Detailed information for compound 313016

Basic information

Technical information
  • TDR Targets ID: 313016
  • Name: 2-[(1R)-1-[[(2S)-2-(cycloheptylcarbamoylamino )-4-methylpentanoyl]amino]-2-(1-methylindol-3 -yl)ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
  • MW: 550.692 | Formula: C30H42N6O4
  • H donors: 5 H acceptors: 5 LogP: 4.79 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@@H](c1nc(c([nH]1)C)C(=O)O)Cc1cn(c2c1cccc2)C)NC(=O)NC1CCCCCC1)C
  • InChi: 1S/C30H42N6O4/c1-18(2)15-24(34-30(40)32-21-11-7-5-6-8-12-21)28(37)33-23(27-31-19(3)26(35-27)29(38)39)16-20-17-36(4)25-14-10-9-13-22(20)25/h9-10,13-14,17-18,21,23-24H,5-8,11-12,15-16H2,1-4H3,(H,31,35)(H,33,37)(H,38,39)(H2,32,34,40)/t23-,24+/m1/s1
  • InChiKey: YMVVCMZSJQRDLI-RPWUZVMVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1R)-1-[[(2S)-2-(cycloheptylcarbamoylamino)-4-methyl-pentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[[(cycloheptylamino)-oxomethyl]amino]-4-methyl-1-oxopentyl]amino]-2-(1-methyl-3-indolyl)ethyl]-5-methyl-1H-imidazole-4-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Endothelin receptor ET-A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 21.1 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.0079 0.0107 0.0091
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0133
Echinococcus granulosus roundabout 2 0.0694 0.2449 0.2437
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Schistosoma mansoni cell adhesion molecule 0.0139 0.0334 0.0334
Brugia malayi Protein kinase domain containing protein 0.0432 0.145 0.145
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0063 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0045 0.0045
Onchocerca volvulus 0.027 0.0834 0.4836
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0215 0.0171
Loa Loa (eye worm) hypothetical protein 0.0224 0.0658 0.0658
Brugia malayi Prion-like- 0.025 0.0758 0.0758
Giardia lamblia Kinase, PLK 0.026 0.0794 0.2206
Entamoeba histolytica casein kinase, putative 0.0095 0.0167 0.0619
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0167 0.0619
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0123 0.0273 0.0273
Echinococcus multilocularis expressed protein 0.0079 0.0105 0.0089
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0267 0.0821 0.0821
Schistosoma mansoni serine/threonine protein kinase 0.026 0.0794 0.0794
Entamoeba histolytica cyclin C, putative 0.0618 0.2163 1
Echinococcus multilocularis Immunoglobulin subtype 0.0139 0.0334 0.0318
Plasmodium falciparum serine/threonine protein kinase, putative 0.0085 0.0127 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0584 0.0584
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0385 0.0369
Loa Loa (eye worm) hypothetical protein 0.0113 0.0237 0.0237
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0215 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0344 0.0344
Schistosoma mansoni cadherin 0.0056 0.0017 0.0017
Giardia lamblia Kinase, AGC PKA 0.0108 0.0215 0.0432
Onchocerca volvulus 0.0499 0.1706 1
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0555 0.192 0.192
Echinococcus multilocularis transfer RNA-Phe 0.0113 0.0237 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0364 0.0364
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0926 0.3337 0.3337
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0139 0.0334 0.0334
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0133 0.031 0.031
Echinococcus granulosus serine:threonine protein kinase N2 0.0272 0.0843 0.0828
Schistosoma mansoni cell adhesion molecule 0.0111 0.0228 0.0228
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0926 0.3337 0.3307
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Onchocerca volvulus 0.0111 0.0228 0.1246
Trypanosoma brucei rac serine-threonine kinase, putative 0.0273 0.0844 0.0802
Onchocerca volvulus 0.0184 0.0507 0.2897
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0119 0.0259 0.0244
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3307
Giardia lamblia Thioredoxin reductase 0.0246 0.0742 0.2047
Trypanosoma cruzi casein kinase, putative 0.0104 0.0199 0.0199
Brugia malayi Casein kinase II, alpha chain 0.0095 0.0167 0.0167
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0926 0.3337 0.3288
Echinococcus multilocularis neurogenic locus protein delta 0.027 0.0834 0.0819
Loa Loa (eye worm) hypothetical protein 0.0134 0.0315 0.0315
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0099 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0246 0.0742 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0215 0.0215
Schistosoma mansoni hemicentin 0.0113 0.0237 0.0237
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.025 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0252 0.0767 0.0752
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0113 0.0236 0.022
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0246 0.0742 0.07
Brugia malayi Cyclin, N-terminal domain containing protein 0.061 0.2129 0.2129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0286 0.0286
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.0084 0.0068
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0926 0.3337 0.2803
Trichomonas vaginalis STE family protein kinase 0.008 0.011 0.0331
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0322 0.103 0.103
Loa Loa (eye worm) hypothetical protein 0.0285 0.0892 0.0892
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0113 0.0236 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.017 0.017
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0156 0.0398 0.0398
Schistosoma mansoni serine/threonine kinase 0.0216 0.0627 0.0627
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0073 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0067 0.0058 0.0107
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0926 0.3337 0.3307
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0246 0.0742 0.0727
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.0236 0.0236
Onchocerca volvulus 0.0111 0.0228 0.1246
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0112 0.0231 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0204 0.0584 0.0584
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.0385 0.0341
Giardia lamblia Kinase, CMGC CLK 0.0147 0.0364 0.089
Schistosoma mansoni serine/threonine protein kinase 0.0806 0.2878 0.2878
Brugia malayi serine/threonine kinase 12 0.0085 0.0127 0.0127
Schistosoma mansoni cell polarity protein 0.027 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus serine:threonine protein kinase 0.0109 0.0219 0.0203
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0499 0.1706 0.1706
Plasmodium vivax tyrosine kinase-like protein, putative 0.0077 0.0097 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Schistosoma mansoni protein kinase 0.0197 0.0555 0.0555
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0926 0.3337 0.3326
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Schistosoma mansoni laminin gamma-3 chain 0.027 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Trichomonas vaginalis glutamate synthase, putative 0.0246 0.0742 0.2223
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0146 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Brugia malayi hypothetical protein 0.0139 0.0334 0.0334
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0213 0.0617 0.0617
Loa Loa (eye worm) TK/INSR protein kinase 0.0142 0.0347 0.0347
Plasmodium falciparum casein kinase 2, alpha subunit 0.0095 0.0167 0.0123
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Loa Loa (eye worm) thyroid receptor interactor 0.0087 0.0136 0.0136
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0926 0.3337 0.3337
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0295 0.0295
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0192 0.0538 0.0538
Plasmodium falciparum calcium-dependent protein kinase 3 0.0096 0.017 0.0126
Loa Loa (eye worm) hypothetical protein 0.0108 0.0215 0.0215
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0147 0.0364 0.0321
Onchocerca volvulus Putative titin 0.0111 0.0228 0.1246
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0207 0.0594 0.0579
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0144 0.0354 0.0354
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0083 0.0083
Echinococcus multilocularis cyclin dependent kinase 0.0113 0.0236 0.022
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.0653 0.0653
Schistosoma mansoni cell adhesion molecule 0.0252 0.0767 0.0767
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0095 0.0167 0.0167
Schistosoma mansoni g1/s-specific cyclin C 0.1222 0.4464 0.4464
Schistosoma mansoni hypothetical protein 0.0056 0.0017 0.0017
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.011 0.0223 0.0207
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0082 0.0115 0.01
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.002 0.0004
Echinococcus granulosus roundabout 2 0.0252 0.0767 0.0752
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0082 0.0115 0.01
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0246 0.0742 0.0742
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0096 0.017 0.0097
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Schistosoma mansoni basigin related 0.0139 0.0334 0.0334
Toxoplasma gondii casein kinase I 0.0104 0.0199 0.0182
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0123 0.0273 0.0256
Echinococcus granulosus casein kinase I delta 0.0104 0.0199 0.0183
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0127 0.0127
Echinococcus multilocularis dual specificity 0.0133 0.031 0.0295
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0246 0.0742 0.0727
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0074 0.0086 0.0086
Echinococcus multilocularis rac serine:threonine kinase 0.0156 0.0398 0.0383
Schistosoma mansoni septate junction protein 0.025 0.0758 0.0758
Brugia malayi Protein kinase domain containing protein 0.0806 0.2878 0.2878
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0127 0.0127
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Treponema pallidum NADH oxidase 0.0926 0.3337 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0246 0.0742 0.0673
Trypanosoma brucei polo-like protein kinase 0.026 0.0794 0.0752
Schistosoma mansoni cell adhesion molecule 0.0113 0.0237 0.0237
Plasmodium falciparum ferrodoxin reductase-like protein 0.0246 0.0742 0.07
Onchocerca volvulus 0.0113 0.0237 0.1298
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0104 0.0199 0.0199
Entamoeba histolytica protein kinase, putative 0.0067 0.0058 0.0107
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0108 0.0215 0.0142
Echinococcus granulosus tyrosine protein kinase otk 0.025 0.0758 0.0743
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0138 0.0332 0.0316
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0252 0.0767 0.0767
Echinococcus multilocularis cyclin dependent kinase 19 0.0806 0.2878 0.2867
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0145 0.0356 0.0341
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0246 0.0742 0.0726
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0247 0.0744 0.0744
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0127 0.0127
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0079 0.0107 0.0063
Plasmodium vivax protein kinase Crk2 0.0113 0.0236 0.0164
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0199 0.0596
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0246 0.0742 0.07
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0111 0.0229 0.0213
Schistosoma mansoni tyrosine kinase 0.0142 0.0347 0.0347
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0129 0.0387
Brugia malayi intracellular kinase 0.0123 0.0273 0.0273
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0926 0.3337 0.3337
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0199 0.0596
Echinococcus multilocularis Immunoglobulin 0.0441 0.1487 0.1473
Loa Loa (eye worm) SRC-1 0.0073 0.0084 0.0084
Loa Loa (eye worm) casein kinase 0.0174 0.0468 0.0468
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0441 0.1487 0.1487
Onchocerca volvulus 0.027 0.0834 0.4836
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0063 0.0045 0.0045
Plasmodium falciparum calcium-dependent protein kinase 5 0.0096 0.017 0.0126
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0108 0.0215 0.0215
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Echinococcus granulosus phospholipase A2 receptor 1 0.0056 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0236 0.0708
Brugia malayi protein kinase C II. 0.0189 0.0524 0.0524
Echinococcus granulosus Glutaredoxin protein 5 0.0119 0.0259 0.0244
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0252 0.0767 0.0752
Brugia malayi basement membrane proteoglycan 0.0139 0.0334 0.0334
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0083 0.0067
Toxoplasma gondii NADPH-glutathione reductase 0.0926 0.3337 0.3326
Schistosoma mansoni myosin-binding protein-related 0.0113 0.0237 0.0237
Echinococcus multilocularis Immunoglobulin 0.0441 0.1487 0.1473
Brugia malayi casein kinase 1, delta 0.0104 0.0199 0.0199
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.068 0.2399 0.2399
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0157 0.0402 0.0402
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0117 0.0249 0.0205
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0192 0.0538 0.0523
Echinococcus multilocularis hemicentin 1 0.025 0.0758 0.0743
Schistosoma mansoni tyrosine kinase 0.0057 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0139 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0281 0.0876 0.0876
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus defective proboscis extension response 0.0441 0.1487 0.1473
Brugia malayi Muscle positioning protein 4 0.027 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0441 0.1488 0.1488
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0926 0.3337 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.015 0.0375 0.0332
Schistosoma mansoni hypothetical protein 0.0098 0.0179 0.0179
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Echinococcus multilocularis down syndrome cell adhesion 0.0111 0.0228 0.0212
Giardia lamblia Kinase, NEK 0.013 0.03 0.0693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0675 0.0675
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0926 0.3337 0.3307
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Echinococcus multilocularis lymphocyte antigen 75 0.0056 0.0017 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0107 0.0321
Onchocerca volvulus Neurogenic locus notch homolog 0.027 0.0834 0.4836
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0926 0.3337 0.3326
Onchocerca volvulus 0.0062 0.004 0.0132
Giardia lamblia NADH oxidase lateral transfer candidate 0.0926 0.3337 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0246 0.0742 0.0742
Schistosoma mansoni nephrin 0.0555 0.1919 0.1919
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0141 0.0343 0.0343
Onchocerca volvulus 0.0111 0.0228 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.0084 0.0068
Brugia malayi probable protein kinase 0.0254 0.0774 0.0774
Schistosoma mansoni basigin related 0.0139 0.0334 0.0334
Echinococcus multilocularis neuroglian 0.0252 0.0767 0.0752
Plasmodium falciparum NIMA related kinase 1 0.013 0.03 0.0256
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0545 0.2394
Brugia malayi protein-tyrosine kinase 0.0056 0.0016 0.0016
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Plasmodium vivax glutathione reductase, putative 0.2673 1 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0441 0.1487 0.1473
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0246 0.0742 0.0727
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0139 0.0334 0.0334
Schistosoma mansoni slit 0.027 0.0835 0.0835
Echinococcus multilocularis serine threonine protein kinase 0.0187 0.0516 0.0501
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0054 0.0038
Echinococcus multilocularis calcium activated potassium channel 0.0129 0.0295 0.028
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0418 0.1399 0.1385
Schistosoma mansoni rap gtpase-activating protein 0.0108 0.0215 0.0215
Trichomonas vaginalis mercuric reductase, putative 0.0926 0.3337 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.0027 0.0027
Brugia malayi cyclin-dependent kinase 9 0.0074 0.0086 0.0086
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.0127 0.0431
Brugia malayi Protein kinase domain containing protein 0.0186 0.0512 0.0512
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.0236 0.022
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.013 0.03 0.0228
Trypanosoma brucei cdc2-related kinase 1 0.0113 0.0236 0.0192
Brugia malayi Protein kinase domain containing protein 0.0109 0.0219 0.0219
Echinococcus granulosus nervana 2 0.0119 0.0259 0.0244
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0139 0.0334 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0538 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus multilocularis neuroglian 0.0552 0.1911 0.1898
Echinococcus multilocularis Immunoglobulin 0.0139 0.0334 0.0318
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0476 0.1619 0.1606
Schistosoma mansoni protein kinase 0.0146 0.0363 0.0363
Onchocerca volvulus 0.0138 0.033 0.185
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0107 0.0107
Plasmodium falciparum glutathione reductase 0.0926 0.3337 0.3307
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.0084 0.0068
Echinococcus multilocularis serine:threonine protein kinase 38 0.0147 0.0366 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Brugia malayi Calcium binding EGF domain containing protein 0.027 0.0834 0.0834
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.017 0.0154
Loa Loa (eye worm) AGC/NDR protein kinase 0.0147 0.0366 0.0366
Schistosoma mansoni glutamate synthase 0.0246 0.0742 0.0742
Schistosoma mansoni basigin related 0.0139 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Echinococcus granulosus delta-like protein 1 0.027 0.0834 0.0819
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0079 0.0105 0.006
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0157 0.0403 0.0387
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0147 0.0366 0.035
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.015 0.0375 0.036
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0139 0.0334 0.0318
Entamoeba histolytica disulphide oxidoreductase, putative 0.0246 0.0742 0.332
Echinococcus multilocularis casein kinase I delta 0.0104 0.0199 0.0183
Giardia lamblia Kinase, CK1 Casein kinase 0.0104 0.0199 0.0383
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0334 0.0334
Schistosoma mansoni protein kinase 0.0085 0.0127 0.0127
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Loa Loa (eye worm) projectin 0.0113 0.0237 0.0237
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0225 0.0664 0.0649
Entamoeba histolytica protein kinase, putative 0.0077 0.0099 0.0297
Echinococcus granulosus titin 0.0111 0.0228 0.0212
Brugia malayi p70 ribosomal S6 kinase beta 0.0267 0.0821 0.0821
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.0286 0.0286
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0079 0.0107 0.0063
Schistosoma mansoni c4b-binding protein beta chain 0.0499 0.1706 0.1706
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0133 0.031 0.0294
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0085 0.0127 0.0111
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.1555 0.1555
Onchocerca volvulus Peroxidasin homolog 0.0111 0.0229 0.1251
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0113 0.0237 0.0237
Trichomonas vaginalis STE family protein kinase 0.0082 0.0115 0.0346
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0236 0.0236
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0236 0.0708
Schistosoma mansoni tyrosine kinase 0.0073 0.0083 0.0083
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0145 0.0356 0.0341
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0118 0.0253 0.0209
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0441 0.1487 0.1487
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Brugia malayi C1-like domain containing protein 0.0209 0.06 0.06
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0085 0.0127 0.0054
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus multilocularis fras1 related extracellular matrix protein 0.0056 0.0017 0.0001
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0246 0.0742 0.0673
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Brugia malayi Protein kinase domain containing protein 0.0192 0.0538 0.0538
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0246 0.0742 0.2223
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0926 0.3337 0.3337
Brugia malayi Immunoglobulin domain containing protein 0.0139 0.0334 0.0334
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0147 0.0364 0.0364
Toxoplasma gondii AGC kinase 0.0108 0.0215 0.0198
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.0385 0.0369
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.008 0.011 0.0352
Brugia malayi Immunoglobulin I-set domain containing protein 0.0252 0.0767 0.0767
Brugia malayi Myb-like DNA-binding domain containing protein 0.0111 0.0228 0.0228
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0246 0.0742 0.0726
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0246 0.0742 0.0742
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0926 0.3337 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0147 0.0364 0.0321
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0247 0.0747 0.0747
Loa Loa (eye worm) AGC/PKA protein kinase 0.0108 0.0215 0.0215
Entamoeba histolytica thioredoxin reductase, putative 0.0246 0.0742 0.332
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0209 0.06 0.06
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0063 0.0045 0.0029
Brugia malayi Peroxidasin 0.025 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Onchocerca volvulus 0.0178 0.0484 0.2762
Loa Loa (eye worm) hypothetical protein 0.0108 0.0215 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0366 0.1095
Schistosoma mansoni cell adhesion molecule 0.0139 0.0334 0.0334
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0139 0.0334 0.0318
Trichomonas vaginalis AGC family protein kinase 0.013 0.03 0.0899
Giardia lamblia High cysteine protein 0.027 0.0834 0.233
Loa Loa (eye worm) LAD-2 short isoform 0.0139 0.0334 0.0334
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.011 0.0223 0.0207
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0339 0.1097 0.1083
Leishmania major trypanothione reductase 0.2673 1 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0225 0.0664 0.0649
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.0385 0.0341
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Loa Loa (eye worm) hypothetical protein 0.0691 0.244 0.244
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0246 0.0742 0.0727
Echinococcus granulosus tyrosine protein kinase Lyn 0.0104 0.02 0.0184
Brugia malayi Cadherin domain containing protein 0.027 0.0834 0.0834
Echinococcus multilocularis titin 0.0111 0.0228 0.0212
Onchocerca volvulus 0.0301 0.0954 0.5544
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.025 0.0758 0.0758
Echinococcus multilocularis serine:threonine protein kinase N2 0.0272 0.0843 0.0828
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0246 0.0742 0.07
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0107 0.0107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0096 0.017 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0112 0.0231 0.0216
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0096 0.017 0.0154
Trypanosoma cruzi rac serine-threonine kinase, putative 0.015 0.0375 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.067 0.067
Toxoplasma gondii aurora kinase 0.0085 0.0127 0.011
Giardia lamblia Kinase, CMGC CDK 0.0113 0.0236 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Schistosoma mansoni protein kinase 0.0095 0.0167 0.0167
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0228 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0127 0.0381
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.0823 0.2466
Brugia malayi Heparan sulfate 0.0139 0.0334 0.0334
Brugia malayi Protein kinase domain containing protein 0.0339 0.1097 0.1097
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0109 0.0219 0.0219
Brugia malayi Protein kinase domain containing protein 0.0142 0.0347 0.0347
Onchocerca volvulus 0.0073 0.0083 0.0386
Entamoeba histolytica PH domain containing protein kinase, putative 0.0114 0.0238 0.095
Echinococcus multilocularis tyrosine protein kinase otk 0.025 0.0758 0.0743
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0108 0.0215 0.02
Schistosoma mansoni glutamate synthase 0.0246 0.0742 0.0742
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0082 0.0115 0.01
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0083 0.0067
Loa Loa (eye worm) hypothetical protein 0.0184 0.0507 0.0507
Echinococcus multilocularis fibropellin Ia 0.027 0.0834 0.0819
Schistosoma mansoni protein kinase 0.0417 0.1396 0.1396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Echinococcus multilocularis casein kinase I gamma 0.0204 0.0584 0.0569
Brugia malayi Protein kinase domain containing protein 0.0147 0.0364 0.0364
Schistosoma mansoni titin 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0147 0.0364 0.0364
Echinococcus granulosus twitchin 0.0583 0.2027 0.2014
Echinococcus granulosus low density lipoprotein receptor ldl 0.0139 0.0334 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0099 0.0099
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0898 0.3229 0.3229
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus multilocularis serine:threonine protein kinase N2 0.0125 0.0281 0.0266
Schistosoma mansoni tyrosine kinase 0.0073 0.0083 0.0083
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0111 0.0228 0.0212
Loa Loa (eye worm) hypothetical protein 0.0139 0.0334 0.0334
Trypanosoma cruzi Protein kinase B 0.0156 0.0398 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.005 0.005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0084 0.0068
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0926 0.3337 0.3288
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0147 0.0366 0.0366
Loa Loa (eye worm) cyclin C 0.1222 0.4464 0.4464
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0926 0.3337 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0339 0.1097 0.6392
Giardia lamblia Aurora kinase 0.0085 0.0127 0.0164
Schistosoma mansoni notch 0.027 0.0834 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0594 0.0594
Trichomonas vaginalis STE family protein kinase 0.0061 0.0036 0.0107
Echinococcus multilocularis glutamate synthase 0.0246 0.0742 0.0727
Echinococcus multilocularis dual specificity 0.0133 0.031 0.0295
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0133
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0246 0.0742 0.07
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0107 0.0321
Schistosoma mansoni vesicular amine transporter 0.0441 0.1487 0.1487
Toxoplasma gondii CMGC kinase, CK2 family 0.0095 0.0167 0.015
Giardia lamblia Kinase, AGC AKT 0.0112 0.023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0141 0.0343 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0273 0.1114
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0127 0.029 0.0275
Schistosoma mansoni titin 0.0111 0.0228 0.0228
Echinococcus granulosus casein kinase ii subunit alpha 0.0095 0.0167 0.0152
Echinococcus granulosus Immunoglobulin 0.0139 0.0334 0.0318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0054 0.0038
Echinococcus multilocularis notch 0.027 0.0834 0.0819
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0353 0.1149 0.1135
Trypanosoma cruzi trypanothione reductase, putative 0.2673 1 1
Schistosoma mansoni hypothetical protein 0.0098 0.0179 0.0179
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0246 0.0742 0.0727
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0228 0.0675 0.0675
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.027 0.0834 0.0834
Echinococcus multilocularis hemicentin 1 0.025 0.0758 0.0743
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0228 0.0675 0.066
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0147 0.0364 0.0364
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.0653 0.0653
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0252 0.0767 0.0752
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.011 0.011
Echinococcus multilocularis insulin growth factor binding 0.0111 0.0228 0.0212
Plasmodium falciparum calcium-dependent protein kinase 2 0.0096 0.017 0.0126
Entamoeba histolytica PH domain containing protein kinase, putative 0.0156 0.0398 0.1705
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Schistosoma mansoni nephrin related 0.0111 0.0228 0.0228
Brugia malayi Serine/threonine-protein kinase SULU 0.0213 0.0617 0.0617
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0246 0.0742 0.0727
Loa Loa (eye worm) hypothetical protein 0.0443 0.1496 0.1496
Leishmania major protein kinase, putative 0.0147 0.0364 0.0321
Echinococcus multilocularis fat cadherin tumor suppressor 0.027 0.0834 0.0819
Echinococcus multilocularis dual specificity 0.0117 0.0249 0.0233
Echinococcus multilocularis nervana 2 0.0119 0.0259 0.0244
Loa Loa (eye worm) Notch2 0.027 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0083 0.012 0.012
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0082 0.0115 0.01
Onchocerca volvulus 0.0113 0.0237 0.1298
Entamoeba histolytica PH domain containing protein kinase, putative 0.0114 0.0238 0.095
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0086 0.0086
Leishmania major protein kinase A catalytic subunit 0.0108 0.0215 0.0171
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.0084 0.0068
Echinococcus granulosus ephrin type A receptor 4 A 0.0078 0.0102 0.0086
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0199 0.0199
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Toxoplasma gondii thioredoxin reductase 0.2673 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Echinococcus multilocularis thioredoxin glutathione reductase 0.2673 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.015 0.0375 0.036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Onchocerca volvulus Tyrosine kinase homolog 0.0429 0.144 0.8423
Echinococcus granulosus Protein kinase C brain isozyme 0.0227 0.067 0.0655
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Toxoplasma gondii AGC kinase 0.0267 0.0821 0.0805
Brugia malayi casein kinase I 0.0104 0.0199 0.0199
Onchocerca volvulus 0.027 0.0834 0.4836
Toxoplasma gondii selenide, water dikinase 0.0246 0.0742 0.0726
Brugia malayi serine/threonine-protein kinase 6 0.0085 0.0127 0.0127
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0254 0.0772 0.0757
Trypanosoma brucei aurora B kinase 0.0085 0.0127 0.0083
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Brugia malayi pregnancy-associated plasma protein-A 0.0499 0.1706 0.1706
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0228 0.0675 0.066
Schistosoma mansoni ephrin receptor 0.0078 0.0102 0.0102
Onchocerca volvulus 0.0111 0.0228 0.1246
Loa Loa (eye worm) glutathione reductase 0.2673 1 1
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Schistosoma mansoni nephrin related 0.0139 0.0334 0.0334
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0085 0.0127 0.0431
Plasmodium vivax calcium-dependent protein kinase, putative 0.0096 0.017 0.0097
Schistosoma mansoni protein kinase 0.0082 0.0115 0.0115
Trichomonas vaginalis STE family protein kinase 0.0082 0.0115 0.0346
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0273 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0598 0.1791
Brugia malayi Kinase associated domain 1 family protein 0.0098 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0084 0.0068
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Schistosoma mansoni hypothetical protein 0.0056 0.0017 0.0017
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0077 0.0097 0.0052
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0246 0.0742 0.0742
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0113 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.025 0.0758 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0273 0.0817
Brugia malayi protein kinase C3,putative 0.0151 0.0379 0.0379
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0107 0.0321
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.013 0.03 0.0283
Brugia malayi Protein kinase c protein 2 0.011 0.0225 0.0225
Echinococcus granulosus fibropellin Ia 0.027 0.0834 0.0819
Schistosoma mansoni protein kinase 0.0197 0.0555 0.0555
Echinococcus granulosus Immunoglobulin 0.0139 0.0334 0.0318
Schistosoma mansoni neuroglian 0.0252 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Schistosoma mansoni nephrin 0.0252 0.0767 0.0767
Trichomonas vaginalis STE family protein kinase 0.013 0.03 0.0899
Loa Loa (eye worm) AUR protein kinase 0.0085 0.0127 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Brugia malayi Cyclin C 0.1222 0.4464 0.4464
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0127 0.0381
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0111 0.0228 0.0212
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus expressed protein 0.0079 0.0105 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.017 0.051
Echinococcus granulosus down syndrome cell adhesion 0.0111 0.0228 0.0212
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0246 0.0742 0.332
Echinococcus granulosus neurogenic locus notch protein 4 0.027 0.0834 0.0819
Schistosoma mansoni titin 0.0111 0.0228 0.0228
Echinococcus multilocularis serine:threonine protein kinase 0.0109 0.0219 0.0203
Echinococcus granulosus dual specificity 0.0133 0.031 0.0295
Echinococcus granulosus serine:threonine protein kinase PLK1 0.026 0.0794 0.0779
Schistosoma mansoni vav2 0.0057 0.0023 0.0023
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0385 0.0369
Echinococcus granulosus protein jagged 2 0.027 0.0834 0.0819
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.011 0.011
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0385 0.0385
Echinococcus granulosus cyclin dependent kinase 9 0.0074 0.0086 0.007
Echinococcus multilocularis 0.0116 0.0248 0.0233
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0108 0.0215 0.0215
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0207 0.0594 0.0579
Brugia malayi Immunoglobulin I-set domain containing protein 0.0167 0.044 0.044
Brugia malayi Immunoglobulin domain containing protein 0.0139 0.0334 0.0334
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0086 0.0237
Brugia malayi Disorganized muscle protein 1 0.0111 0.0228 0.0228
Echinococcus granulosus dual specificity protein kinase clk2 0.0147 0.0364 0.0349
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0417 0.1396 0.1383
Entamoeba histolytica protein kinase , putative 0.0085 0.0127 0.0431
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0077 0.0097 0.008
Schistosoma mansoni protein kinase 0.0185 0.0509 0.0509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Echinococcus granulosus serine/threonine protein kinase 0.0156 0.0398 0.0383
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.007 0.0071 0.0071
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0083 0.0067
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Onchocerca volvulus 0.0499 0.1706 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0147 0.0364 0.0349
Loa Loa (eye worm) hypothetical protein 0.0139 0.0334 0.0334
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Echinococcus multilocularis roundabout 2 0.0252 0.0767 0.0752
Echinococcus granulosus calcium activated potassium channel 0.0129 0.0295 0.028
Trypanosoma cruzi polo-like protein kinase, putative 0.026 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0134 0.0315 0.0315
Leishmania major hypothetical protein, conserved 0.0246 0.0742 0.07
Echinococcus multilocularis ephrin type A receptor 4 A 0.0078 0.0102 0.0086
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0096 0.017 0.0097
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0139 0.0334 0.0334
Echinococcus granulosus cyclin dependent kinase 0.0113 0.0236 0.022
Loa Loa (eye worm) hypothetical protein 0.0134 0.0315 0.0315
Echinococcus granulosus roundabout 2 0.0252 0.0767 0.0752
Giardia lamblia Kinase, CMGC CDK 0.0113 0.0236 0.0497
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Brugia malayi Protein kinase domain containing protein 0.0185 0.0509 0.0509
Echinococcus granulosus fras1 related extracellular matrix protein 0.0056 0.0017 0.0001
Onchocerca volvulus Slit protein homolog 0.0285 0.0892 0.5178
Brugia malayi Doublecortin family protein 0.0144 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0063 0.0045 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus granulosus lymphocyte antigen 75 0.0056 0.0017 0.0001
Onchocerca volvulus 0.0499 0.1706 1
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Brugia malayi glutamate synthase 0.0246 0.0742 0.0742
Plasmodium vivax unspecified product 0.0095 0.0167 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0926 0.3337 0.3307
Onchocerca volvulus Neurogenic locus notch protein homolog 0.027 0.0834 0.4836
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0157 0.0403 0.0387
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2673 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Echinococcus granulosus casein kinase I alpha 0.0104 0.0199 0.0183
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0353 0.1149 0.1149
Onchocerca volvulus 0.0074 0.0086 0.0407
Schistosoma mansoni septate junction protein 0.025 0.0758 0.0758
Entamoeba histolytica protein kinase, putative 0.0133 0.031 0.1292
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0077 0.0099 0.0083
Leishmania major hypothetical protein, conserved 0.0246 0.0742 0.07
Echinococcus granulosus neurogenic locus protein delta 0.027 0.0834 0.0819
Echinococcus granulosus protein jagged 1 0.027 0.0834 0.0819
Onchocerca volvulus 0.0123 0.0273 0.151
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0246 0.0742 0.332
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0056 0.0017 0.0017
Onchocerca volvulus Peroxidasin homolog 0.0111 0.0228 0.1246
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0273 0.0817
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0063 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0108 0.0215 0.0171
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0339 0.1097 0.1097
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0099 0.0099
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0063 0.0045 0.0029
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0246 0.0742 0.07
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0139 0.0334 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0246 0.0742 0.0727
Echinococcus multilocularis roundabout 2 0.0252 0.0767 0.0752
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0224 0.0658 0.0643
Loa Loa (eye worm) TK protein kinase 0.0223 0.0655 0.0655
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0199 0.0199
Entamoeba histolytica protein kinase, putative 0.0079 0.0105 0.0325
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0069 0.0068 0.0068
Brugia malayi Calcium binding EGF domain containing protein 0.027 0.0834 0.0834
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0194 0.0545 0.0545
Entamoeba histolytica protein kinase 2, putative 0.015 0.0375 0.1598
Schistosoma mansoni sulfide quinone reductase 0.0246 0.0742 0.0742
Giardia lamblia Kinase, STE STE20 0.0082 0.0115 0.0127
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0476 0.1619 0.1606
Echinococcus granulosus protein jagged 2 0.027 0.0834 0.0819
Onchocerca volvulus 0.0499 0.1706 1
Leishmania major protein kinase, putative 0.008 0.011 0.0066
Echinococcus granulosus cyclin dependent kinase 1 0.0113 0.0236 0.022
Loa Loa (eye worm) hypothetical protein 0.0062 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0073 0.0083 0.0083
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0096 0.017 0.017
Leishmania major protein kinase A catalytic subunit isoform 1 0.0108 0.0215 0.0171
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0085 0.0127 0.0111
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0108 0.0215 0.0215
Echinococcus granulosus nervana 2 0.0119 0.0259 0.0244
Echinococcus granulosus aurora kinase A 0.0085 0.0127 0.0111
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0108 0.0215 0.0198
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0108 0.0215 0.0215
Trypanosoma cruzi casein kinase II, putative 0.0095 0.0167 0.0167
Schistosoma mansoni fras1 related extracellular matrix protein 0.0056 0.0017 0.0017
Echinococcus multilocularis insulin receptor 0.0142 0.0347 0.0332
Brugia malayi Prion-like- 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0139 0.0334 0.0334
Brugia malayi P38 map kinase family protein 2 0.0152 0.0385 0.0385
Echinococcus multilocularis aurora kinase A 0.0085 0.0127 0.0111
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0085 0.0127 0.0431
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Onchocerca volvulus 0.0499 0.1706 1
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0056 0.0017 0.0017
Loa Loa (eye worm) protein kinase domain-containing protein 0.0204 0.0584 0.0584
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0197 0.0555 0.054
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0096 0.017 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0117 0.0249 0.0205
Plasmodium vivax apical sushi protein, putative 0.0499 0.1706 0.1645
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.002 0.002
Plasmodium falciparum glutathione reductase 0.2673 1 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0223 0.0667
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0207 0.0594 0.0579
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0366 0.1095
Echinococcus multilocularis neurogenic locus protein delta 0.027 0.0834 0.0819
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0063 0.0045 0.0045
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.026 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Onchocerca volvulus Serine\/threonine kinase homolog 0.026 0.0794 0.4598
Schistosoma mansoni protein kinase 0.0417 0.1396 0.1396
Schistosoma mansoni atypical protein kinase C 0.0273 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0115 0.0242 0.0242
Echinococcus multilocularis Immunoglobulin 0.0139 0.0334 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0168 0.0446 0.0446
Trichomonas vaginalis STE family protein kinase 0.0082 0.0115 0.0346
Schistosoma mansoni protein kinase 0.0104 0.0199 0.0199
Schistosoma mansoni serine/threonine-protein kinase 0.0156 0.0398 0.0398
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0252 0.0767 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Plasmodium vivax glycogen synthase kinase 3, putative 0.0123 0.0273 0.02
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0246 0.0742 0.2223
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0083 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0264 0.0791
Loa Loa (eye worm) hypothetical protein 0.0108 0.0215 0.0215
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Brugia malayi Protein kinase domain containing protein 0.0079 0.0105 0.0105
Schistosoma mansoni protein kinase 0.0417 0.1396 0.1396
Schistosoma mansoni tyrosine kinase 0.0073 0.0084 0.0084
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0147 0.0364 0.0321
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0144 0.0353 0.0353
Brugia malayi Calcium binding EGF domain containing protein 0.027 0.0834 0.0834
Entamoeba histolytica casein kinase, putative 0.0104 0.0199 0.0767
Echinococcus granulosus neurogenic locus notch protein 0.027 0.0834 0.0819
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0082 0.0115 0.01
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0119 0.0259 0.0244
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.0084 0.0068
Loa Loa (eye worm) hypothetical protein 0.0139 0.0334 0.0334
Schistosoma mansoni Galactose-specific lectin (PAL) 0.0056 0.0017 0.0017
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0246 0.0742 0.2223
Entamoeba histolytica protein kinase, putative 0.0096 0.017 0.0632
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0157 0.0403 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Entamoeba histolytica cell division protein kinase 2, putative 0.0113 0.0236 0.0943
Trypanosoma cruzi casein kinase, putative 0.0104 0.0199 0.0199
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0273 0.0273
Echinococcus multilocularis mitogen activated protein kinase 0.0079 0.0107 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0213 0.0617 0.0602
Echinococcus multilocularis roundabout 2 0.0694 0.2449 0.2437
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Echinococcus granulosus c4b binding protein beta chain 0.0499 0.1706 0.1693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0141 0.0343 0.0343
Brugia malayi notch-like transmembrane receptor 0.027 0.0834 0.0834
Echinococcus granulosus titin 0.0111 0.0228 0.0212
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.061 0.2129 0.2117
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Plasmodium falciparum calcium-dependent protein kinase 1 0.0096 0.017 0.0126
Trichomonas vaginalis glutathione reductase, putative 0.0926 0.3337 1
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0107 0.0321
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0215 0.0215
Echinococcus multilocularis serine:threonine protein kinase N2 0.0147 0.0366 0.035
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0283 0.0883 0.0883
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0379 0.125 0.1236
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0926 0.3337 0.3326
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Brugia malayi Protein kinase domain containing protein 0.0908 0.3267 0.3267
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0339 0.1097 0.1097
Trypanosoma cruzi trypanothione reductase, putative 0.0926 0.3337 0.3337
Entamoeba histolytica protein kinase, putative 0.0273 0.0844 0.3798
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0129 0.0387
Onchocerca volvulus Basement membrane proteoglycan homolog 0.025 0.0758 0.4383
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.017 0.0154
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Schistosoma mansoni serine/threonine protein kinase 0.0379 0.125 0.125
Loa Loa (eye worm) notch protein 0.027 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Echinococcus multilocularis c4b binding protein beta chain 0.0499 0.1706 0.1693
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0379 0.125 0.1236
Echinococcus granulosus notch 0.027 0.0834 0.0819
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0215 0.0215
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0112 0.023 0.023
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0395 0.1182
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0147 0.0366 0.035
Brugia malayi cell division control protein 2 homolog 0.0113 0.0236 0.0236
Trichomonas vaginalis apoptosis inducing factor, putative 0.0246 0.0742 0.2223
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0085 0.0127 0.0431
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Loa Loa (eye worm) AGC/AKT protein kinase 0.0273 0.0844 0.0844
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Schistosoma mansoni notch 0.027 0.0834 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0664 0.0664
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.067 0.067
Echinococcus granulosus insulin growth factor binding 0.0111 0.0228 0.0212
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0364 0.0364
Onchocerca volvulus 0.0282 0.088 0.5106
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0063 0.0045 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Echinococcus multilocularis cyclin dependent kinase 9 0.0074 0.0086 0.007
Schistosoma mansoni tyrosine kinase 0.0142 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus titin 0.0111 0.0228 0.0212
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0199 0.0183
Echinococcus multilocularis neurogenic locus notch protein 4 0.027 0.0834 0.0819
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.0236 0.0236
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0096 0.017 0.0126
Echinococcus multilocularis PAK box P21 Rho binding 0.0061 0.0036 0.002
Schistosoma mansoni hypothetical protein 0.0113 0.0237 0.0237
Echinococcus granulosus casein kinase i 0.0104 0.0199 0.0183
Echinococcus multilocularis titin 0.0111 0.0228 0.0212
Echinococcus multilocularis protein jagged 1 0.027 0.0834 0.0819
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0083 0.0067
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0273 0.0609
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0108 0.0215 0.0171
Echinococcus multilocularis casein kinase ii subunit alpha 0.0095 0.0167 0.0152
Entamoeba histolytica p21-activated kinase 0.0088 0.0138 0.0483
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0385 0.0369
Entamoeba histolytica protein kinase, putative 0.0085 0.0127 0.0431
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0246 0.0742 0.332
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0246 0.0742 0.2223
Schistosoma mansoni cell adhesion molecule 0.0113 0.0237 0.0237
Brugia malayi hypothetical protein 0.0213 0.0617 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0353 0.0353
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0082 0.0115 0.01
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0077 0.0099 0.0083
Leishmania major protein kinase, putative 0.0096 0.017 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Echinococcus granulosus protein jagged 1 0.027 0.0834 0.0819
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0228 0.0228
Onchocerca volvulus 0.0499 0.1706 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0334 0.0334
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0085 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0108 0.0215 0.0215
Loa Loa (eye worm) one IG domain family member 0.0111 0.0228 0.0228
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Echinococcus granulosus cyclin dependent kinase 5 0.0113 0.0236 0.022
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0123 0.0273 0.0273
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Giardia lamblia Kinase, CDC7 0.0085 0.0129 0.017
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.031 0.1292
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Trypanosoma brucei cdc2-related kinase 3 0.0113 0.0236 0.0192
Brugia malayi Protein kinase domain containing protein 0.0147 0.0366 0.0366
Echinococcus granulosus casein kinase I alpha 0.0104 0.0199 0.0183
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0246 0.0742 0.0742
Brugia malayi hypothetical protein 0.0443 0.1496 0.1496
Loa Loa (eye worm) gastrulation defective protein 1 0.0776 0.2762 0.2762
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0095 0.0167 0.0094
Onchocerca volvulus 0.0111 0.0228 0.1246
Echinococcus multilocularis twitchin 0.0142 0.0344 0.0328
Echinococcus granulosus protein kinase 0.0146 0.0363 0.0347
Echinococcus multilocularis Glutaredoxin protein 5 0.0119 0.0259 0.0244
Onchocerca volvulus Putative cubilin 0.027 0.0834 0.4836
Schistosoma mansoni protein kinase 0.0061 0.0036 0.0036
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.025 0.0758 0.0743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0223 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Plasmodium falciparum thioredoxin reductase 0.2673 1 1
Echinococcus granulosus lachesin 0.025 0.0758 0.0743
Trypanosoma cruzi polo-like protein kinase, putative 0.026 0.0794 0.0794
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.026 0.0794 0.0779
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0113 0.0237 0.0237
Plasmodium vivax serine/threonine kinase-1, putative 0.0147 0.0364 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.0403 0.0403
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0099 0.0296
Schistosoma mansoni protein kinase 0.0353 0.1149 0.1149
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0108 0.0215 0.0171
Echinococcus granulosus serine:threonine protein kinase N2 0.0125 0.0281 0.0266
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0246 0.0742 0.0727
Schistosoma mansoni glutamate synthase 0.0246 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0108 0.0215 0.0171
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0194 0.0545 0.053
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Brugia malayi GCC2 and GCC3 family protein 0.0769 0.2736 0.2736
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0223 0.0667
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0113 0.0236 0.0192
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0246 0.0742 0.07
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0264 0.0791
Echinococcus granulosus cyclin 0.061 0.2129 0.2117
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.058 0.2017 0.2004
Schistosoma mansoni titin 0.0144 0.0353 0.0353
Onchocerca volvulus 0.0111 0.0229 0.1251
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0139 0.0334 0.0334
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0113 0.0236 0.0192
Loa Loa (eye worm) hypothetical protein 0.025 0.0759 0.0759
Echinococcus multilocularis protein kinase shaggy 0.0123 0.0273 0.0257
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.026 0.0794 0.0752
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Schistosoma mansoni cell adhesion molecule 0.025 0.0758 0.0758
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0926 0.3337 0.3307
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0167 0.0502
Entamoeba histolytica protein kinase, putative 0.0123 0.0273 0.1114
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0077 0.0099 0.0083
Echinococcus multilocularis 0.0146 0.0363 0.0347
Brugia malayi Protein kinase domain containing protein 0.0077 0.0099 0.0099
Schistosoma mansoni septate junction protein 0.0139 0.0334 0.0334
Toxoplasma gondii rhoptry neck protein RON9 0.0499 0.1706 0.1692
Brugia malayi Protein kinase domain containing protein 0.0113 0.0236 0.0236
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.008 0.011 0.0352
Plasmodium vivax thioredoxin reductase, putative 0.2673 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0144 0.0353 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0524 0.0524
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0192 0.0538 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0215 0.0215
Giardia lamblia Kinase, CMGC CK2 0.0095 0.0167 0.0286
Leishmania major protein kinase A catalytic subunit isoform 2 0.0108 0.0215 0.0171
Schistosoma mansoni protein kinase 0.0254 0.0774 0.0774
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0335 0.0335
Loa Loa (eye worm) CAMK protein kinase 0.0144 0.0353 0.0353
Loa Loa (eye worm) TK/ROR protein kinase 0.0127 0.029 0.029
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Echinococcus granulosus basement membrane specific heparan sulfate 0.0139 0.0334 0.0318
Schistosoma mansoni serine/threonine kinase 0.0147 0.0366 0.0366
Leishmania major NADH dehydrogenase, putative 0.0246 0.0742 0.07
Echinococcus multilocularis protein jagged 2 0.027 0.0834 0.0819
Echinococcus granulosus C type lectin 0.0056 0.0017 0.0001
Onchocerca volvulus Netrin receptor homolog 0.0139 0.0334 0.1876
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Echinococcus granulosus serine:threonine protein kinase 3 0.0247 0.0744 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0079 0.0107 0.0107
Echinococcus granulosus protein kinase C gamma type 0.0187 0.0516 0.0501
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Onchocerca volvulus 0.0108 0.0215 0.1172
Loa Loa (eye worm) hypothetical protein 0.0113 0.0237 0.0237
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0926 0.3337 0.2803
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0273 0.0273
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0908 0.3267 0.3267
Echinococcus granulosus Immunoglobulin subtype 0.0139 0.0334 0.0318
Plasmodium vivax serine/threonine protein kinase, putative 0.0079 0.0105 0.0031
Loa Loa (eye worm) hypothetical protein 0.0441 0.1487 0.1487
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0056 0.0017 0.0017
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0079 0.0107 0.009
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.068 0.2399 0.2399
Echinococcus multilocularis cyclin dependent kinase 9 0.0082 0.0115 0.0099
Onchocerca volvulus Serine\/threonine kinase homolog 0.0157 0.0403 0.2283
Trypanosoma cruzi casein kinase, putative 0.0104 0.0199 0.0199
Echinococcus granulosus NDR protein kinase 0.0147 0.0366 0.035
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0123 0.0273 0.0257
Echinococcus multilocularis peroxidasin 0.025 0.0759 0.0744
Echinococcus multilocularis 0.0111 0.0228 0.0212
Schistosoma mansoni ste20-related kinase 0.0197 0.0554 0.0554
Leishmania major hypothetical protein, conserved 0.0246 0.0742 0.07
Loa Loa (eye worm) TK/EPH protein kinase 0.0095 0.0167 0.0167
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0246 0.0742 0.0727
Schistosoma mansoni protein kinase C mu 0.0209 0.06 0.06
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Echinococcus granulosus casein kinase I alpha 0.0104 0.0199 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Echinococcus granulosus protein kinase c epsilon type 0.0189 0.0524 0.0509
Brugia malayi putative serine/threonine kinase SADA gamma 0.0063 0.0045 0.0045
Echinococcus granulosus c-Jun N-terminal kinases 0.0254 0.0772 0.0757
Echinococcus granulosus peroxidasin 0.025 0.0759 0.0744
Echinococcus granulosus netrin receptor unc 5 0.0167 0.044 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0545 0.0545
Brugia malayi Cam kinase protein 1 0.0096 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0366 0.0366
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0111 0.0228 0.0228
Onchocerca volvulus 0.0499 0.1706 1
Schistosoma mansoni sulfide quinone reductase 0.0246 0.0742 0.0742
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0228 0.0228
Echinococcus multilocularis protein kinase c iota type 0.0268 0.0825 0.081
Giardia lamblia Kinase, CMGC SRPK 0.0079 0.0105 0.0095
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0197 0.0555 0.054
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0079 0.0107 0.0107
Brugia malayi Protein kinase domain containing protein 0.0157 0.0403 0.0403
Brugia malayi Prion-like- 0.0111 0.0228 0.0228
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0246 0.0742 0.0727
Loa Loa (eye worm) hypothetical protein 0.0138 0.033 0.033
Schistosoma mansoni roundabout 0.025 0.0758 0.0758
Brugia malayi Fibronectin type III domain containing protein 0.0443 0.1496 0.1496
Loa Loa (eye worm) hypothetical protein 0.0443 0.1496 0.1496
Schistosoma mansoni netrin receptor unc5 0.0167 0.044 0.044
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0147 0.0364 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0594 0.0594
Trypanosoma cruzi aurora B kinase, putative 0.0085 0.0127 0.0127
Schistosoma mansoni tyrosine kinase 0.0112 0.0231 0.0231
Echinococcus granulosus cyclin dependent kinase 19 0.0806 0.2878 0.2867
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0246 0.0742 0.0727
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.0236 0.0236
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0385 0.0369
Loa Loa (eye worm) animal heme peroxidase 0.0111 0.0228 0.0228
Echinococcus granulosus insulin receptor 0.0142 0.0347 0.0332
Brugia malayi Immunoglobulin I-set domain containing protein 0.0113 0.0237 0.0237
Brugia malayi hypothetical protein 0.0499 0.1706 0.1706
Schistosoma mansoni titin 0.025 0.0758 0.0758
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.0084 0.0068
Echinococcus multilocularis phospholipase A2 receptor 1 0.0056 0.0017 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0926 0.3337 1
Echinococcus granulosus slit 2 protein 0.0285 0.0892 0.0877
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0108 0.0215 0.0215
Loa Loa (eye worm) cyclin domain-containing protein 0.061 0.2129 0.2129
Brugia malayi STE20-like kinase MST 0.0247 0.0744 0.0744
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.015 0.0375 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0079 0.0104 0.0104
Echinococcus granulosus neural cadherin 0.027 0.0834 0.0819
Echinococcus multilocularis cyclin 0.061 0.2129 0.2117
Schistosoma mansoni notch 0.027 0.0834 0.0834
Entamoeba histolytica casein kinase 1, putative 0.0104 0.0199 0.0767
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.0285 0.0892 0.0892
Entamoeba histolytica serine/threonine protein kinase, putative 0.0063 0.0045 0.0043
Echinococcus granulosus fibroblast growth factor receptor 4 0.0112 0.0231 0.0216
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0147 0.0364 0.0348
Echinococcus granulosus hemicentin 1 0.025 0.0758 0.0743
Echinococcus multilocularis hypothetical protein 0.0098 0.0179 0.0163
Loa Loa (eye worm) hypothetical protein 0.0769 0.2736 0.2736
Schistosoma mansoni tyrosine kinase 0.0073 0.0084 0.0084
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0246 0.0742 0.0742
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0246 0.0742 0.0742
Schistosoma mansoni notch 0.027 0.0834 0.0834
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.0236 0.0236
Plasmodium falciparum glycogen synthase kinase 3 0.0123 0.0273 0.0229
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.0385 0.0385
Entamoeba histolytica protein kinase, putative 0.0079 0.0105 0.0325
Schistosoma mansoni hypothetical protein 0.0246 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni cell adhesion molecule 0.0582 0.2025 0.2025
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.027 0.0834 0.0834
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0117 0.0249 0.0249
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0189 0.0524 0.0524
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0139 0.0334 0.0318
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0199 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0096 0.017 0.017
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0246 0.0742 0.07
Schistosoma mansoni hypothetical protein 0.0056 0.0017 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0107 0.0107
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0133 0.031 0.0267
Echinococcus granulosus Immunoglobulin 0.0441 0.1487 0.1473
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus rho-associated protein kinase 1 0.0312 0.0996 0.0981
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Echinococcus multilocularis C type lectin 0.0056 0.0017 0.0001
Leishmania major protein kinase, putative 0.0147 0.0364 0.0321
Echinococcus multilocularis dual specificity 0.0133 0.031 0.0295
Schistosoma mansoni cell adhesion molecule 0.0252 0.0767 0.0767
Plasmodium falciparum thioredoxin reductase 0.0926 0.3337 0.3307
Brugia malayi map kinase activated protein kinase protein 2 0.0379 0.125 0.125
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0926 0.3337 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0252 0.0767 0.0752
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0147 0.0366 0.035
Loa Loa (eye worm) disorganized muscle protein 1 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0116 0.0248 0.0248
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0246 0.0742 0.332
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0246 0.0742 0.0727
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0056 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.058 0.2017 0.2017
Echinococcus multilocularis nervana 2 0.0119 0.0259 0.0244
Brugia malayi Protein kinase domain containing protein 0.0085 0.0129 0.0129
Brugia malayi Animal haem peroxidase family protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0096 0.017 0.017
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0432 0.145 0.145
Brugia malayi hypothetical protein 0.0108 0.0215 0.0215
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0147 0.0366 0.035
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0063 0.0045 0.0045
Echinococcus granulosus serine threonine protein kinase nrc 0.015 0.0375 0.036
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.0385 0.0369
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Toxoplasma gondii EGF family domain-containing protein 0.027 0.0834 0.0818
Loa Loa (eye worm) TK protein kinase 0.0056 0.0016 0.0016
Echinococcus granulosus leucine rich repeat containing protein 4 0.0111 0.0228 0.0212
Echinococcus multilocularis neurogenic locus notch protein 0.027 0.0834 0.0819
Plasmodium falciparum casein kinase 1 0.0104 0.0199 0.0155
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.0249 0.1002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0113 0.0237 0.0237
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0246 0.0742 0.2047
Giardia lamblia Kinase, CMGC DYRK 0.0133 0.031 0.0725
Loa Loa (eye worm) hypothetical protein 0.0445 0.1503 0.1503
Echinococcus multilocularis cyclin dependent kinase 5 0.0113 0.0236 0.022
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0252 0.0767 0.0767
Entamoeba histolytica protein kinase, putative 0.0082 0.0115 0.0375
Brugia malayi Protein kinase domain containing protein 0.0273 0.0844 0.0844
Entamoeba histolytica cell division protein kinase 2, putative 0.0121 0.0265 0.108
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.017 0.0154
Loa Loa (eye worm) CDC7 protein kinase 0.0085 0.0129 0.0129
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0199 0.0199
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0246 0.0742 0.0726
Onchocerca volvulus 0.0144 0.0353 0.1986
Echinococcus multilocularis casein kinase I delta 0.0104 0.0199 0.0183
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.0236 0.022
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0339 0.1097 0.1097
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0133 0.031 0.0267
Onchocerca volvulus 0.0085 0.0129 0.0662
Loa Loa (eye worm) AGC/PKN protein kinase 0.0272 0.0843 0.0843
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0108 0.0215 0.0215
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0319 0.1019 0.1019
Entamoeba histolytica protein kinase, putative 0.0267 0.0821 0.3691
Mycobacterium tuberculosis Probable oxidoreductase 0.0926 0.3337 0.2803
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0199 0.0183
Onchocerca volvulus 0.0104 0.0199 0.1074
Loa Loa (eye worm) hypothetical protein 0.0098 0.0179 0.0179
Loa Loa (eye worm) thioredoxin reductase 0.2673 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Echinococcus granulosus contactin 0.0252 0.0767 0.0752
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Echinococcus granulosus hypothetical protein 0.0116 0.0248 0.0233
Brugia malayi Prion-like- 0.0111 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Onchocerca volvulus 0.0085 0.0129 0.0662
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0273 0.1114
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0056 0.0017 0.0017
Echinococcus granulosus nephrin 0.0113 0.0237 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0236 0.0236
Brugia malayi Leucine Rich Repeat family protein 0.0111 0.0229 0.0229
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0246 0.0742 0.0742
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0111 0.0228 0.0228
Brugia malayi basement membrane proteoglycan precursor 0.0139 0.0334 0.0334
Giardia lamblia Kinase, NEK 0.013 0.03 0.0693
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0138 0.0332 0.0316
Trichomonas vaginalis STE family protein kinase 0.0082 0.0115 0.0346
Loa Loa (eye worm) hypothetical protein 0.0174 0.0469 0.0469
Echinococcus multilocularis C type lectin domian containing protein 0.0499 0.1706 0.1693
Leishmania major casein kinase, putative 0.0104 0.0199 0.0155
Echinococcus granulosus cyclin dependent kinase 9 0.0082 0.0115 0.0099
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0213 0.0617 0.0602
Giardia lamblia Kinase, CMGC MAPK 0.0079 0.0107 0.0102
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0079 0.0105 0.0087
Onchocerca volvulus 0.0111 0.0228 0.1246
Brugia malayi Immunoglobulin domain containing protein 0.0139 0.0334 0.0334
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0113 0.0236 0.0219
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0096 0.017 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.031 0.031
Echinococcus granulosus protein kinase shaggy 0.0123 0.0273 0.0257
Brugia malayi Lectin C-type domain containing protein 0.0056 0.0017 0.0017
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0111 0.0228 0.0212
Schistosoma mansoni tyrosine kinase 0.0057 0.0021 0.0021
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0806 0.2878 0.2878
Schistosoma mansoni hypothetical protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0108 0.0215 0.0215
Trypanosoma cruzi casein kinase, putative 0.0104 0.0199 0.0199
Plasmodium falciparum protein kinase 5 0.0113 0.0236 0.0192
Schistosoma mansoni protein kinase 0.0082 0.0115 0.0115
Schistosoma mansoni kinase 0.0074 0.0086 0.0086
Brugia malayi Temporarily assigned gene name protein 59 0.0108 0.0215 0.0215
Schistosoma mansoni septate junction protein 0.0139 0.0334 0.0334
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0926 0.3337 0.3307
Schistosoma mansoni tyrosine kinase 0.0057 0.0021 0.0021
Onchocerca volvulus 0.0312 0.0996 0.5794
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0139 0.0334 0.0318
Echinococcus multilocularis netrin receptor unc 5 0.0167 0.044 0.0425
Brugia malayi serine/threonine-protein kinase plk-2 0.026 0.0794 0.0794
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0339 0.1097 0.1083
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0133 0.031 0.031
Trypanosoma cruzi casein kinase, putative 0.0104 0.0199 0.0199
Loa Loa (eye worm) programmed cell death 8 0.0246 0.0742 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0366 0.0366
Echinococcus granulosus dual specificity 0.0133 0.031 0.0295
Echinococcus granulosus neuroglian 0.0552 0.1911 0.1898
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.0742 0.0742
Entamoeba histolytica protein kinase, putative 0.0273 0.0844 0.3798
Trypanosoma brucei protein kinase, putative 0.0123 0.0273 0.0229
Echinococcus multilocularis protein kinase c epsilon type 0.0189 0.0524 0.0509
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Leishmania major protein kinase, putative 0.0085 0.0127 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0127 0.0381
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Brugia malayi Immunoglobulin I-set domain containing protein 0.0252 0.0767 0.0767
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0139 0.0334 0.0334
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0108 0.0215 0.02
Echinococcus granulosus titin 0.0144 0.0353 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0129 0.0387
Brugia malayi Sushi domain 0.0499 0.1706 0.1706
Trypanosoma brucei protein kinase, putative 0.0087 0.0136 0.0092
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0079 0.0105 0.0105
Echinococcus multilocularis neurogenic locus notch protein 0.027 0.0834 0.0819
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0322 0.103 0.103
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0139 0.0334 0.0334
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0385 0.0385
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0111 0.0228 0.0228
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0096 0.017 0.0153
Onchocerca volvulus 0.027 0.0834 0.4836
Plasmodium vivax casein kinase 1, putative 0.0104 0.0199 0.0126
Schistosoma mansoni kinase 0.0277 0.0862 0.0862
Trypanosoma cruzi NADH dehydrogenase, putative 0.0246 0.0742 0.0742
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0077 0.0099 0.0083
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0133 0.031 0.031
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0123 0.0273 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Brugia malayi Delta serrate ligand family protein 0.027 0.0834 0.0834
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0117 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0109 0.0219 0.0219
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.0084 0.0068
Brugia malayi Protein kinase domain containing protein 0.0147 0.0366 0.0366
Entamoeba histolytica protein kinase, putative 0.0117 0.0249 0.1002
Echinococcus granulosus serine:threonine kinase SAD 1 0.0063 0.0045 0.0029
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0254 0.0772 0.0772
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.0772 0.0772
Trypanosoma brucei trypanothione reductase 0.2673 1 1
Echinococcus granulosus titin 0.0144 0.0353 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0111 0.0228 0.0212
Schistosoma mansoni notch 0.027 0.0834 0.0834
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0194 0.0545 0.0545
Onchocerca volvulus 0.0246 0.0742 0.4289
Schistosoma mansoni titin 0.0111 0.0228 0.0228
Plasmodium falciparum calcium-dependent protein kinase 4 0.0096 0.017 0.0126
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0194 0.0545 0.053
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0215 0.0199
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0926 0.3337 0.3307
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0141 0.0343 0.0327
Echinococcus multilocularis rho associated protein kinase 0.0312 0.0996 0.0981
Loa Loa (eye worm) hypothetical protein 0.0443 0.1496 0.1496
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0207 0.0594 0.0579
Brugia malayi serine/threonine protein kinase 6 0.0085 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0178 0.0484 0.0484
Brugia malayi hypothetical protein 0.0056 0.0017 0.0017
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0246 0.0742 0.0726
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.0742 0.0742
Entamoeba histolytica protein kinase, putative 0.0117 0.0249 0.1002
Schistosoma mansoni septate junction protein 0.027 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0074 0.0086 0.0086
Echinococcus granulosus C type lectin domian containing protein 0.0499 0.1706 0.1693
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0105 0.0105
Brugia malayi Protein kinase domain 0.0082 0.0115 0.0115
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0079 0.0107 0.0107
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0379 0.125 0.125
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0112 0.0231 0.0216
Echinococcus multilocularis protein jagged 1 0.027 0.0834 0.0819
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0926 0.3337 0.3307
Giardia lamblia Kinase, AGC PKA 0.015 0.0375 0.0924
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0185 0.0509 0.0509
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.0738 0.0738
Giardia lamblia Kinase, STE STE20 0.008 0.011 0.0112
Echinococcus multilocularis slit 2 protein 0.0285 0.0892 0.0877
Entamoeba histolytica serine/threonine protein kinase, putative 0.026 0.0794 0.3565
Toxoplasma gondii histone kinase SNF1, putative 0.0063 0.0045 0.0027
Brugia malayi protein unc-22 0.0144 0.0353 0.0353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Trichomonas vaginalis AGC family protein kinase 0.0153 0.0388 0.1164
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0926 0.3337 1
Onchocerca volvulus 0.0499 0.1706 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0139 0.0334 0.0318
Echinococcus multilocularis serine:threonine protein kinase 3 0.0247 0.0744 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0215 0.0215
Schistosoma mansoni serine/threonine-protein kinase 0.0156 0.0398 0.0398
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Onchocerca volvulus 0.0499 0.1706 1
Schistosoma mansoni netrin receptor unc5 0.0139 0.0334 0.0334
Echinococcus granulosus dual specificity 0.0133 0.031 0.0295
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0096 0.017 0.0153
Brugia malayi Stress-activated protein kinase jnk-1 0.0254 0.0772 0.0772
Brugia malayi Protein kinase domain containing protein 0.0353 0.1149 0.1149
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0138 0.0332 0.0316
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0108 0.0215 0.0215
Toxoplasma gondii rhoptry neck protein RON1 0.0499 0.1706 0.1692
Brugia malayi phosphoinositide-dependent protein kinase I 0.0077 0.0099 0.0099
Leishmania major casein kinase II, putative 0.0095 0.0167 0.0123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0926 0.3337 0.2803
Toxoplasma gondii AGC kinase 0.0108 0.0215 0.0198
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0079 0.0107 0.0063
Brugia malayi Protein kinase domain containing protein 0.0208 0.0598 0.0598
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0926 0.3337 1
Onchocerca volvulus 0.0499 0.1706 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0056 0.0017 0.0017
Schistosoma mansoni titin 0.0113 0.0237 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus thioredoxin glutathione reductase 0.2673 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0417 0.1396 0.1383
Loa Loa (eye worm) AGC/PKA protein kinase 0.0108 0.0215 0.0215
Brugia malayi Immunoglobulin I-set domain containing protein 0.0443 0.1496 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.031 0.093
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Trypanosoma brucei hypothetical protein, conserved 0.0246 0.0742 0.07
Echinococcus granulosus casein kinase I delta 0.0104 0.0199 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0794 0.2379
Onchocerca volvulus 0.0134 0.0315 0.1762
Echinococcus multilocularis mitogen activated protein kinase 3 0.0079 0.0107 0.0091
Entamoeba histolytica protein kinase, putative 0.0085 0.0127 0.0431
Schistosoma mansoni vam6/vps39 related 0.0108 0.0215 0.0215
Brugia malayi Cadherin domain containing protein 0.027 0.0834 0.0834
Onchocerca volvulus 0.0111 0.0228 0.1246
Echinococcus granulosus mitogen activated protein kinase 3 0.0079 0.0107 0.0091
Brugia malayi Protein kinase domain containing protein 0.0117 0.0249 0.0249
Onchocerca volvulus 0.027 0.0834 0.4836
Brugia malayi MAP kinase sur-1 0.0079 0.0107 0.0107
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0128 0.0383
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.0758 0.0758
Brugia malayi Fes/CIP4 homology domain containing protein 0.0087 0.0136 0.0136
Echinococcus granulosus dual specificity 0.0117 0.0249 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0273 0.0844 0.2528
Echinococcus multilocularis lachesin 0.025 0.0758 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.0843 0.0843
Echinococcus multilocularis serine:threonine protein kinase 0.0109 0.0219 0.0203
Plasmodium falciparum serine/threonine protein kinase 0.0079 0.0105 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0045 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0364 0.1092
Trypanosoma brucei casein kinase I, isoform 2 0.0104 0.0199 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0295 0.0295
Echinococcus granulosus protein kinase c iota type 0.0268 0.0825 0.081
Brugia malayi Hr1 repeat family protein 0.0272 0.0843 0.0843
Echinococcus granulosus glutamate synthase 0.0246 0.0742 0.0727
Brugia malayi EGF-like domain containing protein 0.027 0.0834 0.0834
Echinococcus granulosus oligomeric golgi complex subunit 3 0.061 0.2129 0.2117
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0083 0.0083
Trichomonas vaginalis glutamate synthase, putative 0.0246 0.0742 0.2223
Echinococcus granulosus neuroglian 0.0252 0.0767 0.0752
Schistosoma mansoni peroxidasin 0.0139 0.0335 0.0335
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0127 0.0381
Brugia malayi Protein kinase domain containing protein 0.0086 0.0131 0.0131
Echinococcus granulosus Vam6:Vps39 protein 0.0108 0.0215 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0127 0.029 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0219 0.0656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3337
Trypanosoma cruzi NADH dehydrogenase, putative 0.0246 0.0742 0.0742
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0339 0.1097 0.1097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0246 0.0742 0.0726
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0084 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0236 0.0708
Loa Loa (eye worm) hypothetical protein 0.0441 0.1487 0.1487
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.008 0.011 0.0066
Echinococcus multilocularis neural cadherin 0.027 0.0834 0.0819
Echinococcus granulosus neurogenic locus notch protein 0.027 0.0834 0.0819
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0208 0.0598 0.0598
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.017 0.0154
Echinococcus granulosus serine:threonine protein kinase 0.0109 0.0219 0.0203
Brugia malayi kettin 0.0111 0.0228 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.025 0.0758 0.0758
Echinococcus multilocularis CDC7 cell division cycle 7 0.0085 0.0129 0.0113
Echinococcus granulosus CDC7 cell division cycle 7 0.0085 0.0129 0.0113
Loa Loa (eye worm) hypothetical protein 0.0246 0.0742 0.0742
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0209 0.06 0.06
Trypanosoma brucei Casein kinase II 0.0095 0.0167 0.0123
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0926 0.3337 0.3307
Entamoeba histolytica PH domain containing protein kinase, putative 0.0156 0.0398 0.1705
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Brugia malayi Thioredoxin reductase 0.2673 1 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0246 0.0742 0.07
Giardia lamblia Glutamate synthase 0.0246 0.0742 0.2047
Giardia lamblia Kinase, NEK 0.013 0.03 0.0693
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0105 0.006
Schistosoma mansoni notch 0.027 0.0834 0.0834
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0105 0.0105
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0117 0.0249 0.0747
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0199 0.0183
Echinococcus multilocularis titin 0.0144 0.0353 0.0337
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0138 0.0332 0.0316
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0111 0.0229 0.0213
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0139 0.0334 0.0334
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0353 0.1149 0.1135
Plasmodium falciparum apical sushi protein 0.0499 0.1706 0.1669
Brugia malayi SRC-1 0.0073 0.0084 0.0084
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0123 0.0273 0.0229
Schistosoma mansoni tyrosine kinase 0.0266 0.082 0.082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0252 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0691 0.244 0.244
Plasmodium vivax ferrodoxin reductase, putative 0.0246 0.0742 0.0673
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0147 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0138 0.033 0.033
Echinococcus multilocularis titin 0.0111 0.0228 0.0212
Brugia malayi Immunoglobulin I-set domain containing protein 0.0898 0.3229 0.3229
Echinococcus multilocularis casein kinase i 0.0104 0.0199 0.0183
Schistosoma mansoni titin 0.0111 0.0228 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0045 0.0134
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.002 0.0004
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0117 0.0249 0.0249
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0104 0.0199 0.0199
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0252 0.0767 0.0767
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0246 0.0742 0.2223
Loa Loa (eye worm) hypothetical protein 0.027 0.0834 0.0834
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.0084 0.0068
Entamoeba histolytica hypothetical protein 0.0117 0.0249 0.1002
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0227 0.067 0.0655
Entamoeba histolytica protein kinase, putative 0.0097 0.0175 0.0654
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.017 0.0154
Schistosoma mansoni slit 0.0111 0.0229 0.0229
Schistosoma mansoni disulfide oxidoreductase 0.0246 0.0742 0.0742
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0246 0.0742 0.332
Echinococcus multilocularis myosin iiia 0.008 0.011 0.0095
Trypanosoma brucei NADH dehydrogenase 0.0246 0.0742 0.07
Loa Loa (eye worm) hypothetical protein 0.0111 0.0228 0.0228
Echinococcus granulosus casein kinase I gamma 0.0204 0.0584 0.0569
Loa Loa (eye worm) hypothetical protein 0.0499 0.1706 0.1706
Entamoeba histolytica protein kinase, putative 0.0147 0.0366 0.1551

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.06 uM Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates ChEMBL. 8632420
IC50 (binding) = 0.06 uM Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates ChEMBL. 8632420
IC50 (functional) = 0.087 uM Inhibitory activity of the compound was evaluated by measuring the PI hydrolysis in MMQ cell line ChEMBL. 8632420
IC50 (binding) = 42 uM Inhibitory activity was evaluated against ET- B Binding to Endothelin B receptor from porcine cerebellar membranes ChEMBL. 8632420
IC50 (binding) = 42 uM Inhibitory activity was evaluated against ET- B Binding to Endothelin B receptor from porcine cerebellar membranes ChEMBL. 8632420

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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