Detailed information for compound 313110

Basic information

Technical information
  • TDR Targets ID: 313110
  • Name: 1-(6-bromo-2,2-dimethyl-3,4-dihydrochromen-4- yl)-3-ethylthiourea
  • MW: 343.282 | Formula: C14H19BrN2OS
  • H donors: 2 H acceptors: 0 LogP: 3.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=S)NC1CC(C)(C)Oc2c1cc(Br)cc2
  • InChi: 1S/C14H19BrN2OS/c1-4-16-13(19)17-11-8-14(2,3)18-12-6-5-9(15)7-10(11)12/h5-7,11H,4,8H2,1-3H3,(H2,16,17,19)
  • InChiKey: VIYIBWQRABFNBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(6-bromo-2,2-dimethyl-chroman-4-yl)-3-ethyl-thiourea
  • 1-(6-bromo-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-3-ethylthiourea
  • 1-(6-bromo-2,2-dimethyl-3,4-dihydrochromen-4-yl)-3-ethyl-thiourea
  • 1-(6-bromo-2,2-dimethylchroman-4-yl)-3-ethylthiourea
  • 1-(6-bromo-2,2-dimethyl-4-chromanyl)-3-ethylthiourea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.0128
Loa Loa (eye worm) cytochrome P450 0.0019 0.0035 0.004
Schistosoma mansoni adrenodoxin 0.0024 0.0064 0.0058
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1414 0.8102 0.9532
Echinococcus multilocularis lamin dm0 0.0058 0.026 0.0246
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0174 0.0345
Onchocerca volvulus Putative phospholipase D 0.0021 0.0046 0.0061
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0169 0.0182
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0044
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0138 0.0326
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0082 0.1095
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0181 0.2919
Trichomonas vaginalis Ferredoxin 4 0.0024 0.0064 0.015
Schistosoma mansoni nuclear hormone receptor 0.0429 0.2404 0.2816
Echinococcus granulosus neuropeptide receptor 0.0054 0.0236 0.0261
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0429 0.2404 0.2393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.2407
Schistosoma mansoni hypothetical protein 0.0056 0.0247 0.0274
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Brugia malayi hypothetical protein 0.0429 0.2404 0.463
Schistosoma mansoni coup transcription factor 0.0909 0.518 0.6088
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0679 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.0236 0.0261
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0023 0.0016
Trichomonas vaginalis esterase, putative 0.0039 0.0148 0.0348
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0035 0.0064
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Entamoeba histolytica protein kinase, putative 0.0033 0.0113 0.132
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.2407
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0236 0.0261
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0035 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0148 0.0133
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0028 0.0086 0.0084
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.002 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Loa Loa (eye worm) steroid hormone receptor 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0028 0.0086 0.1172
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0429 0.2404 0.4626
Onchocerca volvulus 0.0042 0.0169 0.0299
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0236 0.0222
Mycobacterium ulcerans oxidoreductase 0.0024 0.0064 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0136 0.0243
Brugia malayi beta-lactamase family protein 0.0039 0.0148 0.0266
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.0782 0.1698
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.026 0.0475
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0236 0.0429
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0035 0.0064
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0028 0.0086 0.0175
Plasmodium vivax SET domain protein, putative 0.0034 0.0119 0.1774
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0111 0.0564 0.1213
Schistosoma mansoni trans-prenyltransferase 0.0028 0.0086 0.0084
Loa Loa (eye worm) nuclear hormone receptor 0.0429 0.2404 0.4626
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.0236 0.0429
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0336 0.0706
Wolbachia endosymbiont of Brugia malayi ferredoxin 0.0024 0.0064 0.6178
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0236 0.0222
Brugia malayi CHD4 protein 0.0016 0.0016 0.0011
Brugia malayi sulfakinin receptor protein 0.0054 0.0236 0.0437
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0236 0.0261
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0181 0.0166
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0137 0.0122
Trypanosoma cruzi adrenodoxin precursor, putative 0.0024 0.0064 0.01
Schistosoma mansoni amine GPCR 0.0411 0.23 0.2694
Leishmania major ferredoxin 2fe-2s-like protein 0.0024 0.0064 0.01
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0161 0.2556
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0039 0.0091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.016 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0044 0.0104
Schistosoma mansoni neuropeptide receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0087 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0679 0.2342
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0111 0.0564 0.2792
Schistosoma mansoni sodium-dependent amino acid transporter 0.0044 0.0181 0.0196
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0041 0.0161 0.0341
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0076 0.018
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0236 0.0261
Echinococcus granulosus dna polymerase kappa 0.0021 0.0044 0.0035
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0236 0.0261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0236 0.0222
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.0236 0.0261
Brugia malayi GnHR receptor homolog 0.0054 0.0236 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Toxoplasma gondii ferredoxin, putative 0.0024 0.0064 0.0625
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0144 0.0251
Loa Loa (eye worm) solute carrier family 6 member 4 0.0261 0.1432 0.2744
Brugia malayi hypothetical protein 0.0042 0.0169 0.0307
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0148 0.0348
Echinococcus multilocularis neuropeptide receptor A26 0.0546 0.3084 0.3074
Brugia malayi nuclear receptor NHR-67 0.0429 0.2404 0.463
Brugia malayi hypothetical protein 0.0018 0.0027 0.0034
Schistosoma mansoni opsin-like receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Onchocerca volvulus 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni tyrosine kinase 0.0041 0.016 0.0171
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0679 0.0784
Echinococcus granulosus lamin dm0 0.0058 0.026 0.0289
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0016 0.0003
Onchocerca volvulus 0.0054 0.0236 0.0429
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0044 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.0909 0.518 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0119 0.0104
Brugia malayi orphan nuclear receptor NR2E1 0.0429 0.2404 0.463
Mycobacterium leprae Probable lipase LipE 0.0039 0.0148 0.3095
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0352 0.1962 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0035 0.0048
Loa Loa (eye worm) hypothetical protein 0.0093 0.0463 0.0869
Onchocerca volvulus 0.0039 0.0148 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Giardia lamblia Farnesyl diphosphate synthase 0.0111 0.0564 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0044 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0035 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.048 0.2701 0.5205
Echinococcus multilocularis tumor protein p63 0.0726 0.4123 0.4115
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0745
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0041 0.0161 0.2107
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0163 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0235
Schistosoma mansoni nuclear hormone receptor 0.0429 0.2404 0.2816
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0024 0.0064 0.0104
Echinococcus multilocularis dnaJ subfamily B 0.0879 0.5007 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.0347 0.0645
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0336 0.0631
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0909 0.518 0.6088
Onchocerca volvulus 0.0108 0.0552 0.1041
Loa Loa (eye worm) hypothetical protein 0.048 0.2701 0.5201
Onchocerca volvulus Adrenodoxin, mitochondrial homolog 0.0024 0.0064 0.0095
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0429 0.2404 0.2393
Trichomonas vaginalis glucosylceramidase, putative 0.0384 0.2144 0.5049
Loa Loa (eye worm) histone methyltransferase 0.002 0.0042 0.0053
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0174 0.2492
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0028 0.0086 0.0802
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0028 0.0086 0.0327
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0001
Brugia malayi Cytochrome P450 family protein 0.0038 0.0144 0.0259
Onchocerca volvulus Protein ultraspiracle homolog 0.0909 0.518 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0148 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0909 0.518 0.6088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.123 0.2353
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0909 0.518 0.6088
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0148 0.0348
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0024 0.0064 0.01
Mycobacterium tuberculosis Possible oxygenase 0.0024 0.0064 0.0212
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0111 0.0564 0.1213
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0153 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0093 0.0463 0.0869
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0946 0.5397 0.5391
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.0236 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0205 0.0483
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0023 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0429 0.2404 0.2816
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0028 0.0086 0.0084
Schistosoma mansoni amine GPCR 0.0054 0.0236 0.0261
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0044 0.0057
Onchocerca volvulus 0.0429 0.2404 0.4626
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0096 0.0481 0.055
Brugia malayi Nuclear hormone receptor E75 0.0429 0.2404 0.463
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Leishmania major solanesyl-diphosphate synthase, putative 0.0028 0.0086 0.015
Loa Loa (eye worm) 2Fe-2S iron-sulfur cluster binding domain-containing protein 0.0024 0.0064 0.0095
Brugia malayi Cytochrome P450 family protein 0.0038 0.0144 0.0259
Onchocerca volvulus 0.0039 0.0148 0.0258
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0028 0.0086 0.0084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0236 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0064 0.01
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0024 0.0064 0.01
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0104 0.0182
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0028 0.0086 0.1577
Trichomonas vaginalis Ferredoxin 6 0.0024 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0021 0.0046 0.006
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0028 0.0086 0.0967
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0044 0.003
Schistosoma mansoni histamine h1 receptor 0.0054 0.0236 0.0261
Schistosoma mansoni intermediate filament proteins 0.0058 0.026 0.0289
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0133 0.1683
Brugia malayi beta-lactamase 0.0039 0.0148 0.0266
Echinococcus multilocularis somatostatin receptor 0.0054 0.0236 0.0222
Echinococcus granulosus GPCR family 2 0.0017 0.0023 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0909 0.518 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0252 0.1383 0.4901
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0035 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0148 0.0348
Trypanosoma brucei unspecified product 0.0021 0.0044 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0028 0.0086 0.1172
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0153 0.0164
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0028 0.0086 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0261 0.1432 0.2751
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0236 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0384 0.2144 0.5049
Onchocerca volvulus 0.0106 0.0539 0.1016
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.0782 0.1698
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0041 0.0161 0.0316
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0148 0.0258
Echinococcus granulosus geminin 0.0181 0.0974 0.1131
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0347 0.0333
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0148 0.0645
Loa Loa (eye worm) beta-lactamase 0.0039 0.0148 0.0258
Echinococcus granulosus acetylcholinesterase 0.0073 0.0347 0.0392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0023 0.0009
Brugia malayi nuclear receptor RXR 0.0429 0.2404 0.463
Echinococcus multilocularis ferredoxin adrenodoxin 0.0024 0.0064 0.0049
Brugia malayi Serotonin receptor 0.0054 0.0236 0.0437
Leishmania major hypothetical protein, conserved 0.0024 0.0064 0.01
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0236 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Echinococcus multilocularis neuropeptide s receptor 0.0546 0.3084 0.3074
Onchocerca volvulus 0.0108 0.0552 0.1041
Onchocerca volvulus 0.0042 0.0169 0.0299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Schistosoma mansoni sodium/chloride dependent transporter 0.0044 0.0181 0.0196
Trypanosoma brucei Emopamil binding protein, putative 0.0148 0.0782 0.1719
Mycobacterium ulcerans lipase LipD 0.0039 0.0148 0.041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0205 0.0414
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0111 0.0564 0.1923
Mycobacterium tuberculosis Conserved protein 0.0039 0.0148 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Loa Loa (eye worm) SRC-1 0.0041 0.016 0.0281
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0236 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0148 0.0348
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0044 0.0082
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0035 0.0064
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0024 0.0064 0.0974
Trypanosoma cruzi adrenodoxin precursor, putative 0.0024 0.0064 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0092 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Brugia malayi ecdysone receptor 0.0429 0.2404 0.463
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0169 0.2703
Echinococcus multilocularis Adrenodoxin, mitochondrial 0.0024 0.0064 0.0049
Echinococcus multilocularis Ankyrin 0.0016 0.0015 0.0001
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.059 0.1114
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0023 0.0008
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Schistosoma mansoni hypothetical protein 0.0181 0.0974 0.1131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Schistosoma mansoni hypothetical protein 0.0181 0.0974 0.1131
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0163 0.0175
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.016 0.0171
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus cpg binding protein 0.0065 0.0302 0.0339
Mycobacterium ulcerans beta-lactamase 0.0039 0.0148 0.041
Schistosoma mansoni amine GPCR 0.0054 0.0236 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0909 0.518 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Onchocerca volvulus 0.0261 0.1432 0.2744
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0429 0.2404 0.2816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0205 0.0483
Trichomonas vaginalis Ferredoxin 7 0.0024 0.0064 0.015
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0336 0.0706
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0019 0.0026
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0153 0.0277
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0039 0.0148 0.1916
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0106 0.0539 0.1016
Mycobacterium ulcerans epimerase 0.0022 0.005 0.0053
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0257 0.1412 0.1647
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.0236 0.0437
Onchocerca volvulus 0.0054 0.0236 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0909 0.518 0.6088
Schistosoma mansoni retinoic acid receptor RXR 0.1014 0.579 0.6807
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0236 0.0261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Mycobacterium tuberculosis Conserved protein 0.0039 0.0148 0.0645
Echinococcus granulosus dna polymerase eta 0.0021 0.0044 0.0035
Treponema pallidum hypothetical protein 0.0121 0.0627 0.4019
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0174 0.0317
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi 2Fe-2S iron-sulfur cluster binding domain containing protein 0.0024 0.0064 0.0104
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0236 0.0222
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0111 0.0564 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0236 0.0222
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0181 0.0196
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0205 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0909 0.518 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0035 0.0064
Brugia malayi Cytochrome P450 family protein 0.006 0.0273 0.0508
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0144 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Leishmania major cytochrome p450-like protein 0.0019 0.0035 0.0036
Loa Loa (eye worm) intermediate filament protein 0.0058 0.026 0.0475
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0044 0.0181 0.0196
Echinococcus multilocularis phospholipase d3 0.0021 0.0046 0.0031
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0028 0.0086 0.0327
Brugia malayi Protein K4 0.0018 0.0027 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Brugia malayi neuropeptide F receptor 0.0054 0.0236 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0044
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.048 0.2701 0.269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0035 0.0064
Mycobacterium tuberculosis Conserved protein 0.0039 0.0148 0.0645
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0023 0.0024
Schistosoma mansoni DNA polymerase eta 0.0021 0.0044 0.0035
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0137 0.0122
Plasmodium falciparum ferredoxin, putative 0.0024 0.0064 0.0758
Brugia malayi Phospholipase D. Active site motif family protein 0.0021 0.0046 0.0069
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.005 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0138 0.0326
Trypanosoma cruzi polyprenyl synthase, putative 0.0028 0.0086 0.015
Schistosoma mansoni lipoxygenase 0.0109 0.0557 0.064
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0555 0.3134 0.6042
Echinococcus granulosus allatostatin A receptor 0.0054 0.0236 0.0261
Brugia malayi Dopamine receptor protein 1 0.0054 0.0236 0.0437
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0169 0.0155
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0252 0.1383 0.7017
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Brugia malayi Protein kinase domain containing protein 0.0015 0.0014 0.0008
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0794 0.4515 0.8715
Echinococcus granulosus tm gpcr rhodopsin 0.0946 0.5397 0.6345
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.0236 0.0261
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0035 0.0036
Plasmodium vivax ferredoxin, putative 0.0024 0.0064 0.0758
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.016 0.0145
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0023 0.0009
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0429 0.2404 0.2816
Leishmania major cardiolipin synthetase, putative 0.0018 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0205 0.3079
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0236 0.0261
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0018 0.0027 0.0089
Schistosoma mansoni biogenic amine receptor 0.0054 0.0236 0.0261
Echinococcus granulosus tumor protein p63 0.0726 0.4123 0.4843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0107 0.0251
Brugia malayi Dopamine receptor 0.0054 0.0236 0.0437
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0028 0.0086 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0148 0.0348
Loa Loa (eye worm) norepinephrine transporter 0.0261 0.1432 0.2744
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0909 0.518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Brugia malayi hypothetical protein 0.0044 0.0181 0.033
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0148 0.0287
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0044 0.0082
Loa Loa (eye worm) polyprenyl synthetase 0.0028 0.0086 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0909 0.518 0.6088
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0041 0.0161 0.0147
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0638 0.0734
Treponema pallidum sodium- and chloride- dependent transporter 0.0261 0.1432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0091 0.0213
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0236 0.0222
Trichomonas vaginalis set domain proteins, putative 0.0257 0.1409 0.3319
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0082 0.0166
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0429 0.2404 0.2816
Leishmania major C-8 sterol isomerase-like protein 0.0794 0.4515 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0073 0.0347 0.0645
Onchocerca volvulus 0.0909 0.518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0019 0.0044
Brugia malayi ORL1-like opioid receptor 0.0054 0.0236 0.0437
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0123 0.0638 0.1376
Mycobacterium ulcerans hypothetical protein 0.0121 0.0627 0.2152
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.1349 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Loa Loa (eye worm) DR-78 0.0429 0.2404 0.4626
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0035 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.048 0.2701 0.5205
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0299
Brugia malayi hypothetical protein 0.048 0.2701 0.5205
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0236 0.0222
Schistosoma mansoni lamin 0.0058 0.026 0.0289
Echinococcus multilocularis 0.0019 0.0035 0.0021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.016 0.0171
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.0236 0.0261
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0236 0.0261
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0148 0.0287
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0909 0.518 0.6088
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0019 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0233 0.0432
Trypanosoma cruzi cardiolipin synthetase, putative 0.0039 0.0148 0.0288
Trypanosoma cruzi Emopamil binding protein, putative 0.0148 0.0782 0.1698
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0679 0.3386
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0169 0.0155
Loa Loa (eye worm) hypothetical protein 0.0406 0.2271 0.4369
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0019 0.0005
Loa Loa (eye worm) polyprenyl synthetase 0.0111 0.0564 0.1064
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.048 0.2701 0.3166
Brugia malayi Carboxylesterase family protein 0.0073 0.0347 0.0652
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0236 0.0261
Brugia malayi steroid hormone receptor 0.0909 0.518 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0161 0.0284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0014 0.0008
Schistosoma mansoni tyrosine kinase 0.0041 0.016 0.0171
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0018 0.0027 0.0045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0174 0.0345
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0041 0.0161 0.0173
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.016 0.0171
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0205 0.0439
Schistosoma mansoni adrenodoxin 0.0024 0.0064 0.0058
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0009
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0064 0.0212
Schistosoma mansoni rab6-interacting 0.0042 0.0169 0.0182
Schistosoma mansoni biogenic amine receptor 0.0054 0.0236 0.0261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0205 0.0377
Onchocerca volvulus 0.0039 0.0148 0.0258
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0148 0.0157
Leishmania major polyprenyl synthase, putative 0.0028 0.0086 0.015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Trypanosoma brucei C-8 sterol isomerase, putative 0.0794 0.4515 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0092 0.0217
Echinococcus granulosus hypothetical protein 0.0798 0.4537 0.5331
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0111 0.0564 0.1235
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi RE15519p 0.0054 0.0236 0.0437
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0076 0.018
Chlamydia trachomatis ferredoxin 0.0024 0.0064 0.0974
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0028 0.0086 0.0802
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0041 0.0161 0.2237
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.0236 0.0261
Echinococcus multilocularis microtubule associated protein 2 0.1483 0.8499 0.8497
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0347 0.0392
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.0236 0.0437
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0236 0.0222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0612 0.3462 0.3452
Schistosoma mansoni cytochrome P450 0.0019 0.0035 0.0024
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0028 0.0086 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0037
Echinococcus multilocularis Protein lozenge 0.0059 0.0269 0.0255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0909 0.518 0.5173
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0082 0.1095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0044 0.0057
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0014 0.000000027476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0035 0.0062
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0174 0.016
Schistosoma mansoni biogenic amine receptor 0.0054 0.0236 0.0261
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0174 0.0188
Brugia malayi Pre-SET motif family protein 0.0034 0.0119 0.021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.048 0.2701 0.5201
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0181 0.0196
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Brugia malayi nuclear receptor RXR 0.048 0.2701 0.5205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0205 0.0483
Mycobacterium ulcerans oxygenase 0.0024 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Leishmania major cytochrome p450-like protein 0.0019 0.0035 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0236 0.0261
Brugia malayi intermediate filament protein 0.0058 0.026 0.0483
Brugia malayi follicle stimulating hormone receptor 0.0054 0.0236 0.0437
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0119 0.0104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0236 0.0261
Echinococcus multilocularis conserved hypothetical protein 0.0744 0.4226 0.4218
Echinococcus granulosus Ankyrin 0.0016 0.0015 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0261 0.1432 0.1671
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0024 0.0064 0.0212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0205 0.0191
Echinococcus multilocularis ecdysone induced protein 78C 0.0909 0.518 0.5173
Loa Loa (eye worm) hypothetical protein 0.0058 0.026 0.0475
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0909 0.518 0.6088
Toxoplasma gondii ABC1 family protein 0.0039 0.0148 0.1905
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0205 0.0369
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0336 0.0623
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.198
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0909 0.518 1
Trypanosoma brucei cardiolipin synthetase, putative 0.0039 0.0148 0.0313
Echinococcus granulosus RUN 0.0042 0.0169 0.0182
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0148 0.0134
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi putative neuropeptide receptor 0.0054 0.0236 0.0437
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0236 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0148 0.0287
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0148 0.0157
Brugia malayi hypothetical protein 0.0039 0.0148 0.0266
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0018 0.0027 0.0015
Brugia malayi Dopamine receptor protein 2 0.0054 0.0236 0.0437
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0148 0.0645
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Onchocerca volvulus 0.0044 0.0181 0.0322
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.016 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0019 0.0017
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0909 0.518 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0042 0.0033
Echinococcus granulosus phospholipase d3 0.0021 0.0046 0.0037
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0236 0.0261
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0747 0.4245 1
Brugia malayi Adrenodoxin-like protein, mitochondrial precursor, putative 0.0024 0.0064 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Schistosoma mansoni cpg binding protein 0.0065 0.0302 0.0339
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0044 0.0181 0.0166
Schistosoma mansoni opsin-like receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Schistosoma mansoni nuclear receptor 0.0429 0.2404 0.2816
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0035 0.0064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.048 0.2701 0.3166
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.013 0.0116
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Echinococcus multilocularis lamin 0.0058 0.026 0.0246
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0143 0.075 0.3749
Schistosoma mansoni amine GPCR 0.0054 0.0236 0.0261
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.016 0.0171
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0236 0.0222
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0137 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0429 0.2404 0.4626
Echinococcus granulosus tyrosine kinase 0.0037 0.0137 0.0144
Onchocerca volvulus 0.0054 0.0236 0.0429
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0061
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0082 0.0399 0.0753
Brugia malayi isocitrate dehydrogenase 0.0017 0.0023 0.0024
Brugia malayi G-protein coupled receptor 0.0054 0.0236 0.0437
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0174 0.037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0336 0.0379
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0273 0.05
Brugia malayi Death domain containing protein 0.0015 0.0014 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0909 0.518 0.6088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.002 0.0006
Echinococcus multilocularis phospholipase D 0.0098 0.0491 0.0477
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0384 0.037
Schistosoma mansoni sodium/chloride dependent transporter 0.0044 0.0181 0.0196
Toxoplasma gondii adrenodoxin-type ferredoxin, putative 0.0024 0.0064 0.0625
Loa Loa (eye worm) hypothetical protein 0.0794 0.4515 0.8714
Schistosoma mansoni loxhd1 0.0042 0.0169 0.0182
Echinococcus granulosus Adrenodoxin mitochondrial 0.0024 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0113 0.0116
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0679 0.2342
Brugia malayi CXXC zinc finger family protein 0.0062 0.0282 0.0525
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0336 0.0379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0082 0.0141
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0205 0.0414
Trypanosoma cruzi polyprenyl synthase, putative 0.0028 0.0086 0.015
Brugia malayi nuclear receptor NHR-88 0.0909 0.518 1
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0236 0.0222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0119 0.1463
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0143 0.075 0.2597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0119 0.0123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0104 0.0106
Onchocerca volvulus 0.0054 0.0236 0.0429
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0039 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0909 0.518 0.5173
Trypanosoma brucei electron transfer protein, putative 0.0024 0.0064 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Onchocerca volvulus 0.0054 0.0236 0.0429
Entamoeba histolytica phospholipase D, putative 0.0111 0.0566 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0174 0.0188
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0028 0.0086 0.015
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Plasmodium vivax cardiolipin synthetase, putative 0.0018 0.0027 0.0089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0909 0.518 0.6088
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.0236 0.0437
Giardia lamblia [2Fe-2S] ferredoxin 0.0024 0.0064 0.0373
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0035 0.0188
Onchocerca volvulus 0.0054 0.0236 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Giardia lamblia GTOR 0.0048 0.0205 0.3091
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0174 0.016
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0174 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0236 0.0261
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0148 0.0157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0679 0.0666
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0015 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0909 0.518 0.6088
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0009
Echinococcus granulosus lamin 0.0058 0.026 0.0289
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0041 0.0161 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0679 0.2342
Echinococcus granulosus serotonin receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0555 0.3134 0.6039
Echinococcus granulosus carboxylesterase 5A 0.0073 0.0347 0.0392
Echinococcus granulosus g protein coupled receptor 0.0054 0.0236 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi G-protein coupled receptor 0.0054 0.0236 0.0437
Echinococcus granulosus sex peptide receptor 0.0054 0.0236 0.0261
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Leishmania major ferredoxin, 2fe-2s-like protein 0.0024 0.0064 0.01
Loa Loa (eye worm) carboxylesterase 0.0073 0.0347 0.0645
Onchocerca volvulus 0.0054 0.0236 0.0429
Plasmodium falciparum amino acid transporter, putative 0.0044 0.0181 0.2919
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0148 0.0312
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Schistosoma mansoni nuclear receptor 0.0429 0.2404 0.2816
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0144 0.0303
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus multilocularis serotonin receptor 0.0054 0.0236 0.0222
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Schistosoma mansoni cpg binding protein 0.0065 0.0302 0.0339
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0181 0.0196
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0137 0.0144
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0148 0.0645
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0236 0.0222
Onchocerca volvulus 0.0044 0.0181 0.0322
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0282 0.0517
Brugia malayi Doublecortin family protein 0.0042 0.0169 0.0307
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0679 0.1469
Echinococcus multilocularis dna polymerase eta 0.0021 0.0044 0.003
Schistosoma mansoni hypothetical protein 0.0042 0.0169 0.0182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0044 0.0035
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.0322
Brugia malayi ecdysteroid receptor 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.0236 0.0437
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0044 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Brugia malayi Polyprenyl synthetase family protein 0.0028 0.0086 0.0147
Echinococcus granulosus g protein coupled receptor 0.0054 0.0236 0.0261
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0096 0.0481 0.055
Brugia malayi cytochrome P450 0.0019 0.0035 0.0048
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.0539 0.0619
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni polycystin 1-related 0.0042 0.0169 0.0182
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0157
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0148 0.041
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0909 0.518 1
Onchocerca volvulus 0.0054 0.0236 0.0429
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0181 0.0196
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0082 0.0141
Onchocerca volvulus 0.0044 0.0181 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Brugia malayi hypothetical protein 0.0042 0.0169 0.0307
Brugia malayi nuclear receptor NHR-88 0.0429 0.2404 0.463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0054 0.0236 0.0429
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.016 0.0145
Entamoeba histolytica phospholipase D, putative 0.0111 0.0566 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0148 0.0348
Schistosoma mansoni amine GPCR 0.0054 0.0236 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0909 0.518 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.0044 0.0057
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0161 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0236 0.0222
Schistosoma mansoni opsin-like receptor 0.0054 0.0236 0.0261
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.016 0.0171
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0221 0.1205 0.4254
Brugia malayi hypothetical protein 0.0018 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.021
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0041 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0174 0.0409
Brugia malayi Pre-SET motif family protein 0.0226 0.123 0.236
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0028 0.0086 0.0802
Echinococcus multilocularis RUN 0.0042 0.0169 0.0155
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0236 0.0222
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0399 0.6959
Brugia malayi neuropeptide F receptor 0.0054 0.0236 0.0437
Mycobacterium ulcerans oxidoreductase 0.0024 0.0064 0.0104
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0236 0.0222
Schistosoma mansoni hypothetical protein 0.0054 0.0236 0.0261
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0028 0.0086 0.0327
Schistosoma mansoni hypothetical protein 0.0054 0.0236 0.0261
Mycobacterium leprae conserved hypothetical protein 0.0022 0.005 0.0402
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0638 0.219
Trichomonas vaginalis Ferredoxin 3 0.0024 0.0064 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0169 0.0182
Brugia malayi Polyprenyl synthetase family protein 0.0111 0.0564 0.1072
Brugia malayi hypothetical protein 0.0474 0.2667 0.514
Schistosoma mansoni RAR-like nuclear receptor 0.0909 0.518 0.6088
Trypanosoma cruzi Emopamil binding protein, putative 0.0148 0.0782 0.1698
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0019 0.0005
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0495 0.2787 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0161 0.2556
Schistosoma mansoni nuclear hormone receptor 0.0909 0.518 0.6088
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0019 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0266
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0336 0.0706
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0044 0.0181 0.033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0236 0.0222
Trichomonas vaginalis helicase, putative 0.0014 0.0006 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0429 0.2404 0.463
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0111 0.0564 0.8246
Brugia malayi Uncoordinated protein 44 0.0015 0.0014 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0119 0.0202
Schistosoma mansoni lamin 0.0058 0.026 0.0289
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0909 0.518 0.5173
Echinococcus multilocularis nuclear receptor nhr 48 0.0429 0.2404 0.2393
Brugia malayi nuclear hormone receptor family member odr-7 0.0429 0.2404 0.463
Schistosoma mansoni neuropeptide receptor 0.0054 0.0236 0.0261
Schistosoma mansoni hypothetical protein 0.0054 0.0236 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0689 0.0795
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0044 0.0082
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0185 0.0997 0.0984
Plasmodium falciparum adrenodoxin-type ferredoxin, putative 0.0024 0.0064 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Schistosoma mansoni lozenge 0.0059 0.0269 0.03
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0028 0.0086 0.1404
Plasmodium falciparum transporter, putative 0.0044 0.0181 0.2919
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0608 0.891
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0044 0.0057
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.0236 0.0429
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0161 0.0379
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0336 0.073
Echinococcus granulosus tm gpcr rhodopsin 0.0612 0.3462 0.4063
Echinococcus granulosus acetylcholinesterase 0.0073 0.0347 0.0392
Echinococcus granulosus Nuclear hormone receptor HR96 0.0429 0.2404 0.2816
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.016 0.0145
Brugia malayi hypothetical protein 0.0429 0.2404 0.463
Brugia malayi SRC-1 0.0041 0.016 0.0289
Leishmania major hypothetical protein, conserved 0.0039 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0424
Mycobacterium ulcerans endonuclease IV 0.0082 0.0399 0.1324
Echinococcus multilocularis musashi 0.0058 0.026 0.0246
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0161 0.0379
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0236 0.0429
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0236 0.0222
Onchocerca volvulus 0.0062 0.0282 0.0517
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0679 0.0784
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0119 0.0123
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0181 0.0196
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0144 0.0278
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0236 0.0261
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0028 0.0086 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0236 0.0261
Brugia malayi Phospholipase D. Active site motif family protein 0.0039 0.0148 0.0268
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0041 0.0075
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.005 0.0077
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.002 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0153 0.0139
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0014 0.000000027476
Brugia malayi tailless protein 0.0429 0.2404 0.463
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0023 0.0024
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0181 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0035 0.0064
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0161 0.0316
Echinococcus granulosus ferredoxin 0.0024 0.0064 0.0058
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0236 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0254 0.0463
Loa Loa (eye worm) hypothetical protein 0.0261 0.1432 0.2744
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0123 0.0638 0.3171
Leishmania major farnesyl pyrophosphate synthase 0.0111 0.0564 0.1213
Echinococcus granulosus nuclear receptor nhr 48 0.0429 0.2404 0.2816
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0023 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0909 0.518 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0044 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.033
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0111 0.0564 0.055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.0236 0.0261
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0148 0.0645
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0909 0.518 0.6088
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0384 0.0435
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.2407
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Mycobacterium ulcerans electron transfer protein 0.0024 0.0064 0.0104
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0174 0.0345
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0096 0.0481 0.0468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0131
Echinococcus multilocularis acetylcholinesterase 0.0073 0.0347 0.0333
Leishmania major cytochrome p450-like protein 0.0038 0.0144 0.0278
Onchocerca volvulus 0.0046 0.0189 0.0339
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0082 0.0399 1
Onchocerca volvulus 0.0058 0.026 0.0475
Echinococcus multilocularis geminin 0.0181 0.0974 0.0961
Schistosoma mansoni cpg binding protein 0.0062 0.0282 0.0315
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0023 0.0008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0429 0.2404 0.463
Onchocerca volvulus 0.0054 0.0236 0.0429
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0236 0.0222
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0236 0.0222
Toxoplasma gondii endonuclease IV APN 0.0082 0.0399 0.5738
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0174 0.0188
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0044 0.0181 0.0166
Trichomonas vaginalis Ferredoxin 2 0.0024 0.0064 0.015
Echinococcus multilocularis sex peptide receptor 0.0054 0.0236 0.0222
Echinococcus granulosus Nuclear hormone receptor HR96 0.0429 0.2404 0.2816
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0119 0.0123
Brugia malayi hypothetical protein 0.048 0.2701 0.5205
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0909 0.518 0.6088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0148 0.0348
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0044 0.003
Loa Loa (eye worm) hypothetical protein 0.048 0.2701 0.5201
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0148 0.0287
Echinococcus granulosus neuropeptide receptor A26 0.0546 0.3084 0.3618
Trypanosoma cruzi adrenodoxin precursor, putative 0.0024 0.0064 0.01
Leishmania major DNA polymerase eta, putative 0.0021 0.0044 0.0057
Echinococcus multilocularis cpg binding protein 0.0065 0.0302 0.0288
Loa Loa (eye worm) hypothetical protein 0.0909 0.518 1
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0236 0.0429
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0044 0.0058
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.0236 0.0261
Treponema pallidum quinoline 2-oxidoreductase 0.0119 0.0611 0.3898
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.198
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.0236 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0909 0.518 0.6088
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0044 0.0034
Loa Loa (eye worm) hypothetical protein 0.0373 0.2079 0.3998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0233 0.0432
Loa Loa (eye worm) hypothetical protein 0.0373 0.2079 0.3998
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0104 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0236 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0035 0.0064
Onchocerca volvulus 0.0474 0.2667 0.5136
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0044 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0008
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0137 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0909 0.518 1
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0028 0.0086 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0035 0.0064
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.0144 0.0396
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0111 0.0564 0.0648
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0236 0.0222
Echinococcus multilocularis GPCR, family 2 0.0017 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0109 0.0553 0.1042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0299
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0019 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0174 0.0188
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0044 0.0181 0.0166
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0638 0.0624
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0909 0.518 0.5173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0148 0.0645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0909 0.518 0.6088
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0794 0.4515 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0169 0.0155
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0123 0.0638 0.0734
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0148 0.0348
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0119 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0044 0.0112
Echinococcus multilocularis serotonin transporter 0.0261 0.1432 0.142
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.016 0.0171
Trichomonas vaginalis aldehyde oxidase, putative 0.0747 0.4245 1
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0096 0.0481 0.055
Onchocerca volvulus 0.0054 0.0236 0.0429
Leishmania major hypothetical protein, conserved 0.0148 0.0782 0.1698
Brugia malayi AKH receptor 0.0054 0.0236 0.0437
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0035 0.0064
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0035 0.0036
Chlamydia trachomatis endonuclease IV 0.0082 0.0399 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Brugia malayi Carboxylesterase family protein 0.0073 0.0347 0.0652
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0024 0.0064 0.0104
Loa Loa (eye worm) runx1 0.0059 0.0269 0.0493
Onchocerca volvulus 0.0054 0.0236 0.0429
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.0236 0.0429
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0236 0.0222
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0123 0.0638 0.1214
Plasmodium vivax amine transporter, putative 0.0044 0.0181 0.2919
Onchocerca volvulus 0.0058 0.026 0.0475
Onchocerca volvulus Bile acid receptor homolog 0.0909 0.518 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0023 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0044 0.0112
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.001
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0082 0.0399 0.1943
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0236 0.0261
Echinococcus granulosus phospholipase D1 0.0111 0.0566 0.065
Leishmania major hypothetical protein, conserved 0.0027 0.0082 0.0141
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0035 0.0064
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0054 0.0236 0.0429
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0144 0.0251
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0016
Schistosoma mansoni zinc finger protein 0.0429 0.2404 0.2816
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.002 0.0007
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0111 0.0564 1
Onchocerca volvulus 0.0054 0.0236 0.0429
Onchocerca volvulus 0.0054 0.0236 0.0429
Mycobacterium ulcerans electron transfer protein FdxB 0.0024 0.0064 0.0104
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0909 0.518 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0111 0.0564 0.1329
Echinococcus granulosus serotonin transporter 0.0261 0.1432 0.1671
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0236 0.0261
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.005 0.0139
Brugia malayi nuclear hormone receptor 0.0909 0.518 1
Brugia malayi nuclear hormone receptor 0.0429 0.2404 0.463
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0205 0.0439
Onchocerca volvulus 0.0054 0.0236 0.0429
Echinococcus granulosus intermediate filament protein 0.0058 0.026 0.0289
Brugia malayi Phospholipase d protein 1 0.0111 0.0566 0.1075
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0082 0.0903
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0018 0.0027 0.0089
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0322
Loa Loa (eye worm) hypothetical protein 0.0072 0.0342 0.0635
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0044 0.0181 0.4119
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0035 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0023 0.0024
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.048 0.2701 0.3166
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0028 0.0086 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.005 0.0053
Schistosoma mansoni adenoreceptor 0.0054 0.0236 0.0261
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0028 0.0086 0.0072
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0035 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0144 0.0251
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Onchocerca volvulus 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Onchocerca volvulus 0.0429 0.2404 0.4626
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trypanosoma cruzi cardiolipin synthetase, putative 0.0039 0.0148 0.0288
Echinococcus multilocularis serotonin receptor 0.0054 0.0236 0.0222
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.0236 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0261 0.1432 0.2744
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0429 0.2404 0.2393
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0909 0.518 1
Echinococcus granulosus neuropeptide receptor 0.0054 0.0236 0.0261
Echinococcus granulosus fmrfamide receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0044 0.0057
Trichomonas vaginalis Ferredoxin 1 0.0024 0.0064 0.015
Schistosoma mansoni hypothetical protein 0.0054 0.0236 0.0261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0909 0.518 0.6088
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.033
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0024 0.0064 0.0212
Echinococcus multilocularis FTZ F1 alpha 0.0909 0.518 0.5173
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0189 0.0206
Brugia malayi conserved hypotetical protein 0.0429 0.2404 0.463
Brugia malayi hypothetical protein 0.0109 0.0553 0.105
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0014 0.000000023346
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0205 0.0414
Onchocerca volvulus Neuropeptide F receptor homolog 0.0054 0.0236 0.0429
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0534 0.3014 0.3004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.048 0.2701 0.5201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0148 0.0348
Loa Loa (eye worm) hypothetical protein 0.0072 0.0342 0.0635
Brugia malayi protein-tyrosine kinase 0.0037 0.0137 0.0245
Schistosoma mansoni glutathione synthetase 0.0028 0.0086 0.0084
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0429 0.2404 0.463
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0174 0.0188
Echinococcus multilocularis phospholipase D1 0.0111 0.0566 0.0552
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0093 0.0463 0.8032
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0174 0.0188
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0236 0.0222
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0082 0.0399 0.6959
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0041 0.0161 0.0292
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0087 0.0085
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0143 0.075 0.2597
Toxoplasma gondii ferodoxin FD 0.0024 0.0064 0.0625
Schistosoma mansoni microtubule-associated protein tau 0.1483 0.8499 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0352 0.1962 0.7002
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.0236 0.0429
Onchocerca volvulus 0.0148 0.0782 0.1486
Brugia malayi larval opioid receptor 0.0054 0.0236 0.0437
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0909 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.0309
Loa Loa (eye worm) nuclear receptor NHR-67 0.0429 0.2404 0.4626
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0909 0.518 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0092 0.0217
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0148 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0148 0.2311
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0035 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.203 0.4782
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1014 0.579 0.6807
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0909 0.518 0.5173
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0148 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0909 0.518 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0174 0.0409
Brugia malayi photoreceptor-specific nuclear receptor 0.0909 0.518 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0373 0.2079 0.4003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.0236 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0555 0.3134 0.7382
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0113 0.0099
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0236 0.0222
Brugia malayi Melatonin receptor type 1A 0.0054 0.0236 0.0437
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0252 0.1383 0.4901
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0258
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.0322
Loa Loa (eye worm) hypothetical protein 0.0474 0.2667 0.5136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0909 0.518 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0429 0.2404 0.2393
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0111 0.0564 0.1329
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0057 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0025
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0028 0.0086 0.0084
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0429 0.2404 0.4626
Echinococcus granulosus orexin receptor type 2 0.0054 0.0236 0.0261
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0041 0.0161 0.0173
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.016 0.0145
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0148 0.0157
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0909 0.518 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.0236 0.0437
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.016 0.0171
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0352 0.1962 0.7002
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0205 0.0225
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0373 0.2079 0.2434
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0111 0.0564 0.0648
Toxoplasma gondii hypothetical protein 0.0044 0.0181 0.2407
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0044 0.0035
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0111 0.0564 0.1923
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0236 0.0222
Onchocerca volvulus 0.0257 0.141 0.2702
Loa Loa (eye worm) TK protein kinase 0.0037 0.0137 0.0237
Loa Loa (eye worm) TK protein kinase 0.0033 0.0113 0.0191
Onchocerca volvulus 0.0054 0.0236 0.0429
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0236 0.0222
Brugia malayi Serotonin receptor 0.055 0.3103 0.5984
Loa Loa (eye worm) serotonin transporter b 0.0261 0.1432 0.2744
Schistosoma mansoni neuropeptide receptor 0.0054 0.0236 0.0261
Schistosoma mansoni phospholipase D 0.0111 0.0566 0.065
Schistosoma mansoni rab6-interacting 0.0042 0.0169 0.0182
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0747 0.4245 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0133 0.0314
Loa Loa (eye worm) hypothetical protein 0.0474 0.2667 0.5136
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0035 0.0064
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0111 0.0564 0.1329
Schistosoma mansoni hypothetical protein 0.0879 0.5007 0.5884
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0174 0.2482
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0035 0.0024
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0236 0.0222
Echinococcus granulosus microtubule associated protein 2 0.1483 0.8499 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.002 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0236 0.0222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0148 0.0157
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0044 0.0066
Echinococcus granulosus dnaJ subfamily B 0.0879 0.5007 0.5884
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0028 0.0086 0.015
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.026 0.0483
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0174 0.0409
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0336 0.0322
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0179
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0161 0.0316
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Echinococcus granulosus phospholipase D 0.0098 0.0491 0.0562
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0185 0.0997 0.1158
Loa Loa (eye worm) phospholipase D 0.0021 0.0046 0.0061
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Trypanosoma brucei cardiolipin synthetase 0.0039 0.0148 0.0313
Onchocerca volvulus Glucosylceramidase homolog 0.0364 0.203 0.3903
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0023 0.0009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0181 0.0196
Loa Loa (eye worm) hypothetical protein 0.048 0.2701 0.5201
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Brugia malayi hypothetical protein 0.0027 0.0082 0.0139
Brugia malayi G protein-coupled receptor 0.0054 0.0236 0.0437
Brugia malayi M-phase phosphoprotein, mpp8 0.0108 0.0552 0.1048
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0082 0.1095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0909 0.518 0.5173
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.0347 0.0333
Mycobacterium ulcerans hypothetical protein 0.0022 0.005 0.0053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0909 0.518 0.5173
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0028 0.0086 0.015
Loa Loa (eye worm) hypothetical protein 0.0108 0.0552 0.1041
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0169 0.0299
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.198
Toxoplasma gondii hypothetical protein 0.0044 0.0181 0.2407
Loa Loa (eye worm) hypothetical protein 0.0261 0.1432 0.2744
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0236 0.0222
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0028 0.0086 0.0147
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0236 0.0429
Schistosoma mansoni lipoxygenase 0.0185 0.0997 0.1158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0909 0.518 0.6088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0023 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0044 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0164 0.0386
Echinococcus granulosus g protein coupled receptor 0.0054 0.0236 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Loa Loa (eye worm) hypothetical protein 0.0073 0.0347 0.0645
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0028 0.0086 0.0186
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.016 0.0171
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0148 0.0645
Loa Loa (eye worm) hypothetical protein 0.048 0.2701 0.5201
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0044 0.0082
Echinococcus granulosus somatostatin receptor 0.0054 0.0236 0.0261
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0018 0.0027 0.0089
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.0782 0.1698
Brugia malayi beta-lactamase family protein 0.0039 0.0148 0.0266
Mycobacterium ulcerans hypothetical protein 0.0039 0.0148 0.041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0233 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0148 0.0348
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0679 0.0784
Brugia malayi hypothetical protein 0.0054 0.0236 0.0437
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0205 0.3079
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0336 0.5597
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0169 0.0182
Treponema pallidum hypothetical protein 0.01 0.0503 0.3099
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0429
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0638 0.219
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0181 0.0166
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0042 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0044 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0148 0.041
Schistosoma mansoni myosin xvIII 0.0054 0.0236 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0909 0.518 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0261 0.1432 0.1671
Schistosoma mansoni neuropeptide receptor 0.0054 0.0236 0.0261
Schistosoma mansoni nuclear receptor nhr-48 0.0429 0.2404 0.2816
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0076 0.018
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0174 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0091 0.0213
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0205 0.0414
Trypanosoma brucei NADH-ubiquinone oxidoreductase complex I subunit, putative 0.0024 0.0064 0.0125
Loa Loa (eye worm) hypothetical protein 0.0429 0.2404 0.4626
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0169 0.2703
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.0236 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0909 0.518 0.6088
Echinococcus granulosus thyroid hormone receptor alpha 0.0429 0.2404 0.2816
Onchocerca volvulus 0.0024 0.0064 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0181 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0236 0.0261
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0148 0.3095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0236 0.0261
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0068
Echinococcus granulosus neuropeptide s receptor 0.0546 0.3084 0.3618
Schistosoma mansoni hypothetical protein 0.0036 0.0136 0.0143

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 3.7 uM Myorelaxant activity of thecompound against insulinsecretion in the pancreatic islets ofrat; (activity expressed as ED50) ChEMBL. 15658874
pED50 (binding) = 5.43 Inhibition of SUR2A/kir6.2 channel in Wistar rat thoracic aorta assessed as relaxation of Kcl-induced contraction ChEMBL. 18353509
Residual secretion (functional) = 80.8 % Percentage of residual insulinsecretion value in the pancreaticislets of rat after treatment with thecompound at 10 uM concentration ChEMBL. 15658874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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