Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 200 uM | Inhibitory concentration for cellular activity in jurkat assay | ChEMBL. | 15964758 |
IC50 (functional) | > 200 uM | Inhibitory concentration for cellular activity in jurkat assay | ChEMBL. | 15964758 |
k3/ki (binding) | = 0 1/m/s | Binding affinity against Caspase-6 | ChEMBL. | 15964758 |
k3/ki (binding) | = 0 1/m/s | Binding affinity against Caspase-6 | ChEMBL. | 15964758 |
k3/ki (binding) | = 2 1/m/s | Binding affinity against Caspase-8 | ChEMBL. | 15964758 |
k3/ki (binding) | = 2 1/m/s | Binding affinity against Caspase-8 | ChEMBL. | 15964758 |
k3/ki (binding) | = 41 1/m/s | Binding affinity against mouse Caspase-1 | ChEMBL. | 15964758 |
k3/ki (binding) | = 41 1/m/s | Binding affinity against mouse Caspase-1 | ChEMBL. | 15964758 |
k3/ki (binding) | = 958 1/m/s | Binding affinity against Caspase-3 | ChEMBL. | 15964758 |
k3/ki (binding) | = 958 1/m/s | Binding affinity against Caspase-3 | ChEMBL. | 15964758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.