Detailed information for compound 313296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.516 | Formula: C25H29N3O3
  • H donors: 1 H acceptors: 1 LogP: 3.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\c1ccccc1)/CN1CCN(CC1)C[C@@H]1ON=C2[C@H]1COc1c2ccc(c1)O
  • InChi: 1S/C25H29N3O3/c1-18(13-19-5-3-2-4-6-19)15-27-9-11-28(12-10-27)16-24-22-17-30-23-14-20(29)7-8-21(23)25(22)26-31-24/h2-8,13-14,22,24,29H,9-12,15-17H2,1H3/b18-13+/t22-,24-/m0/s1
  • InChiKey: UCFVOQSSWZQWNE-ZCIIVOIYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor alpha 2C Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0467 0.1012 0.1012
Giardia lamblia Kinase, CMGC DYRK 0.0299 0.0531 0.1125
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0168 0.0153 0.0142
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0331 0.0622 0.0548
Giardia lamblia Kinase, PLK 0.0582 0.1341 0.3768
Giardia lamblia Kinase, CAMK CAMKL 0.0185 0.0203 0.0054
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0331 0.0623 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0186 0.0176
Echinococcus multilocularis fat cadherin tumor suppressor 0.0364 0.0716 0.0668
Echinococcus granulosus casein kinase I delta 0.0234 0.0344 0.0294
Echinococcus granulosus netrin receptor unc 5 0.0263 0.0426 0.0376
Echinococcus multilocularis serine:threonine protein kinase 38 0.0347 0.0667 0.0619
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0331 0.0623 0.0623
Echinococcus granulosus expressed protein 0.0179 0.0186 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0254 0.04 0.1229
Brugia malayi Protein kinase domain containing protein 0.0331 0.0622 0.0611
Onchocerca volvulus 0.0194 0.0228 0.0939
Echinococcus multilocularis serine:threonine protein kinase 0.0246 0.0378 0.0328
Echinococcus granulosus protein tyrosine kinase 0.0621 0.1452 0.1407
Onchocerca volvulus 0.0163 0.014 0.0552
Echinococcus granulosus cGMP dependent protein kinase 1 0.0182 0.0194 0.0143
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0244 0.0371 0.0296
Brugia malayi Immunoglobulin domain containing protein 0.02 0.0247 0.0237
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0248 0.0384 0.0334
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0582 0.1341 0.1296
Trypanosoma cruzi casein kinase, putative 0.0234 0.0344 0.0334
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0163 0.014 0.0129
Onchocerca volvulus 0.0141 0.0077 0.0276
Onchocerca volvulus Serine\/threonine kinase homolog 0.0582 0.1341 0.5855
Onchocerca volvulus Neurogenic locus notch homolog 0.0364 0.0716 0.3095
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0329 0.0616 0.0567
Entamoeba histolytica protein kinase domain containing protein 0.0436 0.0924 0.3959
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.079 0.1937 0.1937
Trichomonas vaginalis STE family protein kinase 0.0293 0.0514 0.158
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0436 0.0924 0.0877
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Brugia malayi Protein kinase domain containing protein 0.2028 0.5486 0.5481
Echinococcus granulosus Down syndrome cell adhesion molecule 0.022 0.0303 0.0253
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0153 0.0153
Giardia lamblia Kinase, CMGC MAPK 0.0181 0.019 0.0013
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Trypanosoma cruzi cdc2-related kinase 3 0.0256 0.0407 0.0396
Loa Loa (eye worm) hypothetical protein 0.0401 0.0823 0.0823
Echinococcus multilocularis titin 0.0168 0.0153 0.0102
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0331 0.0623 0.0549
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0277 0.0468 0.0418
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0182 0.0194 0.0143
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0293 0.0514 0.0439
Echinococcus multilocularis twitchin 0.0239 0.0357 0.0307
Schistosoma mansoni vesicular amine transporter 0.0661 0.1568 0.1559
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0331 0.0623 0.0574
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0168 0.0153 0.0142
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0759 0.1849 0.1849
Schistosoma mansoni protein kinase 0.033 0.0619 0.0608
Schistosoma mansoni cell adhesion molecule 0.0368 0.0728 0.0718
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.0506 0.0495
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.02 0.0247 0.0237
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.1248 0.3251 0.3198
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0492 0.1084 0.1038
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0343 0.0655 0.0655
Echinococcus multilocularis c src tyrosine kinase 0.0202 0.0253 0.0202
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Trypanosoma cruzi cdc2-related kinase 1 0.0256 0.0407 0.0396
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0299 0.0531 0.0521
Echinococcus multilocularis serine threonine protein kinase 0.0435 0.092 0.0872
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0407 0.0396
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0667 0.0657
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Brugia malayi protein unc-22 0.0258 0.0414 0.0403
Schistosoma mansoni protein kinase 0.0415 0.0863 0.0853
Echinococcus granulosus calcium activated potassium channel 0.0291 0.0506 0.0456
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0469 0.1016 0.1016
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0299 0.0531 0.0457
Echinococcus granulosus peroxidasin 0.0369 0.0729 0.0681
Echinococcus granulosus mitogen activated protein kinase 3 0.0181 0.019 0.0139
Brugia malayi Sushi domain 0.0672 0.1599 0.159
Entamoeba histolytica protein kinase, putative 0.0197 0.0237 0.0773
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.019 0.0585
Echinococcus multilocularis 0.033 0.0619 0.057
Loa Loa (eye worm) AUR protein kinase 0.0254 0.04 0.04
Schistosoma mansoni serine/threonine kinase 0.0347 0.0667 0.0657
Onchocerca volvulus Peroxidasin homolog 0.0168 0.0153 0.0611
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0337 0.064 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0156 0.0146
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0388 0.0784 0.0774
Loa Loa (eye worm) TK/EGFR protein kinase 0.0747 0.1815 0.1815
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.0622 0.0611
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0329 0.0616 0.0567
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0432 0.0912 0.0865
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Loa Loa (eye worm) Notch2 0.0364 0.0716 0.0716
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0217 0.0296 0.0245
Loa Loa (eye worm) AGC/PKG protein kinase 0.0182 0.0194 0.0194
Brugia malayi Immunoglobulin I-set domain containing protein 0.0388 0.0784 0.0774
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus multilocularis serine:threonine protein kinase N2 0.0626 0.1467 0.1423
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0354 0.0687 0.0677
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0331 0.0623 0.0549
Echinococcus multilocularis calcium dependent protein kinase 0.0146 0.0091 0.004
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0368 0.0728 0.0679
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0187 0.0209 0.0209
Echinococcus granulosus tyrosine protein kinase shark 0.0373 0.0743 0.0695
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0169 0.0156 0.0105
Loa Loa (eye worm) TK/ABL protein kinase 0.0141 0.0077 0.0077
Brugia malayi Doublecortin family protein 0.0325 0.0604 0.0594
Brugia malayi Protein kinase domain containing protein 0.0459 0.0989 0.098
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0274 0.0457 0.0407
Brugia malayi Cadherin domain containing protein 0.0364 0.0716 0.0706
Onchocerca volvulus 0.0277 0.0468 0.1999
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0241 0.0362 0.0362
Schistosoma mansoni cell adhesion molecule 0.0168 0.0153 0.0142
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0528 0.1186 0.114
Echinococcus multilocularis c4b binding protein beta chain 0.0672 0.1599 0.1556
Brugia malayi casein kinase I 0.0234 0.0344 0.0334
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0179 0.0186 0.0109
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.3603 1 1
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Plasmodium falciparum calcium-dependent protein kinase 2 0.0217 0.0296 0.022
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0672 0.1599 0.1599
Echinococcus multilocularis expressed protein 0.0179 0.0186 0.0135
Loa Loa (eye worm) hypothetical protein 0.0397 0.0812 0.0812
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0878 0.219 0.2149
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0369 0.0731 0.0731
Echinococcus multilocularis mitogen activated protein kinase 3 0.0181 0.019 0.0139
Brugia malayi cyclin-dependent kinase 9 0.0164 0.0143 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0141 0.0077 0.0031
Giardia lamblia Aurora kinase 0.0254 0.04 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.1178 0.1168
Echinococcus granulosus casein kinase I gamma 0.0459 0.0989 0.0942
Brugia malayi SRC-1 0.0329 0.0616 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Brugia malayi STE20-like kinase MST 0.0553 0.1258 0.1249
Loa Loa (eye worm) protein kinase domain-containing protein 0.0459 0.0989 0.0989
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Echinococcus multilocularis Immunoglobulin 0.0661 0.1568 0.1524
Echinococcus granulosus dual specificity 0.0263 0.0428 0.0378
Onchocerca volvulus 0.0364 0.0716 0.3095
Brugia malayi Protein kinase domain containing protein 0.0141 0.0077 0.0067
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0202 0.0253 0.0242
Loa Loa (eye worm) hypothetical protein 0.0299 0.0529 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0849 0.2106 0.2097
Echinococcus granulosus Glutaredoxin protein 5 0.0266 0.0436 0.0386
Schistosoma mansoni nephrin related 0.0168 0.0153 0.0142
Plasmodium falciparum glutathione reductase 0.3603 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0238 0.0354 0.0304
Echinococcus multilocularis protein jagged 1 0.0364 0.0716 0.0668
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0499 0.1104 0.1057
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0331 0.0623 0.0549
Trypanosoma brucei protein kinase, putative 0.0197 0.0237 0.016
Trichomonas vaginalis CK1 family protein kinase 0.0234 0.0344 0.1058
Trichomonas vaginalis CK1 family protein kinase 0.0234 0.0344 0.1058
Schistosoma mansoni basigin related 0.02 0.0247 0.0237
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0153 0.0153
Trichomonas vaginalis glutamate synthase, putative 0.0331 0.0623 0.1915
Schistosoma mansoni cell adhesion molecule 0.0187 0.0209 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.04 0.0389
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0329 0.0616 0.0567
Plasmodium falciparum protein serine/threonine kinase-1 0.0331 0.0622 0.0548
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0228 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0156 0.0146
Brugia malayi Furin-like cysteine rich region family protein 0.0747 0.1815 0.1806
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus multilocularis neurogenic locus notch protein 0.0364 0.0716 0.0668
Echinococcus multilocularis epidermal growth factor receptor 0.0747 0.1815 0.1772
Brugia malayi probable protein kinase 0.0571 0.1308 0.1299
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0759 0.1849 0.1807
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0185 0.0204 0.0153
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Trypanosoma cruzi cdc2-related kinase 3 0.0256 0.0407 0.0396
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0176 0.0166
Brugia malayi Immunoglobulin domain containing protein 0.02 0.0247 0.0237
Plasmodium falciparum casein kinase 1 0.0234 0.0344 0.0268
Schistosoma mansoni hemicentin 0.0187 0.0209 0.0199
Echinococcus granulosus casein kinase i 0.0234 0.0344 0.0294
Brugia malayi Protein kinase domain containing protein 0.0134 0.0055 0.0045
Brugia malayi protein-tyrosine kinase 0.0268 0.0441 0.0431
Brugia malayi Peroxidasin 0.0369 0.0729 0.0719
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0194 0.0183
Brugia malayi basement membrane proteoglycan precursor 0.02 0.0247 0.0237
Onchocerca volvulus 0.0672 0.1599 0.6994
Loa Loa (eye worm) TK protein kinase 0.0559 0.1275 0.1275
Toxoplasma gondii aurora kinase 0.0254 0.04 0.0324
Brugia malayi Immunoglobulin I-set domain containing protein 0.02 0.0247 0.0237
Leishmania major NADH dehydrogenase, putative 0.0331 0.0623 0.0549
Echinococcus granulosus fibropellin Ia 0.0364 0.0716 0.0668
Echinococcus multilocularis leucine rich repeat containing protein 4 0.02 0.0247 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0407 0.0396
Echinococcus granulosus titin 0.0258 0.0414 0.0364
Schistosoma mansoni basigin related 0.02 0.0247 0.0237
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0244 0.0371 0.0361
Leishmania major trypanothione reductase 0.3603 1 1
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Giardia lamblia Kinase, AGC PKA 0.0337 0.064 0.148
Echinococcus multilocularis roundabout 2 0.1049 0.2679 0.2641
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0217 0.0296 0.0245
Onchocerca volvulus 0.0672 0.1599 0.6994
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0241 0.0362 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0626 0.1467 0.1458
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0391 0.0794 0.0746
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0559 0.1275 0.1265
Entamoeba histolytica protein kinase, putative 0.0347 0.0667 0.2767
Schistosoma mansoni hypothetical protein 0.0219 0.0301 0.0291
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0331 0.0623 0.0457
Loa Loa (eye worm) programmed cell death 8 0.0331 0.0623 0.0623
Loa Loa (eye worm) TK/ALK protein kinase 0.0327 0.0611 0.0611
Trichomonas vaginalis AGC family protein kinase 0.0293 0.0514 0.158
Brugia malayi Stress-activated protein kinase jnk-1 0.0569 0.1304 0.1295
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0329 0.0616 0.0567
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0254 0.04 0.1527
Trypanosoma brucei casein kinase I, isoform 2 0.0234 0.0344 0.0268
Brugia malayi SH2 domain containing protein 0.0141 0.0077 0.0067
Onchocerca volvulus 0.0672 0.1599 0.6994
Leishmania major protein kinase, putative 0.0331 0.0622 0.0548
Onchocerca volvulus Slit protein homolog 0.0412 0.0853 0.37
Echinococcus multilocularis roundabout 2 0.0388 0.0784 0.0736
Loa Loa (eye worm) hypothetical protein 0.0219 0.0301 0.0301
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Schistosoma mansoni titin 0.0258 0.0414 0.0403
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Entamoeba histolytica protein kinase, putative 0.0155 0.0117 0.0217
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Brugia malayi EGF-like domain containing protein 0.0412 0.0853 0.0843
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1248 0.3251 1
Plasmodium vivax ferrodoxin reductase, putative 0.0331 0.0623 0.0457
Plasmodium falciparum glutathione reductase 0.1248 0.3251 0.3198
Brugia malayi Cyclin C 0.1756 0.4705 0.47
Onchocerca volvulus 0.0672 0.1599 0.6994
Trichomonas vaginalis CMGC family protein kinase 0.0194 0.0228 0.07
Toxoplasma gondii AGC kinase 0.0613 0.143 0.1363
Echinococcus multilocularis notch 0.0364 0.0716 0.0668
Schistosoma mansoni titin 0.0168 0.0153 0.0142
Echinococcus granulosus protein jagged 2 0.0364 0.0716 0.0668
Echinococcus multilocularis dual specificity 0.0299 0.0531 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.1304 0.1295
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1248 0.3251 0.2803
Brugia malayi intracellular kinase 0.0277 0.0468 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0131 0.0121
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0164 0.0143 0.0143
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0176 0.0176 0.0125
Schistosoma mansoni rap gtpase-activating protein 0.0241 0.0362 0.0352
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0329 0.0616 0.0567
Echinococcus multilocularis mitogen activated protein kinase 14 0.0343 0.0655 0.0607
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0169 0.0156 0.0146
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Toxoplasma gondii EGF family domain-containing protein 0.0364 0.0716 0.0643
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0364 0.0716 0.3095
Brugia malayi Protein kinase domain containing protein 0.0246 0.0378 0.0367
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0331 0.0622 0.0611
Echinococcus granulosus Protein kinase C brain isozyme 0.0525 0.1178 0.1132
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0331 0.0623 0.0612
Loa Loa (eye worm) SRC-1 0.0329 0.0616 0.0616
Schistosoma mansoni protein kinase 0.0934 0.2351 0.2343
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0181 0.019 0.019
Onchocerca volvulus 0.0168 0.0153 0.0611
Brugia malayi Protein kinase domain containing protein 0.0141 0.0077 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0192 0.0223 0.0686
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0471 0.1023 0.0977
Loa Loa (eye worm) TK protein kinase 0.0331 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Trypanosoma cruzi casein kinase, putative 0.0234 0.0344 0.0334
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0331 0.0623 0.2561
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus granulosus contactin 0.0388 0.0784 0.0736
Plasmodium falciparum calcium-dependent protein kinase 1 0.0217 0.0296 0.022
Loa Loa (eye worm) projectin 0.0187 0.0209 0.0209
Entamoeba histolytica protein kinase domain containing protein 0.0263 0.0428 0.1658
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0175 0.0175 0.0175
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0347 0.0667 0.0619
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0506 0.1124 0.1078
Brugia malayi Immunoglobulin I-set domain containing protein 0.02 0.0247 0.0237
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0337 0.064 0.063
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.0378 0.1162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0388 0.0784 0.0774
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0331 0.0623 0.0612
Echinococcus multilocularis hemicentin 1 0.0368 0.0728 0.0679
Brugia malayi Protein kinase domain containing protein 0.0688 0.1645 0.1636
Brugia malayi serine/threonine-protein kinase PAK 7 0.05 0.1106 0.1096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0263 0.0426 0.0415
Echinococcus multilocularis tyrosine protein kinase Srms 0.0268 0.0441 0.0391
Echinococcus multilocularis serine:threonine protein kinase 3 0.0553 0.1258 0.1213
Schistosoma mansoni growth factor receptor-bound protein 0.0132 0.0052 0.0041
Onchocerca volvulus 0.0168 0.0153 0.0611
Echinococcus granulosus protein jagged 1 0.0364 0.0716 0.0668
Schistosoma mansoni slit 0.0365 0.0718 0.0708
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Schistosoma mansoni kinase 0.0622 0.1455 0.1446
Echinococcus granulosus neurogenic locus notch protein 4 0.0364 0.0716 0.0668
Echinococcus granulosus roundabout 2 0.0388 0.0784 0.0736
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0331 0.0623 0.0612
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0436 0.0924 0.0924
Entamoeba histolytica protein kinase, putative 0.0185 0.0204 0.0621
Brugia malayi Temporarily assigned gene name protein 59 0.0241 0.0362 0.0352
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.0468 0.1438
Trichomonas vaginalis CAMK family protein kinase 0.0248 0.0384 0.118
Echinococcus granulosus serine:threonine protein kinase N2 0.0279 0.0473 0.0423
Echinococcus granulosus tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.02 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.026 0.0417 0.0417
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.1124 0.1114
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0141 0.0077 0.0067
Onchocerca volvulus 0.0168 0.0153 0.0611
Trypanosoma cruzi trypanothione reductase, putative 0.3603 1 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0217 0.0296 0.022
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0379 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.02 0.0247 0.0247
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0688 0.1645 0.1645
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0181 0.019 0.0113
Echinococcus granulosus growth factor receptor bound protein 2 0.0134 0.0058 0.0006
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Brugia malayi serine/threonine-protein kinase 6 0.0254 0.04 0.0389
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Trichomonas vaginalis apoptosis inducing factor, putative 0.0331 0.0623 0.1915
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus multilocularis cyclin 0.0878 0.219 0.2149
Schistosoma mansoni tyrosine kinase 0.0329 0.0616 0.0606
Echinococcus granulosus CDC7 cell division cycle 7 0.0194 0.0228 0.0177
Echinococcus granulosus c src tyrosine kinase 0.0202 0.0253 0.0202
Echinococcus granulosus nephrin 0.0187 0.0209 0.0158
Echinococcus multilocularis protein jagged 1 0.0364 0.0716 0.0668
Echinococcus multilocularis transfer RNA-Phe 0.0187 0.0209 0.0158
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0277 0.0468 0.0468
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0371 0.0361
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0175 0.0174 0.0096
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0479 0.1045 0.1045
Schistosoma mansoni septate junction protein 0.0368 0.0728 0.0718
Echinococcus multilocularis tyrosine protein kinase Src42A 0.02 0.0246 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.044 0.0933 0.0923
Onchocerca volvulus 0.0141 0.0077 0.0276
Loa Loa (eye worm) hypothetical protein 0.02 0.0247 0.0247
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0553 0.1258 0.1258
Echinococcus granulosus cyclin 0.0878 0.219 0.2149
Echinococcus granulosus neurogenic locus protein delta 0.0364 0.0716 0.0668
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.019 0.018
Onchocerca volvulus 0.0241 0.0362 0.1533
Loa Loa (eye worm) glutathione reductase 0.3603 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.3603 1 1
Schistosoma mansoni protein kinase 0.0254 0.04 0.0389
Plasmodium falciparum serine/threonine protein kinase, putative 0.0254 0.04 0.0324
Leishmania major hypothetical protein, conserved 0.0331 0.0623 0.0549
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Echinococcus granulosus neural cadherin 0.0364 0.0716 0.0668
Echinococcus multilocularis cyclin dependent kinase 9 0.0164 0.0143 0.0092
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3198
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0476 0.1037 0.0991
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0141 0.0078 0.0067
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0217 0.0296 0.0125
Schistosoma mansoni cell adhesion molecule 0.0187 0.0209 0.0199
Trypanosoma brucei aurora B kinase 0.0254 0.04 0.0324
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0185 0.0203 0.003
Entamoeba histolytica protein kinase, putative 0.0263 0.0428 0.1658
Toxoplasma gondii histone kinase SNF1, putative 0.0169 0.0156 0.0079
Echinococcus granulosus casein kinase I alpha 0.0234 0.0344 0.0294
Plasmodium vivax serine/threonine protein kinase, putative 0.0179 0.0186 0.0013
Echinococcus granulosus mitogen activated protein kinase 0.0181 0.019 0.0139
Loa Loa (eye worm) hypothetical protein 0.0132 0.0052 0.0052
Toxoplasma gondii CMGC kinase, CK2 family 0.0216 0.0291 0.0215
Loa Loa (eye worm) hypothetical protein 0.0646 0.1523 0.1523
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0161 0.0135 0.0124
Toxoplasma gondii thioredoxin reductase 0.3603 1 1
Echinococcus granulosus serine:threonine kinase SAD 1 0.0169 0.0156 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Trypanosoma cruzi cdc2-related kinase 1 0.0256 0.0407 0.0396
Loa Loa (eye worm) hypothetical protein 0.0681 0.1624 0.1624
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0217 0.0296 0.0125
Echinococcus granulosus mitogen activated protein kinase 14 0.0343 0.0655 0.0607
Loa Loa (eye worm) hypothetical protein 0.1036 0.2643 0.2643
Echinococcus granulosus nervana 2 0.0266 0.0436 0.0386
Schistosoma mansoni serine/threonine-protein kinase 0.0354 0.0687 0.0677
Echinococcus granulosus neuroglian 0.0388 0.0784 0.0736
Schistosoma mansoni titin 0.0168 0.0153 0.0142
Brugia malayi Immunoglobulin I-set domain containing protein 0.0215 0.029 0.028
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0479 0.1045 0.0998
Echinococcus granulosus casein kinase I delta 0.0234 0.0344 0.0294
Plasmodium falciparum calcium-dependent protein kinase 4 0.0217 0.0296 0.022
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0569 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus granulosus slit 2 protein 0.0412 0.0853 0.0806
Echinococcus granulosus cyclin dependent kinase 0.0256 0.0407 0.0357
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0269 0.0443 0.0368
Entamoeba histolytica PH domain containing protein kinase, putative 0.0354 0.0687 0.2859
Echinococcus granulosus neuroglian 0.0829 0.2048 0.2007
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0331 0.0623 0.1915
Brugia malayi Protein kinase domain containing protein 0.0415 0.0863 0.0853
Entamoeba histolytica thioredoxin reductase, putative 0.0331 0.0623 0.2561
Echinococcus granulosus protein kinase shaggy 0.0277 0.0468 0.0418
Loa Loa (eye worm) hypothetical protein 0.0192 0.0224 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Brugia malayi Casein kinase II, alpha chain 0.0216 0.0291 0.0281
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0169 0.0156 0.0079
Loa Loa (eye worm) AGC/NDR protein kinase 0.0347 0.0667 0.0667
Plasmodium falciparum apical sushi protein 0.0672 0.1599 0.1534
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0688 0.1645 0.1645
Echinococcus granulosus tyrosine protein kinase otk 0.0368 0.0728 0.0679
Echinococcus multilocularis neuroglian 0.0388 0.0784 0.0736
Echinococcus granulosus titin 0.0258 0.0414 0.0364
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Leishmania major casein kinase II, putative 0.0216 0.0291 0.0215
Loa Loa (eye worm) CAMK protein kinase 0.0258 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0185 0.0202 0.0202
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0388 0.0784 0.0736
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0244 0.0371 0.0296
Echinococcus granulosus protein kinase 0.033 0.0619 0.057
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0582 0.1341 0.1273
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0353 0.0684 0.0684
Echinococcus multilocularis calcium activated potassium channel 0.0291 0.0506 0.0456
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.1248 0.3251 0.3132
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0917 0.2301 0.2293
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.0357 0.0347
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0175 0.0174 0.0096
Echinococcus multilocularis casein kinase I gamma 0.0459 0.0989 0.0942
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0331 0.0623 0.0574
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0432 0.0912 0.0912
Trypanosoma cruzi Protein kinase B 0.0354 0.0687 0.0677
Plasmodium falciparum NIMA related kinase 1 0.0293 0.0514 0.0439
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0168 0.0153 0.0102
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0878 0.219 0.2149
Plasmodium vivax glutathione reductase, putative 0.3603 1 1
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0241 0.0362 0.0287
Onchocerca volvulus Peroxidasin homolog 0.0168 0.0155 0.0618
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0254 0.04 0.1527
Giardia lamblia Kinase, NEK 0.0293 0.0514 0.1068
Echinococcus granulosus delta-like protein 1 0.0364 0.0716 0.0668
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.1248 0.3251 0.2803
Echinococcus granulosus hypothetical protein 0.026 0.0417 0.0367
Brugia malayi Protein kinase domain containing protein 0.079 0.1937 0.1928
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0181 0.019 0.0113
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0168 0.0153 0.0102
Schistosoma mansoni serine/threonine kinase 0.0484 0.1059 0.1049
Trichomonas vaginalis mercuric reductase, putative 0.1248 0.3251 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Echinococcus granulosus serine:threonine protein kinase 3 0.0553 0.1258 0.1213
Echinococcus granulosus Immunoglobulin 0.0661 0.1568 0.1524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Brugia malayi Immunoglobulin I-set domain containing protein 0.0681 0.1624 0.1615
Onchocerca volvulus 0.0138 0.0068 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0371 0.0361
Loa Loa (eye worm) hypothetical protein 0.0681 0.1624 0.1624
Trypanosoma cruzi trypanothione reductase, putative 0.1248 0.3251 0.3244
Trypanosoma brucei NADH dehydrogenase 0.0331 0.0623 0.0549
Echinococcus granulosus leucine rich repeat containing protein 4 0.0168 0.0153 0.0102
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Plasmodium vivax serine/threonine kinase-1, putative 0.0331 0.0622 0.0456
Schistosoma mansoni cell adhesion molecule 0.02 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0331 0.0623 0.0574
Echinococcus granulosus tyrosine protein kinase ABL1 0.0141 0.0077 0.0026
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0185 0.0204 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Brugia malayi P38 map kinase family protein 2 0.0343 0.0655 0.0645
Schistosoma mansoni hypothetical protein 0.0331 0.0623 0.0612
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0729 0.1762 0.1762
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0299 0.0531 0.0457
Schistosoma mansoni glutamate synthase 0.0331 0.0623 0.0612
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.1248 0.3251 0.3132
Leishmania major protein kinase, putative 0.0183 0.0196 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0156 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Schistosoma mansoni sulfide quinone reductase 0.0331 0.0623 0.0612
Echinococcus multilocularis hypothetical protein 0.0219 0.0301 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0293 0.0514 0.0346
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0263 0.0428 0.0428
Leishmania major casein kinase, putative 0.0234 0.0344 0.0268
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0268 0.0441 0.0391
Echinococcus granulosus tyrosine protein kinase Src42A 0.0329 0.0616 0.0567
Schistosoma mansoni serine/threonine-protein kinase 0.0354 0.0687 0.0677
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0312 0.0567 0.0518
Echinococcus granulosus twitchin 0.09 0.2253 0.2212
Echinococcus multilocularis casein kinase I alpha 0.0234 0.0344 0.0294
Treponema pallidum NADH oxidase 0.1248 0.3251 1
Brugia malayi Protein kinase domain containing protein 0.0179 0.0186 0.0176
Brugia malayi Variant SH3 domain containing protein 0.0132 0.0052 0.0041
Schistosoma mansoni titin 0.0168 0.0153 0.0142
Echinococcus multilocularis tyrosine protein kinase HCK 0.0197 0.0237 0.0186
Brugia malayi Protein kinase domain containing protein 0.0347 0.0667 0.0657
Echinococcus multilocularis cyclin dependent kinase 1 0.0256 0.0407 0.0357
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0234 0.0344 0.0344
Giardia lamblia Kinase, STE STE20 0.0185 0.0204 0.0059
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0331 0.0623 0.0549
Echinococcus multilocularis protein kinase c epsilon type 0.044 0.0933 0.0886
Schistosoma mansoni nck2/grb4 0.0132 0.0052 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0254 0.04 0.1229
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0368 0.0728 0.0728
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0277 0.0468 0.0393
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0244 0.0371 0.0296
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.1248 0.3251 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0256 0.0407 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0549 0.1247 0.1238
Echinococcus granulosus cyclin dependent kinase 5 0.0256 0.0407 0.0357
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0331 0.0623 0.0574
Entamoeba histolytica protein kinase, putative 0.0176 0.0176 0.0491
Echinococcus multilocularis down syndrome cell adhesion 0.0168 0.0153 0.0102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0268 0.0441 0.0391
Loa Loa (eye worm) hypothetical protein 0.0688 0.1645 0.1645
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0244 0.0371 0.0361
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.02 0.0247 0.0197
Echinococcus multilocularis insulin growth factor binding 0.0168 0.0153 0.0102
Echinococcus granulosus c-Jun N-terminal kinases 0.0569 0.1304 0.1259
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Schistosoma mansoni serine/threonine protein kinase 0.0354 0.0686 0.0676
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0862 0.2143 0.2102
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.1248 0.3251 0.3244
Schistosoma mansoni septate junction protein 0.0364 0.0716 0.0706
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0331 0.0623 0.0457
Trichomonas vaginalis CMGC family protein kinase 0.0331 0.0622 0.1912
Leishmania major protein kinase A catalytic subunit isoform 2 0.0244 0.0371 0.0296
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0476 0.1037 0.0991
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0185 0.0204 0.0153
Trypanosoma brucei protein kinase, putative 0.0277 0.0468 0.0393
Entamoeba histolytica protein kinase domain containing protein 0.0299 0.0531 0.2137
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0849 0.2106 0.2065
Schistosoma mansoni nephrin related 0.02 0.0247 0.0237
Echinococcus granulosus tyrosine protein kinase HCK 0.0197 0.0237 0.0186
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0168 0.0155 0.0103
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0717 0.1728 0.1719
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0241 0.0362 0.0312
Giardia lamblia Kinase, CMGC CDK 0.0256 0.0407 0.0719
Onchocerca volvulus 0.0187 0.0209 0.0859
Leishmania major protein kinase, putative 0.0331 0.0622 0.0548
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0312 0.0567 0.0517
Brugia malayi notch-like transmembrane receptor 0.0364 0.0716 0.0706
Giardia lamblia Kinase, CMGC CK2 0.0216 0.0291 0.0342
Trypanosoma brucei Casein kinase II 0.0216 0.0291 0.0215
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0331 0.0623 0.1915
Echinococcus multilocularis Immunoglobulin subtype 0.02 0.0247 0.0197
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Entamoeba histolytica cell division protein kinase 2, putative 0.0256 0.0407 0.1559
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Echinococcus granulosus cyclin dependent kinase 9 0.018 0.019 0.0139
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Entamoeba histolytica protein kinase, putative 0.022 0.0304 0.1081
Loa Loa (eye worm) hypothetical protein 0.0748 0.1816 0.1816
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0181 0.019 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0467 0.1012 0.3114
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.1029 0.2623 0.2623
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0325 0.0604 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0194 0.0228 0.07
Echinococcus multilocularis neurogenic locus protein delta 0.0364 0.0716 0.0668
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0331 0.0623 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.0407 0.1251
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.022 0.0303 0.0303
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0331 0.0623 0.1423
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Loa Loa (eye worm) hypothetical protein 0.0169 0.0156 0.0156
Brugia malayi hypothetical protein 0.0479 0.1045 0.1035
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0344 0.0334
Loa Loa (eye worm) hypothetical protein 0.0412 0.0853 0.0853
Schistosoma mansoni protein kinase 0.0139 0.0071 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0465 0.1006 0.0997
Schistosoma mansoni septate junction protein 0.02 0.0247 0.0237
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0277 0.0468 0.0418
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0194 0.0183
Echinococcus multilocularis tyrosine kinase 0.0141 0.0077 0.0026
Trichomonas vaginalis STE family protein kinase 0.0139 0.0071 0.0217
Loa Loa (eye worm) hypothetical protein 0.02 0.0247 0.0247
Onchocerca volvulus Putative titin 0.0168 0.0153 0.0611
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1064 0.2724 0.2686
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0161 0.0135 0.0083
Echinococcus granulosus serine:threonine protein kinase 0.0246 0.0378 0.0328
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.033 0.0619 0.0619
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Echinococcus multilocularis NCK adaptor protein 0.0134 0.0058 0.0006
Echinococcus multilocularis casein kinase I alpha 0.0234 0.0344 0.0294
Echinococcus multilocularis titin 0.0258 0.0414 0.0364
Brugia malayi Immunoglobulin I-set domain containing protein 0.0388 0.0784 0.0774
Loa Loa (eye worm) hypothetical protein 0.0389 0.0787 0.0787
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0415 0.0863 0.0863
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.0143 0.0336
Brugia malayi Protein kinase domain containing protein 0.0256 0.0407 0.0396
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0388 0.0784 0.0736
Schistosoma mansoni serine/threonine protein kinase 0.1027 0.2617 0.2609
Brugia malayi ephrin receptor 1 precursor 0.0135 0.006 0.0049
Plasmodium falciparum glycogen synthase kinase 3 0.0277 0.0468 0.0393
Trichomonas vaginalis STE family protein kinase 0.0185 0.0204 0.0629
Entamoeba histolytica serine/threonine protein kinase, putative 0.0169 0.0156 0.0398
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1604 0.427 0.427
Onchocerca volvulus 0.0672 0.1599 0.6994
Loa Loa (eye worm) hypothetical protein 0.0662 0.157 0.157
Brugia malayi Cadherin domain containing protein 0.0364 0.0716 0.0706
Onchocerca volvulus 0.0168 0.0155 0.0618
Schistosoma mansoni septate junction protein 0.02 0.0247 0.0237
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0217 0.0296 0.022
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0118 0.0011 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1248 0.3251 1
Echinococcus multilocularis epidermal growth factor receptor 0.0521 0.1166 0.112
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0299 0.0531 0.0521
Echinococcus multilocularis cyclin dependent kinase 9 0.018 0.019 0.0139
Loa Loa (eye worm) hypothetical protein 0.0299 0.0529 0.0529
Schistosoma mansoni roundabout 0.0368 0.0728 0.0718
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0241 0.0362 0.0352
Loa Loa (eye worm) hypothetical protein 0.0661 0.1568 0.1568
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0347 0.0667 0.0619
Echinococcus granulosus tyrosine kinase 0.0268 0.0441 0.0391
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1248 0.3251 0.3198
Schistosoma mansoni tyrosine kinase 0.0329 0.0616 0.0606
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0917 0.2301 0.2293
Echinococcus multilocularis cyclin dependent kinase 5 0.0256 0.0407 0.0357
Brugia malayi Protein kinase domain containing protein 0.0331 0.0621 0.0611
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3198
Onchocerca volvulus 0.0168 0.0153 0.0611
Echinococcus multilocularis tyrosine protein kinase 0.0331 0.0621 0.0572
Echinococcus granulosus dual specificity 0.0299 0.0531 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Echinococcus multilocularis aurora kinase A 0.0254 0.04 0.035
Brugia malayi Disorganized muscle protein 1 0.0168 0.0153 0.0142
Schistosoma mansoni g1/s-specific cyclin C 0.1756 0.4705 0.47
Schistosoma mansoni netrin receptor unc5 0.02 0.0247 0.0237
Giardia lamblia Glutamate synthase 0.0331 0.0623 0.1423
Schistosoma mansoni cell adhesion molecule 0.0881 0.2199 0.219
Brugia malayi Protein kinase domain containing protein 0.0141 0.0077 0.0067
Loa Loa (eye worm) LAD-2 short isoform 0.02 0.0247 0.0247
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1248 0.3251 0.3198
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0354 0.0686 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.0506 0.0495
Trypanosoma cruzi NADH dehydrogenase, putative 0.0331 0.0623 0.0612
Loa Loa (eye worm) thyroid receptor interactor 0.022 0.0304 0.0304
Schistosoma mansoni ephrin receptor 0.0208 0.0268 0.0258
Echinococcus multilocularis neural cadherin 0.0364 0.0716 0.0668
Loa Loa (eye worm) hypothetical protein 0.0241 0.0362 0.0362
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.019 0.0585
Onchocerca volvulus 0.0141 0.0077 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.0989 0.098
Onchocerca volvulus 0.0364 0.0716 0.3095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Trypanosoma brucei rac serine-threonine kinase, putative 0.0629 0.1477 0.141
Schistosoma mansoni cell polarity protein 0.0364 0.0716 0.0706
Schistosoma mansoni glutamate synthase 0.0331 0.0623 0.0612
Trichomonas vaginalis CAMK family protein kinase 0.0248 0.0384 0.118
Echinococcus granulosus tyrosine protein kinase Srms 0.0585 0.1349 0.1304
Brugia malayi Protein kinase c protein 2 0.0249 0.0388 0.0377
Trichomonas vaginalis glutamate synthase, putative 0.0331 0.0623 0.1915
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Echinococcus multilocularis neurogenic locus notch protein 0.0364 0.0716 0.0668
Brugia malayi hypothetical protein 0.0141 0.0077 0.0067
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0337 0.064 0.0591
Echinococcus granulosus down syndrome cell adhesion 0.0168 0.0153 0.0102
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.0052 0.0052
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0331 0.0622 0.0548
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.02 0.0247 0.0197
Brugia malayi Protein kinase domain containing protein 0.1183 0.3063 0.3056
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0132 0.0052 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0598 0.1388 0.4269
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0582 0.1341 0.1296
Trypanosoma cruzi casein kinase, putative 0.0234 0.0344 0.0334
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0254 0.04 0.035
Schistosoma mansoni protein kinase 0.079 0.1937 0.1928
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.0407 0.1251
Echinococcus multilocularis mitogen activated protein kinase 11 0.0343 0.0655 0.0607
Brugia malayi Immunoglobulin I-set domain containing protein 0.0201 0.0249 0.0238
Schistosoma mansoni vav2 0.0177 0.0181 0.0171
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Loa Loa (eye worm) cyclin C 0.1756 0.4705 0.4705
Echinococcus multilocularis hemicentin 1 0.0368 0.0728 0.0679
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0241 0.0362 0.0312
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0256 0.0407 0.0357
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0254 0.04 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Brugia malayi C1-like domain containing protein 0.0469 0.1016 0.1007
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0256 0.0407 0.0331
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0388 0.0784 0.0736
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0141 0.0078 0.0067
Echinococcus multilocularis cyclin dependent kinase 1 0.0256 0.0407 0.0357
Schistosoma mansoni cell adhesion molecule 0.02 0.0247 0.0237
Echinococcus granulosus N chimaerin 0.0161 0.0135 0.0083
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0217 0.0296 0.022
Schistosoma mansoni tyrosine kinase 0.0391 0.0794 0.0784
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0234 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0307 0.0554 0.0554
Brugia malayi Protein kinase domain containing protein 0.0432 0.0912 0.0903
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1183 0.3063 0.3063
Echinococcus granulosus dual specificity protein kinase clk2 0.0331 0.0622 0.0573
Entamoeba histolytica protein kinase, putative 0.0179 0.0186 0.0537
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0337 0.064 0.0591
Onchocerca volvulus 0.0397 0.0812 0.3519
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1248 0.3251 0.2803
Loa Loa (eye worm) hypothetical protein 0.0261 0.042 0.042
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.02 0.0247 0.0197
Echinococcus multilocularis glutamate synthase 0.0331 0.0623 0.0574
Entamoeba histolytica protein kinase, putative 0.0155 0.0117 0.0217
Toxoplasma gondii NADPH-glutathione reductase 0.1248 0.3251 0.3198
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Echinococcus multilocularis tyrosine protein kinase Abl 0.0202 0.0253 0.0202
Echinococcus granulosus titin 0.0168 0.0153 0.0102
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0331 0.0623 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0296 0.0285
Entamoeba histolytica protein kinase, putative 0.0254 0.04 0.1527
Entamoeba histolytica protein kinase domain containing protein 0.0277 0.0468 0.1842
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0217 0.0296 0.0245
Onchocerca volvulus 0.0299 0.0529 0.227
Echinococcus granulosus protein jagged 1 0.0364 0.0716 0.0668
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0331 0.0623 0.2561
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0169 0.0156 0.0079
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0256 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.0436 0.0924 0.0914
Echinococcus granulosus basement membrane specific heparan sulfate 0.02 0.0247 0.0197
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2028 0.5486 0.5486
Loa Loa (eye worm) animal heme peroxidase 0.0168 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0187 0.0209 0.0209
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0238 0.0354 0.0304
Echinococcus granulosus titin 0.0168 0.0153 0.0102
Echinococcus granulosus protein kinase C gamma type 0.0435 0.092 0.0872
Schistosoma mansoni protein kinase 0.0185 0.0204 0.0194
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Brugia malayi protein kinase C3,putative 0.034 0.0647 0.0636
Brugia malayi Protein kinase domain containing protein 0.0627 0.1471 0.1461
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0759 0.1849 0.8096
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0331 0.0622 0.0622
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Schistosoma mansoni tyrosine kinase 0.0202 0.0253 0.0242
Schistosoma mansoni tyrosine kinase 0.0451 0.0965 0.0955
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0302 0.0539 0.0529
Echinococcus multilocularis casein kinase I alpha 0.0234 0.0344 0.0294
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.019 0.0585
Brugia malayi map kinase activated protein kinase protein 2 0.0849 0.2106 0.2097
Entamoeba histolytica protein kinase 2, putative 0.0337 0.064 0.2642
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Giardia lamblia NADH oxidase lateral transfer candidate 0.1248 0.3251 1
Echinococcus granulosus epidermal growth factor receptor 0.0747 0.1815 0.1772
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0329 0.0616 0.0567
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0388 0.0784 0.0736
Onchocerca volvulus 0.0234 0.0344 0.1454
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.1124 0.1114
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.157 0.4173 0.4143
Leishmania major hypothetical protein, conserved 0.0331 0.0623 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0667 0.0657
Echinococcus granulosus neurogenic locus notch protein 0.0364 0.0716 0.0668
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0661 0.1568 0.1559
Schistosoma mansoni serine/threonine protein kinase 0.0465 0.1006 0.0997
Trichomonas vaginalis STE family protein kinase 0.0185 0.0204 0.0629
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0331 0.0623 0.0574
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1248 0.3251 0.3198
Echinococcus granulosus NDR protein kinase 0.0347 0.0667 0.0619
Echinococcus granulosus insulin growth factor binding 0.0168 0.0153 0.0102
Echinococcus granulosus lachesin 0.0368 0.0728 0.0679
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Echinococcus multilocularis nervana 2 0.0266 0.0436 0.0386
Echinococcus multilocularis protein kinase c iota type 0.0615 0.1437 0.1392
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0849 0.2106 0.2065
Entamoeba histolytica protein kinase, putative 0.0179 0.0186 0.0537
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0183 0.0196 0.0185
Schistosoma mansoni myosin-binding protein-related 0.0187 0.0209 0.0199
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0183 0.0196 0.0582
Brugia malayi serine/threonine kinase 12 0.0254 0.04 0.0389
Echinococcus granulosus C type lectin domian containing protein 0.0672 0.1599 0.1556
Echinococcus granulosus low density lipoprotein receptor ldl 0.02 0.0247 0.0197
Echinococcus multilocularis nervana 2 0.0266 0.0436 0.0386
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0388 0.0784 0.0736
Schistosoma mansoni tyrosine kinase 0.0647 0.1527 0.1518
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Trichomonas vaginalis STE family protein kinase 0.0185 0.0204 0.0629
Entamoeba histolytica protein kinase, putative 0.0629 0.1477 0.6524
Brugia malayi casein kinase 1, delta 0.0234 0.0344 0.0334
Onchocerca volvulus 0.0168 0.0153 0.0611
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0331 0.0623 0.0549
Leishmania major protein kinase, putative 0.0217 0.0296 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.0506 0.0495
Schistosoma mansoni protein kinase 0.0476 0.1037 0.1027
Entamoeba histolytica protein kinase, putative 0.0629 0.1477 0.6524
Echinococcus granulosus serine:threonine protein kinase N2 0.0626 0.1467 0.1423
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Brugia malayi Protein kinase domain containing protein 0.0966 0.2441 0.2433
Echinococcus multilocularis casein kinase I delta 0.0234 0.0344 0.0294
Schistosoma mansoni atypical protein kinase C 0.0628 0.1474 0.1465
Loa Loa (eye worm) hypothetical protein 0.0241 0.0362 0.0362
Echinococcus granulosus cGMP dependent protein kinase 1 0.0182 0.0194 0.0143
Echinococcus multilocularis Glutaredoxin protein 5 0.0266 0.0436 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0479 0.1045 0.1035
Giardia lamblia Kinase, STE STE20 0.0183 0.0196 0.0031
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0192 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0413 0.0858 0.3652
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0169 0.0156 0.0156
Plasmodium falciparum protein kinase 5 0.0256 0.0407 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0582 0.1341 0.1332
Toxoplasma gondii rhoptry neck protein RON1 0.0672 0.1599 0.1534
Echinococcus granulosus thioredoxin glutathione reductase 0.3603 1 1
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.022 0.0303 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.07 0.168 0.1671
Echinococcus multilocularis dual specificity 0.0299 0.0531 0.0482
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Entamoeba histolytica protein kinase , putative 0.0254 0.04 0.1527
Schistosoma mansoni tyrosine kinase 0.0373 0.0743 0.0733
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0217 0.0296 0.0296
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0299 0.0531 0.0457
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0465 0.1006 0.096
Brugia malayi MAP kinase sur-1 0.0181 0.019 0.018
Brugia malayi Protein kinase domain containing protein 0.0194 0.0228 0.0217
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.1248 0.3251 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0234 0.0344 0.0344
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0183 0.0196 0.0119
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1248 0.3251 0.3244
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0759 0.1849 0.1807
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0266 0.0436 0.0386
Schistosoma mansoni nephrin 0.0388 0.0784 0.0774
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.0242 0.0232
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Schistosoma mansoni basigin related 0.02 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1248 0.3251 0.3198
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0161 0.0135 0.0124
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0506 0.1124 0.1078
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Echinococcus multilocularis protein jagged 2 0.0364 0.0716 0.0668
Echinococcus multilocularis N chimaerin 0.0161 0.0135 0.0083
Schistosoma mansoni peroxidasin 0.0201 0.0249 0.0238
Entamoeba histolytica protein kinase domain containing protein 0.0254 0.04 0.1527
Trypanosoma cruzi casein kinase, putative 0.0234 0.0344 0.0334
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1248 0.3251 0.3244
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0156 0.0146
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Schistosoma mansoni septate junction protein 0.0368 0.0728 0.0718
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0169 0.0156 0.0146
Echinococcus granulosus cyclin dependent kinase 1 0.0256 0.0407 0.0357
Loa Loa (eye worm) hypothetical protein 0.0681 0.1624 0.1624
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0185 0.0204 0.0153
Brugia malayi phosphoinositide-dependent protein kinase I 0.0176 0.0176 0.0166
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0364 0.0716 0.0706
Schistosoma mansoni tyrosine kinase 0.0434 0.0915 0.0905
Loa Loa (eye worm) CDC7 protein kinase 0.0194 0.0228 0.0228
Echinococcus granulosus tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.02 0.0247 0.0247
Brugia malayi Immunoglobulin I-set domain containing protein 0.022 0.0303 0.0293
Brugia malayi Leucine Rich Repeat family protein 0.0168 0.0155 0.0144
Brugia malayi Temporarily assigned gene name protein 59 0.0278 0.0469 0.0458
Trypanosoma cruzi casein kinase, putative 0.0234 0.0344 0.0334
Loa Loa (eye worm) AUR protein kinase 0.0254 0.04 0.04
Onchocerca volvulus 0.0141 0.0077 0.0276
Brugia malayi Calcium binding EGF domain containing protein 0.0364 0.0716 0.0706
Schistosoma mansoni serine/threonine protein kinase 0.0432 0.0912 0.0903
Schistosoma mansoni tyrosine kinase 0.0521 0.1166 0.1156
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0172 0.0167 0.0116
Giardia lamblia High cysteine protein 0.0364 0.0716 0.1728
Brugia malayi Heparan sulfate 0.02 0.0247 0.0237
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0254 0.04 0.035
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0263 0.0428 0.0418
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0216 0.0291 0.0291
Brugia malayi Calcium binding EGF domain containing protein 0.0364 0.0716 0.0706
Echinococcus multilocularis tyrosine protein kinase otk 0.0368 0.0728 0.0679
Trichomonas vaginalis STE family protein kinase 0.0185 0.0204 0.0629
Echinococcus multilocularis tyrosine protein kinase shark 0.0373 0.0743 0.0695
Echinococcus multilocularis neurogenic locus notch protein 4 0.0364 0.0716 0.0668
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0331 0.0623 0.0549
Brugia malayi Protein kinase domain containing protein 0.0759 0.1849 0.184
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0331 0.0623 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0371 0.0361
Loa Loa (eye worm) hypothetical protein 0.0307 0.0554 0.0554
Giardia lamblia Kinase, AGC AKT 0.0252 0.0396 0.0684
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1248 0.3251 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Echinococcus granulosus titin 0.0168 0.0153 0.0102
Echinococcus granulosus nervana 2 0.0266 0.0436 0.0386
Schistosoma mansoni protein kinase 0.0216 0.0291 0.0281
Plasmodium vivax unspecified product 0.0216 0.0291 0.012
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0331 0.0623 0.2561
Brugia malayi Protein kinase domain containing protein 0.0303 0.054 0.053
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Loa Loa (eye worm) hypothetical protein 0.0331 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0277 0.0468 0.0457
Brugia malayi Protein kinase domain containing protein 0.0176 0.0176 0.0166
Entamoeba histolytica cyclin C, putative 0.0891 0.2226 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0471 0.1023 0.0977
Echinococcus granulosus protein kinase c epsilon type 0.044 0.0933 0.0886
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Brugia malayi GCC2 and GCC3 family protein 0.1036 0.2643 0.2635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0337 0.064 0.0475
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Brugia malayi Prion-like- 0.0168 0.0153 0.0142
Brugia malayi Thioredoxin reductase 0.3603 1 1
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0731 0.2248
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Giardia lamblia Kinase, NEK 0.0293 0.0514 0.1068
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0185 0.0204 0.0153
Trypanosoma brucei polo-like protein kinase 0.0582 0.1341 0.1273
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0182 0.0194 0.0117
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0263 0.0428 0.0418
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0187 0.0209 0.0209
Schistosoma mansoni tyrosine kinase 0.0438 0.0928 0.0919
Echinococcus multilocularis Immunoglobulin 0.0661 0.1568 0.1524
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0159 0.0129 0.0129
Entamoeba histolytica cell division protein kinase 2, putative 0.0272 0.0453 0.1776
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.02 0.0247 0.0237
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.05 0.1106 0.1106
Entamoeba histolytica protein kinase, putative 0.0217 0.0296 0.1045
Onchocerca volvulus 0.0414 0.0859 0.3725
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0263 0.0428 0.0353
Loa Loa (eye worm) hypothetical protein 0.0256 0.0407 0.0407
Schistosoma mansoni tyrosine kinase 0.0647 0.1527 0.1518
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0717 0.1728 0.1728
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0256 0.0407 0.0407
Toxoplasma gondii selenide, water dikinase 0.0331 0.0623 0.0549
Trichomonas vaginalis CK1 family protein kinase 0.0234 0.0344 0.1058
Brugia malayi pregnancy-associated plasma protein-A 0.0672 0.1599 0.159
Schistosoma mansoni slit 0.0168 0.0155 0.0144
Leishmania major hypothetical protein, conserved 0.0331 0.0623 0.0549
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0331 0.0623 0.0549
Loa Loa (eye worm) one IG domain family member 0.0168 0.0153 0.0153
Schistosoma mansoni tyrosine kinase 0.0621 0.1452 0.1442
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Leishmania major protein kinase A catalytic subunit isoform 1 0.0244 0.0371 0.0296
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0168 0.0155 0.0103
Echinococcus granulosus neurogenic locus notch protein 0.0364 0.0716 0.0668
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0934 0.2351 0.2311
Echinococcus multilocularis tyrosine protein kinase Blk 0.0268 0.0441 0.0391
Echinococcus multilocularis basement membrane specific heparan sulfate 0.02 0.0247 0.0197
Entamoeba histolytica protein kinase, putative 0.0254 0.04 0.1527
Brugia malayi hypothetical protein 0.02 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0141 0.0077 0.0077
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0331 0.0623 0.1915
Giardia lamblia Kinase, NEK 0.0293 0.0514 0.1068
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0312 0.0567 0.0518
Onchocerca volvulus 0.0187 0.0209 0.0859
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0347 0.0667 0.0619
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0759 0.1849 0.184
Brugia malayi Cam kinase protein 1 0.0217 0.0296 0.0285
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0187 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Trypanosoma brucei SNF1-related protein kinases, putative 0.0169 0.0156 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.0428 0.0418
Echinococcus granulosus aurora kinase A 0.0254 0.04 0.035
Brugia malayi serine/threonine-protein kinase plk-2 0.0582 0.1341 0.1332
Schistosoma mansoni titin 0.0187 0.0209 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.0468 0.1438
Echinococcus multilocularis titin 0.0168 0.0153 0.0102
Trypanosoma brucei cdc2-related kinase 1 0.0256 0.0407 0.0331
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0256 0.0407 0.0331
Loa Loa (eye worm) AUR protein kinase 0.0254 0.04 0.04
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0368 0.0728 0.0718
Trypanosoma cruzi polo-like protein kinase, putative 0.0582 0.1341 0.1332
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0246 0.0378 0.0378
Onchocerca volvulus 0.0168 0.0153 0.0611
Onchocerca volvulus 0.0672 0.1599 0.6994
Brugia malayi SH2 domain containing protein 0.0471 0.1023 0.1014
Brugia malayi Immunoglobulin I-set domain containing protein 0.1604 0.427 0.4264
Entamoeba histolytica protein kinase domain containing protein 0.0216 0.0291 0.1024
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Loa Loa (eye worm) thioredoxin reductase 0.3603 1 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0436 0.0924 0.0877
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0216 0.0291 0.012
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0331 0.0623 0.2561
Echinococcus granulosus cyclin dependent kinase 9 0.0164 0.0143 0.0092
Echinococcus granulosus hemicentin 1 0.0368 0.0728 0.0679
Echinococcus multilocularis cyclin dependent kinase 0.0256 0.0407 0.0357
Entamoeba histolytica casein kinase, putative 0.0216 0.0291 0.1024
Loa Loa (eye worm) AGC/PKN protein kinase 0.0626 0.1467 0.1467
Onchocerca volvulus 0.0672 0.1599 0.6994
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.0531 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Schistosoma mansoni hypothetical protein 0.0187 0.0209 0.0199
Entamoeba histolytica casein kinase 1, putative 0.0234 0.0344 0.1269
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0331 0.0623 0.0612
Onchocerca volvulus Tyrosine kinase homolog 0.091 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0369 0.0729 0.0729
Brugia malayi Protein kinase domain containing protein 0.0647 0.1527 0.1518
Echinococcus multilocularis rac serine:threonine kinase 0.0354 0.0687 0.0638
Plasmodium vivax glycogen synthase kinase 3, putative 0.0277 0.0468 0.0299
Loa Loa (eye worm) hypothetical protein 0.02 0.0247 0.0247
Loa Loa (eye worm) AGC/PKA protein kinase 0.0244 0.0371 0.0371
Onchocerca volvulus 0.0194 0.0228 0.0939
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.044 0.0933 0.0933
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.079 0.1937 0.1895
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0331 0.0623 0.0574
Loa Loa (eye worm) hypothetical protein 0.0226 0.0322 0.0322
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0331 0.0623 0.0574
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.1248 0.3251 0.3198
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Onchocerca volvulus 0.0672 0.1599 0.6994
Echinococcus granulosus tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0343 0.0655 0.0582
Brugia malayi Protein kinase domain containing protein 0.0467 0.1012 0.1003
Echinococcus multilocularis C type lectin domian containing protein 0.0672 0.1599 0.1556
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0217 0.0296 0.0125
Echinococcus multilocularis dual specificity 0.0299 0.0531 0.0482
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0244 0.0371 0.0296
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Onchocerca volvulus 0.0141 0.0077 0.0276
Echinococcus granulosus cyclin dependent kinase 19 0.1183 0.3063 0.3027
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0252 0.0396 0.0386
Schistosoma mansoni hypothetical protein 0.0219 0.0301 0.0291
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0217 0.0296 0.022
Entamoeba histolytica protein kinase, putative 0.0263 0.0428 0.1658
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0187 0.0209 0.0158
Giardia lamblia Kinase, CK1 Casein kinase 0.0234 0.0344 0.0514
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0179 0.0186 0.0109
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0182 0.0194 0.0143
Echinococcus multilocularis myosin iiia 0.0183 0.0196 0.0145
Schistosoma mansoni vam6/vps39 related 0.0241 0.0362 0.0352
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Entamoeba histolytica p21-activated kinase 0.0202 0.0251 0.0838
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0258 0.0414 0.0414
Entamoeba histolytica protein kinase, putative 0.0299 0.0531 0.2137
Giardia lamblia Kinase, CMGC GSK 0.0277 0.0468 0.0917
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0168 0.0153 0.0102
Loa Loa (eye worm) hypothetical protein 0.0246 0.0378 0.0378
Echinococcus granulosus notch 0.0364 0.0716 0.0668
Onchocerca volvulus 0.0364 0.0716 0.3095
Echinococcus multilocularis casein kinase ii subunit alpha 0.0216 0.0291 0.0241
Brugia malayi Protein kinase domain containing protein 0.0354 0.0686 0.0676
Mycobacterium tuberculosis Probable oxidoreductase 0.1248 0.3251 0.2803
Onchocerca volvulus Netrin receptor homolog 0.023 0.0331 0.1398
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Onchocerca volvulus 0.0672 0.1599 0.6994
Brugia malayi Protein kinase domain containing protein 0.0688 0.1645 0.1636
Echinococcus multilocularis fibropellin Ia 0.0364 0.0716 0.0668
Echinococcus multilocularis Immunoglobulin 0.02 0.0247 0.0197
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0118 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.0623 0.0612
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0263 0.0428 0.0353
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Brugia malayi protein kinase C II. 0.044 0.0933 0.0923
Schistosoma mansoni tyrosine kinase 0.0451 0.0965 0.0955
Trypanosoma brucei trypanothione reductase 0.3603 1 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0331 0.0623 0.0574
Echinococcus multilocularis insulin receptor 0.0647 0.1527 0.1483
Brugia malayi hypothetical protein 0.0241 0.0362 0.0352
Trypanosoma cruzi polo-like protein kinase, putative 0.0582 0.1341 0.1332
Brugia malayi Serine/threonine-protein kinase SULU 0.0479 0.1045 0.1035
Loa Loa (eye worm) hypothetical protein 0.0661 0.1568 0.1568
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0217 0.0296 0.0245
Echinococcus multilocularis peroxidasin 0.0369 0.0729 0.0681
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.0186 0.0109
Echinococcus granulosus dual specificity 0.0299 0.0531 0.0482
Giardia lamblia Kinase, CMGC GSK 0.0277 0.0468 0.0917
Brugia malayi RhoGAP domain containing protein 0.0161 0.0135 0.0124
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0465 0.1006 0.096
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0234 0.0344 0.0334
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0266 0.0436 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus granulosus glutamate synthase 0.0331 0.0623 0.0574
Echinococcus multilocularis CDC7 cell division cycle 7 0.0194 0.0228 0.0177
Loa Loa (eye worm) hypothetical protein 0.0862 0.2143 0.2143
Echinococcus granulosus pro neuregulin 2 membrane bound 0.02 0.0247 0.0197
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0181 0.019 0.018
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0492 0.1084 0.1038
Onchocerca volvulus 0.0672 0.1599 0.6994
Echinococcus granulosus insulin receptor 0.0647 0.1527 0.1483
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0244 0.0371 0.0361
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0331 0.0623 0.0574
Plasmodium falciparum ferrodoxin reductase-like protein 0.0331 0.0623 0.0549
Schistosoma mansoni tyrosine kinase 0.0202 0.0253 0.0242
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0244 0.0371 0.0361
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0141 0.0077 0.0026
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0244 0.0371 0.0201
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0181 0.019 0.018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Loa Loa (eye worm) hypothetical protein 0.0414 0.0859 0.0859
Onchocerca volvulus Serine\/threonine kinase homolog 0.0354 0.0686 0.2963
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0217 0.0296 0.022
Giardia lamblia Kinase, CMGC CDK 0.0256 0.0407 0.0719
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0331 0.0623 0.1915
Entamoeba histolytica disulphide oxidoreductase, putative 0.0331 0.0623 0.2561
Echinococcus multilocularis serine:threonine protein kinase N2 0.0279 0.0473 0.0423
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0331 0.0623 0.0612
Echinococcus granulosus tyrosine protein kinase Src64B 0.0329 0.0616 0.0567
Brugia malayi Protein kinase domain containing protein 0.0369 0.0731 0.0721
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0312 0.0567 0.0517
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus granulosus epidermal growth factor receptor 0.0521 0.1166 0.112
Trichomonas vaginalis AGC family protein kinase 0.0254 0.04 0.1229
Loa Loa (eye worm) hypothetical protein 0.0388 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0469 0.1016 0.1007
Schistosoma mansoni cell adhesion molecule 0.0388 0.0784 0.0774
Loa Loa (eye worm) hypothetical protein 0.0401 0.0823 0.0823
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.1248 0.3251 0.3198
Echinococcus granulosus Immunoglobulin subtype 0.02 0.0247 0.0197
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0277 0.0468 0.0468
Echinococcus multilocularis mitogen activated protein kinase 0.0181 0.019 0.0139
Schistosoma mansoni disulfide oxidoreductase 0.0331 0.0623 0.0612
Brugia malayi Immunoglobulin I-set domain containing protein 0.0258 0.0414 0.0403
Onchocerca volvulus 0.0331 0.0623 0.2683
Schistosoma mansoni nephrin 0.0848 0.2105 0.2096
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.019 0.0585
Giardia lamblia Kinase, CAMK CAMKL 0.0185 0.0203 0.0054
Plasmodium vivax thioredoxin reductase, putative 0.3603 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0354 0.0687 0.0638
Entamoeba histolytica PH domain containing protein kinase, putative 0.0354 0.0687 0.2859
Echinococcus granulosus tyrosine protein kinase 0.0331 0.0621 0.0572
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0161 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0233 0.0339 0.0339
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.02 0.0247 0.0237
Schistosoma mansoni tyrosine kinase 0.0451 0.0965 0.0955
Echinococcus granulosus casein kinase I alpha 0.0234 0.0344 0.0294
Loa Loa (eye worm) hypothetical protein 0.0993 0.252 0.252
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0934 0.2351 0.2311
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0331 0.0623 0.0574
Echinococcus granulosus Vam6:Vps39 protein 0.0241 0.0362 0.0312
Echinococcus multilocularis dual specificity 0.0263 0.0428 0.0378
Echinococcus multilocularis dual specificity protein kinase clk2 0.0331 0.0622 0.0573
Schistosoma mansoni cell adhesion molecule 0.0388 0.0784 0.0774
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0274 0.0457 0.0407
Loa Loa (eye worm) hypothetical protein 0.0368 0.0728 0.0728
Schistosoma mansoni protein kinase 0.0476 0.1037 0.1027
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0244 0.0371 0.0321
Echinococcus multilocularis expressed conserved protein 0.0182 0.0194 0.0143
Onchocerca volvulus 0.0364 0.0716 0.3095
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0183 0.0196 0.0185
Echinococcus multilocularis raf serine:threonine protein kinase 0.016 0.0131 0.008
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0343 0.0655 0.0645
Trichomonas vaginalis AGC family protein kinase 0.0254 0.04 0.1229
Brugia malayi Muscle positioning protein 4 0.0364 0.0716 0.0706
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0217 0.0296 0.0296
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0354 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0299 0.0529 0.0529
Schistosoma mansoni ste20-related kinase 0.0442 0.0939 0.093
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0156 0.0481
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0391 0.0794 0.0746
Onchocerca volvulus Putative cubilin 0.0364 0.0716 0.3095
Echinococcus multilocularis 0.0207 0.0267 0.0216
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0343 0.0655 0.0582
Brugia malayi glutamate synthase 0.0331 0.0623 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.1178 0.1168
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0254 0.04 0.1527
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0759 0.1849 0.1849
Onchocerca volvulus 0.0364 0.0716 0.3095
Schistosoma mansoni adapter molecule crk 0.0132 0.0052 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0731 0.2248
Brugia malayi Variant SH3 domain containing protein 0.0132 0.0052 0.0041
Echinococcus granulosus Immunoglobulin 0.02 0.0247 0.0197
Brugia malayi Calcium binding EGF domain containing protein 0.0364 0.0716 0.0706
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Brugia malayi Hr1 repeat family protein 0.0626 0.1467 0.1458
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.1248 0.3251 1
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.0457 0.0447
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0329 0.0616 0.0567
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.1248 0.3251 0.3216
Brugia malayi Egg laying defective protein 4 0.0182 0.0194 0.0183
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0153 0.0153
Brugia malayi Fibronectin type III domain containing protein 0.0681 0.1624 0.1615
Plasmodium falciparum cGMP-dependent protein kinase 0.0182 0.0194 0.0117
Loa Loa (eye worm) hypothetical protein 0.1029 0.2623 0.2623
Schistosoma mansoni protein kinase 0.0185 0.0204 0.0194
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0217 0.0296 0.0285
Echinococcus multilocularis mitogen activated protein kinase 14 0.0343 0.0655 0.0607
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0274 0.0457 0.0457
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0331 0.0623 0.0549
Echinococcus granulosus roundabout 2 0.0388 0.0784 0.0736
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0241 0.0362 0.0352
Echinococcus multilocularis protein tyrosine kinase 0.0621 0.1452 0.1407
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0217 0.0296 0.0245
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0667 0.1583 0.1539
Brugia malayi Prion-like- 0.0168 0.0153 0.0142
Brugia malayi serine/threonine protein kinase 6 0.0254 0.04 0.0389
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0153 0.0153
Onchocerca volvulus 0.0137 0.0065 0.0221
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0331 0.0623 0.0612
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0391 0.0794 0.0746
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.0291 0.0896
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1064 0.2724 0.2686
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Trichomonas vaginalis glutathione reductase, putative 0.1248 0.3251 1
Entamoeba histolytica casein kinase, putative 0.0234 0.0344 0.1269
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0667 0.1583 0.1539
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0966 0.2441 0.2441
Loa Loa (eye worm) casein kinase 0.0388 0.0785 0.0785
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0331 0.0623 0.0549
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0161 0.0135 0.0083
Brugia malayi Variant SH3 domain containing protein 0.0161 0.0135 0.0124
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0153 0.0142
Schistosoma mansoni protein kinase 0.0571 0.1308 0.1299
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0181 0.019 0.018
Schistosoma mansoni protein kinase 0.0934 0.2351 0.2343
Loa Loa (eye worm) hypothetical protein 0.02 0.0247 0.0247
Trypanosoma cruzi aurora B kinase, putative 0.0254 0.04 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.1183 0.3063 0.3056
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0368 0.0728 0.3147
Entamoeba histolytica PH domain containing protein kinase, putative 0.026 0.0418 0.1611
Toxoplasma gondii AGC kinase 0.0244 0.0371 0.0296
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0331 0.0623 0.0549
Giardia lamblia Kinase, CMGC CLK 0.0331 0.0622 0.142
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.0414 0.0403
Brugia malayi Cyclin, N-terminal domain containing protein 0.0878 0.219 0.2182
Echinococcus granulosus tyrosine protein kinase Lyn 0.04 0.0821 0.0773
Brugia malayi putative serine/threonine kinase SADA gamma 0.0169 0.0156 0.0146
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0168 0.0153 0.0102
Onchocerca volvulus 0.0307 0.0554 0.238
Loa Loa (eye worm) TK protein kinase 0.04 0.0819 0.0819
Echinococcus multilocularis rho associated protein kinase 0.07 0.168 0.1637
Onchocerca volvulus 0.07 0.168 0.7349
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0347 0.0667 0.0619
Trypanosoma cruzi NADH dehydrogenase, putative 0.0331 0.0623 0.0612
Echinococcus multilocularis neurogenic locus protein delta 0.0364 0.0716 0.0668
Plasmodium falciparum calcium-dependent protein kinase 3 0.0217 0.0296 0.022
Plasmodium falciparum thioredoxin reductase 0.1248 0.3251 0.3198
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0432 0.0912 0.0865
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.0622 0.0611
Toxoplasma gondii AGC kinase 0.0244 0.0371 0.0296
Schistosoma mansoni netrin receptor unc5 0.0263 0.0426 0.0415
Echinococcus granulosus activin receptor type 0.0141 0.0078 0.0026
Echinococcus multilocularis slit 2 protein 0.0412 0.0853 0.0806
Echinococcus granulosus calcium dependent protein kinase 0.0146 0.0091 0.004
Brugia malayi Delta serrate ligand family protein 0.0364 0.0716 0.0706
Echinococcus granulosus raf serine:threonine protein kinase 0.016 0.0131 0.008
Brugia malayi hypothetical protein 0.0681 0.1624 0.1615
Schistosoma mansoni tyrosine kinase 0.0521 0.1166 0.1156
Onchocerca volvulus 0.0672 0.1599 0.6994
Trichomonas vaginalis AGC family protein kinase 0.0244 0.0371 0.1141
Echinococcus multilocularis titin 0.0168 0.0153 0.0102
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0331 0.0622 0.0611
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0298 0.0526 0.1619
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0436 0.0924 0.0914
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.1248 0.3251 0.3244
Plasmodium vivax apical sushi protein, putative 0.0672 0.1599 0.1451
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0613 0.143 0.143
Brugia malayi p70 ribosomal S6 kinase beta 0.0613 0.143 0.1421
Brugia malayi Protein kinase domain containing protein 0.0263 0.0428 0.0418
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0354 0.0686 0.0638
Brugia malayi Protein kinase domain containing protein 0.0327 0.0611 0.0601
Trypanosoma cruzi casein kinase II, putative 0.0216 0.0291 0.0281
Brugia malayi Prion-like- 0.0168 0.0153 0.0142
Schistosoma mansoni kinase 0.0164 0.0143 0.0132
Echinococcus multilocularis roundabout 2 0.0388 0.0784 0.0736
Brugia malayi Tyrosine-protein kinase abl-1 0.0202 0.0253 0.0242
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0142 0.0081 0.0048
Loa Loa (eye worm) disorganized muscle protein 1 0.0168 0.0153 0.0153
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0183 0.0196 0.0582
Brugia malayi Protein kinase domain containing protein 0.0141 0.0077 0.0067
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0169 0.0156 0.0079
Onchocerca volvulus 0.0141 0.0077 0.0276
Echinococcus granulosus dual specificity 0.0299 0.0531 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0176 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0143 0.0132
Brugia malayi Prion-like- 0.0368 0.0728 0.0718
Brugia malayi Immunoglobulin I-set domain containing protein 0.0368 0.0728 0.0718
Echinococcus granulosus protein kinase c iota type 0.0615 0.1437 0.1392
Loa Loa (eye worm) TK/INSR protein kinase 0.0647 0.1527 0.1527
Entamoeba histolytica PH domain containing protein kinase, putative 0.026 0.0418 0.1611
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0277 0.0468 0.0393
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0331 0.0622 0.0548
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0368 0.0728 0.0728
Echinococcus granulosus cGMP dependent protein kinase 0.0182 0.0194 0.0143
Schistosoma mansoni protein kinase 0.0934 0.2351 0.2343
Loa Loa (eye worm) hypothetical protein 0.0528 0.1185 0.1185
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Loa Loa (eye worm) cyclin domain-containing protein 0.0878 0.219 0.219
Echinococcus granulosus tyrosine kinase 0.0141 0.0077 0.0026
Echinococcus granulosus roundabout 2 0.1049 0.2679 0.2641
Schistosoma mansoni protein kinase 0.0141 0.0078 0.0067
Schistosoma mansoni tyrosine kinase 0.0138 0.0067 0.0056
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0849 0.2106 0.2106
Schistosoma mansoni growth factor receptor-bound protein 0.0134 0.0058 0.0047
Onchocerca volvulus 0.0629 0.1475 0.6447
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Loa Loa (eye worm) TK/EPH protein kinase 0.0246 0.0377 0.0377
Echinococcus multilocularis death associated protein kinase 1 0.0958 0.242 0.238
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0215 0.029 0.029
Brugia malayi Fes/CIP4 homology domain containing protein 0.022 0.0304 0.0293
Loa Loa (eye worm) TK protein kinase 0.0268 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0187 0.0209 0.0209
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0172 0.0167 0.0116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0329 0.0616 0.0567
Loa Loa (eye worm) hypothetical protein 0.0168 0.0153 0.0153
Schistosoma mansoni laminin gamma-3 chain 0.0364 0.0716 0.0706
Echinococcus multilocularis neuroglian 0.0829 0.2048 0.2007
Brugia malayi Immunoglobulin domain containing protein 0.02 0.0247 0.0237
Echinococcus granulosus mitogen activated protein kinase 11 0.0343 0.0655 0.0607
Brugia malayi Animal haem peroxidase family protein 0.0168 0.0153 0.0142
Plasmodium vivax protein kinase Crk2 0.0256 0.0407 0.0237
Plasmodium vivax calcium-dependent protein kinase, putative 0.0217 0.0296 0.0125
Echinococcus multilocularis PAK box P21 Rho binding 0.0139 0.0071 0.0019
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0274 0.0457 0.0447
Brugia malayi kettin 0.0168 0.0153 0.0142
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0181 0.019 0.0113
Entamoeba histolytica protein kinase domain containing protein 0.0277 0.0468 0.1842
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0364 0.0716 0.0706
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0132 0.0052 0.0041
Plasmodium falciparum serine/threonine protein kinase KIN 0.0169 0.0156 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.0453 0.1395
Brugia malayi Kinase associated domain 1 family protein 0.0219 0.0301 0.0291
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Brugia malayi hypothetical protein 0.0672 0.1599 0.159
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0176 0.0542
Trichomonas vaginalis STE family protein kinase 0.0183 0.0196 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.0623 0.0612
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0331 0.0623 0.2561
Loa Loa (eye worm) TK/FAK protein kinase 0.0627 0.1471 0.1471
Brugia malayi Sex muscle abnormal protein 5 0.0132 0.0052 0.0041
Plasmodium falciparum casein kinase 2, alpha subunit 0.0216 0.0291 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0329 0.0616 0.0567
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0465 0.1006 0.096
Echinococcus multilocularis serine:threonine protein kinase N2 0.0347 0.0667 0.0619
Brugia malayi Protein kinase domain 0.0185 0.0204 0.0194
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0217 0.0296 0.0245
Echinococcus multilocularis mitogen activated protein kinase 11 0.0343 0.0655 0.0607
Brugia malayi Protein kinase domain containing protein 0.0417 0.0869 0.0859
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0465 0.1006 0.096
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0118 0.0011 0.0011
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Echinococcus multilocularis 0.026 0.0417 0.0367
Loa Loa (eye worm) TK protein kinase 0.0197 0.0237 0.0237
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0525 0.1178 0.1132
Onchocerca volvulus 0.0168 0.0153 0.0611
Entamoeba histolytica protein kinase, putative 0.0142 0.0081 0.0048
Brugia malayi Protein kinase domain containing protein 0.0629 0.1477 0.1468
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0244 0.0371 0.0361
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1248 0.3251 0.3198
Entamoeba histolytica protein kinase, putative 0.0613 0.143 0.6307
Echinococcus granulosus protein jagged 2 0.0364 0.0716 0.0668
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0244 0.0371 0.0296
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.079 0.1937 0.1895
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0331 0.0623 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.0759 0.1849 0.184
Echinococcus granulosus c4b binding protein beta chain 0.0672 0.1599 0.1556
Trichomonas vaginalis CAMK family protein kinase 0.0582 0.1341 0.4125
Echinococcus granulosus casein kinase I alpha 0.0234 0.0344 0.0294
Leishmania major protein kinase, putative 0.0254 0.04 0.0324
Echinococcus granulosus serine threonine protein kinase nrc 0.0337 0.064 0.0591
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0331 0.0623 0.0549
Echinococcus granulosus serine:threonine protein kinase 0.0246 0.0378 0.0328
Mycobacterium ulcerans flavoprotein disulfide reductase 0.1248 0.3251 1
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1248 0.3251 0.3244
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0661 0.1568 0.1524
Echinococcus multilocularis 0.0168 0.0153 0.0102
Loa Loa (eye worm) hypothetical protein 0.0192 0.0224 0.0224
Entamoeba histolytica protein kinase domain containing protein 0.0141 0.0078 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0388 0.0784 0.0784
Brugia malayi basement membrane proteoglycan 0.02 0.0247 0.0237
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0299 0.0531 0.0531
Schistosoma mansoni c4b-binding protein beta chain 0.0672 0.1599 0.159
Schistosoma mansoni serine/threonine protein kinase 0.0528 0.1186 0.1176
Loa Loa (eye worm) AGC/PKA protein kinase 0.0244 0.0371 0.0371
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.1248 0.3251 0.3216
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0181 0.019 0.0113
Echinococcus multilocularis casein kinase I delta 0.0234 0.0344 0.0294
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Schistosoma mansoni glutamate synthase 0.0331 0.0623 0.0612
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0661 0.1568 0.1559
Toxoplasma gondii rhoptry neck protein RON9 0.0672 0.1599 0.1534
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.1248 0.3251 0.3198
Loa Loa (eye worm) TK/FER protein kinase 0.0141 0.0077 0.0077
Entamoeba histolytica serine/threonine protein kinase, putative 0.0582 0.1341 0.5895
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0569 0.1304 0.1259
Echinococcus multilocularis Immunoglobulin 0.02 0.0247 0.0197
Loa Loa (eye worm) notch protein 0.0364 0.0716 0.0716
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0331 0.0623 0.0574
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0185 0.0204 0.0153
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0179 0.0186 0.0176
Echinococcus multilocularis ephrin type A receptor 4 A 0.0208 0.0268 0.0218
Schistosoma mansoni hypothetical protein 0.02 0.0247 0.0237
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0582 0.1341 0.1341
Leishmania major protein kinase A catalytic subunit 0.0244 0.0371 0.0296
Schistosoma mansoni tyrosine kinase 0.0747 0.1815 0.1806
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Echinococcus multilocularis casein kinase i 0.0234 0.0344 0.0294
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0209 0.0199
Loa Loa (eye worm) hypothetical protein 0.0244 0.0371 0.0371
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0176 0.0176 0.0125
Brugia malayi cell division control protein 2 homolog 0.0256 0.0407 0.0396
Entamoeba histolytica protein kinase, putative 0.0277 0.0468 0.1842
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0248 0.0384 0.0334
Echinococcus multilocularis protein kinase shaggy 0.0277 0.0468 0.0418
Schistosoma mansoni protein kinase 0.0234 0.0344 0.0334
Echinococcus granulosus tyrosine protein kinase Src42A 0.02 0.0246 0.0196
Echinococcus granulosus Immunoglobulin 0.02 0.0247 0.0197
Trichomonas vaginalis AGC family protein kinase 0.0629 0.1477 0.4542
Echinococcus multilocularis activin receptor type 0.0141 0.0078 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0331 0.0623 0.0549
Giardia lamblia Kinase, CDC7 0.0194 0.0228 0.0134
Loa Loa (eye worm) hypothetical protein 0.0138 0.0068 0.0068
Brugia malayi EGF-like domain containing protein 0.0364 0.0716 0.0706
Schistosoma mansoni notch 0.0364 0.0716 0.0706
Onchocerca volvulus 0.0258 0.0414 0.1761
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0256 0.0407 0.0407
Echinococcus granulosus ephrin type A receptor 4 A 0.0208 0.0268 0.0218
Schistosoma mansoni titin 0.0168 0.0153 0.0142
Loa Loa (eye worm) hypothetical protein 0.0217 0.0296 0.0296
Trypanosoma brucei cdc2-related kinase 3 0.0256 0.0407 0.0331
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0241 0.0362 0.0352
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0521 0.1166 0.112
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0176 0.0176 0.0176
Schistosoma mansoni titin 0.0168 0.0153 0.0142
Echinococcus granulosus defective proboscis extension response 0.0661 0.1568 0.1524
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.02 0.0247 0.0197
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0179 0.0186 0.0186
Giardia lamblia Thioredoxin reductase 0.0331 0.0623 0.1423
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0528 0.1186 0.114
Echinococcus multilocularis serine:threonine protein kinase 0.0246 0.0378 0.0328
Echinococcus granulosus casein kinase ii subunit alpha 0.0216 0.0291 0.0241
Loa Loa (eye worm) hypothetical protein 0.0499 0.1104 0.1104
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0277 0.0468 0.0457
Plasmodium vivax casein kinase 1, putative 0.0234 0.0344 0.0174
Schistosoma mansoni hypothetical protein 0.0364 0.0716 0.0706
Echinococcus multilocularis lachesin 0.0368 0.0728 0.0679
Toxoplasma gondii casein kinase I 0.0234 0.0344 0.0268
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0528 0.1186 0.1186
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0119 0.0015 0.0015
Loa Loa (eye worm) gastrulation defective protein 1 0.1112 0.2859 0.2859
Loa Loa (eye worm) AGC/AKT protein kinase 0.0629 0.1477 0.1477
Trichomonas vaginalis AGC family protein kinase 0.0363 0.0714 0.2195
Loa Loa (eye worm) TK/ROR protein kinase 0.0238 0.0354 0.0354
Echinococcus multilocularis netrin receptor unc 5 0.0263 0.0426 0.0376
Trichomonas vaginalis AGC family protein kinase 0.0385 0.0778 0.2392
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.0453 0.1395
Schistosoma mansoni protein kinase C mu 0.0469 0.1016 0.1007
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.0407 0.1251
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0459 0.0988 0.0988
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0331 0.0622 0.0611
Plasmodium falciparum serine/threonine protein kinase 0.0179 0.0186 0.0109
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0343 0.0655 0.0645
Loa Loa (eye worm) hypothetical protein 0.0672 0.1599 0.1599
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0331 0.0623 0.1915
Schistosoma mansoni sulfide quinone reductase 0.0331 0.0623 0.0612
Echinococcus granulosus tyrosine protein kinase Blk 0.0268 0.0441 0.0391
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0479 0.1045 0.0998
Schistosoma mansoni hypothetical protein 0.0168 0.0153 0.0142
Schistosoma mansoni neuroglian 0.0388 0.0784 0.0774
Loa Loa (eye worm) hypothetical protein 0.0364 0.0716 0.0716
Giardia lamblia Kinase, AGC PKA 0.0244 0.0371 0.0602
Echinococcus granulosus fibroblast growth factor receptor 4 0.0391 0.0794 0.0746
Plasmodium falciparum thioredoxin reductase 0.3603 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0194 0.0228 0.07
Trichomonas vaginalis CMGC family protein kinase 0.0299 0.0531 0.1634
Brugia malayi Myb-like DNA-binding domain containing protein 0.0168 0.0153 0.0142
Entamoeba histolytica hypothetical protein 0.0263 0.0428 0.1658
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0331 0.0622 0.0611
Schistosoma mansoni titin 0.0368 0.0728 0.0718
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0296 0.091
Echinococcus granulosus rho-associated protein kinase 1 0.07 0.168 0.1637
Echinococcus multilocularis cyclin dependent kinase 19 0.1183 0.3063 0.3027
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.02 0.0247 0.0237
Schistosoma mansoni hypothetical protein 0.0241 0.0362 0.0352

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.5 mg kg-1 Effective dose for reversal of medetomidine-induced loss of righting by subcutaneous administration ChEMBL. 15771448
ED50 (functional) = 2.5 mg kg-1 Effective dose for reversal of medetomidine-induced loss of righting by subcutaneous administration ChEMBL. 15771448
ED50 (functional) > 10 mg kg-1 Effective dose for antagonism of pCA-induced excitation by subcutaneous administration ChEMBL. 15771448
ED50 (functional) > 10 mg kg-1 Effective dose for antagonism of pCA-induced excitation by subcutaneous administration ChEMBL. 15771448
Ki (functional) = 0.1 nM Binding affinity for alpha-2C adrenergic receptor ChEMBL. 15771448
Ki (functional) = 0.1 nM Binding affinity for alpha-2C adrenergic receptor ChEMBL. 15771448
Ki (binding) = 0.2 nM Binding affinity for alpha-2A adrenergic receptor ChEMBL. 15771448
Ki (binding) = 0.2 nM Binding affinity for alpha-2A adrenergic receptor ChEMBL. 15771448
Ki (functional) = 3.6 nM Binding affinity for serotonin transporter ChEMBL. 15771448
Ki (functional) = 3.6 nM Binding affinity for serotonin transporter ChEMBL. 15771448

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.