase, putative 0.025 0.0351 0.0315
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0684 0.1576 0.1566
Trichomonas vaginalis STE family protein kinase 0.0183 0.0162 0.0409
Onchocerca volvulus 0.0191 0.0185 0.0735
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0344 0.0615 0.0615
Schistosoma mansoni tyrosine kinase 0.0608 0.1362 0.1351
Echinococcus granulosus peroxidasin 0.0373 0.0699 0.0699
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0264 0.0391 0.0391
Trypanosoma brucei protein kinase, putative 0.0187 0.0172 0.0136
Brugia malayi Peroxidasin 0.0373 0.0699 0.0687
Brugia malayi Delta serrate ligand family protein 0.037 0.069 0.0679
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Echinococcus granulosus glutamate synthase 0.0337 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0761 0.1793 0.1783
Onchocerca volvulus 0.037 0.069 0.3052
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.0325 0.0314
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Trichomonas vaginalis AGC family protein kinase 0.025 0.0351 0.0999
Echinococcus multilocularis nervana 2 0.0264 0.0391 0.0391
Brugia malayi basement membrane proteoglycan 0.0203 0.0218 0.0206
Trichomonas vaginalis AGC family protein kinase 0.025 0.0351 0.0999
Leishmania major casein kinase II, putative 0.0214 0.0247 0.0211
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0512 0.1091 0.1091
Brugia malayi phosphoinositide-dependent protein kinase I 0.0174 0.0135 0.0123
Schistosoma mansoni notch 0.037 0.069 0.0679
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0429 0.0856 0.0844
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0215 0.0252 0.0252
Echinococcus granulosus tyrosine protein kinase Blk 0.0264 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0305 0.0507 0.0495
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0241 0.0325 0.0196
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0337 0.0596 0.0562
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Schistosoma mansoni titin 0.017 0.0123 0.0111
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Loa Loa (eye worm) AUR protein kinase 0.025 0.0351 0.0339
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0215 0.0252 0.024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.127 0.3233 1
Brugia malayi Protein kinase domain containing protein 0.0177 0.0145 0.0133
Schistosoma mansoni cell adhesion molecule 0.0892 0.2163 0.2154
Plasmodium vivax glycogen synthase kinase 3, putative 0.0275 0.042 0.0292
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Echinococcus multilocularis peroxidasin 0.0373 0.0699 0.0699
Echinococcus multilocularis cyclin dependent kinase 19 0.1043 0.259 0.259
Echinococcus granulosus protein kinase c epsilon type 0.0436 0.0875 0.0875
Brugia malayi Protein kinase domain containing protein 0.0464 0.0954 0.0943
Onchocerca volvulus 0.0305 0.0507 0.2212
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0337 0.0596 0.0596
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0215 0.0252 0.0252
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0328 0.0571 0.0536
Trichomonas vaginalis AGC family protein kinase 0.0182 0.0158 0.0398
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0578 0.1276 0.1243
Echinococcus granulosus down syndrome cell adhesion 0.017 0.0123 0.0123
Schistosoma mansoni protein kinase 0.0183 0.0162 0.015
Giardia lamblia Kinase, NEK 0.0291 0.0465 0.1058
Echinococcus multilocularis tyrosine protein kinase Blk 0.0264 0.039 0.039
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0139 0.0037 0.0031
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0337 0.0596 0.0562
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.037 0.069 0.0679
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Brugia malayi Thioredoxin reductase 0.3665 1 1
Echinococcus granulosus titin 0.017 0.0123 0.0123
Echinococcus multilocularis protein jagged 1 0.037 0.069 0.069
Brugia malayi hypothetical protein 0.0203 0.0218 0.0206
Echinococcus granulosus notch 0.037 0.069 0.069
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0203 0.0218 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0191 0.0185 0.048
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0166 0.0114 0.0102
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.127 0.3233 0.3208
Loa Loa (eye worm) TK protein kinase 0.0264 0.039 0.0379
Loa Loa (eye worm) hypothetical protein 0.0392 0.0752 0.074
Plasmodium falciparum plasmepsin I 0.0236 0.0311 0.0275
Echinococcus granulosus serine:threonine protein kinase 12 B 0.025 0.0351 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0502 0.1063 0.1063
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0159 0.0094 0.0082
Echinococcus multilocularis neurogenic locus protein delta 0.037 0.069 0.069
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0189 0.0178 0.0165
Brugia malayi pregnancy-associated plasma protein-A 0.0684 0.1576 0.1566
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.036 0.0349
Echinococcus granulosus tyrosine protein kinase otk 0.0373 0.0697 0.0697
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.127 0.3233 0.3208
Loa Loa (eye worm) hypothetical protein 0.0174 0.0136 0.0124
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0171 0.0128 0.0128
Onchocerca volvulus 0.0684 0.1576 0.7114
Trichomonas vaginalis CK1 family protein kinase 0.0232 0.0299 0.0837
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.017 0.0123 0.0123
Echinococcus granulosus basement membrane specific heparan sulfate 0.0203 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Src64B 0.0325 0.0561 0.0561
Echinococcus multilocularis tyrosine protein kinase Abl 0.0199 0.0207 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0429 0.0856 0.0844
Echinococcus multilocularis serine:threonine protein kinase N2 0.0277 0.0427 0.0427
Plasmodium falciparum plasmepsin II 0.0236 0.0311 0.0275
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0177 0.0145 0.0108
Schistosoma mansoni notch 0.037 0.069 0.0679
Loa Loa (eye worm) hypothetical protein 0.0222 0.027 0.0258
Brugia malayi Protein kinase domain containing protein 0.0754 0.1773 0.1763
Loa Loa (eye worm) AGC/NDR protein kinase 0.0344 0.0615 0.0603
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Echinococcus multilocularis protein jagged 1 0.037 0.069 0.069
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0309 0.0517 0.0517
Giardia lamblia Kinase, NEK 0.0291 0.0465 0.1058
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0328 0.0571 0.0536
Schistosoma mansoni hypothetical protein 0.0189 0.0178 0.0165
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Trichomonas vaginalis AGC family protein kinase 0.025 0.0351 0.0999
Plasmodium falciparum protein kinase 5 0.0254 0.036 0.0325
Brugia malayi cell division control protein 2 homolog 0.0254 0.036 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0114 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.0332 0.094
Trypanosoma cruzi polo-like protein kinase, putative 0.0578 0.1276 0.1243
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0261 0.0381 0.0346
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0174 0.0135 0.0135
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0166 0.0114 0.0078
Giardia lamblia Kinase, CMGC GSK 0.0275 0.042 0.0912
Schistosoma mansoni serine/threonine protein kinase 0.0578 0.1276 0.1265
Loa Loa (eye worm) hypothetical protein 0.0191 0.0183 0.0171
Plasmodium vivax serine/threonine protein kinase 6, putative 0.025 0.0351 0.0222
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0215 0.0252 0.024
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Echinococcus granulosus protein kinase C gamma type 0.0431 0.0862 0.0862
Loa Loa (eye worm) thioredoxin reductase 0.3665 1 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0214 0.0247 0.0211
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0465 0.0957 0.0946
Brugia malayi Protein kinase domain containing protein 0.0674 0.1547 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.0252 0.0689
Brugia malayi Cyclin C 0.1531 0.3971 0.3963
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0482 0.0471
Onchocerca volvulus 0.0684 0.1576 0.7114
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0232 0.0299 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Loa Loa (eye worm) CDC7 protein kinase 0.0191 0.0185 0.0173
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0215 0.0252 0.0252
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0373 0.0697 0.0697
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0337 0.0596 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Giardia lamblia Kinase, CDC7 0.0191 0.0185 0.0152
Schistosoma mansoni kinase 0.0617 0.1387 0.1377
Plasmodium falciparum calcium-dependent protein kinase 2 0.0215 0.0252 0.0216
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0254 0.036 0.0349
Echinococcus granulosus raf serine:threonine protein kinase 0.0159 0.0092 0.0092
Onchocerca volvulus 0.0668 0.1531 0.6907
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.0218 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0404 0.0392
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0433 0.0867 0.0856
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Loa Loa (eye worm) hypothetical protein 0.0254 0.0363 0.0351
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0712 0.1657 0.1646
Schistosoma mansoni septate junction protein 0.037 0.069 0.0679
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.036 0.1028
Schistosoma mansoni tyrosine kinase 0.0638 0.1446 0.1436
Plasmodium falciparum calcium-dependent protein kinase 5 0.0215 0.0252 0.0216
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0496 0.1045 0.1034
Echinococcus multilocularis tyrosine protein kinase Srms 0.0264 0.039 0.039
Brugia malayi Protein kinase domain containing protein 0.0412 0.0808 0.0796
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0241 0.0325 0.029
Onchocerca volvulus 0.017 0.0125 0.0459
Echinococcus granulosus protein kinase c iota type 0.061 0.1368 0.1368
Echinococcus granulosus leucine rich repeat containing protein 4 0.017 0.0123 0.0123
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0337 0.0596 0.0596
Brugia malayi casein kinase I 0.0232 0.0299 0.0287
Onchocerca volvulus 0.017 0.0123 0.0452
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0337 0.0596 0.0562
Leishmania major hypothetical protein, conserved 0.0337 0.0596 0.0562
Brugia malayi Immunoglobulin I-set domain containing protein 0.0204 0.022 0.0208
Entamoeba histolytica protein kinase , putative 0.025 0.0351 0.1775
Loa Loa (eye worm) hypothetical protein 0.0203 0.0218 0.0206
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Schistosoma mansoni protein kinase 0.0928 0.2265 0.2255
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0166 0.0114 0.0078
Echinococcus granulosus protein jagged 2 0.037 0.069 0.069
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0264 0.039 0.039
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0674 0.1547 0.1537
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0203 0.0218 0.0206
Onchocerca volvulus 0.037 0.069 0.3052
Brugia malayi hypothetical protein 0.0688 0.1589 0.1579
Entamoeba histolytica casein kinase, putative 0.0232 0.0299 0.1487
Mycobacterium tuberculosis Probable oxidoreductase 0.127 0.3233 0.2803
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.0635 0.0624
Trypanosoma cruzi casein kinase II, putative 0.0214 0.0247 0.0211
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0365 0.0676 0.0665
Echinococcus granulosus serine:threonine protein kinase 0.0244 0.0332 0.0332
Echinococcus granulosus neural cadherin 0.037 0.069 0.069
Echinococcus granulosus serine threonine protein kinase nrc 0.0334 0.0589 0.0589
Brugia malayi serine/threonine-protein kinase plk-2 0.0578 0.1276 0.1265
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0239 0.0319 0.0283
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis nervana 2 0.0264 0.0391 0.0391
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0337 0.0596 0.0471
Loa Loa (eye worm) TK/INSR protein kinase 0.0638 0.1446 0.1436
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0337 0.0596 0.0585
Trypanosoma brucei trypanothione reductase 0.3665 1 1
Schistosoma mansoni tyrosine kinase 0.0443 0.0896 0.0885
Brugia malayi protein kinase C II. 0.0436 0.0875 0.0864
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0461 0.0948 0.0948
Brugia malayi Prion-like- 0.017 0.0123 0.0111
Plasmodium falciparum plasmepsin VI 0.0236 0.0311 0.0275
Echinococcus granulosus nervana 2 0.0264 0.0391 0.0391
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Brugia malayi Immunoglobulin I-set domain containing protein 0.0217 0.0257 0.0245
Echinococcus multilocularis Immunoglobulin 0.0669 0.1535 0.1535
Schistosoma mansoni roundabout 0.0373 0.0697 0.0686
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0475 0.0985 0.0985
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Entamoeba histolytica protein kinase, putative 0.0275 0.042 0.2159
Echinococcus granulosus dual specificity 0.0297 0.0482 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0147 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.0571 0.0559
Leishmania major protein kinase A catalytic subunit isoform 2 0.0241 0.0325 0.029
Onchocerca volvulus 0.0684 0.1576 0.7114
Schistosoma mansoni tyrosine kinase 0.0638 0.1446 0.1436
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0483 0.101 0.101
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0241 0.0325 0.029
Entamoeba histolytica protein kinase domain containing protein 0.0214 0.0247 0.1201
Trypanosoma brucei NADH dehydrogenase 0.0337 0.0596 0.0562
Echinococcus granulosus neuroglian 0.0839 0.2014 0.2014
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0199 0.0187
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0337 0.0596 0.1766
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0179 0.0148 0.0112
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0436 0.0875 0.0864
Echinococcus multilocularis cyclin 0.0764 0.1801 0.1801
Echinococcus granulosus tyrosine protein kinase Src42A 0.0197 0.0201 0.0201
Loa Loa (eye worm) AGC/PKA protein kinase 0.0241 0.0325 0.0314
Echinococcus granulosus low density lipoprotein receptor ldl 0.0203 0.0218 0.0218
Giardia lamblia Kinase, CK1 Casein kinase 0.0232 0.0299 0.0521
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0328 0.0571 0.0559
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0337 0.0596 0.0596
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0275 0.042 0.0385
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.035 0.0632 0.0621
Loa Loa (eye worm) hypothetical protein 0.064 0.1453 0.1443
Schistosoma mansoni titin 0.0373 0.0697 0.0686
Echinococcus granulosus twitchin 0.0909 0.2212 0.2212
Onchocerca volvulus 0.0684 0.1576 0.7114
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0462 0.095 0.0938
Echinococcus granulosus neurogenic locus notch protein 0.037 0.069 0.069
Entamoeba histolytica protein kinase, putative 0.0218 0.0259 0.1267
Echinococcus multilocularis dual specificity 0.0297 0.0482 0.0482
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0674 0.1547 0.1537
Loa Loa (eye worm) disorganized muscle protein 1 0.017 0.0123 0.0111
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.127 0.3233 0.3208
Giardia lamblia Kinase, CMGC CLK 0.0328 0.0571 0.1399
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.034 0.0604 0.0569
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Onchocerca volvulus 0.0191 0.0185 0.0735
Echinococcus granulosus dual specificity 0.0261 0.0381 0.0381
Echinococcus granulosus cGMP dependent protein kinase 1 0.0178 0.0147 0.0147
Trypanosoma cruzi casein kinase, putative 0.0232 0.0299 0.0263
Loa Loa (eye worm) AUR protein kinase 0.025 0.0351 0.0339
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1057 0.263 0.263
Echinococcus multilocularis activin receptor type 0.0139 0.0037 0.0037
Echinococcus multilocularis serine:threonine protein kinase 0.0244 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Brugia malayi Fes/CIP4 homology domain containing protein 0.0218 0.0261 0.0249
Echinococcus multilocularis casein kinase I alpha 0.0232 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Giardia lamblia Kinase, CMGC GSK 0.0275 0.042 0.0912
Entamoeba histolytica protein kinase, putative 0.0297 0.0482 0.2504
Echinococcus granulosus hypothetical protein 0.0258 0.0373 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Brugia malayi Temporarily assigned gene name protein 59 0.0239 0.0319 0.0307
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0183 0.0162 0.0162
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0181 0.0154 0.0682
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0328 0.0571 0.0536
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.034 0.0604 0.0569
Echinococcus granulosus N chimaerin 0.0159 0.0094 0.0094
Entamoeba histolytica protein kinase, putative 0.0183 0.0162 0.0728
Brugia malayi Calcium binding EGF domain containing protein 0.037 0.069 0.0679
Entamoeba histolytica protein kinase, putative 0.025 0.0351 0.1775
Loa Loa (eye worm) hypothetical protein 0.0241 0.0325 0.0314
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0472 0.0976 0.0976
Schistosoma mansoni slit 0.0371 0.0692 0.068
Trichomonas vaginalis AGC family protein kinase 0.0365 0.0676 0.2015
Giardia lamblia Kinase, STE STE20 0.0181 0.0154 0.0052
Schistosoma mansoni glutamate synthase 0.0337 0.0596 0.0585
Echinococcus granulosus Protein kinase C brain isozyme 0.0521 0.1115 0.1115
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0754 0.1773 0.1773
Echinococcus granulosus aurora kinase A 0.025 0.0351 0.0351
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Schistosoma mansoni ste20-related kinase 0.0438 0.0882 0.0871
Brugia malayi Cam kinase protein 1 0.0215 0.0252 0.024
Loa Loa (eye worm) hypothetical protein 0.0297 0.0483 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.035 0.0634 0.0623
Echinococcus granulosus casein kinase ii subunit alpha 0.0214 0.0247 0.0247
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0344 0.0615 0.0615
Trichomonas vaginalis AGC family protein kinase 0.0352 0.0638 0.1897
Schistosoma mansoni cell adhesion molecule 0.0392 0.0752 0.074
Echinococcus multilocularis NCK adaptor protein 0.0133 0.0018 0.0018
Echinococcus granulosus serine:threonine protein kinase N2 0.0621 0.1398 0.1398
Echinococcus multilocularis neural cadherin 0.037 0.069 0.069
Brugia malayi Cadherin domain containing protein 0.037 0.069 0.0679
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Brugia malayi Protein kinase domain containing protein 0.0365 0.0676 0.0665
Schistosoma mansoni cell adhesion molecule 0.0373 0.0697 0.0686
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0337 0.0596 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.027 0.0406 0.1171
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.034 0.0604 0.0593
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0222 0.0273 0.0273
Echinococcus granulosus nephrin 0.0189 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.1042 0.2588 0.2579
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0183 0.0162 0.0162
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0392 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0271 0.041 0.0398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.127 0.3233 1
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Plasmodium falciparum serine/threonine protein kinase KIN 0.0166 0.0114 0.0078
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0183 0.0162 0.0162
Echinococcus granulosus tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.127 0.3233 0.3233
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0222 0.0273 0.0273
Brugia malayi Protein kinase domain containing protein 0.0414 0.0813 0.0802
Loa Loa (eye worm) CAMK/PHK protein kinase 0.035 0.0634 0.0623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0179 0.0148 0.0112
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Entamoeba histolytica cell division protein kinase 2, putative 0.0254 0.036 0.1828
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Toxoplasma gondii AGC kinase 0.0241 0.0325 0.029
Echinococcus multilocularis epidermal growth factor receptor 0.0512 0.1091 0.1091
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0309 0.0518 0.0518
Echinococcus multilocularis titin 0.017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Schistosoma mansoni tyrosine kinase 0.0387 0.0736 0.0725
Giardia lamblia Aurora kinase 0.025 0.0351 0.0688
Schistosoma mansoni cell polarity protein 0.037 0.069 0.0679
Echinococcus granulosus serine:threonine protein kinase N2 0.0277 0.0427 0.0427
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0337 0.0596 0.0596
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0328 0.0571 0.0536
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Schistosoma mansoni sulfide quinone reductase 0.0337 0.0596 0.0585
Echinococcus granulosus tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0189 0.0178 0.0165
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0784 0.1859 0.1859
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0148 0.0366
Echinococcus granulosus titin 0.0259 0.0375 0.0375
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0327 0.0568 0.0556
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0236 0.0311 0.0311
Schistosoma mansoni tyrosine kinase 0.0442 0.0893 0.0881
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Brugia malayi RhoGAP domain containing protein 0.0159 0.0094 0.0082
Entamoeba histolytica casein kinase 1, putative 0.0232 0.0299 0.1487
Brugia malayi Protein kinase domain containing protein 0.035 0.0634 0.0623
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Entamoeba histolytica PH domain containing protein kinase, putative 0.0351 0.0635 0.335
Plasmodium vivax thioredoxin reductase, putative 0.3665 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.127 0.3233 0.3208
Loa Loa (eye worm) hypothetical protein 0.0395 0.076 0.0748
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0464 0.0954 0.0943
Echinococcus granulosus neuroglian 0.0392 0.0752 0.0752
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Trichomonas vaginalis CMGC family protein kinase 0.0275 0.042 0.1215
Echinococcus multilocularis mitogen activated protein kinase 3 0.0179 0.0148 0.0148
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0203 0.0218 0.0206
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0392 0.0752 0.074
Trichomonas vaginalis CAMK family protein kinase 0.027 0.0406 0.1171
Trichomonas vaginalis glutamate synthase, putative 0.0337 0.0596 0.1766
Schistosoma mansoni protein kinase 0.0928 0.2265 0.2255
Loa Loa (eye worm) gastrulation defective protein 1 0.0973 0.2392 0.2383
Entamoeba histolytica hypothetical protein 0.0261 0.0381 0.1943
Schistosoma mansoni protein kinase 0.0327 0.0568 0.0556
Schistosoma mansoni vam6/vps39 related 0.0239 0.0319 0.0307
Brugia malayi SH2 domain containing protein 0.0139 0.0037 0.0025
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0261 0.0381 0.0346
Entamoeba histolytica hypothetical protein 0.0405 0.0787 0.4197
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0159 0.0094 0.0094
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0159 0.0094 0.0082
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Brugia malayi EGF-like domain containing protein 0.0418 0.0824 0.0813
Plasmodium falciparum thioredoxin reductase 0.127 0.3233 0.3208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0222 0.0273 0.0261
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0241 0.0325 0.029
Giardia lamblia Glutamate synthase 0.0337 0.0596 0.1482
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0337 0.0596 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.127 0.3233 0.3224
Schistosoma mansoni serine/threonine protein kinase 0.0433 0.0867 0.0856
Schistosoma mansoni tyrosine kinase 0.0296 0.0481 0.047
Loa Loa (eye worm) hypothetical protein 0.0674 0.1547 0.1537
Schistosoma mansoni tyrosine kinase 0.0512 0.1091 0.108
Plasmodium falciparum apical sushi protein 0.0684 0.1576 0.1545
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.017 0.0123 0.0123
Trichomonas vaginalis STE family protein kinase 0.0183 0.0162 0.0409
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0157 0.0089 0.0077
Loa Loa (eye worm) hypothetical protein 0.0386 0.0735 0.0724
Entamoeba histolytica casein kinase, putative 0.0214 0.0247 0.1201
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Echinococcus granulosus dual specificity 0.0297 0.0482 0.0482
Onchocerca volvulus 0.0139 0.0037 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0135 0.0123
Brugia malayi hypothetical protein 0.0139 0.0037 0.0025
Echinococcus granulosus phosphorylase kinase gamma subunit 0.035 0.0634 0.0634
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0264 0.039 0.039
Echinococcus granulosus protein tyrosine kinase 0.0608 0.1362 0.1362
Echinococcus multilocularis protein tyrosine kinase 0.0608 0.1362 0.1362
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis tyrosine protein kinase 0.0324 0.056 0.056
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0215 0.0252 0.0121
Leishmania major hypothetical protein, conserved 0.0337 0.0596 0.0562
Brugia malayi intracellular kinase 0.0275 0.042 0.0408
Schistosoma mansoni protein kinase 0.0928 0.2265 0.2255
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0523 0.1123 0.1112
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0181 0.0154 0.0118
Echinococcus multilocularis hemicentin 1 0.0373 0.0697 0.0697
Schistosoma mansoni septate junction protein 0.0373 0.0697 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Echinococcus granulosus hemicentin 1 0.0373 0.0697 0.0697
Entamoeba histolytica protein kinase, putative 0.0177 0.0145 0.063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0259 0.0375 0.0363
Echinococcus granulosus insulin receptor 0.0638 0.1446 0.1446
Toxoplasma gondii AGC kinase 0.0608 0.1362 0.133
Echinococcus multilocularis PAK box P21 Rho binding 0.0137 0.0031 0.0031
Brugia malayi Protein kinase domain containing protein 0.1043 0.259 0.2581
Trypanosoma brucei Casein kinase II 0.0214 0.0247 0.0211
Schistosoma mansoni glutamate synthase 0.0337 0.0596 0.0585
Schistosoma mansoni cell adhesion molecule 0.0392 0.0752 0.074
Schistosoma mansoni titin 0.017 0.0123 0.0111
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0669 0.1535 0.1524
Onchocerca volvulus Peroxidasin homolog 0.017 0.0125 0.0459
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0215 0.0252 0.0216
Brugia malayi p70 ribosomal S6 kinase beta 0.0608 0.1362 0.1351
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Leishmania major protein kinase, putative 0.025 0.0351 0.0315
Schistosoma mansoni nephrin related 0.017 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.0166 0.0114 0.0102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0933 0.228 0.2271
Schistosoma mansoni protein kinase 0.0566 0.1243 0.1232
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0179 0.0148 0.0112
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0392 0.0752 0.0752
Schistosoma mansoni vesicular amine transporter 0.0669 0.1535 0.1524
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0959 0.2353 0.2344
Trypanosoma cruzi casein kinase, putative 0.0232 0.0299 0.0263
Trichomonas vaginalis glutathione reductase, putative 0.127 0.3233 1
Echinococcus granulosus titin 0.017 0.0123 0.0123
Brugia malayi Variant SH3 domain containing protein 0.0159 0.0094 0.0082
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0337 0.0596 0.0562
Loa Loa (eye worm) hypothetical protein 0.0872 0.2109 0.2099
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0259 0.0375 0.0363
Onchocerca volvulus 0.0337 0.0596 0.2622
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0114 0.0102
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0174 0.0135 0.0123
Loa Loa (eye worm) hypothetical protein 0.0393 0.0754 0.0743
Brugia malayi Cadherin domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis roundabout 2 0.1061 0.2643 0.2643
Loa Loa (eye worm) LAD-2 short isoform 0.0203 0.0218 0.0206
Trypanosoma brucei aurora B kinase 0.025 0.0351 0.0315
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0241 0.0325 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0337 0.0596 0.0562
Brugia malayi protein unc-22 0.0259 0.0375 0.0363
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0337 0.0596 0.0562
Echinococcus multilocularis neurogenic locus notch protein 4 0.037 0.069 0.069
Echinococcus multilocularis rho associated protein kinase 0.0695 0.1607 0.1607
Loa Loa (eye worm) hypothetical protein 0.0393 0.0754 0.0743
Loa Loa (eye worm) hypothetical protein 0.0305 0.0507 0.0495
Onchocerca volvulus 0.0695 0.1607 0.7257
Echinococcus multilocularis serine:threonine protein kinase 38 0.0344 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0608 0.1362 0.1351
Loa Loa (eye worm) Notch2 0.037 0.069 0.0679
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.127 0.3233 0.3208
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0241 0.0325 0.029
Trypanosoma brucei rac serine-threonine kinase, putative 0.0624 0.1408 0.1376
Schistosoma mansoni disulfide oxidoreductase 0.0337 0.0596 0.0585
Loa Loa (eye worm) cyclin domain-containing protein 0.0764 0.1801 0.1791
Echinococcus multilocularis serine:threonine protein kinase 0.0244 0.0332 0.0332
Schistosoma mansoni notch 0.037 0.069 0.0679
Schistosoma mansoni titin 0.0259 0.0375 0.0363
Echinococcus multilocularis N chimaerin 0.0159 0.0094 0.0094
Schistosoma mansoni tyrosine kinase 0.0512 0.1091 0.108
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0203 0.0218 0.0218
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0337 0.0596 0.0562
Echinococcus multilocularis cyclin dependent kinase 1 0.0254 0.036 0.036
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0246 0.0338 0.0338
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0337 0.0596 0.0596
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0754 0.1773 0.1763
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Trypanosoma cruzi casein kinase, putative 0.0232 0.0299 0.0263
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0297 0.0482 0.0471
Echinococcus multilocularis roundabout 2 0.0392 0.0752 0.0752
Echinococcus multilocularis casein kinase ii subunit alpha 0.0214 0.0247 0.0247
Echinococcus granulosus activin receptor type 0.0139 0.0037 0.0037
Giardia lamblia Kinase, AGC PKA 0.0241 0.0325 0.0606
Schistosoma mansoni serine/threonine protein kinase 0.0523 0.1123 0.1112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Onchocerca volvulus 0.0684 0.1576 0.7114
Schistosoma mansoni basigin related 0.0203 0.0218 0.0206
Mycobacterium ulcerans flavoprotein disulfide reductase 0.127 0.3233 1
Loa Loa (eye worm) TK protein kinase 0.0194 0.0193 0.0181
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0166 0.0114 0.0078
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0657 0.1501 0.1501
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.127 0.3233 0.3208
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Loa Loa (eye worm) hypothetical protein 0.0669 0.1535 0.1524
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0565 0.1239 0.1239
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0203 0.0218 0.0218
Giardia lamblia Kinase, PLK 0.0578 0.1276 0.3677
Giardia lamblia Thioredoxin reductase 0.0337 0.0596 0.1482
Echinococcus granulosus casein kinase I delta 0.0232 0.0299 0.0299
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0179 0.0148 0.0112
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.127 0.3233 0.3233
Loa Loa (eye worm) hypothetical protein 0.0244 0.0332 0.032
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0334 0.0589 0.0589
Loa Loa (eye worm) AGC/AKT protein kinase 0.0624 0.1408 0.1397
Brugia malayi ephrin receptor 1 precursor 0.0134 0.0021 0.0009
Toxoplasma gondii CMGC kinase, CK2 family 0.0214 0.0247 0.0211
Trichomonas vaginalis CK1 family protein kinase 0.0232 0.0299 0.0837
Echinococcus multilocularis death associated protein kinase 1 0.0938 0.2295 0.2295
Brugia malayi Protein kinase domain containing protein 0.0139 0.0037 0.0025
Echinococcus granulosus cyclin dependent kinase 19 0.1043 0.259 0.259
Schistosoma mansoni serine/threonine protein kinase 0.0843 0.2025 0.2015
Brugia malayi Protein kinase domain containing protein 0.0139 0.0037 0.0025
Echinococcus multilocularis neurogenic locus protein delta 0.037 0.069 0.069
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0784 0.1859 0.1859
Onchocerca volvulus 0.0139 0.0037 0.0056
Schistosoma mansoni hypothetical protein 0.0218 0.026 0.0248
Brugia malayi Protein kinase domain containing protein 0.0254 0.036 0.0349
Schistosoma mansoni titin 0.017 0.0123 0.0111
Echinococcus granulosus mitogen activated protein kinase 14 0.034 0.0604 0.0604
Schistosoma mansoni titin 0.017 0.0123 0.0111
Brugia malayi MAP kinase sur-1 0.0179 0.0148 0.0136
Onchocerca volvulus 0.0275 0.042 0.1813
Onchocerca volvulus 0.0139 0.0037 0.0056
Brugia malayi Protein kinase domain containing protein 0.0324 0.056 0.0549
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0175 0.0138 0.0006
Echinococcus multilocularis netrin receptor unc 5 0.0265 0.0393 0.0393
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Brugia malayi Cyclin, N-terminal domain containing protein 0.0764 0.1801 0.1791
Schistosoma mansoni ephrin receptor 0.0206 0.0226 0.0214
Echinococcus granulosus protein jagged 2 0.037 0.069 0.069
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.017 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0337 0.0596 0.0585
Brugia malayi protein kinase C3,putative 0.0337 0.0595 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0215 0.0252 0.0216
Echinococcus granulosus NCK adaptor protein 0.013 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0621 0.1398 0.1388
Brugia malayi Protein kinase domain containing protein 0.0174 0.0135 0.0123
Schistosoma mansoni notch 0.037 0.069 0.0679
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.042 0.2159
Trichomonas vaginalis STE family protein kinase 0.0183 0.0162 0.0409
Schistosoma mansoni c4b-binding protein beta chain 0.0684 0.1576 0.1566
Echinococcus granulosus expressed protein 0.0177 0.0145 0.0145
Schistosoma mansoni laminin gamma-3 chain 0.037 0.069 0.0679
Echinococcus multilocularis casein kinase I alpha 0.0232 0.0299 0.0299
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0269 0.0404 0.0404
Echinococcus multilocularis mitogen activated protein kinase 11 0.034 0.0604 0.0604
Plasmodium falciparum calcium-dependent protein kinase 4 0.0215 0.0252 0.0216
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0461 0.0948 0.0948
Echinococcus granulosus slit 2 protein 0.0418 0.0824 0.0824
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0461 0.0948 0.0948
Echinococcus granulosus tyrosine protein kinase 0.0324 0.056 0.056
Schistosoma mansoni cell adhesion molecule 0.0189 0.0178 0.0165
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0344 0.0615 0.0615
Entamoeba histolytica protein kinase, putative 0.0261 0.0381 0.1943
Loa Loa (eye worm) TK/ROR protein kinase 0.0239 0.0318 0.0306
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0269 0.0404 0.0392
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0375 0.0705 0.0693
Brugia malayi Calcium binding EGF domain containing protein 0.037 0.069 0.0679
Echinococcus granulosus delta-like protein 1 0.037 0.069 0.069
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0275 0.042 0.0385
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0236 0.0311 0.0311
Trypanosoma cruzi Protein kinase B 0.0351 0.0635 0.06
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Loa Loa (eye worm) hypothetical protein 0.1054 0.2622 0.2613
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0236 0.0311 0.0299
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0523 0.1123 0.1123
Brugia malayi Egg laying defective protein 4 0.0178 0.0147 0.0135
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.034 0.0604 0.0569
Schistosoma mansoni sulfide quinone reductase 0.0337 0.0596 0.0585
Loa Loa (eye worm) hypothetical protein 0.0684 0.1576 0.1566
Brugia malayi SH2 domain containing protein 0.0462 0.0949 0.0938
Loa Loa (eye worm) protein kinase domain-containing protein 0.0456 0.0931 0.092
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.036 0.1028
Loa Loa (eye worm) TK protein kinase 0.0392 0.0752 0.074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.017 0.0123 0.0111
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0392 0.0752 0.074
Plasmodium falciparum thioredoxin reductase 0.3665 1 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0334 0.0589 0.0554
Schistosoma mansoni protein kinase 0.0472 0.0976 0.0965
Echinococcus granulosus netrin receptor unc 5 0.0265 0.0393 0.0393
Brugia malayi GCC2 and GCC3 family protein 0.1054 0.2622 0.2613
Echinococcus granulosus rho-associated protein kinase 1 0.0695 0.1607 0.1607
Plasmodium falciparum calcium-dependent protein kinase 3 0.0215 0.0252 0.0216
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Schistosoma mansoni rap gtpase-activating protein 0.0239 0.0319 0.0307
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0203 0.0218 0.0206
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0199 0.0207 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Plasmodium vivax ferrodoxin reductase, putative 0.0337 0.0596 0.0471
Entamoeba histolytica protein kinase, putative 0.0261 0.0381 0.1943
Echinococcus granulosus pro neuregulin 2 membrane bound 0.017 0.0123 0.0123
Trichomonas vaginalis AGC family protein kinase 0.0241 0.0325 0.0919
Echinococcus granulosus casein kinase I alpha 0.0232 0.0299 0.0299
Brugia malayi Protein kinase domain containing protein 0.0191 0.0185 0.0173
Leishmania major protein kinase, putative 0.0328 0.0571 0.0536
Schistosoma mansoni tyrosine kinase 0.0734 0.1717 0.1707
Echinococcus multilocularis aurora kinase A 0.025 0.0351 0.0351
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.042 0.2159
Trypanosoma cruzi cdc2-related kinase 3 0.0254 0.036 0.0325
Giardia lamblia Kinase, CMGC SRPK 0.0177 0.0145 0.0022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0578 0.1276 0.1276
Leishmania major protein kinase A catalytic subunit isoform 1 0.0241 0.0325 0.029
Schistosoma mansoni septate junction protein 0.0203 0.0218 0.0206
Loa Loa (eye worm) projectin 0.0189 0.0178 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0147 0.0135
Plasmodium vivax unspecified product 0.0214 0.0247 0.0117
Schistosoma mansoni protein kinase 0.0137 0.0031 0.0019
Toxoplasma gondii EGF family domain-containing protein 0.037 0.069 0.0656
Schistosoma mansoni tyrosine kinase 0.0199 0.0207 0.0195
Entamoeba histolytica PH domain containing protein kinase, putative 0.0257 0.0371 0.1887
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0236 0.0311 0.0299
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0275 0.042 0.0408
Trypanosoma cruzi NADH dehydrogenase, putative 0.0337 0.0596 0.0562
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Loa Loa (eye worm) TK/ABL protein kinase 0.0139 0.0037 0.0025
Schistosoma mansoni nephrin related 0.0203 0.0218 0.0206
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Echinococcus granulosus epidermal growth factor receptor 0.0512 0.1091 0.1091
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0239 0.0319 0.0283
Entamoeba histolytica protein kinase, putative 0.0177 0.0145 0.063
Schistosoma mansoni protein kinase 0.0214 0.0247 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.036 0.1028
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0215 0.0252 0.0216
Loa Loa (eye worm) hypothetical protein 0.0255 0.0365 0.0353
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0244 0.0332 0.032
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0523 0.1123 0.1123
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0483 0.101 0.101
Entamoeba histolytica protein kinase, putative 0.0215 0.0252 0.1225
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.0669 0.1535 0.1524
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0337 0.0596 0.0596
Plasmodium falciparum serine/threonine protein kinase 0.0177 0.0145 0.0108
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.127 0.3233 0.3208
Schistosoma mansoni basigin related 0.0203 0.0218 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.0457 0.0446
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Echinococcus multilocularis 0.0327 0.0568 0.0568
Echinococcus granulosus mitogen activated protein kinase 11 0.034 0.0604 0.0604
Brugia malayi hypothetical protein 0.0475 0.0985 0.0974
Schistosoma mansoni titin 0.017 0.0123 0.0111
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.017 0.0125 0.0125
Echinococcus granulosus Immunoglobulin 0.0669 0.1535 0.1535
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0337 0.0596 0.1766
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0754 0.1773 0.1763
Onchocerca volvulus 0.017 0.0123 0.0452
Onchocerca volvulus 0.017 0.0123 0.0452
Brugia malayi Protein kinase domain containing protein 0.0344 0.0615 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.0325 0.0314
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0325 0.0561 0.0561
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0254 0.036 0.0325
Brugia malayi Protein kinase domain containing protein 0.0429 0.0856 0.0844
Trypanosoma cruzi cdc2-related kinase 3 0.0254 0.036 0.0325
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0297 0.0482 0.0447
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0297 0.0482 0.0447
Echinococcus granulosus mitogen activated protein kinase 0.0179 0.0148 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Echinococcus multilocularis slit 2 protein 0.0418 0.0824 0.0824
Echinococcus granulosus titin 0.0259 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0462 0.0949 0.0949
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.0457 0.0446
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0173 0.0132 0.0095
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Echinococcus granulosus roundabout 2 0.0392 0.0752 0.0752
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0325 0.0561 0.0561
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Loa Loa (eye worm) TK/EGFR protein kinase 0.0734 0.1717 0.1707
Schistosoma mansoni tyrosine kinase 0.0325 0.0561 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0148 0.0366
Echinococcus multilocularis Immunoglobulin subtype 0.0203 0.0218 0.0218
Echinococcus granulosus C type lectin domian containing protein 0.0684 0.1576 0.1576
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Plasmodium falciparum ferrodoxin reductase-like protein 0.0337 0.0596 0.0562
Trichomonas vaginalis AGC family protein kinase 0.025 0.0351 0.0999
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0615 0.0603
Echinococcus multilocularis serine:threonine protein kinase N2 0.0344 0.0615 0.0615
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0261 0.0381 0.0346
Onchocerca volvulus 0.037 0.069 0.3052
Trypanosoma cruzi casein kinase, putative 0.0232 0.0299 0.0263
Loa Loa (eye worm) AGC/PKG protein kinase 0.0178 0.0147 0.0135
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0337 0.0596 0.0596
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0178 0.0147 0.0147
Plasmodium falciparum serine/threonine protein kinase, putative 0.025 0.0351 0.0315
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0328 0.0571 0.0536
Leishmania major NADH dehydrogenase, putative 0.0337 0.0596 0.0562
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0189 0.0178 0.0165
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0337 0.0596 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Giardia lamblia Kinase, CMGC DYRK 0.0297 0.0482 0.1113
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0462 0.0949 0.0949
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0241 0.0325 0.029
Echinococcus multilocularis ephrin type A receptor 4 A 0.0206 0.0226 0.0226
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0181 0.0154 0.0118
Toxoplasma gondii aspartyl protease ASP1 0.0236 0.0311 0.0275
Onchocerca volvulus Serine\/threonine kinase homolog 0.0578 0.1276 0.5737
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.0338 0.0958
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0197 0.0201 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Echinococcus multilocularis protein kinase c iota type 0.061 0.1368 0.1368
Loa Loa (eye worm) TK/EPH protein kinase 0.0244 0.0332 0.032
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0185 0.0173
Entamoeba histolytica protein kinase domain containing protein 0.0433 0.0867 0.4639
Trichomonas vaginalis AGC family protein kinase 0.0291 0.0465 0.1356
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0764 0.1801 0.1801
Brugia malayi Protein kinase domain containing protein 0.2014 0.5335 0.5329
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) SRC-1 0.0325 0.0561 0.0549
Echinococcus granulosus tyrosine protein kinase shark 0.0366 0.0679 0.0679
Onchocerca volvulus 0.0139 0.0037 0.0056
Echinococcus granulosus tyrosine protein kinase Srms 0.0573 0.1263 0.1263
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0433 0.0867 0.0856
Echinococcus multilocularis protein kinase shaggy 0.0275 0.042 0.042
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0337 0.0596 0.0562
Onchocerca volvulus 0.0395 0.076 0.3371
Trypanosoma brucei SNF1-related protein kinases, putative 0.0166 0.0114 0.0078
Echinococcus granulosus protein jagged 1 0.037 0.069 0.069
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0254 0.036 0.0325
Loa Loa (eye worm) hypothetical protein 0.0239 0.0319 0.0307
Trichomonas vaginalis STE family protein kinase 0.0181 0.0154 0.0384
Plasmodium falciparum NIMA related kinase 1 0.0291 0.0465 0.043
Trichomonas vaginalis CK1 family protein kinase 0.0232 0.0299 0.0837
Echinococcus granulosus mitogen activated protein kinase 3 0.0179 0.0148 0.0148
Echinococcus multilocularis down syndrome cell adhesion 0.017 0.0123 0.0123
Brugia malayi STE20-like kinase MST 0.0549 0.1194 0.1184
Echinococcus granulosus casein kinase I gamma 0.0456 0.0931 0.0931
Echinococcus granulosus tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0261 0.0381 0.0346
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0657 0.1501 0.1501
Echinococcus granulosus c4b binding protein beta chain 0.0684 0.1576 0.1576
Echinococcus multilocularis casein kinase I gamma 0.0456 0.0931 0.0931
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.025 0.0351 0.1775
Schistosoma mansoni protein kinase 0.0139 0.0037 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.1115 0.1104
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0239 0.0318 0.0318
Plasmodium falciparum glutathione reductase 0.3665 1 1
Brugia malayi Protein kinase domain containing protein 0.0784 0.1859 0.1849
Echinococcus granulosus nervana 2 0.0264 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.0496 0.1045 0.1034
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0337 0.0596 0.3138
Onchocerca volvulus Neurogenic locus notch protein homolog 0.037 0.069 0.3052
Trichomonas vaginalis AGC family protein kinase 0.0365 0.0676 0.2015
Loa Loa (eye worm) hypothetical protein 0.0297 0.0483 0.0471
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Echinococcus granulosus calcium dependent protein kinase 0.0145 0.0054 0.0054
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0171 0.0128 0.0128
Brugia malayi Furin-like cysteine rich region family protein 0.0734 0.1717 0.1707
Echinococcus multilocularis insulin growth factor binding 0.017 0.0123 0.0123
Onchocerca volvulus Putative cubilin 0.037 0.069 0.3052
Brugia malayi Immunoglobulin domain containing protein 0.0203 0.0218 0.0206
Toxoplasma gondii casein kinase I 0.0232 0.0299 0.0263
Brugia malayi casein kinase 1, delta 0.0232 0.0299 0.0287
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0203 0.0218 0.0218
Brugia malayi Tyrosine-protein kinase abl-1 0.0199 0.0207 0.0195
Loa Loa (eye worm) hypothetical protein 0.0191 0.0183 0.0171
Toxoplasma gondii aurora kinase 0.025 0.0351 0.0315
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0337 0.0596 0.0562
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Echinococcus multilocularis 0.017 0.0123 0.0123
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0334 0.0589 0.0463
Leishmania major casein kinase, putative 0.0232 0.0299 0.0263
Schistosoma mansoni tyrosine kinase 0.0136 0.0029 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0191 0.0185 0.048
Loa Loa (eye worm) hypothetical protein 0.0236 0.0311 0.0299
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0177 0.0145 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.0218 0.0206
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0266 0.0396 0.036
Brugia malayi probable protein kinase 0.0566 0.1243 0.1232
Echinococcus multilocularis epidermal growth factor receptor 0.0734 0.1717 0.1717
Trypanosoma cruzi cdc2-related kinase 1 0.0254 0.036 0.0325
Onchocerca volvulus Peroxidasin homolog 0.017 0.0123 0.0452
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.0189 0.0178 0.0165
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0754 0.1773 0.1763
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.0635 0.0624
Brugia malayi Protein kinase domain containing protein 0.0614 0.138 0.1369
Schistosoma mansoni hemicentin 0.0189 0.0178 0.0165
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis raf serine:threonine protein kinase 0.0159 0.0092 0.0092
Brugia malayi glutamate synthase 0.0337 0.0596 0.0585
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0429 0.0855 0.0855
Echinococcus granulosus neurogenic locus notch protein 0.037 0.069 0.069
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.017 0.0123 0.0111
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0392 0.0752 0.0752
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0181 0.0154 0.0682
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0217 0.0257 0.0245
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Loa Loa (eye worm) AGC/PKA protein kinase 0.0241 0.0325 0.0314
Brugia malayi Protein kinase domain containing protein 0.0456 0.0931 0.092
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Schistosoma mansoni cell adhesion molecule 0.017 0.0123 0.0111
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0322 0.0554 0.0542
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Echinococcus granulosus titin 0.017 0.0123 0.0123
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0239 0.0319 0.0307
Onchocerca volvulus Putative titin 0.017 0.0123 0.0452
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0275 0.042 0.042
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.037 0.069 0.0679
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0178 0.0147 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.1115 0.1104
Onchocerca volvulus 0.0684 0.1576 0.7114
Plasmodium vivax plasmepsin IV, putative 0.0236 0.0311 0.0181
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0269 0.0404 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Brugia malayi map kinase activated protein kinase protein 2 0.0843 0.2025 0.2015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0392 0.0752 0.074
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0177 0.0145 0.0108
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0578 0.1276 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0179 0.0148 0.0136
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0373 0.0697 0.0686
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.3665 1 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0215 0.0252 0.0216
Echinococcus multilocularis C type lectin domian containing protein 0.0684 0.1576 0.1576
Echinococcus granulosus neurogenic locus notch protein 4 0.037 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis dual specificity 0.0297 0.0482 0.0482
Echinococcus granulosus c src tyrosine kinase 0.0199 0.0207 0.0207
Onchocerca volvulus 0.0684 0.1576 0.7114
Plasmodium falciparum glutathione reductase 0.127 0.3233 0.3208
Brugia malayi Immunoglobulin I-set domain containing protein 0.1609 0.4191 0.4184
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.127 0.3233 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0337 0.0596 0.3138
Echinococcus multilocularis neurogenic locus notch protein 0.037 0.069 0.069
Entamoeba histolytica protein kinase, putative 0.0608 0.1362 0.7388
Trichomonas vaginalis AGC family protein kinase 0.0174 0.0135 0.0324
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Echinococcus multilocularis mitogen activated protein kinase 14 0.034 0.0604 0.0604
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0325 0.0561 0.0561
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0275 0.042 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0565 0.1239 0.1229
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.127 0.3233 0.2803
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0239 0.0319 0.0283
Plasmodium vivax serine/threonine protein kinase, putative 0.0177 0.0145 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0092 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0148 0.0366
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0933 0.228 0.2271
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0325 0.0561 0.0561
Entamoeba histolytica SH2-protein kinase domain containing protein 0.014 0.0039 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Schistosoma mansoni tyrosine kinase 0.0366 0.0679 0.0668
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Plasmodium vivax apical sushi protein, putative 0.0684 0.1576 0.1463
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0337 0.0596 0.0562
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0521 0.1115 0.1115
Schistosoma mansoni hypothetical protein 0.0337 0.0596 0.0585
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.0338 0.0958
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0337 0.0596 0.0596
Brugia malayi serine/threonine-protein kinase PAK 7 0.0496 0.1045 0.1034
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0615 0.0603
Schistosoma mansoni vav2 0.0176 0.014 0.0128
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0373 0.0697 0.3085
Echinococcus multilocularis neuroglian 0.0392 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.023 0.0294 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0381 0.0369
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Echinococcus granulosus tyrosine protein kinase HCK 0.0194 0.0193 0.0193
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0236 0.0311 0.0275
Onchocerca volvulus 0.0684 0.1576 0.7114
Schistosoma mansoni protein kinase C mu 0.0465 0.0957 0.0946
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0328 0.0571 0.0536
Loa Loa (eye worm) hypothetical protein 0.0203 0.0218 0.0206
Plasmodium vivax protein kinase Crk2 0.0254 0.036 0.0231
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0337 0.0596 0.0562
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0241 0.0325 0.029
Schistosoma mansoni netrin receptor unc5 0.0203 0.0218 0.0206
Echinococcus multilocularis titin 0.0259 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0674 0.1547 0.1537
Schistosoma mansoni peroxidasin 0.0204 0.022 0.0208
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0182 0.0158 0.0146
Brugia malayi Prion-like- 0.0373 0.0697 0.0686
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0214 0.0247 0.0235
Brugia malayi serine/threonine protein kinase 6 0.025 0.0351 0.0339
Loa Loa (eye worm) TK protein kinase 0.0556 0.1216 0.1205
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0203 0.0218 0.0206
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1043 0.259 0.2581
Schistosoma mansoni nephrin 0.0392 0.0752 0.074
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Loa Loa (eye worm) AGC/PKN protein kinase 0.0621 0.1398 0.1388
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0321 0.0309
Loa Loa (eye worm) hypothetical protein 0.067 0.1536 0.1526
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0215 0.0252 0.0216
Echinococcus granulosus protein jagged 1 0.037 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Leishmania major trypanothione reductase 0.3665 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0337 0.0596 0.0562
Entamoeba histolytica protein kinase domain containing protein 0.025 0.0351 0.1775
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0325 0.0561 0.0561
Onchocerca volvulus 0.0684 0.1576 0.7114
Brugia malayi Protein kinase domain containing protein 0.0139 0.0037 0.0025
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0239 0.0319 0.0319
Entamoeba histolytica disulphide oxidoreductase, putative 0.0337 0.0596 0.3138
Echinococcus multilocularis casein kinase I delta 0.0232 0.0299 0.0299
Echinococcus granulosus NDR protein kinase 0.0344 0.0615 0.0615
Brugia malayi Immunoglobulin I-set domain containing protein 0.0556 0.1216 0.1205
Brugia malayi Stress-activated protein kinase jnk-1 0.0565 0.1239 0.1229
Giardia lamblia Kinase, NEK 0.0291 0.0465 0.1058
Brugia malayi Doublecortin family protein 0.0322 0.0554 0.0542
Brugia malayi Protein kinase domain containing protein 0.0328 0.0571 0.0559
Loa Loa (eye worm) CAMK protein kinase 0.0259 0.0375 0.0363
Echinococcus granulosus tyrosine kinase 0.0139 0.0037 0.0037
Echinococcus multilocularis fibropellin Ia 0.037 0.069 0.069
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0159 0.0094 0.0082
Echinococcus multilocularis casein kinase I delta 0.0232 0.0299 0.0299
Schistosoma mansoni notch 0.037 0.069 0.0679
Echinococcus granulosus fibroblast growth factor receptor 4 0.0387 0.0736 0.0736
Echinococcus granulosus tyrosine protein kinase Lyn 0.0395 0.0759 0.0759
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0412 0.0808 0.0796
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.017 0.0123 0.0111
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0337 0.0596 0.0585
Echinococcus multilocularis neurogenic locus notch protein 0.037 0.069 0.069
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0275 0.042 0.0408
Schistosoma mansoni cell adhesion molecule 0.0189 0.0178 0.0165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0177 0.0145 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.0325 0.0314
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0215 0.0252 0.0252
Schistosoma mansoni tyrosine kinase 0.0199 0.0207 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Echinococcus granulosus tyrosine protein kinase Src42A 0.0325 0.0561 0.0561
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0843 0.2025 0.2015
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0179 0.0148 0.0112
Schistosoma mansoni nephrin 0.0858 0.2068 0.2059
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0203 0.0218 0.0218
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0549 0.1194 0.1184
Loa Loa (eye worm) glutathione reductase 0.3665 1 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0239 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0203 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0373 0.0697 0.0686
Schistosoma mansoni serine/threonine kinase 0.0472 0.0977 0.0966
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0139 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0436 0.0875 0.0864
Brugia malayi C1-like domain containing protein 0.0465 0.0957 0.0946
Leishmania major dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Loa Loa (eye worm) thyroid receptor interactor 0.0218 0.0261 0.0249
Entamoeba histolytica protein kinase, putative 0.0153 0.0077 0.0254
Brugia malayi serine/threonine-protein kinase 6 0.025 0.0351 0.0339
Echinococcus multilocularis thioredoxin glutathione reductase 0.3665 1 1
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Brugia malayi Sushi domain 0.0684 0.1576 0.1566
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.025 0.0351 0.1775
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0337 0.0596 0.0585
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0252 0.024
Toxoplasma gondii thioredoxin reductase 0.3665 1 1
Echinococcus multilocularis insulin receptor 0.0638 0.1446 0.1446
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0166 0.0114 0.0114
Schistosoma mansoni myosin-binding protein-related 0.0189 0.0178 0.0165
Echinococcus multilocularis cyclin dependent kinase 1 0.0254 0.036 0.036
Echinococcus multilocularis CDC7 cell division cycle 7 0.0191 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0148 0.0136
Echinococcus granulosus cGMP dependent protein kinase 0.0178 0.0147 0.0147
Trypanosoma brucei casein kinase I, isoform 2 0.0232 0.0299 0.0263
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0174 0.0135 0.0135
Brugia malayi Protein kinase domain containing protein 0.0261 0.0381 0.0369
Brugia malayi Immunoglobulin I-set domain containing protein 0.0688 0.1589 0.1579
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0337 0.0596 0.0562
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis serine:threonine protein kinase 3 0.0549 0.1194 0.1194
Brugia malayi protein-tyrosine kinase 0.0264 0.039 0.0379
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0496 0.1045 0.1045
Entamoeba histolytica cell division protein kinase 2, putative 0.0262 0.0384 0.1959
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0337 0.0596 0.0562
Echinococcus granulosus ephrin type A receptor 4 A 0.0206 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Echinococcus granulosus contactin 0.0392 0.0752 0.0752
Echinococcus granulosus serine:threonine protein kinase 0.0244 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0337 0.0596 0.0471
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0392 0.0752 0.0752
Echinococcus multilocularis twitchin 0.024 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0189 0.0178 0.0165
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0433 0.0867 0.0867
Loa Loa (eye worm) TK/FAK protein kinase 0.0614 0.138 0.1369
Brugia malayi EGF-like domain containing protein 0.037 0.069 0.0679
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0215 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Echinococcus multilocularis c4b binding protein beta chain 0.0684 0.1576 0.1576
Schistosoma mansoni serine/threonine protein kinase 0.0502 0.1063 0.1052
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.0375 0.0363
Trypanosoma cruzi trypanothione reductase, putative 0.3665 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0114 0.0102
Echinococcus multilocularis calcium dependent protein kinase 0.0145 0.0054 0.0054
Echinococcus multilocularis calcium activated potassium channel 0.0288 0.0457 0.0457
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0246 0.0338 0.0338
Trichomonas vaginalis CMGC family protein kinase 0.0275 0.042 0.1215
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0325 0.0561 0.0561
Schistosoma mansoni hypothetical protein 0.0203 0.0218 0.0206
Onchocerca volvulus 0.017 0.0123 0.0452
Brugia malayi ribosomal protein S6 kinase alpha 3 0.025 0.035 0.0338
Brugia malayi Disorganized muscle protein 1 0.017 0.0123 0.0111
Giardia lamblia Kinase, AGC PKA 0.0334 0.0589 0.1458
Echinococcus multilocularis myosin iiia 0.0181 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0373 0.0697 0.0686
Onchocerca volvulus Netrin receptor homolog 0.0231 0.0298 0.1253
Echinococcus granulosus Immunoglobulin 0.0203 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0688 0.1589 0.1579
Schistosoma mansoni growth factor receptor-bound protein 0.0133 0.0018 0.0006
Schistosoma mansoni cell adhesion molecule 0.0203 0.0218 0.0206
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.035 0.0634 0.0634
Toxoplasma gondii rhoptry neck protein RON1 0.0684 0.1576 0.1545
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Echinococcus granulosus calcium activated potassium channel 0.0288 0.0457 0.0457
Trypanosoma cruzi polo-like protein kinase, putative 0.0578 0.1276 0.1243
Brugia malayi SRC-1 0.0325 0.0561 0.0549
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0843 0.2025 0.2025
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0351 0.0635 0.06
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0295 0.0478 0.1397
Schistosoma mansoni tyrosine kinase 0.0425 0.0845 0.0834
Echinococcus granulosus neurogenic locus protein delta 0.037 0.069 0.069
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Plasmodium vivax glutathione reductase, putative 0.3665 1 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.0319 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Entamoeba histolytica protein kinase 2, putative 0.0334 0.0589 0.3096
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0928 0.2265 0.2265
Schistosoma mansoni septate junction protein 0.0373 0.0697 0.0686
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.127 0.3233 0.3142
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.017 0.0123 0.0111
Echinococcus granulosus dual specificity protein kinase clk2 0.0328 0.0571 0.0571
Schistosoma mansoni tyrosine kinase 0.0443 0.0896 0.0885
Echinococcus multilocularis expressed protein 0.0177 0.0145 0.0145
Toxoplasma gondii histone kinase SNF1, putative 0.0166 0.0114 0.0078
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0179 0.0148 0.0112
Echinococcus granulosus cyclin 0.0764 0.1801 0.1801
Trichomonas vaginalis mercuric reductase, putative 0.127 0.3233 1
Brugia malayi Serine/threonine-protein kinase SULU 0.0475 0.0985 0.0974
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0291 0.0465 0.0338
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.025 0.0351 0.1775
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.0325 0.0325
Echinococcus multilocularis dual specificity 0.0261 0.0381 0.0381
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.127 0.3233 0.2803
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0215 0.0252 0.0252
Trypanosoma cruzi NADH dehydrogenase, putative 0.0337 0.0596 0.0562
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Loa Loa (eye worm) hypothetical protein 0.0137 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0688 0.1589 0.1579
Echinococcus granulosus serine:threonine protein kinase 3 0.0549 0.1194 0.1194
Echinococcus multilocularis Immunoglobulin 0.0669 0.1535 0.1535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0325 0.0561 0.0561
Trypanosoma cruzi trypanothione reductase, putative 0.127 0.3233 0.3208
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Toxoplasma gondii AGC kinase 0.0241 0.0325 0.029
Echinococcus granulosus tyrosine kinase 0.0264 0.039 0.039
Echinococcus granulosus serine/threonine protein kinase 0.0351 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.1042 0.2588 0.2579
Brugia malayi P38 map kinase family protein 2 0.034 0.0604 0.0593
Loa Loa (eye worm) hypothetical protein 0.0218 0.026 0.0248
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0254 0.036 0.0325
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0392 0.0752 0.0752
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.036 0.0349
Loa Loa (eye worm) hypothetical protein 0.0411 0.0805 0.0794
Plasmodium falciparum protein serine/threonine kinase-1 0.0328 0.0571 0.0536
Loa Loa (eye worm) hypothetical protein 0.0418 0.0824 0.0813
Entamoeba histolytica cyclin C, putative 0.0775 0.1833 1
Echinococcus multilocularis rac serine:threonine kinase 0.0351 0.0635 0.0635
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0269 0.0404 0.0404
Trypanosoma cruzi casein kinase, putative 0.0232 0.0299 0.0263
Brugia malayi Casein kinase II, alpha chain 0.0214 0.0247 0.0235
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0475 0.0985 0.0985
Brugia malayi Prion-like- 0.017 0.0123 0.0111
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0565 0.1239 0.1229
Onchocerca volvulus 0.017 0.0123 0.0452
Onchocerca volvulus 0.0232 0.0299 0.1259
Trichomonas vaginalis AGC family protein kinase 0.0174 0.0135 0.0324
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Entamoeba histolytica protein kinase, putative 0.0344 0.0615 0.324
Loa Loa (eye worm) hypothetical protein 0.0688 0.1589 0.1579
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0275 0.042 0.042
Echinococcus multilocularis tyrosine protein kinase HCK 0.0194 0.0193 0.0193
Echinococcus multilocularis glutamate synthase 0.0337 0.0596 0.0596
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0215 0.0252 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0241 0.0325 0.029
Loa Loa (eye worm) casein kinase 0.0386 0.0733 0.0722
Brugia malayi Protein kinase domain 0.0183 0.0162 0.015
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0215 0.0252 0.0121
Loa Loa (eye worm) hypothetical protein 0.0258 0.0373 0.0361
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0387 0.0736 0.0736
Loa Loa (eye worm) hypothetical protein 0.0373 0.0699 0.0687
Trichomonas vaginalis CMGC family protein kinase 0.0191 0.0185 0.048
Onchocerca volvulus 0.0259 0.0375 0.1608
Trypanosoma brucei protein kinase, putative 0.0275 0.042 0.0385
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0373 0.0697 0.0686
Echinococcus multilocularis lachesin 0.0373 0.0697 0.0697
Giardia lamblia Kinase, AGC AKT 0.025 0.035 0.0685
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.127 0.3233 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0241 0.0325 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0299 0.0287
Echinococcus multilocularis growth factor receptor bound protein 2 0.013 0.0012 0.0012
Echinococcus multilocularis protein kinase c epsilon type 0.0436 0.0875 0.0875
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0337 0.0596 0.0562
Echinococcus multilocularis transfer RNA-Phe 0.0189 0.0178 0.0178
Echinococcus multilocularis notch 0.037 0.069 0.069
Leishmania major protein kinase, putative 0.0328 0.0571 0.0536
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0337 0.0596 0.3138
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.127 0.3233 0.3224
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Echinococcus multilocularis tyrosine protein kinase otk 0.0373 0.0697 0.0697
Schistosoma mansoni serine/threonine-protein kinase 0.0351 0.0635 0.0623
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0843 0.2025 0.2025
Brugia malayi putative serine/threonine kinase SADA gamma 0.0166 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0203 0.0218 0.0206
Echinococcus granulosus c-Jun N-terminal kinases 0.0565 0.1239 0.1239
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0166 0.0114 0.0078
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0337 0.0596 0.1766
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0145 0.0133
Trypanosoma brucei cdc2-related kinase 1 0.0254 0.036 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0545 0.1183 0.1173
Echinococcus granulosus cyclin dependent kinase 1 0.0254 0.036 0.036
Leishmania major protein kinase A catalytic subunit 0.0241 0.0325 0.029
Brugia malayi Fibronectin type III domain containing protein 0.0688 0.1589 0.1579
Echinococcus granulosus Glutaredoxin protein 5 0.0264 0.0391 0.0391
Echinococcus granulosus Vam6:Vps39 protein 0.0239 0.0319 0.0319
Loa Loa (eye worm) one IG domain family member 0.017 0.0123 0.0111
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0712 0.1657 0.1646
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0203 0.0218 0.0218
Schistosoma mansoni titin 0.0189 0.0178 0.0165
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0254 0.036 0.036
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0472 0.0976 0.0976
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0241 0.0325 0.029
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0203 0.0218 0.0206
Entamoeba histolytica protein kinase domain containing protein 0.0297 0.0482 0.2504
Schistosoma mansoni protein kinase 0.0784 0.1859 0.1849
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0183 0.0162 0.0162
Plasmodium falciparum glycogen synthase kinase 3 0.0275 0.042 0.0385
Echinococcus granulosus cyclin dependent kinase 5 0.0254 0.036 0.036
Echinococcus multilocularis titin 0.017 0.0123 0.0123
Echinococcus multilocularis Immunoglobulin 0.0203 0.0218 0.0218
Loa Loa (eye worm) notch protein 0.037 0.069 0.0679
Echinococcus multilocularis mitogen activated protein kinase 0.0179 0.0148 0.0148
Brugia malayi Calcium binding EGF domain containing protein 0.037 0.069 0.0679
Loa Loa (eye worm) TK/ALK protein kinase 0.0321 0.0551 0.0539
Trypanosoma cruzi hypothetical protein, conserved 0.0337 0.0596 0.0562
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0334 0.0589 0.0589
Plasmodium vivax calcium-dependent protein kinase, putative 0.0215 0.0252 0.0121
Loa Loa (eye worm) hypothetical protein 0.0215 0.0252 0.024
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0166 0.0114 0.0078
Brugia malayi Protein kinase domain containing protein 0.0139 0.0037 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.034 0.0604 0.0569
Entamoeba histolytica thioredoxin reductase, putative 0.0337 0.0596 0.3138
Trichomonas vaginalis CAMK family protein kinase 0.0578 0.1276 0.3888
Schistosoma mansoni protein kinase 0.0183 0.0162 0.015
Brugia malayi Muscle positioning protein 4 0.037 0.069 0.0679
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0337 0.0596 0.3138
Brugia malayi Immunoglobulin domain containing protein 0.0203 0.0218 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.0571 0.0559
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0173 0.0132 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0624 0.1408 0.43
Echinococcus multilocularis casein kinase i 0.0232 0.0299 0.0299
Trichomonas vaginalis CMGC family protein kinase 0.0297 0.0482 0.1409
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0337 0.0596 0.1482
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0723 0.1687 0.1677
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0183 0.0162 0.0162
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.127 0.3233 0.3142
Trichomonas vaginalis glutamate synthase, putative 0.0337 0.0596 0.1766
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0297 0.0482 0.0447
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0325 0.0561 0.0561
Onchocerca volvulus 0.0239 0.0319 0.1351
Brugia malayi Immunoglobulin I-set domain containing protein 0.0265 0.0393 0.0381
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0309 0.0517 0.0517
Onchocerca volvulus Tyrosine kinase homolog 0.0907 0.2205 1
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.017 0.0123 0.0111
Schistosoma mansoni serine/threonine-protein kinase 0.0351 0.0635 0.0623
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0291 0.0465 0.043
Entamoeba histolytica protein kinase domain containing protein 0.0261 0.0381 0.1943
Echinococcus multilocularis Immunoglobulin 0.0203 0.0218 0.0218
Echinococcus multilocularis cyclin dependent kinase 0.0254 0.036 0.036
Onchocerca volvulus Serine\/threonine kinase homolog 0.035 0.0634 0.2795
Plasmodium falciparum casein kinase 1 0.0232 0.0299 0.0263
Echinococcus granulosus cGMP dependent protein kinase 1 0.0178 0.0147 0.0147
Loa Loa (eye worm) animal heme peroxidase 0.017 0.0123 0.0111
Brugia malayi Protein kinase domain containing protein 0.0132 0.0016 0.0004
Treponema pallidum NADH oxidase 0.127 0.3233 1
Brugia malayi Temporarily assigned gene name protein 59 0.0276 0.0423 0.0412
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0669 0.1535 0.1524
Onchocerca volvulus 0.0684 0.1576 0.7114
Onchocerca volvulus 0.0189 0.0178 0.0701
Brugia malayi Prion-like- 0.017 0.0123 0.0111
Schistosoma mansoni g1/s-specific cyclin C 0.1531 0.3971 0.3963
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Trypanosoma cruzi cdc2-related kinase 1 0.0254 0.036 0.0325
Echinococcus granulosus roundabout 2 0.0392 0.0752 0.0752
Schistosoma mansoni neuroglian 0.0392 0.0752 0.074
Onchocerca volvulus Slit protein homolog 0.0418 0.0824 0.3665
Echinococcus multilocularis 0.0258 0.0373 0.0373
Echinococcus granulosus casein kinase i 0.0232 0.0299 0.0299
Echinococcus granulosus growth factor receptor bound protein 2 0.0133 0.0018 0.0018
Onchocerca volvulus 0.0137 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0987 0.2432 0.2423
Trichomonas vaginalis AGC family protein kinase 0.0382 0.0722 0.2158
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0373 0.0697 0.0686
Loa Loa (eye worm) hypothetical protein 0.0297 0.0483 0.0471
Schistosoma mansoni notch 0.037 0.069 0.0679
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0297 0.0482 0.0471
Plasmodium falciparum cGMP-dependent protein kinase 0.0178 0.0147 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0502 0.1063 0.1052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.127 0.3233 1
Brugia malayi Kinase associated domain 1 family protein 0.0218 0.026 0.0248
Brugia malayi Heparan sulfate 0.0203 0.0218 0.0206
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0669 0.1535 0.1535
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.127 0.3233 0.3208
Schistosoma mansoni netrin receptor unc5 0.0265 0.0393 0.0381
Schistosoma mansoni hypothetical protein 0.017 0.0123 0.0111
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0344 0.0615 0.0615
Brugia malayi hypothetical protein 0.0239 0.0319 0.0307
Entamoeba histolytica protein kinase, putative 0.0624 0.1408 0.7642
Echinococcus granulosus serine:threonine kinase SAD 1 0.0166 0.0114 0.0114
Echinococcus granulosus dual specificity 0.0297 0.0482 0.0482
Echinococcus granulosus protein kinase 0.0327 0.0568 0.0568
Leishmania major dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Echinococcus granulosus insulin growth factor binding 0.017 0.0123 0.0123
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1609 0.4191 0.4184
Loa Loa (eye worm) AUR protein kinase 0.025 0.0351 0.0339
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0928 0.2265 0.2265
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0325 0.0561 0.0561
Schistosoma mansoni glutamate synthase 0.0337 0.0596 0.0585
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0254 0.036 0.0349
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0754 0.1773 0.8018
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0232 0.0299 0.0287
Echinococcus multilocularis titin 0.017 0.0123 0.0123
Entamoeba histolytica protein kinase domain containing protein 0.0139 0.0037 0.0032
Leishmania major hypothetical protein, conserved 0.0337 0.0596 0.0562
Onchocerca volvulus 0.037 0.069 0.3052
Echinococcus multilocularis c src tyrosine kinase 0.0199 0.0207 0.0207
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0337 0.0596 0.0596
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0232 0.0299 0.0287
Giardia lamblia Kinase, CMGC CDK 0.0254 0.036 0.0719
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0179 0.0148 0.0112
Brugia malayi Protein kinase domain containing protein 0.0321 0.0551 0.0539
Schistosoma mansoni serine/threonine protein kinase 0.102 0.2525 0.2516
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0465 0.0957 0.0946
Loa Loa (eye worm) TK/FER protein kinase 0.0462 0.0949 0.0938
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.0948 0.0937
Onchocerca volvulus 0.0139 0.0037 0.0056
Onchocerca volvulus 0.0411 0.0805 0.358
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0275 0.042 0.0408
Schistosoma mansoni septate junction protein 0.0203 0.0218 0.0206
Schistosoma mansoni basigin related 0.0203 0.0218 0.0206
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0236 0.0311 0.0873
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0985 0.0974
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0123 0.0111
Onchocerca volvulus 0.0162 0.0101 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.1043 0.259 0.2581
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0114 0.0259
Onchocerca volvulus 0.0139 0.0037 0.0056
Echinococcus granulosus Immunoglobulin 0.0203 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0037 0.0025
Brugia malayi hypothetical protein 0.0684 0.1576 0.1566
Schistosoma mansoni tyrosine kinase 0.0325 0.0561 0.0549
Brugia malayi Protein kinase domain containing protein 0.0244 0.0332 0.032
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0181 0.0154 0.0118
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0309 0.0518 0.0518
Schistosoma mansoni protein kinase 0.0232 0.0299 0.0287
Brugia malayi Animal haem peroxidase family protein 0.017 0.0123 0.0111
Brugia malayi Immunoglobulin I-set domain containing protein 0.0392 0.0752 0.074
Trichomonas vaginalis apoptosis inducing factor, putative 0.0337 0.0596 0.1766
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0429 0.0855 0.0855
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1057 0.263 0.263
Echinococcus multilocularis cyclin dependent kinase 5 0.0254 0.036 0.036
Entamoeba histolytica protein kinase, putative 0.0153 0.0077 0.0254
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0387 0.0736 0.0736
Trypanosoma brucei cdc2-related kinase 3 0.0254 0.036 0.0325
Trichomonas vaginalis CAMK family protein kinase 0.0464 0.0954 0.2881
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0162 0.0101 0.0065
Schistosoma mansoni hypothetical protein 0.0218 0.026 0.0248
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0203 0.0218 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0328 0.0571 0.1686
Echinococcus multilocularis hemicentin 1 0.0373 0.0697 0.0697
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0159 0.0094 0.0094
Toxoplasma gondii NADPH-glutathione reductase 0.127 0.3233 0.3208
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0178 0.0147 0.0147
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0261 0.0381 0.0369
Echinococcus multilocularis 0.0203 0.0218 0.0218
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.127 0.3233 0.2803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0392 0.0752 0.074
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0337 0.0596 0.0562
Loa Loa (eye worm) hypothetical protein 0.0139 0.0037 0.0025
Echinococcus granulosus protein kinase shaggy 0.0275 0.042 0.042
Echinococcus multilocularis dual specificity protein kinase clk2 0.0328 0.0571 0.0571
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.017 0.0123 0.0111
Echinococcus multilocularis hypothetical protein 0.0218 0.026 0.026
Entamoeba histolytica protein kinase, putative 0.025 0.0351 0.1775
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Echinococcus granulosus fibropellin Ia 0.037 0.069 0.069
Onchocerca volvulus 0.0297 0.0483 0.21
Echinococcus granulosus CDC7 cell division cycle 7 0.0191 0.0185 0.0185
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0215 0.0252 0.024
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Echinococcus multilocularis serine threonine protein kinase 0.0431 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.0239 0.0319 0.0307
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.0178 0.0165
Echinococcus granulosus lachesin 0.0373 0.0697 0.0697
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0189 0.0178 0.0178
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0433 0.0867 0.0867
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0254 0.036 0.0349
Entamoeba histolytica protein kinase, putative 0.0174 0.0135 0.0575
Loa Loa (eye worm) programmed cell death 8 0.0337 0.0596 0.0585
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.017 0.0123 0.0123
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2014 0.5335 0.5329
Schistosoma mansoni cell adhesion molecule 0.0203 0.0218 0.0206
Entamoeba histolytica PH domain containing protein kinase, putative 0.0351 0.0635 0.335
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.0457 0.0446
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0214 0.0247 0.0117
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0239 0.0319 0.0319
Onchocerca volvulus Neurogenic locus notch homolog 0.037 0.069 0.3052
Toxoplasma gondii selenide, water dikinase 0.0337 0.0596 0.0562
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0232 0.0299 0.0287
Brugia malayi Protein kinase domain containing protein 0.0139 0.0037 0.0025
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0872 0.2109 0.2109
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0334 0.0589 0.0554
Brugia malayi Immunoglobulin domain containing protein 0.0203 0.0218 0.0206
Leishmania major acetoin dehydrogenase e3 component-like protein 0.127 0.3233 0.3208
Echinococcus granulosus Immunoglobulin subtype 0.0203 0.0218 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.127 0.3233 0.3208
Echinococcus multilocularis tyrosine protein kinase shark 0.0366 0.0679 0.0679
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0328 0.0571 0.0536
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.025 0.0351 0.0351
Echinococcus multilocularis protein jagged 2 0.037 0.069 0.069
Brugia malayi Protein kinase c protein 2 0.0247 0.0342 0.033
Trypanosoma brucei polo-like protein kinase 0.0578 0.1276 0.1243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0337 0.0596 0.1766
Schistosoma mansoni hypothetical protein 0.037 0.069 0.0679
Onchocerca volvulus 0.0625 0.1409 0.635
Echinococcus multilocularis tyrosine kinase 0.0139 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0148 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.0931 0.092
Plasmodium falciparum plasmepsin IV 0.0236 0.0311 0.0275
Schistosoma mansoni protein kinase 0.025 0.0351 0.0339
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0764 0.1801 0.1801
Echinococcus granulosus tyrosine protein kinase ABL1 0.0139 0.0037 0.0037
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0337 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0111
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0337 0.0596 0.0562
Entamoeba histolytica protein kinase, putative 0.014 0.0039 0.0045
Onchocerca volvulus 0.037 0.069 0.3052
Entamoeba histolytica serine/threonine protein kinase, putative 0.0578 0.1276 0.6909
Trichomonas vaginalis CAMK family protein kinase 0.0586 0.1299 0.3961
Loa Loa (eye worm) hypothetical protein 0.0203 0.0218 0.0206
Echinococcus granulosus roundabout 2 0.1061 0.2643 0.2643
Brugia malayi serine/threonine kinase 12 0.025 0.0351 0.0339
Echinococcus granulosus cyclin dependent kinase 0.0254 0.036 0.036
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0239 0.0319 0.0307
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1551 0.4025 0.4025
Brugia malayi notch-like transmembrane receptor 0.037 0.069 0.0679
Brugia malayi Leucine Rich Repeat family protein 0.017 0.0125 0.0113
Echinococcus multilocularis mitogen activated protein kinase 14 0.034 0.0604 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0214 0.0247 0.0676
Giardia lamblia Kinase, CMGC CDK 0.0254 0.036 0.0719
Brugia malayi kettin 0.017 0.0123 0.0111
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0177 0.0145 0.0108
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.0679

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) % Percent inhibition of the compound against Plasmodium falciparum at 5 microM; Not determined ChEMBL. 14695825
Inhibition (functional) 0 % Percent inhibition of the compound against Plasmodium falciparum at 5 microM; Not determined ChEMBL. 14695825
Ki (binding) = 4.4 nM Inhibitory activity against protease plasmepsin I (Plm I) of Plasmodium falciparum ChEMBL. 14695825
Ki (binding) = 4.4 nM Inhibitory activity against protease plasmepsin I (Plm I) of Plasmodium falciparum ChEMBL. 14695825
Ki (binding) = 15 nM Inhibitory activity against protease plasmepsin II (Plm II) of Plasmodium falciparum ChEMBL. 14695825
Ki (binding) = 15 nM Inhibitory activity against protease plasmepsin II (Plm II) of Plasmodium falciparum ChEMBL. 14695825
Ki (binding) > 2000 nM Inhibitory activity of the compound against human cathepsin D ChEMBL. 14695825
Ki (binding) > 2000 nM Inhibitory activity of the compound against human cathepsin D ChEMBL. 14695825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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