Detailed information for compound 313361

Basic information

Technical information
  • TDR Targets ID: 313361
  • Name: 3-[1-[3-(dimethylamino)propyl]indazol-3-yl]-4 -(1-isoquinolin-4-ylindol-3-yl)pyrrole-2,5-di one
  • MW: 540.614 | Formula: C33H28N6O2
  • H donors: 1 H acceptors: 4 LogP: 4.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(CCCn1nc(c2c1cccc2)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)c1cncc2c1cccc2)C
  • InChi: 1S/C33H28N6O2/c1-37(2)16-9-17-39-27-15-8-6-13-24(27)31(36-39)30-29(32(40)35-33(30)41)25-20-38(26-14-7-5-12-23(25)26)28-19-34-18-21-10-3-4-11-22(21)28/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,35,40,41)
  • InChiKey: LMIPLKOPDQGFNB-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-[1-[3-(dimethylamino)propyl]indazol-3-yl]-4-[1-(4-isoquinolyl)indol-3-yl]pyrrole-2,5-dione
  • 3-[1-[3-(dimethylamino)propyl]-3-indazolyl]-4-[1-(4-isoquinolyl)-3-indolyl]pyrrole-2,5-dione
  • 3-[1-[3-(dimethylamino)propyl]indazol-3-yl]-4-[1-(4-isoquinolyl)indol-3-yl]-3-pyrroline-2,5-quinone
  • 3-[1-(3-dimethylaminopropyl)indazol-3-yl]-4-(1-isoquinolin-4-ylindol-3-yl)pyrrole-2,5-dione
  • 3-[1-(3-dimethylaminopropyl)indazol-3-yl]-4-[1-(4-isoquinolyl)indol-3-yl]pyrrole-2,5-dione
  • 3-[1-(3-dimethylaminopropyl)-3-indazolyl]-4-[1-(4-isoquinolyl)-3-indolyl]pyrrole-2,5-dione
  • 3-[1-(3-dimethylaminopropyl)indazol-3-yl]-4-[1-(4-isoquinolyl)indol-3-yl]-3-pyrroline-2,5-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens protein kinase C, gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0057 0.0317 0.025
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0292 0.02
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Echinococcus multilocularis RNA directed DNA polymerase 0.0143 0.176 0.1708
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0292 0.0964
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0219 0.3039 0.2972
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0143 0.176 0.1708
Echinococcus granulosus tyrosine protein kinase otk 0.0063 0.0419 0.036
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.239 0.2343
Echinococcus multilocularis hemicentin 1 0.0063 0.0419 0.036
Entamoeba histolytica protein kinase, putative 0.0057 0.0317 0.1087
Schistosoma mansoni tyrosine kinase 0.0176 0.2323 0.2275
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0094 0.011
Toxoplasma gondii selenide, water dikinase 0.0058 0.0327 0.0235
Treponema pallidum NADH oxidase 0.0219 0.3039 1
Brugia malayi Protein kinase c protein 2 0.019 0.2558 0.2507
Echinococcus multilocularis cyclin 0.0099 0.1018 0.0963
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0065 0.0451 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0419 0.036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.1814 0.1757
Echinococcus granulosus protein kinase c iota type 0.0195 0.2646 0.26
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.3039 0.2803
Brugia malayi Protein kinase domain containing protein 0.0056 0.0292 0.0225
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0204 0.2786 0.2741
Schistosoma mansoni protein kinase C 0.0043 0.0071 0.0009
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0063 0.0419 0.1665
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0065 0.0451 0.036
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0058 0.0327 0.0267
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Schistosoma mansoni tyrosine kinase 0.0067 0.0487 0.0428
Onchocerca volvulus Slit protein homolog 0.0064 0.0423 0.1685
Loa Loa (eye worm) hypothetical protein 0.0181 0.2407 0.2407
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0058 0.0327 0.0267
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0058 0.0327 0.0235
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0094 0.011
Echinococcus granulosus defective proboscis extension response 0.0107 0.1156 0.1101
Echinococcus granulosus roundabout 2 0.0067 0.0478 0.0419
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0058 0.0327 0.0235
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0392 0.0332
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Onchocerca volvulus 0.0058 0.0327 0.1224
Schistosoma mansoni cell adhesion molecule 0.0146 0.1805 0.1754
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0392 0.1452
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0057 0.0317 0.0257
Giardia lamblia High cysteine protein 0.0064 0.0423 0.1118
Loa Loa (eye worm) hypothetical protein 0.0067 0.0478 0.0478
Echinococcus granulosus neuroglian 0.0067 0.0478 0.0419
Onchocerca volvulus 0.0118 0.1335 0.6044
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0219 0.3039 0.2972
Schistosoma mansoni cell polarity protein 0.0064 0.0423 0.0364
Trichomonas vaginalis glutathione reductase, putative 0.0219 0.3039 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0058 0.0327 0.0267
Loa Loa (eye worm) hypothetical protein 0.0167 0.2162 0.2162
Entamoeba histolytica protein kinase, putative 0.0057 0.0317 0.1087
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0058 0.0327 0.0235
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0065 0.0451 0.036
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0142 0.1746 0.1695
Onchocerca volvulus 0.0118 0.1335 0.6044
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus granulosus neuroglian 0.0136 0.1639 0.1587
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Plasmodium falciparum thioredoxin reductase 0.0219 0.3039 0.2972
Echinococcus granulosus peroxidasin 0.0063 0.0419 0.036
Leishmania major hypothetical protein, conserved 0.0058 0.0327 0.0235
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0058 0.0327 0.0235
Trypanosoma cruzi NADH dehydrogenase, putative 0.0058 0.0327 0.0235
Schistosoma mansoni laminin gamma-3 chain 0.0064 0.0423 0.0364
Loa Loa (eye worm) Csnk2b protein 0.0044 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Plasmodium falciparum glutathione reductase 0.0219 0.3039 0.2972
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0392 0.0301
Echinococcus multilocularis tyrosine protein kinase otk 0.0063 0.0419 0.036
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0392 0.0332
Loa Loa (eye worm) hypothetical protein 0.0181 0.2411 0.2411
Schistosoma mansoni g1/s-specific cyclin C 0.0199 0.2714 0.2669
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0058 0.0327 0.0235
Brugia malayi Calcium binding EGF domain containing protein 0.0064 0.0423 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Schistosoma mansoni nephrin 0.0139 0.1697 0.1646
Plasmodium falciparum glutathione reductase 0.0631 1 1
Plasmodium vivax unspecified product 0.0166 0.2145 0.2071
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0292 0.0672
Echinococcus multilocularis cyclin dependent kinase 19 0.0132 0.1569 0.1517
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0219 0.3039 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0219 0.3039 0.2995
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Echinococcus multilocularis lachesin 0.0063 0.0419 0.036
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus granulosus protein jagged 1 0.0064 0.0423 0.0364
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Leishmania major casein kinase II, putative 0.0166 0.2145 0.2071
Echinococcus multilocularis peroxidasin 0.0063 0.0419 0.036
Loa Loa (eye worm) AGC/AKT protein kinase 0.0057 0.0317 0.0317
Echinococcus granulosus neural cadherin 0.0064 0.0423 0.0364
Brugia malayi Peroxidasin 0.0063 0.0419 0.0353
Echinococcus multilocularis mitogen activated protein kinase 3 0.0065 0.0451 0.0392
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0392 0.0332
Schistosoma mansoni protein kinase C mu 0.0043 0.0069 0.0007
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0058 0.0327 0.0235
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Echinococcus granulosus serine:threonine protein kinase N2 0.0057 0.0317 0.0257
Echinococcus granulosus neurogenic locus notch protein 4 0.0064 0.0423 0.0364
Schistosoma mansoni tyrosine kinase 0.02 0.2727 0.2682
Trypanosoma brucei cdc2-related kinase 3 0.0056 0.0292 0.02
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0292 0.02
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0132 0.1569 0.1569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Schistosoma mansoni cell adhesion molecule 0.0063 0.0419 0.036
Plasmodium falciparum protein kinase 5 0.0056 0.0292 0.02
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Loa Loa (eye worm) TK/INSR protein kinase 0.02 0.2727 0.2727
Echinococcus granulosus cyclin dependent kinase 19 0.0132 0.1569 0.1517
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0219 0.3039 1
Brugia malayi Protein kinase domain containing protein 0.0132 0.1569 0.1511
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0219 0.3039 0.2972
Loa Loa (eye worm) cyclin domain-containing protein 0.0099 0.1018 0.1018
Echinococcus multilocularis neuroglian 0.0136 0.1639 0.1587
Echinococcus multilocularis protein jagged 1 0.0064 0.0423 0.0364
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0219 0.3039 0.2991
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0219 0.3039 0.2972
Loa Loa (eye worm) hypothetical protein 0.0111 0.1215 0.1215
Schistosoma mansoni neuroglian 0.0067 0.0478 0.0419
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0058 0.0327 0.0235
Trichomonas vaginalis mercuric reductase, putative 0.0219 0.3039 1
Echinococcus multilocularis neurogenic locus protein delta 0.0064 0.0423 0.0364
Echinococcus granulosus casein kinase ii subunit alpha 0.0166 0.2145 0.2097
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0219 0.3039 0.2972
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0392 0.1012
Giardia lamblia Thioredoxin reductase 0.0058 0.0327 0.0791
Loa Loa (eye worm) AGC/PKN protein kinase 0.0057 0.0317 0.0317
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0058 0.0327 0.1135
Entamoeba histolytica casein kinase, putative 0.0166 0.2145 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1558 0.1558
Loa Loa (eye worm) thioredoxin reductase 0.0631 1 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.2229 0.2229
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0057 0.0317 0.0317
Onchocerca volvulus 0.0064 0.0423 0.1685
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0043 0.0069 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0317 0.0257
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0292 0.02
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Echinococcus granulosus neurogenic locus notch protein 0.0064 0.0423 0.0364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Schistosoma mansoni tyrosine kinase 0.018 0.239 0.2343
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0057 0.0317 0.0317
Entamoeba histolytica protein kinase, putative 0.0062 0.0392 0.1452
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0219 0.3039 0.2972
Onchocerca volvulus 0.0118 0.1335 0.6044
Leishmania major hypothetical protein, conserved 0.0058 0.0327 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0292 0.081
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0292 0.0292
Trypanosoma brucei rac serine-threonine kinase, putative 0.0057 0.0317 0.0225
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0067 0.0478 0.0419
Loa Loa (eye worm) notch protein 0.0064 0.0423 0.0423
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0058 0.0327 0.0235
Echinococcus multilocularis neurogenic locus notch protein 0.0064 0.0423 0.0364
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0058 0.0327 0.0235
Loa Loa (eye worm) TK/EGFR protein kinase 0.0284 0.415 0.415
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0111 0.1215 0.1215
Brugia malayi Casein kinase II, alpha chain 0.0166 0.2145 0.2091
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0065 0.0451 0.036
Schistosoma mansoni cell adhesion molecule 0.0067 0.0478 0.0419
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0219 0.3039 0.2972
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0168 0.0107
Brugia malayi p70 ribosomal S6 kinase beta 0.0057 0.0317 0.025
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Echinococcus multilocularis serine:threonine protein kinase N2 0.0057 0.0317 0.0257
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0058 0.0327 0.0927
Schistosoma mansoni cell adhesion molecule 0.0067 0.0478 0.0419
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.01 0.1041 0.1041
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0327 0.0235
Entamoeba histolytica protein kinase, putative 0.0057 0.0317 0.1087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.0094 0.0033
Echinococcus granulosus cyclin 0.0099 0.1018 0.0963
Echinococcus granulosus delta-like protein 1 0.0064 0.0423 0.0364
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Echinococcus multilocularis serine:threonine protein kinase N2 0.0057 0.0317 0.0257
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0161 0.2059 0.2004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0219 0.3039 1
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0451 0.1343
Schistosoma mansoni tyrosine kinase 0.0176 0.2323 0.2275
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Brugia malayi glutamate synthase 0.0058 0.0327 0.026
Echinococcus granulosus slit 2 protein 0.0064 0.0423 0.0364
Echinococcus multilocularis serine threonine protein kinase 0.0205 0.2806 0.2762
Echinococcus granulosus RNA directed DNA polymerase 0.0143 0.176 0.1708
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0058 0.0327 0.0267
Echinococcus granulosus epidermal growth factor receptor 0.0284 0.415 0.4113
Schistosoma mansoni unc-13 (munc13) 0.0043 0.0071 0.0009
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Trichomonas vaginalis apoptosis inducing factor, putative 0.0058 0.0327 0.0927
Toxoplasma gondii thioredoxin reductase 0.0631 1 1
Echinococcus granulosus lachesin 0.0063 0.0419 0.036
Schistosoma mansoni sulfide quinone reductase 0.0058 0.0327 0.0267
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0063 0.0419 0.0419
Onchocerca volvulus 0.0064 0.0423 0.1685
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0058 0.0327 0.0927
Trypanosoma cruzi NADH dehydrogenase, putative 0.0058 0.0327 0.0235
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.3039 1
Onchocerca volvulus 0.0118 0.1335 0.6044
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0292 0.0232
Schistosoma mansoni unc-13 (munc13) 0.0043 0.0071 0.0009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0219 0.3039 0.2803
Brugia malayi Cadherin domain containing protein 0.0064 0.0423 0.0357
Brugia malayi Prion-like- 0.0063 0.0419 0.0353
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0292 0.0232
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Trypanosoma brucei protein kinase, putative 0.0062 0.0392 0.0301
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Loa Loa (eye worm) hypothetical protein 0.0205 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Echinococcus multilocularis 0.0086 0.0803 0.0746
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0204 0.2786 0.2741
Loa Loa (eye worm) AGC/NDR protein kinase 0.0057 0.0317 0.0317
Echinococcus multilocularis notch 0.0064 0.0423 0.0364
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0392 0.1452
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0058 0.0327 0.0235
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Loa Loa (eye worm) gastrulation defective protein 1 0.0127 0.1495 0.1495
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0064 0.0423 0.0364
Schistosoma mansoni atypical protein kinase C 0.0203 0.2769 0.2724
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0292 0.0232
Plasmodium vivax protein kinase Crk2 0.0056 0.0292 0.02
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0065 0.0451 0.036
Echinococcus multilocularis roundabout 2 0.0067 0.0478 0.0419
Brugia malayi Calcium binding EGF domain containing protein 0.0064 0.0423 0.0357
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Onchocerca volvulus 0.0118 0.1335 0.6044
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Leishmania major hypothetical protein, conserved 0.0058 0.0327 0.0235
Echinococcus multilocularis neurogenic locus notch protein 4 0.0064 0.0423 0.0364
Schistosoma mansoni glutamate synthase 0.0058 0.0327 0.0267
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.0094 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0317 0.0257
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0292 0.0232
Echinococcus multilocularis insulin receptor 0.02 0.2727 0.2682
Plasmodium falciparum casein kinase 2, alpha subunit 0.0166 0.2145 0.2071
Brugia malayi Cadherin domain containing protein 0.0064 0.0423 0.0357
Echinococcus multilocularis fat cadherin tumor suppressor 0.0064 0.0423 0.0364
Giardia lamblia Glutamate synthase 0.0058 0.0327 0.0791
Echinococcus multilocularis protein kinase c iota type 0.0195 0.2646 0.26
Brugia malayi Protein kinase domain containing protein 0.0073 0.0579 0.0514
Toxoplasma gondii CMGC kinase, CK2 family 0.0166 0.2145 0.2071
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Loa Loa (eye worm) hypothetical protein 0.0171 0.2229 0.2229
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Brugia malayi Protein kinase domain containing protein 0.02 0.2727 0.2677
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0451 0.0392
Echinococcus multilocularis epidermal growth factor receptor 0.0284 0.415 0.4113
Giardia lamblia Kinase, CMGC MAPK 0.0065 0.0451 0.1213
Echinococcus multilocularis protein kinase c epsilon type 0.01 0.1041 0.0985
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Onchocerca volvulus 0.0118 0.1335 0.6044
Brugia malayi hypothetical protein 0.0111 0.1215 0.1154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0043 0.0069 0.0069
Giardia lamblia NADH oxidase lateral transfer candidate 0.0219 0.3039 1
Schistosoma mansoni tyrosine kinase 0.018 0.239 0.2343
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0219 0.3039 1
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0292 0.0672
Onchocerca volvulus 0.0064 0.0423 0.1685
Brugia malayi pregnancy-associated plasma protein-A 0.0118 0.1335 0.1275
Echinococcus multilocularis Immunoglobulin 0.0107 0.1156 0.1101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0107 0.1156 0.1156
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0219 0.3039 0.2972
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0219 0.3039 0.2995
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0058 0.0327 0.0235
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0053 0.0243 0.0645
Echinococcus multilocularis protein jagged 2 0.0064 0.0423 0.0364
Trypanosoma brucei protein kinase, putative 0.0065 0.0451 0.036
Trypanosoma cruzi trypanothione reductase, putative 0.0219 0.3039 0.2972
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0058 0.0327 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0043 0.0071 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0166 0.2145 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1215 0.1215
Plasmodium falciparum apical sushi protein 0.0118 0.1335 0.1252
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.3454 0.3413
Echinococcus granulosus roundabout 2 0.0067 0.0478 0.0419
Schistosoma mansoni sulfide quinone reductase 0.0058 0.0327 0.0267
Schistosoma mansoni glutamate synthase 0.0058 0.0327 0.0267
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0219 0.3039 0.2995
Echinococcus granulosus protein kinase c epsilon type 0.01 0.1041 0.0985
Loa Loa (eye worm) cyclin C 0.0199 0.2714 0.2714
Echinococcus multilocularis slit 2 protein 0.0064 0.0423 0.0364
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Echinococcus granulosus fibropellin Ia 0.0064 0.0423 0.0364
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0063 0.0419 0.0419
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0058 0.0327 0.0235
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0065 0.0451 0.036
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0392 0.0301
Echinococcus multilocularis roundabout 2 0.0174 0.2287 0.2239
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Echinococcus granulosus c4b binding protein beta chain 0.0118 0.1335 0.1281
Plasmodium falciparum ferrodoxin reductase-like protein 0.0058 0.0327 0.0235
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0058 0.0327 0.0927
Trypanosoma brucei trypanothione reductase 0.0631 1 1
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Onchocerca volvulus 0.0064 0.0423 0.1685
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.1569 0.1517
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0058 0.0327 0.0267
Leishmania major NADH dehydrogenase, putative 0.0058 0.0327 0.0235
Echinococcus multilocularis mitogen activated protein kinase 0.0065 0.0451 0.0392
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0118 0.1335 0.1335
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0219 0.3039 0.2972
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0058 0.0327 0.0267
Brugia malayi Delta serrate ligand family protein 0.0064 0.0423 0.0357
Brugia malayi Hr1 repeat family protein 0.0057 0.0317 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0451 0.1343
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0392 0.0301
Echinococcus multilocularis fibropellin Ia 0.0064 0.0423 0.0364
Loa Loa (eye worm) programmed cell death 8 0.0058 0.0327 0.0327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Brugia malayi Protein kinase domain containing protein 0.0057 0.0317 0.025
Echinococcus granulosus glutamate synthase 0.0058 0.0327 0.0267
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0057 0.0317 0.0317
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0067 0.0478 0.0419
Schistosoma mansoni septate junction protein 0.0063 0.0419 0.036
Echinococcus granulosus hemicentin 1 0.0063 0.0419 0.036
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0058 0.0327 0.0267
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0058 0.0327 0.1135
Schistosoma mansoni glutamate synthase 0.0058 0.0327 0.0267
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Echinococcus multilocularis neuroglian 0.0067 0.0478 0.0419
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0327 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0392 0.1145
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0166 0.2145 0.2145
Echinococcus multilocularis thioredoxin glutathione reductase 0.0631 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0451 0.1343
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.015 0.1873 0.1873
Brugia malayi cell division control protein 2 homolog 0.0056 0.0292 0.0225
Echinococcus granulosus insulin receptor 0.02 0.2727 0.2682
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0058 0.0327 0.0235
Schistosoma mansoni slit 0.0064 0.0423 0.0364
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Toxoplasma gondii AGC kinase 0.0057 0.0317 0.0225
Schistosoma mansoni tyrosine kinase 0.0176 0.2323 0.2275
Schistosoma mansoni protein kinase 0.0166 0.2145 0.2097
Echinococcus multilocularis c4b binding protein beta chain 0.0118 0.1335 0.1281
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0099 0.0038
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0057 0.0317 0.0257
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0631 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.3039 0.2803
Schistosoma mansoni serine/threonine kinase 0.0057 0.0317 0.0257
Echinococcus multilocularis unc 13 (munc13) 0.0043 0.0071 0.0009
Echinococcus multilocularis casein kinase ii subunit alpha 0.0166 0.2145 0.2097
Onchocerca volvulus 0.0118 0.1335 0.6044
Echinococcus granulosus Immunoglobulin 0.0107 0.1156 0.1101
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0317 0.0257
Echinococcus granulosus notch 0.0064 0.0423 0.0364
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0392 0.0301
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0058 0.0327 0.0235
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0058 0.0327 0.0235
Echinococcus granulosus neurogenic locus notch protein 0.0064 0.0423 0.0364
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0058 0.0327 0.0267
Echinococcus multilocularis neurogenic locus protein delta 0.0064 0.0423 0.0364
Echinococcus multilocularis protein jagged 1 0.0064 0.0423 0.0364
Schistosoma mansoni septate junction protein 0.0064 0.0423 0.0364
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0058 0.0327 0.026
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Echinococcus multilocularis hemicentin 1 0.0063 0.0419 0.036
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0166 0.2145 0.2071
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Echinococcus granulosus contactin 0.0067 0.0478 0.0419
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0058 0.0327 0.0235
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0058 0.0327 0.0927
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0292 0.0232
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0219 0.3039 1
Schistosoma mansoni tyrosine kinase 0.0284 0.415 0.4113
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.1215 0.1154
Echinococcus granulosus protein jagged 1 0.0064 0.0423 0.0364
Trypanosoma cruzi casein kinase II, putative 0.0166 0.2145 0.2071
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Echinococcus granulosus NDR protein kinase 0.0057 0.0317 0.0257
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0058 0.0327 0.0267
Echinococcus granulosus mitogen activated protein kinase 0.0065 0.0451 0.0392
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0292 0.02
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus granulosus Protein kinase C brain isozyme 0.0243 0.3454 0.3413
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0451 0.1343
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0392 0.0392
Echinococcus multilocularis glutamate synthase 0.0058 0.0327 0.0267
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0161 0.2059 0.2004
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0478 0.0419
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0219 0.3039 0.2972
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0069 0.0007
Loa Loa (eye worm) hypothetical protein 0.0167 0.2162 0.2162
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0292 0.02
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Schistosoma mansoni c4b-binding protein beta chain 0.0118 0.1335 0.1281
Brugia malayi Muscle positioning protein 4 0.0064 0.0423 0.0357
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0099 0.0031
Trypanosoma brucei Casein kinase II 0.0166 0.2145 0.2071
Loa Loa (eye worm) hypothetical protein 0.0069 0.0512 0.0512
Echinococcus granulosus mitogen activated protein kinase 3 0.0065 0.0451 0.0392
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0292 0.0232
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0152 0.1911 0.1911
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0063 0.0419 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Toxoplasma gondii NADPH-glutathione reductase 0.0219 0.3039 0.2972
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0292 0.081
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0292 0.0964
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0219 0.3039 0.2972
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Brugia malayi intracellular kinase 0.0062 0.0392 0.0326
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0392 0.0332
Echinococcus granulosus neurogenic locus protein delta 0.0064 0.0423 0.0364
Loa Loa (eye worm) hypothetical protein 0.0143 0.176 0.176
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Plasmodium vivax glutathione reductase, putative 0.0631 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0065 0.0451 0.036
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0317 0.0894
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0292 0.0232
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus granulosus protein jagged 2 0.0064 0.0423 0.0364
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0071 0.0552 0.0552
Brugia malayi Cyclin C 0.0199 0.2714 0.2664
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0292 0.0292
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0067 0.0478 0.0478
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0058 0.0327 0.0235
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0243 0.3454 0.3413
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1041 0.0985
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0058 0.0327 0.0235
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Giardia lamblia Kinase, CMGC CK2 0.0166 0.2145 0.6966
Entamoeba histolytica cyclin C, putative 0.01 0.1043 0.4625
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0107 0.1156 0.1156
Brugia malayi Fibronectin type III domain containing protein 0.0111 0.1215 0.1154
Echinococcus granulosus twitchin 0.014 0.1713 0.1662
Echinococcus granulosus protein kinase shaggy 0.0062 0.0392 0.0332
Brugia malayi Thioredoxin reductase 0.0631 1 1
Onchocerca volvulus Putative cubilin 0.0064 0.0423 0.1685
Onchocerca volvulus 0.0118 0.1335 0.6044
Echinococcus granulosus protein kinase C gamma type 0.0205 0.2806 0.2762
Entamoeba histolytica disulphide oxidoreductase, putative 0.0058 0.0327 0.1135
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Brugia malayi notch-like transmembrane receptor 0.0064 0.0423 0.0357
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0058 0.0327 0.0267
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0043 0.0069 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0058 0.0327 0.0927
Schistosoma mansoni roundabout 0.0063 0.0419 0.036
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0292 0.0232
Plasmodium vivax apical sushi protein, putative 0.0118 0.1335 0.1252
Schistosoma mansoni nephrin 0.0067 0.0478 0.0419
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0058 0.0327 0.1135
Trypanosoma brucei NADH dehydrogenase 0.0058 0.0327 0.0235
Loa Loa (eye worm) hypothetical protein 0.0224 0.3132 0.3132
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0064 0.0423 0.0364
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Loa Loa (eye worm) hypothetical protein 0.0142 0.1746 0.1746
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0058 0.0327 0.0267
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Trypanosoma brucei cdc2-related kinase 1 0.0056 0.0292 0.02
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0057 0.0317 0.0257
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0107 0.1156 0.1101
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0392 0.0301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.018 0.239 0.2343
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0292 0.0232
Echinococcus granulosus unc 13 munc13 0.0043 0.0071 0.0009
Loa Loa (eye worm) glutathione reductase 0.0631 1 1
Brugia malayi protein kinase C II. 0.01 0.1041 0.0979
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0099 0.0038
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0107 0.1156 0.1101
Onchocerca volvulus 0.0118 0.1335 0.6044
Echinococcus multilocularis neurogenic locus notch protein 0.0064 0.0423 0.0364
Onchocerca volvulus 0.0167 0.2162 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0099 0.1018 0.0963
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0219 0.3039 1
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0058 0.0327 0.0327
Toxoplasma gondii rhoptry neck protein RON9 0.0118 0.1335 0.1252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0392 0.1012
Schistosoma mansoni vesicular amine transporter 0.011 0.1206 0.1151
Leishmania major trypanothione reductase 0.0631 1 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0064 0.0423 0.1685
Plasmodium vivax thioredoxin reductase, putative 0.0631 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0478 0.0412
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0058 0.0327 0.0267
Echinococcus granulosus roundabout 2 0.0174 0.2287 0.2239
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Echinococcus multilocularis Immunoglobulin 0.0107 0.1156 0.1101
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0064 0.0423 0.0357
Trypanosoma cruzi trypanothione reductase, putative 0.0631 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0064 0.0423 0.0357
Brugia malayi EGF-like domain containing protein 0.0064 0.0423 0.0357
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0058 0.0327 0.0235
Onchocerca volvulus Neurogenic locus notch homolog 0.0064 0.0423 0.1685
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0069 0.0007
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0057 0.0317 0.0257
Brugia malayi protein kinase C3,putative 0.0142 0.175 0.1693
Echinococcus multilocularis C type lectin domian containing protein 0.0118 0.1335 0.1281
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0057 0.0317 0.0257
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0219 0.3039 0.2972
Entamoeba histolytica protein kinase, putative 0.0057 0.0317 0.1087
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0317 0.0257
Entamoeba histolytica thioredoxin reductase, putative 0.0058 0.0327 0.1135
Loa Loa (eye worm) hypothetical protein 0.0167 0.2162 0.2162
Schistosoma mansoni septate junction protein 0.0063 0.0419 0.036
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0057 0.0317 0.0257
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0058 0.0327 0.026
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0419
Onchocerca volvulus 0.0062 0.0392 0.1535
Brugia malayi Csnk2b protein 0.0044 0.0094 0.0026
Echinococcus granulosus epidermal growth factor receptor 0.018 0.239 0.2343
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0058 0.0327 0.0791
Echinococcus granulosus C type lectin domian containing protein 0.0118 0.1335 0.1281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0478 0.0412
Brugia malayi MAP kinase sur-1 0.0065 0.0451 0.0385
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0099 0.0099
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Onchocerca volvulus 0.0118 0.1335 0.6044
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0043 0.0071 0.0009
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0056 0.0292 0.02
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0065 0.0451 0.036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0419 0.0353
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0099 0.1018 0.0963
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0478 0.0419
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0058 0.0327 0.1135
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0146 0.1814 0.1814
Schistosoma mansoni tyrosine kinase 0.02 0.2727 0.2682
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0327 0.0235
Loa Loa (eye worm) hypothetical protein 0.0107 0.1156 0.1156
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0168 0.0107
Toxoplasma gondii EGF family domain-containing protein 0.0064 0.0423 0.0332
Trichomonas vaginalis glutamate synthase, putative 0.0058 0.0327 0.0927
Plasmodium falciparum thioredoxin reductase 0.0631 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0058 0.0327 0.1135
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0094 0.0148
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0107 0.1156 0.1101
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Echinococcus multilocularis neural cadherin 0.0064 0.0423 0.0364
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0392 0.1145
Loa Loa (eye worm) hypothetical protein 0.0064 0.0423 0.0423
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0056 0.0292 0.02
Schistosoma mansoni titin 0.0063 0.0419 0.036
Schistosoma mansoni hypothetical protein 0.0058 0.0327 0.0267
Brugia malayi Cyclin, N-terminal domain containing protein 0.0099 0.1018 0.0956
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Echinococcus multilocularis roundabout 2 0.0067 0.0478 0.0419
Loa Loa (eye worm) hypothetical protein 0.0118 0.1335 0.1335
Loa Loa (eye worm) Notch2 0.0064 0.0423 0.0423
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0058 0.0327 0.0235
Schistosoma mansoni notch 0.0064 0.0423 0.0364
Schistosoma mansoni disulfide oxidoreductase 0.0058 0.0327 0.0267
Echinococcus granulosus thioredoxin glutathione reductase 0.0631 1 1
Brugia malayi GCC2 and GCC3 family protein 0.0181 0.2411 0.2359
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.0094 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.3454 0.3413
Echinococcus granulosus protein jagged 2 0.0064 0.0423 0.0364
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0058 0.0327 0.0327
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0057 0.0317 0.0317
Onchocerca volvulus 0.0064 0.0423 0.1685
Brugia malayi Sushi domain 0.0118 0.1335 0.1275
Brugia malayi hypothetical protein 0.0118 0.1335 0.1275
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0478 0.0419
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0292 0.0232
Plasmodium vivax ferrodoxin reductase, putative 0.0058 0.0327 0.0235
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0478 0.0412
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0065 0.0451 0.0451
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.3039 0.2803
Echinococcus multilocularis serine:threonine protein kinase 38 0.0057 0.0317 0.0257
Trichomonas vaginalis glutamate synthase, putative 0.0058 0.0327 0.0927
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2145 0.7011
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0292 0.081
Brugia malayi Protein kinase domain containing protein 0.0057 0.0317 0.025
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0067 0.0478 0.0419
Toxoplasma gondii rhoptry neck protein RON1 0.0118 0.1335 0.1252
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0219 0.3039 0.2972
Brugia malayi Furin-like cysteine rich region family protein 0.0284 0.415 0.4109
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0219 0.3039 0.2972

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.015 uM Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.015 uM Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (functional) = 0.086 uM Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2 ChEMBL. 15771419
IC50 (functional) = 0.086 uM Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2 ChEMBL. 15771419
IC50 (binding) = 0.092 uM Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.092 uM Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.25 uM Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.25 uM Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.29 uM Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 0.29 uM Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP ChEMBL. 15771419
IC50 (binding) = 1.3 uM Inhibition of rabbit Glycogen synthase kinase-3 beta ChEMBL. 15771419
IC50 (binding) = 1.3 uM Inhibition of rabbit Glycogen synthase kinase-3 beta ChEMBL. 15771419
Ki (binding) = 0.49 uM Inhibition of [3H]-astemizole binding to Potassium channel HERG ChEMBL. 15771419
Ki (binding) = 0.49 uM Inhibition of [3H]-astemizole binding to Potassium channel HERG ChEMBL. 15771419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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