Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) | Human immunodeficiency virus type 1 Tat protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | squamous cell carcinoma antigen | Human immunodeficiency virus type 1 Tat protein | 86 aa | 79 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.0187 | 0.0187 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0999 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0999 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.0187 | 0.0167 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0999 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2235 | 0.2235 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0999 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0999 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0187 | 0.0187 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.8278 | 0.8278 |
Echinococcus granulosus | dihydrofolate reductase | 0.0999 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0999 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0999 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0999 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0999 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0999 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.033 | 0.3053 | 0.3053 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0999 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.3053 | 1 |
Onchocerca volvulus | 0.0286 | 0.2596 | 1 | |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.002 | 0.002 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0999 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.0187 | 0.0187 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.0187 | 0.0187 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.3053 | 0.3053 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0999 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0999 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2235 | 0.2235 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.8278 | 0.8278 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.3053 | 0.3053 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.3053 | 0.3053 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.8278 | 0.8278 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.0187 | 0.0167 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 19.38 uM | PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibitory concentration against human immuno deficiency virus type 1 integrase (3'-processing) | ChEMBL. | 15634005 |
IC50 (binding) | > 100 uM | Inhibitory concentration against human immuno deficiency virus type 1 integrase (Strand Transfer) | ChEMBL. | 15634005 |
IC50 (binding) | > 100 uM | Inhibitory concentration against human immuno deficiency virus type 1 integrase (3'-processing) | ChEMBL. | 15634005 |
IC50 (binding) | > 100 uM | Inhibitory concentration against human immuno deficiency virus type 1 integrase (Strand Transfer) | ChEMBL. | 15634005 |
Potency (binding) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.