Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuropeptide Y receptor type 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g protein coupled receptor | Neuropeptide Y receptor type 5 | 445 aa | 431 aa | 25.8 % |
Echinococcus multilocularis | g protein coupled receptor | Neuropeptide Y receptor type 5 | 445 aa | 432 aa | 25.2 % |
Echinococcus multilocularis | g protein coupled receptor | Neuropeptide Y receptor type 5 | 445 aa | 456 aa | 22.6 % |
Onchocerca volvulus | Neuropeptide Y receptor type 5 | 445 aa | 401 aa | 23.9 % | |
Echinococcus multilocularis | serotonin receptor | Neuropeptide Y receptor type 5 | 445 aa | 431 aa | 21.3 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Neuropeptide Y receptor type 5 | 445 aa | 420 aa | 22.6 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Neuropeptide Y receptor type 5 | 445 aa | 376 aa | 27.4 % |
Onchocerca volvulus | Neuropeptide Y receptor type 5 | 445 aa | 415 aa | 20.7 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Neuropeptide Y receptor type 5 | 445 aa | 420 aa | 21.9 % |
Echinococcus granulosus | g protein coupled receptor | Neuropeptide Y receptor type 5 | 445 aa | 455 aa | 21.5 % |
Schistosoma mansoni | amine GPCR | Neuropeptide Y receptor type 5 | 445 aa | 435 aa | 23.2 % |
Echinococcus multilocularis | neuropeptides capa receptor | Neuropeptide Y receptor type 5 | 445 aa | 436 aa | 20.2 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 7.7 nM | Inhibitory concentration required for Metabolic stability after 1 hour at an incubation concentration of 1 uM | ChEMBL. | 15982873 |
IC50 (binding) | = 7.7 nM | Inhibition of [125I]-PYY binding to the rat NPY Y5 receptor in C6 cells | ChEMBL. | 15771450 |
IC50 (binding) | = 7.7 nM | Inhibition of [125I]-PYY binding to the rat NPY Y5 receptor in C6 cells | ChEMBL. | 15771450 |
Inhibition (functional) | = 93.3 % | Inhibition of PYY effect on forskolin-stimulated cyclic AMP formation in C6 cells expressing rat NPY Y5 receptor | ChEMBL. | 15771450 |
Inhibition (functional) | = 93.3 % | Inhibition of PYY effect on forskolin-stimulated cyclic AMP formation in C6 cells expressing rat NPY Y5 receptor | ChEMBL. | 15771450 |
Stability (ADMET) | = 0.9 % | Metabolic stability after 1 hour in Rat liver microsomes at 37 degree C an incubation concentration of 1 uM | ChEMBL. | 15982873 |
Stability (ADMET) | = 5.4 % | Metabolic stability after 1 hour in human liver microsomes at 37 degree C an incubation concentration of 1 uM | ChEMBL. | 15982873 |
T1/2 (ADMET) | = 2.5 min | Half life period after 1 hour in Rat liver microsomes at 37 degree C an incubation concentration of 1 uM | ChEMBL. | 15982873 |
T1/2 (ADMET) | = 14.4 min | Half life period after 1 hour in human liver microsomes at 37 degree C an incubation concentration of 1 uM | ChEMBL. | 15982873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.